ECSP088102A - Compuestos para el tratamiento de infecciones bacterianas resistentes a múltiples fármacos - Google Patents
Compuestos para el tratamiento de infecciones bacterianas resistentes a múltiples fármacosInfo
- Publication number
- ECSP088102A ECSP088102A EC2008008102A ECSP088102A ECSP088102A EC SP088102 A ECSP088102 A EC SP088102A EC 2008008102 A EC2008008102 A EC 2008008102A EC SP088102 A ECSP088102 A EC SP088102A EC SP088102 A ECSP088102 A EC SP088102A
- Authority
- EC
- Ecuador
- Prior art keywords
- treatment
- compounds
- bacterial infections
- medicaments
- multiple drugs
- Prior art date
Links
- 208000035143 Bacterial infection Diseases 0.000 title abstract 4
- 208000022362 bacterial infectious disease Diseases 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003814 drug Substances 0.000 title abstract 4
- 229940079593 drug Drugs 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract 3
- 241000282412 Homo Species 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 241000282414 Homo sapiens Species 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 abstract 1
- 210000004369 blood Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos que presentan actividad antibacteriana, a procesos para su preparación, a composiciones farmacéuticas que los contienen como ingrediente activo, a su uso como medicamentos y a su uso en la fabricación de medicamentos para uso en el tratamiento de infecciones bacterianas en animales de sangre caliente, tales como seres humanos. En particular, esta invención se refiere a compuestos útiles para el tratamiento de infecciones bacterianas en animales de sangre caliente, tales como seres humanos, más particularmente, al uso de estos compuestos en la fabricación de medicamentos para uso en el tratamiento de infecciones bacterianas en animales de sangre caliente, tales como seres humanos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69134005P | 2005-06-16 | 2005-06-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP088102A true ECSP088102A (es) | 2008-02-20 |
Family
ID=36956054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2008008102A ECSP088102A (es) | 2005-06-16 | 2008-01-11 | Compuestos para el tratamiento de infecciones bacterianas resistentes a múltiples fármacos |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7875715B2 (es) |
| EP (2) | EP1893599A1 (es) |
| JP (1) | JP5204649B2 (es) |
| KR (2) | KR101351160B1 (es) |
| CN (1) | CN101243068B (es) |
| AR (1) | AR054781A1 (es) |
| AU (1) | AU2006258879C1 (es) |
| BR (1) | BRPI0611747A2 (es) |
| CA (1) | CA2610900A1 (es) |
| EC (1) | ECSP088102A (es) |
| IL (1) | IL187581A0 (es) |
| MX (1) | MX2007015297A (es) |
| MY (1) | MY150958A (es) |
| NO (1) | NO20080338L (es) |
| NZ (1) | NZ565110A (es) |
| RU (1) | RU2008100306A (es) |
| TW (1) | TW200716623A (es) |
| UY (1) | UY29608A1 (es) |
| WO (1) | WO2006134378A1 (es) |
| ZA (1) | ZA200710563B (es) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2405848C (en) * | 2000-04-17 | 2010-11-09 | Vivometrics, Inc. | Systems and methods for ambulatory monitoring of physiological signs |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| EP1900732A4 (en) * | 2005-06-24 | 2009-11-18 | Toyama Chemical Co Ltd | NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF |
| ES2340531T3 (es) * | 2005-10-21 | 2010-06-04 | Glaxo Group Limited | Compuestos triciclos peri-condensados utiles como agentes antibacterianos. |
| EP2001887B1 (en) | 2006-04-06 | 2010-09-15 | Glaxo Group Limited | Pyrrolo-quinoxalinone derivatives as antibacterials |
| AU2007268749B2 (en) | 2006-05-26 | 2012-07-26 | Taisho Pharmaceutical Co., Ltd. | Novel heterocyclic compound or salt thereof and intermediate thereof |
| TW200815425A (en) * | 2006-06-08 | 2008-04-01 | Speedel Experimenta Ag | 2,5-disubstituted piperidines |
| EP2049517B1 (en) * | 2006-07-20 | 2013-11-27 | Novartis AG | Amino-piperidine derivatives as cetp inhibitors |
| EP1992628A1 (en) | 2007-05-18 | 2008-11-19 | Glaxo Group Limited | Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones |
| PE20081551A1 (es) * | 2006-07-20 | 2009-01-09 | Glaxo Group Ltd | Derivados de quinolona como antibacterianos |
| US20100144717A1 (en) * | 2006-12-15 | 2010-06-10 | Janelle Comita-Prevoir | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents |
| WO2008071964A1 (en) * | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Naphthyridine bactericides |
| WO2008071981A1 (en) * | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Piperidines for the treatment of bacterial infections |
| WO2008071962A1 (en) * | 2006-12-15 | 2008-06-19 | Astrazeneca Ab | Pteridines and pyrimidinopyridines as antibacterial agents |
| TW200831517A (en) * | 2006-12-15 | 2008-08-01 | Astrazeneca Ab | Chemical compounds |
| GB0707704D0 (en) * | 2007-04-20 | 2007-05-30 | Glaxo Group Ltd | Compounds |
| AU2008240764C1 (en) * | 2007-04-20 | 2011-10-20 | Glaxo Group Limited | Tricyclic nitrogen containing compounds as antibacterial agents |
| GB2452696B (en) | 2007-08-02 | 2009-09-23 | Cambridge Entpr Ltd | 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one and its use in pharmaceutical compositions |
| US7662967B2 (en) | 2007-08-02 | 2010-02-16 | Cambridge Enterprise Limited | Anti-inflammatory compounds and compositions |
| CN101910150B (zh) | 2007-11-05 | 2013-09-18 | 诺瓦提斯公司 | 作为cetp抑制剂、可用于治疗疾病如高脂血症或动脉硬化的4-苄基氨基-1-羧基酰基哌啶衍生物 |
| JP5620636B2 (ja) * | 2007-11-26 | 2014-11-05 | 富山化学工業株式会社 | 新規な複素環化合物またはその塩を含有する抗菌剤 |
| CN101874032B (zh) * | 2007-11-26 | 2013-02-06 | 富山化学工业株式会社 | 二氮杂萘衍生物一水合物及其制备方法 |
| MX2010006063A (es) | 2007-12-03 | 2010-07-01 | Novartis Ag | Derivados de 4-bencil-amino-pirrolidina 1,2-disustituida como inhibidores de la proteina de transferencia de colesteril-ester (cetp) utiles para el tratamiento de las enfermedades tales como hiperlipidemia o arterioesclerosis. |
| KR101592046B1 (ko) | 2008-02-22 | 2016-02-05 | 액테리온 파마슈티칼 리미티드 | 옥사졸리디논 유도체 |
| US7960377B2 (en) | 2008-03-28 | 2011-06-14 | Cara Therapeutics, Inc. | Substituted pyridoxazines |
| TW200944529A (en) | 2008-04-15 | 2009-11-01 | Actelion Pharmaceuticals Ltd | Tricyclic antibiotics |
| MX2010012855A (es) * | 2008-06-03 | 2010-12-21 | Actelion Pharmaceuticals Ltd | Derivados de [4-(1-amino-etil)-ciclohexil]-metil-amina y [6-(1-amino-etil)-tetrahidro-piran-3-il]-metil-amina como antibacterianos. |
| RU2516701C2 (ru) | 2008-10-10 | 2014-05-20 | Актелион Фармасьютиклз Лтд | Оксазолидиниловые антибиотики |
| EP2352734A1 (en) | 2008-10-17 | 2011-08-10 | Glaxo Group Limited | Tricyclic nitrogen compounds used as antibacterials |
| TW201022279A (en) * | 2008-11-14 | 2010-06-16 | Astrazeneca Ab | Chemical compounds |
| AR076222A1 (es) | 2009-04-09 | 2011-05-26 | Actelion Pharmaceuticals Ltd | Derivados 2-hidroxietil-1h-quinolin-ona y sus analogos azaisotericos con actividad antibacteriana y composiciones farmaceuticas que los contienen |
| EP2674430A4 (en) | 2011-02-07 | 2014-07-02 | Daiichi Sankyo Co Ltd | AMINO-GROUP-PYRROLIDINONE DERIVATIVES |
| GB201106814D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compounds |
| RU2014108919A (ru) | 2011-08-11 | 2015-09-20 | Актелион Фармасьютиклз Лтд | Хиназолин-2,4-дионовые производные |
| BR112015001959A2 (pt) * | 2012-08-01 | 2017-07-04 | Merck Sharp & Dohme | composto, composição farmacêutica, métodos para melhorar os déficits cognitivos, para prevenir ou tratar déficits cognitivos distúrbios neurodegenerativos ou neuropsiquiátricos, para o tratamento ou prevenção de doenças inflamatórias e de dor neuropática, uso de um composto, e, processo para preparar um composto |
| WO2014024056A1 (en) | 2012-08-06 | 2014-02-13 | Daiichi Sankyo Company, Limited | Pyrrolidine derivatives with antibacterial properties |
| US10702521B2 (en) | 2014-08-22 | 2020-07-07 | Glaxosmithkline Intellectual Property Development Limited | Methods for treating neisseria gonorrhoeae infection with substituted 1,2-dihydro-2A,5,8A-triazaacenaphthylene-3,8-diones |
| GB201509006D0 (en) * | 2015-05-26 | 2015-07-08 | Redx Pharma Plc | Antibacterial compounds |
| AU2016301188A1 (en) | 2015-08-06 | 2018-02-15 | Chimerix, Inc. | Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents |
| TW201722965A (zh) | 2015-08-16 | 2017-07-01 | 葛蘭素史密斯克藍智慧財產發展有限公司 | 用於抗菌應用之化合物 |
| ME03738B (me) * | 2016-06-08 | 2021-01-20 | Acraf | Novi antibakterijski spojevi |
| CN107641099A (zh) * | 2016-07-20 | 2018-01-30 | 广东东阳光药业有限公司 | 取代的4‑羟基喹啉类化合物的制备方法 |
| WO2018026877A1 (en) | 2016-08-05 | 2018-02-08 | Calitor Sciences, Llc | Process for preparing substituted quinolin-4-ol compounds |
| ES3011607T3 (en) | 2017-09-21 | 2025-04-07 | Chimerix Inc | Morphic forms of 4-amino-7-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-methyl-7h-pyrrolo(2,3-d)pyrimidine-5-carboxamide and uses thereof |
| KR20200115597A (ko) * | 2018-01-29 | 2020-10-07 | 카딜라 핼쓰캐어 리미티드 | 항세균제로서 유용한 헤테로사이클릭 화합물 |
| EP3604288B1 (en) | 2018-08-02 | 2024-04-10 | Development Center for Biotechnology | Regioselective one-step process for synthesizing 2-hydroxyquinoxaline |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CA3150681A1 (en) | 2019-08-14 | 2021-02-18 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| US11851426B2 (en) | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| YU39992B (en) * | 1976-04-02 | 1985-06-30 | Janssen Pharmaceutica Nv | Process for obtaining new piperazine and piperidine derivatives |
| DE2804416A1 (de) * | 1978-02-02 | 1979-08-09 | Boehringer Mannheim Gmbh | Neue purin-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| CA1317940C (en) * | 1987-09-25 | 1993-05-18 | Georges H. P. Van Daele | Substituted n-(1-alkyl-3-hydroxy-4-piperidinyl)benzamides |
| FR2621583B1 (fr) | 1987-10-07 | 1990-02-23 | Pf Medicament | Nouveaux derives de benzotriazine-1,2,4 one-3, leur procede de preparation et les compositions pharmaceutiques les contenant |
| JP2886570B2 (ja) * | 1989-09-29 | 1999-04-26 | エーザイ株式会社 | 縮合ヘテロ環を有する化合物 |
| SE9103752D0 (sv) * | 1991-12-18 | 1991-12-18 | Astra Ab | New compounds |
| US5567711A (en) * | 1995-04-19 | 1996-10-22 | Abbott Laboratories | Indole-3-carbonyl and indole-3-sulfonyl derivatives as platelet activating factor antagonists |
| DE19601265A1 (de) * | 1996-01-16 | 1997-07-17 | Bayer Ag | 2-Oxo- und 2-Thio-1,2-dihydrochinolinyl-oxazolidinone |
| JPH09268121A (ja) | 1996-04-04 | 1997-10-14 | Shiseido Co Ltd | 皮膚外用剤 |
| WO1998007703A1 (en) * | 1996-08-22 | 1998-02-26 | Meiji Seika Kaisha, Ltd. | Quinoline derivatives and psychotropic agent |
| GB9822440D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| GB9822450D0 (en) | 1998-10-14 | 1998-12-09 | Smithkline Beecham Plc | Medicaments |
| JP2002535323A (ja) | 1999-01-20 | 2002-10-22 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | プロテインキナーゼ阻害剤としてのピペリジニルキノリン |
| GB9914486D0 (en) | 1999-06-21 | 1999-08-18 | Smithkline Beecham Plc | Medicaments |
| GB9917406D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| GB9917408D0 (en) | 1999-07-23 | 1999-09-22 | Smithkline Beecham Plc | Compounds |
| EP1305308B1 (en) | 2000-07-26 | 2006-12-20 | Smithkline Beecham Plc | Aminopiperidine quinolines and their azaisosteric analogues with antibacterial activity |
| AU2001280891A1 (en) | 2000-08-01 | 2002-02-13 | Schering Corporation | Uses of mammalian genes and related reagents |
| WO2002020238A1 (en) | 2000-09-05 | 2002-03-14 | Ato B.V. | Expanded biopolymer-based articles and process of producing these |
| AU2002223528A1 (en) * | 2000-09-19 | 2002-04-02 | Boeringer Ingelheim Pharma Gmbh & Co. Kg | New n, n'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors |
| WO2002024684A1 (en) | 2000-09-21 | 2002-03-28 | Smithkline Beecham P.L.C. | Quinoline derivatives as antibacterials |
| FR2816618B1 (fr) * | 2000-11-15 | 2002-12-27 | Aventis Pharma Sa | Derives heterocyclylalcoyl piperidine, leur preparation et les compositions qui les contiennent |
| US6603005B2 (en) * | 2000-11-15 | 2003-08-05 | Aventis Pharma S.A. | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them |
| GB0031088D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0031086D0 (en) | 2000-12-20 | 2001-01-31 | Smithkline Beecham Plc | Medicaments |
| GB0101577D0 (en) | 2001-01-22 | 2001-03-07 | Smithkline Beecham Plc | Compounds |
| FR2822154B1 (fr) | 2001-03-13 | 2005-10-21 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur preparation et les compositions qui les contiennent |
| GB0112834D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
| EP1470131A2 (en) | 2002-01-29 | 2004-10-27 | Glaxo Group Limited | Aminopiperidine compounds, process for their preparation, and pharmaceutical compositions containing them |
| US7312212B2 (en) | 2002-01-29 | 2007-12-25 | Glaxo Group Limited | Aminopiperidine derivatives |
| AR040336A1 (es) * | 2002-06-26 | 2005-03-30 | Glaxo Group Ltd | Compuesto de piperidina, uso del mismo para la fabricacion de un medicamento, composicion farmaceutica que lo comprende y procedimiento para preparar dicho compuesto |
| TW200406413A (en) | 2002-06-26 | 2004-05-01 | Glaxo Group Ltd | Compounds |
| GB0217294D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicaments |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| EP1551829B1 (de) | 2002-10-10 | 2010-04-07 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | Neue verbindungen mit antibakterieller aktivität |
| AR042486A1 (es) | 2002-12-18 | 2005-06-22 | Glaxo Group Ltd | Compuesto de quinolina y naftiridina halosustituido en la posicion 3, procedimiento para preparar el compuesto, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion . |
| TW200507841A (en) | 2003-03-27 | 2005-03-01 | Glaxo Group Ltd | Antibacterial agents |
| FR2852954B1 (fr) * | 2003-03-28 | 2006-07-14 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| US7232833B2 (en) | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| DE10316081A1 (de) | 2003-04-08 | 2004-10-21 | Morphochem AG Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| CN101348824A (zh) * | 2003-06-12 | 2009-01-21 | 卫材R&D管理有限公司 | 神经细胞保护剂 |
| MY145634A (en) | 2003-12-29 | 2012-03-15 | Bristol Myers Squibb Co | Pyrrolotriazine compounds as kinase inhibitors |
| RU2374244C2 (ru) | 2004-01-07 | 2009-11-27 | Арикс Терапьютикс | Стереоизомерные соединения и способы лечения желудочно-кишечных расстройств и расстройств центральной нервной системы |
| WO2006002047A2 (en) | 2004-06-15 | 2006-01-05 | Glaxo Group Limited | Antibacterial agents |
| FR2872164B1 (fr) | 2004-06-29 | 2006-11-17 | Aventis Pharma Sa | Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent |
| EA011552B1 (ru) * | 2004-06-30 | 2009-04-28 | Янссен Фармацевтика Н.В. | Производные хиназолиндиона в качестве ингибиторов parp |
| JP2008505920A (ja) | 2004-07-08 | 2008-02-28 | グラクソ グループ リミテッド | 抗菌剤 |
| JP2008509222A (ja) | 2004-08-09 | 2008-03-27 | グラクソ グループ リミテッド | 抗菌剤 |
| DE102004041163A1 (de) | 2004-08-25 | 2006-03-02 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Neue Verbindungen mit antibakterieller Aktivität |
| JP4887297B2 (ja) | 2004-09-24 | 2012-02-29 | アクテリオン ファーマシューティカルズ リミテッド | 新規二環式抗生物質 |
| DE602005021133D1 (de) | 2004-10-05 | 2010-06-17 | Actelion Pharmaceuticals Ltd | Neue piperidin-antibiotika |
| JP5314244B2 (ja) | 2004-10-27 | 2013-10-16 | 富山化学工業株式会社 | 新規な含窒素複素環化合物およびその塩 |
| JP4058106B2 (ja) | 2005-02-18 | 2008-03-05 | アストラゼネカ アクチボラグ | 抗菌性のピペリジン誘導体 |
| WO2006099884A1 (en) | 2005-03-24 | 2006-09-28 | Actelion Percurex Ag | Beta-aminoalcohol antibiotics |
| MX2007014507A (es) | 2005-05-24 | 2008-02-07 | Astrazeneca Ab | Aminopiperidin quinolinas y sus analogos azaisostericos con actividad antibacteriana. |
| MY150958A (en) * | 2005-06-16 | 2014-03-31 | Astrazeneca Ab | Compounds for the treatment of multi-drug resistant bacterial infections |
| EP1900732A4 (en) | 2005-06-24 | 2009-11-18 | Toyama Chemical Co Ltd | NEW NITROGENATED HETEROCYCLIC COMPOUND AND SALT THEREOF |
| EP1943222A1 (de) | 2005-10-13 | 2008-07-16 | Morphochem Aktiengesellschaft Für Kombinatorische Chemie | 5-chinolinderivate mit antibakterieller aktivität |
| WO2007118130A2 (en) | 2006-04-06 | 2007-10-18 | Glaxo Group Limited | Antibacterial agents |
| AU2007268749B2 (en) | 2006-05-26 | 2012-07-26 | Taisho Pharmaceutical Co., Ltd. | Novel heterocyclic compound or salt thereof and intermediate thereof |
| US20100144717A1 (en) * | 2006-12-15 | 2010-06-10 | Janelle Comita-Prevoir | 2-quinolinone and 2-quinoxalinone-derivatives and their use as antibacterial agents |
| TW200831517A (en) | 2006-12-15 | 2008-08-01 | Astrazeneca Ab | Chemical compounds |
-
2006
- 2006-06-14 MY MYPI20062824 patent/MY150958A/en unknown
- 2006-06-16 EP EP06744233A patent/EP1893599A1/en not_active Withdrawn
- 2006-06-16 EP EP10178524A patent/EP2289890A1/en not_active Withdrawn
- 2006-06-16 NZ NZ565110A patent/NZ565110A/en not_active IP Right Cessation
- 2006-06-16 CN CN2006800293947A patent/CN101243068B/zh not_active Expired - Fee Related
- 2006-06-16 WO PCT/GB2006/002207 patent/WO2006134378A1/en not_active Ceased
- 2006-06-16 RU RU2008100306/04A patent/RU2008100306A/ru not_active Application Discontinuation
- 2006-06-16 JP JP2008516408A patent/JP5204649B2/ja not_active Expired - Fee Related
- 2006-06-16 TW TW095121757A patent/TW200716623A/zh unknown
- 2006-06-16 KR KR1020137021678A patent/KR101351160B1/ko not_active Expired - Fee Related
- 2006-06-16 MX MX2007015297A patent/MX2007015297A/es active IP Right Grant
- 2006-06-16 AU AU2006258879A patent/AU2006258879C1/en not_active Ceased
- 2006-06-16 BR BRPI0611747-3A patent/BRPI0611747A2/pt not_active IP Right Cessation
- 2006-06-16 KR KR1020077029378A patent/KR20080021031A/ko not_active Ceased
- 2006-06-16 AR ARP060102576A patent/AR054781A1/es not_active Application Discontinuation
- 2006-06-16 CA CA002610900A patent/CA2610900A1/en not_active Abandoned
- 2006-06-16 UY UY29608A patent/UY29608A1/es unknown
- 2006-06-16 US US11/917,394 patent/US7875715B2/en not_active Expired - Fee Related
-
2007
- 2007-11-22 IL IL187581A patent/IL187581A0/en unknown
- 2007-12-04 ZA ZA200710563A patent/ZA200710563B/xx unknown
-
2008
- 2008-01-11 EC EC2008008102A patent/ECSP088102A/es unknown
- 2008-01-16 NO NO20080338A patent/NO20080338L/no not_active Application Discontinuation
-
2010
- 2010-12-09 US US12/964,366 patent/US8124602B2/en not_active Expired - Fee Related
-
2012
- 2012-01-11 US US13/348,143 patent/US20120108577A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN101243068B (zh) | 2012-08-08 |
| KR20130108468A (ko) | 2013-10-02 |
| EP2289890A1 (en) | 2011-03-02 |
| IL187581A0 (en) | 2008-03-20 |
| EP1893599A1 (en) | 2008-03-05 |
| ZA200710563B (en) | 2008-12-31 |
| NZ565110A (en) | 2011-05-27 |
| MX2007015297A (es) | 2008-02-21 |
| JP5204649B2 (ja) | 2013-06-05 |
| US8124602B2 (en) | 2012-02-28 |
| AU2006258879B2 (en) | 2009-11-19 |
| KR101351160B1 (ko) | 2014-01-14 |
| KR20080021031A (ko) | 2008-03-06 |
| UY29608A1 (es) | 2007-01-31 |
| AU2006258879C1 (en) | 2011-09-01 |
| US20110092495A1 (en) | 2011-04-21 |
| CA2610900A1 (en) | 2006-12-21 |
| MY150958A (en) | 2014-03-31 |
| CN101243068A (zh) | 2008-08-13 |
| RU2008100306A (ru) | 2009-07-27 |
| AR054781A1 (es) | 2007-07-18 |
| AU2006258879A1 (en) | 2006-12-21 |
| NO20080338L (no) | 2008-02-29 |
| US20100152441A1 (en) | 2010-06-17 |
| WO2006134378A1 (en) | 2006-12-21 |
| TW200716623A (en) | 2007-05-01 |
| JP2008543819A (ja) | 2008-12-04 |
| US20120108577A1 (en) | 2012-05-03 |
| US7875715B2 (en) | 2011-01-25 |
| BRPI0611747A2 (pt) | 2008-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ECSP088102A (es) | Compuestos para el tratamiento de infecciones bacterianas resistentes a múltiples fármacos | |
| UY28757A1 (es) | Compuestos de pirazolina substituidos, su preparación y su uso como medicamentos | |
| CR11854A (es) | Compuestos de piridina | |
| UY30373A1 (es) | Derivados de fenilalanina, procedimientos de preparacion y aplicaciones | |
| ECSP099451A (es) | Compuestos de urea policíclicos antibacterianos | |
| UY31539A1 (es) | Agentes antelminticos y su uso | |
| CR20130432A (es) | 1,3-oxazinas como inhibidores de la bace1 y/o de la bace2 | |
| UY30762A1 (es) | Sal fumarato de (alfa s, beta r)-6-bromo-alfa-[2(dimetilamino) etil]-2-metoxi-alfa-1-naftalenil-beta-fenil-3-quinolinaetanol | |
| UY29093A1 (es) | Derivados de 4-oxo-3. 4-dihidroquinazolin-6-carboxamida, inhibidores de b-raf, composiciones que los contienen, procesos de preparación y aplicaiones. | |
| PA8720801A1 (es) | Nuevas combinaciones terapeuticas para el tratamiento de la depresion | |
| UY28732A1 (es) | Derivados de acido 7-fenilamino-4-quinolona-3-carboxilico, procesos para su preparación y su uso como medicamentos. | |
| CO5640037A2 (es) | Derivados de la quinazolina para el tratamiento del cancer | |
| ECSP066990A (es) | Formulaciones con liberación controlada de principio activo que contienen vardenafilo | |
| UY30282A1 (es) | Compuestos quimicos | |
| CO6710926A2 (es) | Compuestos de n-heteroarilo | |
| ATE487720T1 (de) | 5,6,7,8-tetrahydropteridin-derivate als hsp90- hemmer | |
| GT200500378A (es) | Macrolidos | |
| ECSP045353A (es) | Derivados de benzoxazinona, su preparación y aplicación como medicamentos | |
| UY30544A1 (es) | Compuestos de pirrolo-piperidina y sales farmacéuticametne aceptables de los mismos, procesos de fabricacion, composiciones y aplicaciones | |
| UY28702A1 (es) | Derivados de quinazolina | |
| UY33003A (es) | Asociaciones farmacéuticas, composiciones farmacéuticas, medicamento y método para el tratamiento de animales | |
| UY28366A1 (es) | Compuestos químicos | |
| UY29561A1 (es) | Derivados de quinazolina, composiciones farmacéuticas que los contienen, procedimientos de preparación y aplicaciones | |
| UY30880A1 (es) | 7-alcoxicinolin-3-carboxamidas sustituidas y sales farmacéuticamente aceptables de las mismas, procedimientos de preparacion y aplicaciones | |
| ATE392889T1 (de) | Orale antimikrobielle pharmazeutische zusammensetzungen |