ECSP088215A - Derivados de pirazina y como inhibidores pi3k. - Google Patents

Derivados de pirazina y como inhibidores pi3k.

Info

Publication number
ECSP088215A
ECSP088215A EC2008008215A ECSP088215A ECSP088215A EC SP088215 A ECSP088215 A EC SP088215A EC 2008008215 A EC2008008215 A EC 2008008215A EC SP088215 A ECSP088215 A EC SP088215A EC SP088215 A ECSP088215 A EC SP088215A
Authority
EC
Ecuador
Prior art keywords
diseases
pi3k inhibitors
derivatives
pirazine
pirazine derivatives
Prior art date
Application number
EC2008008215A
Other languages
English (en)
Inventor
Dennis Church
Pascale Gaillard
Anna Quattropani
Vincent Pomel
Thomas Rueckle
Jasna Klicic
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Publication of ECSP088215A publication Critical patent/ECSP088215A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)

Abstract

La presente invención se refiere a derivados pirazina de la Fórmula (I) en particular para el tratamiento y/o profilaxis de trastornos autoinmunes y/o enfermedades inflamatorias, enfermedades cardiovasculares, enfermedades neurodegenerativas, infecciones bacterianas o virales, enfermedades del riñón, agregación plaquetaria, cáncer, trasplantes, rechazo a injertos o daños pulmonares.
EC2008008215A 2005-08-26 2008-02-22 Derivados de pirazina y como inhibidores pi3k. ECSP088215A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05107838 2005-08-26

Publications (1)

Publication Number Publication Date
ECSP088215A true ECSP088215A (es) 2008-03-26

Family

ID=35276409

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008215A ECSP088215A (es) 2005-08-26 2008-02-22 Derivados de pirazina y como inhibidores pi3k.

Country Status (17)

Country Link
US (3) US8071597B2 (es)
EP (2) EP2351745A1 (es)
JP (1) JP5226513B2 (es)
KR (1) KR20080049767A (es)
CN (1) CN101296909B (es)
AU (1) AU2006283846B2 (es)
BR (1) BRPI0615233A2 (es)
CA (1) CA2618479C (es)
EA (1) EA015937B1 (es)
EC (1) ECSP088215A (es)
ES (1) ES2456000T3 (es)
IL (1) IL189737A (es)
MX (1) MX2008002723A (es)
NZ (1) NZ565749A (es)
UA (1) UA100358C2 (es)
WO (1) WO2007023186A1 (es)
ZA (1) ZA200801822B (es)

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