ECSP088509A - Derivados de 1,2,5-tiazolidinadiona sustituidos por 1-orto-fluoro-fenilo como inhibidores de ptp-asa - Google Patents

Derivados de 1,2,5-tiazolidinadiona sustituidos por 1-orto-fluoro-fenilo como inhibidores de ptp-asa

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Publication number
ECSP088509A
ECSP088509A EC2008008509A ECSP088509A ECSP088509A EC SP088509 A ECSP088509 A EC SP088509A EC 2008008509 A EC2008008509 A EC 2008008509A EC SP088509 A ECSP088509 A EC SP088509A EC SP088509 A ECSP088509 A EC SP088509A
Authority
EC
Ecuador
Prior art keywords
compounds
inhibitors
diseases
formula
treatment
Prior art date
Application number
EC2008008509A
Other languages
English (en)
Inventor
David Barnes
Gary Mark Coppola
Travis Stams
Sidney Wolf Topiol
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37903424&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088509(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP088509A publication Critical patent/ECSP088509A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
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  • Diabetes (AREA)
  • Obesity (AREA)
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  • Hematology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Communicable Diseases (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pulmonology (AREA)

Abstract

Los compuestos de la Fórmula, son inhibidores de las fosfatasas de proteína tirosina (PTPasas), y por lo tanto, se pueden emplear para el tratamiento de las condiciones mediadas por la actividad de la PTPasa. Los compuestos de la presente invención también se pueden emplear como inhibidores de otras enzimas caracterizadas por una región de enlace de fosfotirosina, tal como el dominio SH2. De acuerdo con lo anterior, los compuestos de la Fórmula (I) se pueden emplear para la prevención y/o el tratamiento de resistencia a la insulina asociada con obesidad, intolerancia a la glucosa, diabetes mellitus, hipertensión y enfermedades isquémicas de los vasos sanguíneos grandes y pequeños, condiciones que acompañan a la diabetes tipo 2, incluyendo hiperlipidemia, hipertrigliceridemia, ateroesclerosis, restenosis vascular, síndrome de intestino irritable, pancreatitis, tumores de células adiposas y carcinomas, tales como liposarcoma, dislipidemia, y otros trastornos en donde se indique la resistencia a la insulina. En adición, los compuestos de la presente invención se pueden emplear para tratar y/o prevenir cáncer, osteoporosis, enfermedades neurodegenerativas e infecciosas, y enfermedades que involucren inflamación y al sistema inmune.
EC2008008509A 2005-12-08 2008-06-06 Derivados de 1,2,5-tiazolidinadiona sustituidos por 1-orto-fluoro-fenilo como inhibidores de ptp-asa ECSP088509A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74849205P 2005-12-08 2005-12-08

Publications (1)

Publication Number Publication Date
ECSP088509A true ECSP088509A (es) 2008-07-30

Family

ID=37903424

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008509A ECSP088509A (es) 2005-12-08 2008-06-06 Derivados de 1,2,5-tiazolidinadiona sustituidos por 1-orto-fluoro-fenilo como inhibidores de ptp-asa

Country Status (23)

Country Link
US (1) US8252820B2 (es)
EP (1) EP1963293A1 (es)
JP (1) JP2009518419A (es)
KR (1) KR20080075218A (es)
CN (1) CN101336235A (es)
AR (1) AR058285A1 (es)
AU (1) AU2006321902B2 (es)
BR (1) BRPI0619567A2 (es)
CA (1) CA2631007A1 (es)
CR (1) CR10047A (es)
EC (1) ECSP088509A (es)
GT (1) GT200800093A (es)
IL (1) IL191711A0 (es)
MA (1) MA30018B1 (es)
NO (1) NO20083030L (es)
NZ (1) NZ568663A (es)
PE (2) PE20100470A1 (es)
RU (1) RU2008127262A (es)
TN (1) TNSN08248A1 (es)
TW (1) TW200800928A (es)
UA (1) UA94921C2 (es)
WO (1) WO2007067612A1 (es)
ZA (1) ZA200804489B (es)

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