ECSP088539A - MÉTODO DE UTILIZACIÓN DE b-HIDROXI-b-METILBUTIRATO - Google Patents

MÉTODO DE UTILIZACIÓN DE b-HIDROXI-b-METILBUTIRATO

Info

Publication number
ECSP088539A
ECSP088539A EC2008008539A ECSP088539A ECSP088539A EC SP088539 A ECSP088539 A EC SP088539A EC 2008008539 A EC2008008539 A EC 2008008539A EC SP088539 A ECSP088539 A EC SP088539A EC SP088539 A ECSP088539 A EC SP088539A
Authority
EC
Ecuador
Prior art keywords
type
increase
hmb
cytokines
cytosine
Prior art date
Application number
EC2008008539A
Other languages
English (en)
Inventor
Pradip Mukerji
Debra L Thomas
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of ECSP088539A publication Critical patent/ECSP088539A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/02Nutrients, e.g. vitamins, minerals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pediatric Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un método para el tratamiento a un individuo que tenga una condición caracterizada por un desequilibrio en la producción de los niveles de citocina tipo 1 y tipo 2, que comprende la administración al individuo de una cantidad efectiva de b-hidroxi-b-metilbutirato (HMB) para modularlo o de lo contrario causa un incremento en la proporción de los niveles de citocina del tipo 1 al tipo 2 incluyendo un incremento en la proporción de citocinas tipo 1 al tipo 2 sin el incremento correspondiente a los niveles de citosina tipo 2. También son revelados los métodos del uso de (HMB) para tratamiento de asma y alergias. Los métodos de la presente invención están basados en el descubrimiento de la producción de moduladores de citosina (HMB), especialmente por el incremento de citocinas tipo 1 sin el correspondiente incremento de citosinas tipo 2.
EC2008008539A 2005-12-19 2008-06-16 MÉTODO DE UTILIZACIÓN DE b-HIDROXI-b-METILBUTIRATO ECSP088539A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75225305P 2005-12-19 2005-12-19
PCT/US2006/048303 WO2007075605A2 (en) 2005-12-19 2006-12-19 Use of beta-hydroxy-beta-methylbutyrate to modulate the imbalance in type and type 2 cytokine production

Publications (1)

Publication Number Publication Date
ECSP088539A true ECSP088539A (es) 2008-07-30

Family

ID=38066532

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008539A ECSP088539A (es) 2005-12-19 2008-06-16 MÉTODO DE UTILIZACIÓN DE b-HIDROXI-b-METILBUTIRATO

Country Status (17)

Country Link
US (4) US8778992B2 (es)
EP (2) EP1968564B1 (es)
JP (2) JP5227182B2 (es)
CN (2) CN101374509B (es)
AU (1) AU2006331950A1 (es)
BR (1) BRPI0620083A2 (es)
CA (1) CA2632262C (es)
CR (1) CR10085A (es)
EC (1) ECSP088539A (es)
ES (2) ES2548305T3 (es)
MY (1) MY180733A (es)
NZ (2) NZ593182A (es)
RU (2) RU2469719C2 (es)
SV (1) SV2009002948A (es)
TW (1) TWI424840B (es)
WO (1) WO2007075605A2 (es)
ZA (1) ZA200805297B (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
JP5227182B2 (ja) 2005-12-19 2013-07-03 アボット・ラボラトリーズ 1型および2型サイトカイン産生における不均衡を調節するためのベータ−ヒドロキシ−ベータ−メチルブチラートの使用
US9404924B2 (en) 2008-12-04 2016-08-02 Massachusetts Institute Of Technology Method of performing one-step, single cell RT-PCR
JP5675638B2 (ja) * 2008-12-04 2015-02-25 マサチューセッツ インスティテュート オブ テクノロジー アレルギー反応を診断するための方法
US11173167B2 (en) 2008-12-09 2021-11-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9770424B2 (en) 2008-12-09 2017-09-26 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
WO2010068696A1 (en) 2008-12-09 2010-06-17 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9707241B2 (en) 2008-12-09 2017-07-18 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9539224B2 (en) 2008-12-09 2017-01-10 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
US9259430B2 (en) 2008-12-09 2016-02-16 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
ES2700777T3 (es) * 2009-07-03 2019-02-19 Nutreco Nederland Bv Pienso animal o comida para humanos para mejorar las propiedades de la barrera intestinal
US9693577B2 (en) 2010-01-29 2017-07-04 Abbott Laboratories Method of preparing a nutritional powder comprising spray dried HMB
PH12012501350A1 (en) * 2010-01-29 2016-07-08 Abbott Lab Nutritional powders comprising spray dried hmb
CA2785522C (en) * 2010-01-29 2015-09-29 Abbott Laboratories Nutritional emulsions comprising calcium hmb and soluble protein
BR112012018174A2 (pt) 2010-01-29 2019-08-27 Abbott Lab líquidos nutricionais embalados assepticamente compreendendo hmb.
SG182807A1 (en) * 2010-01-29 2012-09-27 Abbott Lab Plastic packaged nutritonal liquids comprising hmb
ES2481865T3 (es) 2010-01-29 2014-07-31 Abbott Laboratories Emulsiones nutricionales que comprenden HMB de calcio
TWI526161B (zh) 2010-06-10 2016-03-21 亞培公司 包含鈣hmb及可溶性蛋白質之實質上透明營養液
BR112013020643A2 (pt) 2011-02-17 2016-08-02 Abbott Lab métodos para melhorar o desenvolvimento cerebral e a função cognitiva usando beta-hidróxi-beta-metilbutirato
CN102524332A (zh) * 2011-12-19 2012-07-04 北京康比特体育科技股份有限公司 一种减肥压缩饼干及其制备方法
HK1205692A1 (en) * 2012-03-19 2015-12-24 Abbott Laboratories Beta-hydroxy-beta-methylbutyric acid for improving glucose tolerance
US20150119339A1 (en) * 2012-06-11 2015-04-30 Abbott Laboratories Use of hmb to improve health outcomes for hospitalized patients
US20150238447A1 (en) * 2012-09-17 2015-08-27 Abbott Laboratories Beta-hydroxy-beta-methylbutryic acid-containing compositions and uses thereof
JP2016513701A (ja) 2013-03-14 2016-05-16 アボット・ラボラトリーズAbbott Laboratories 長期身体不活動に関連するインスリン抵抗性の治療
US20140272000A1 (en) * 2013-03-14 2014-09-18 Metabolic Technologies, Inc. Liquids and Foodstuffs Containing beta-hydroxy-beta-methylbutyrate (HMB) in the Free Acid Form and Methods of Manufacturing or Producing the Same
CN105188417B (zh) * 2013-03-15 2017-08-08 雅培制药有限公司 包括β‑羟基‑β‑甲基丁酸钙、酪蛋白磷酸肽和蛋白质的营养组合物
US12208073B2 (en) 2015-09-16 2025-01-28 Metabolic Technologies, LLC Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma
PT3349745T (pt) 2015-09-16 2024-03-18 Metabolic Tech Inc Composições e métodos de utilização de beta-hidroxi-beta metilbutirato (hmb) para melhorar a recuperação de traumatismos de tecidos moles
JOP20190146A1 (ar) 2016-12-19 2019-06-18 Axcella Health Inc تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
MX2020001765A (es) 2017-08-14 2020-07-29 Axcella Health Inc Composiciones de aminoacidos para el tratamiento de enfermedad hepatica.
CN112839643A (zh) 2018-06-20 2021-05-25 胺细拉健康公司 用于治疗肌肉中脂肪浸润的组合物及方法
JP7156683B2 (ja) * 2018-09-28 2022-10-19 株式会社東洋新薬 経口組成物
CA3182874A1 (en) * 2020-06-15 2021-12-23 Karina BETTEGA FELIPE Compositions and methods of use of .beta.-hydroxy-.beta.-methylbutyrate (hmb) and chemotherapy agents

Family Cites Families (117)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3408210A (en) 1965-06-14 1968-10-29 Wilbert A. Heyman Dehydration of foods
US3542560A (en) 1967-12-06 1970-11-24 American Home Prod Infant formula with fat composition like human milk
GB1446965A (en) 1974-02-14 1976-08-18 Agricultural Vegetable Prod Preparation of food products
US4104290A (en) 1975-02-07 1978-08-01 H.L.S. Ltd., Industrial Engineering Company Process for separating oils and fats into liquid and solid fractions
US4311645A (en) 1980-03-24 1982-01-19 Hoffmann-La Roche Inc. Synthesis of SRS-active compounds
US4742081A (en) 1986-01-06 1988-05-03 Alfred Stracher Carnitine coupled pharmaceutical agents
US4866040A (en) 1986-01-06 1989-09-12 Alfred Stracher Aminocarnitine directed pharmaceutical agents
ES2052066T3 (es) 1988-10-31 1994-07-01 Sandoz Nutrition Ltd Mejoras en o relacionadas con compuestos organicos.
US5000975A (en) 1988-12-29 1991-03-19 American Home Products Corporation Randomized palm oil fat composition for infant formulas
CA2010511A1 (en) 1989-03-01 1990-09-01 Roberto L. Ceriani Method of enhancing cancer therapy by administration of unsaturated fatty acids
US5457130A (en) 1989-03-20 1995-10-10 Cancer Research Campaign Technology Limited Eicosapentaenoic acid used to treat cachexia
US5087472A (en) 1990-01-30 1992-02-11 Iowa State University Research Foundation, Inc. Feed compositions for domestics animals containing hydroxymethylbutyrate
US5028440A (en) 1990-01-30 1991-07-02 Iowa State University Research Foundation, Inc. Method of raising meat producing animals to increase lean tissue development
US4992470A (en) 1990-02-08 1991-02-12 Iowa State University Research Foundation, Inc. Method of enhancing immune response of mammals
US5167957A (en) 1990-09-06 1992-12-01 Virginia Tech Intellectual Properties, Inc. Compositions and methods for the treatment of dietary deficiencies
US5601860A (en) 1990-11-30 1997-02-11 American Home Products Corporation Corandomized fat compositions for infant formulas
KR100219771B1 (ko) 1991-03-18 1999-10-01 이치로 키타사토 돼지용 사료 및 이를 사용하는 돼지 사육법
US5171442A (en) 1991-10-18 1992-12-15 Nakshbendi Ghassan F Water purification apparatus
US5223285A (en) 1992-03-31 1993-06-29 Abbott Laboratories Nutritional product for pulmonary patients
ES2142353T3 (es) 1992-09-16 2000-04-16 Univ Iowa State Res Found Inc Procedimiento para reducir los niveles de colesterol total y de colesterol asociado a lipoproteinas de baja densidad en sangre.
US5447732A (en) 1992-11-25 1995-09-05 Ajinomoto Co., Inc. High-absorption mineral-containing composition and foods
US5348979A (en) 1992-12-23 1994-09-20 Iowa State University Research Foundation Inc. Method of promoting nitrogen retention in humans
JP2761294B2 (ja) 1993-05-13 1998-06-04 ロデルス−クロクラーン エステル交換トリグリセリドブレンド由来のヒト母乳脂肪代用品
US6136858A (en) 1994-01-10 2000-10-24 Abbott Laboratories Infant formula and methods of improving infant stool patterns
US5780451A (en) 1994-04-01 1998-07-14 Abbott Laboratories Nutritional product for a person having ulcerative colitis
US5444054A (en) 1994-04-01 1995-08-22 Abbott Labatories Method of treating ulcerative colitis
US5952314A (en) 1994-04-01 1999-09-14 Demichele; Stephen Joseph Nutritional product for a person having ulcerative colitis
US5576287A (en) 1994-04-29 1996-11-19 Wake Forest University Method for treating acute renal disease and failure
US5726146A (en) 1994-12-06 1998-03-10 Natural Supplement Association, Incorporated Non-steroidal, anabolic dietary supplement and method to increase lean mass without linked increase fat mass
KR0140248B1 (ko) 1995-03-23 1998-06-15 한상기 신규한 카제인 포스포펩티드, 그것을 포함하는 카제인 및 그 제조방법
DE19528461A1 (de) 1995-08-03 1997-02-06 Braun Melsungen Ag Präparat zur Ernährung
US5641531A (en) 1995-09-28 1997-06-24 Abbott Laboratories Nutritional liquid supplement beverage and method of making same
WO1997037546A1 (en) 1996-04-11 1997-10-16 Loders Croklaan B.V. Free flowing fat compositions
US6077828A (en) 1996-04-25 2000-06-20 Abbott Laboratories Method for the prevention and treatment of cachexia and anorexia
US5756469A (en) 1996-07-26 1998-05-26 Beale; Paxton K. Composition of pyruvate and anti-cortisol compounds and method for increasing protein concentration in a mammal
US7504376B2 (en) 1996-08-12 2009-03-17 Natural Alternatives International Methods and compositions for increasing the anaerobic working capacity in tissues
US6080788A (en) 1997-03-27 2000-06-27 Sole; Michael J. Composition for improvement of cellular nutrition and mitochondrial energetics
DE29707308U1 (de) 1997-04-23 1997-06-26 Kunz, Armin, 66450 Bexbach Präparat zur Muskelerhaltung bzw. zur Förderung des Muskelaufbaus
US6660258B1 (en) 1997-05-09 2003-12-09 Pharma Pacific Pty Ltd Oromucosal cytokine compositions and uses thereof
US6103764A (en) 1997-11-07 2000-08-15 Iowa State University Research Foundation, Inc. Method for increasing the aerobic capacity of muscle
US6475539B1 (en) 1998-05-07 2002-11-05 Abbott Laboratories Nutritionally complete low pH enteral formula
JP4175698B2 (ja) 1998-06-19 2008-11-05 サントリー株式会社 新規なトリグリセリド及びそれを含む組成物
US6031000A (en) 1998-06-23 2000-02-29 Iowa State University Research Foundation, Inc. Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use
CA2338638C (en) 1998-07-30 2009-03-17 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of l-carnitine and its alkanoyl derivatives in the preparation of medicaments with anticancer activity
US5976550A (en) 1998-11-20 1999-11-02 Engel; Peter H. Dietary food supplement
US20010008641A1 (en) 1998-11-25 2001-07-19 R. Douglas Krotzer Nutritionally active composition for bodybuilding
US6294206B1 (en) 1999-04-09 2001-09-25 Abbott Laboratories Powdered human milk fortifier
US6291525B1 (en) 1999-09-08 2001-09-18 Iowa State University Research Foundation, Inc. Method for improving a human's perception of his emotional state
EP1221865B1 (en) 1999-10-18 2007-01-03 Muscletech Research and Development Inc. Food supplement for increasing lean mass and strength
GB9929919D0 (en) 1999-12-17 2000-02-09 Hannah Research Inst The Calcium phosphate nanoclusters and their applications
US6521591B1 (en) 2000-02-10 2003-02-18 N.V. Nutricia Pharmaceutical composition for muscular anabolism
US7250397B2 (en) 2000-02-23 2007-07-31 Zealand Pharma A/S Antiarrhythmic peptides
CA2404799C (en) 2000-04-06 2007-08-07 Conlinco, Inc. Conjugated linoleic acid compositions
JP4625156B2 (ja) 2000-04-10 2011-02-02 イーエヌ大塚製薬株式会社 癌化学療法に伴う副作用軽減剤
US6420342B1 (en) 2000-05-08 2002-07-16 N.V. Nutricia Nutritional preparation comprising ribose and medical use thereof
US20050106219A1 (en) 2000-05-30 2005-05-19 Karlheinz Bortlik Primary composition comprising a lipophilic bioactive compound
US6592878B2 (en) 2000-08-03 2003-07-15 North Carolina State University Enhancement of development of oviparous species by in ovo feeding
US20030176514A1 (en) 2000-08-29 2003-09-18 Martin Fuhrmann Method for preparing a mixture that can be granulated and carnitine-magnesium hydroxycitrate
US20030203070A1 (en) 2000-09-26 2003-10-30 The Procter & Gamble Company Compositions containing sorbitan monoesters
EP1198991B1 (en) 2000-10-20 2012-12-19 Nutriz N.V: Non-dairy products derived from rice
US20030165604A1 (en) 2001-02-15 2003-09-04 Kazufumi Tsubaki Products containing $g(b)-glucan
JP3735070B2 (ja) 2001-03-26 2006-01-11 花王株式会社 容器詰乳化飲料
US6620427B2 (en) 2001-04-24 2003-09-16 Abbott Laboratories Method for improving bone mineralization
US20030021877A1 (en) 2001-06-13 2003-01-30 Cain Frederick William Micronised fat particles
DE10145818C1 (de) 2001-09-17 2002-10-10 Alfill Engineering Gmbh & Co K Sterilisiervorrichtung mit H202-Verdampfer
JP2003137790A (ja) 2001-11-01 2003-05-14 Mie Kariyou Kk β−2,1(β2→β1)結合連鎖フラクトースオリゴマーを含有するフラクトオリゴ糖を有効成分とする医薬
GB2381451A (en) 2001-11-01 2003-05-07 New Technology Res Ltd Pharmaco-dietary preparation having nutrition-supplementing and nutrition-enhancing effect
US7419596B2 (en) 2001-12-12 2008-09-02 Martek Biosciences Corporation Extraction and winterization of lipids from oilseed and microbial sources
US7168581B2 (en) 2001-12-21 2007-01-30 Rexam Medical Packaging Inc. Closure for a retort processed container having a peelable seal
DE10163676A1 (de) * 2001-12-21 2003-07-10 Phenion Gmbh & Co Kg Verwendung von Hyperforin oder Extrakten aus Johanniskraut gegen anaphylaktische Schockzustände oder Osteoporose
DE60328675D1 (de) * 2002-04-23 2009-09-17 Aventis Pharma Inc 3-(substitutierte amino)-1h-indole-2-carbonsäureester und 3-(substitutierte amino)-benzoäbüthiophen-2-carbonsäureester verbindungen als inhibitoren der interleukin-4 genexpression
SE0201581D0 (sv) 2002-05-29 2002-05-29 Scandinavian Biotechnology Res New improved acyltransferase
US20040013787A1 (en) 2002-06-28 2004-01-22 Theuer Richard C. Fat compositions for infant formula and methods therefor
US20040048925A1 (en) 2002-09-09 2004-03-11 Wiley David B. Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives
US20040106678A1 (en) 2002-09-17 2004-06-03 Dobbins Thomas A Compositions for the parenteral administration of calcium and magnesium
WO2004035624A2 (en) 2002-10-14 2004-04-29 Novo Nordisk A/S Glucagon - like peptide - 2 variants
US7445807B2 (en) 2002-10-15 2008-11-04 Western Holdings, Llc Agglomerated granular protein-rich nutritional supplement
GB0301554D0 (en) 2003-01-23 2003-02-26 Molecularnature Ltd Immunostimulatory compositions
US7332178B2 (en) 2003-04-25 2008-02-19 Abbott Laboratories Stable nutritional powder containing ascorbyl palmitate
FR2856596B1 (fr) 2003-06-27 2007-04-27 Bioprojet Soc Civ Nouvelle association medicamenteuse psychiatrique et utilisation d'une antagoniste ou agoniste inverse du recepteur h3 de l'histamine pour preparer un medicament prevenant des effets indesirables de psychotropes.
JP2008500271A (ja) 2003-10-14 2008-01-10 ザ・プロウボウスト・フェロウズ・アンド・スカラーズ・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン・エリザベス・ニア・ダブリン 免疫介在性疾患の治療および/または予防におけるアデニル酸シクラーゼ
IL158555A0 (en) 2003-10-22 2004-05-12 Enzymotec Ltd Human breast milk lipid mimetic as dietary supplement
DE602004016385D1 (de) 2003-12-24 2008-10-16 Nutricia Nv Zusammensetzungen mit pantothensäure oder derivaten davon und ihre verwendung zur stimulierung des appetits
US7696241B2 (en) 2004-03-04 2010-04-13 Bristol-Myers Squibb Company Bicyclic compounds as modulators of androgen receptor function and method
US20050215640A1 (en) 2004-03-26 2005-09-29 Baxter Jeffrey H HMB compositions and uses thereof
US20050249650A1 (en) 2004-05-07 2005-11-10 Fmc Technologies, Inc. Immersion retort
MX2007002912A (es) 2004-09-09 2007-05-16 Nestec Sa Productos nutricionales teniendo calidad mejorada y metodos y sistemas considerando los mismos.
US8557551B2 (en) 2004-09-10 2013-10-15 Dsm Ip Assets B.V. Compositions and methods for making and modifying oils
PL371081A1 (pl) 2004-11-08 2006-05-15 Sgp & Sons Ab Preparat farmaceutyczny wpływający na procesy wzrostu i mineralizacji układu kostno-szkieletowego oraz chorób kości i chrząstki wieku dojrzałego u ludzi i zwierząt oraz zastosowanie preparatu farmaceutycznego w procesie wzrostu i mineralizacji układu kostno-szkieletowego oraz chorób kości i chrząstki wieku dojrzałego u ludzi i zwierząt
US8067052B2 (en) 2005-02-25 2011-11-29 Siddharth Shastri Nutritional composition and a container for the convenient transport and storage of the nutritional composition
CA2537452C (en) 2005-03-09 2013-12-24 Abbott Laboratories Concentrated human milk fortifier liquid
RU2413430C2 (ru) 2005-04-27 2011-03-10 Энзимотек Лтд. Композиция жировой основы (варианты) и способ ее получения (варианты), композиция заменителя жира женского молока и способ ее получения (варианты), смесь для детского питания
CA2606300A1 (en) 2005-06-06 2006-12-14 Bristol-Myers Squibb Company Low-phytate infant formulas
JP2009506012A (ja) 2005-08-26 2009-02-12 ネステク ソシエテ アノニム 肥満患者の栄養素
MY147363A (en) 2005-09-20 2012-11-30 Nestec Sa Water dispersible composition and method for preparing same
US20090182050A1 (en) 2005-10-07 2009-07-16 Ocean Nutrition Canada, Ltd. Salts of Fatty Acids and Methods of Making and Using thereof
WO2007056176A2 (en) 2005-11-03 2007-05-18 Southwest Immunology, Inc. Compositions for preventing and reducing delayed onset muscle soreness
JP5227182B2 (ja) 2005-12-19 2013-07-03 アボット・ラボラトリーズ 1型および2型サイトカイン産生における不均衡を調節するためのベータ−ヒドロキシ−ベータ−メチルブチラートの使用
PL1981358T3 (pl) 2006-01-31 2011-04-29 Nestec Sa Kompozycja żywieniowa dla noworodków z niską wagą urodzeniową
US20080119552A1 (en) 2006-11-17 2008-05-22 Novus International Inc. Matrix-embedded compositions having organic acids and fatty acids
US20080194407A1 (en) 2007-02-14 2008-08-14 Ashmead H Dewayne High nitrogen containing chelate compositions suitable for plant delivery
US20090110674A1 (en) 2007-10-24 2009-04-30 Loizou Nicos C Health supplement
US8029830B2 (en) 2008-04-18 2011-10-04 Nuvocare Health Services Inc. Composition and method for promoting internal health and external appearance
BRPI0912571A2 (pt) 2008-05-21 2015-07-28 Stokely Van Camp Inc Bebida de recuperação à base de leite
WO2010068696A1 (en) 2008-12-09 2010-06-17 Metabolic Technologies, Inc. Nutritional intervention for improving muscular function and strength
JP2009155336A (ja) 2009-03-31 2009-07-16 Tsujido Chemical Corp 治療剤
US20090312419A1 (en) 2009-08-12 2009-12-17 Kneller Bruce W CREATINE -ßALANINATE: A NOVEL SALT FOR INCREASING ATHLETIC PERFORMANCE
PL217815B1 (pl) 2009-12-14 2014-08-29 Olimp Lab Spółka Z Ograniczoną Odpowiedzialnością Napój izotoniczny z chelatami
CN101785566A (zh) 2010-01-22 2010-07-28 北京康比特体育科技股份有限公司 一种含有hmb的运动饮料
ES2481865T3 (es) 2010-01-29 2014-07-31 Abbott Laboratories Emulsiones nutricionales que comprenden HMB de calcio
TWI526161B (zh) 2010-06-10 2016-03-21 亞培公司 包含鈣hmb及可溶性蛋白質之實質上透明營養液
US10869843B2 (en) 2010-11-23 2020-12-22 Chemi Nutra Method for increasing muscle mass and strength
CN103269695A (zh) 2010-12-27 2013-08-28 雅培制药有限公司 使用β-羟基-β-甲基丁酸盐促进废用一段时期之后肌肉恢复的方法
WO2012097061A1 (en) 2011-01-13 2012-07-19 Abbott Laboratories Nutritional compositions and methods for improving skeletal muscle protein metabolism
WO2013056048A2 (en) 2011-10-13 2013-04-18 Abbott Laboratories Nutritional products comprising beta-alanine
WO2013170189A1 (en) 2012-05-11 2013-11-14 Abbott Laboratories Combination of beta - hydroxy - beta - methylbutyrate and beta - alanine for increasing muscle blood flow
US20150119339A1 (en) 2012-06-11 2015-04-30 Abbott Laboratories Use of hmb to improve health outcomes for hospitalized patients

Also Published As

Publication number Publication date
MY180733A (en) 2020-12-08
EP2082738A1 (en) 2009-07-29
US8796333B2 (en) 2014-08-05
CN102225060A (zh) 2011-10-26
BRPI0620083A2 (pt) 2011-11-01
WO2007075605A2 (en) 2007-07-05
JP2009520029A (ja) 2009-05-21
JP5696168B2 (ja) 2015-04-08
AU2006331950A1 (en) 2007-07-05
US20120189709A1 (en) 2012-07-26
WO2007075605A3 (en) 2008-06-26
US20120178811A1 (en) 2012-07-12
US8778992B2 (en) 2014-07-15
RU2469719C2 (ru) 2012-12-20
JP2013136587A (ja) 2013-07-11
EP1968564B1 (en) 2015-09-16
US20070142469A1 (en) 2007-06-21
TWI424840B (zh) 2014-02-01
CA2632262A1 (en) 2007-07-05
TW200800151A (en) 2008-01-01
SV2009002948A (es) 2009-02-19
US20120177744A1 (en) 2012-07-12
CN101374509B (zh) 2013-06-19
CN101374509A (zh) 2009-02-25
ES2548305T3 (es) 2015-10-15
ZA200805297B (en) 2009-05-27
EP2082738A8 (en) 2010-06-23
JP5227182B2 (ja) 2013-07-03
ES2548432T3 (es) 2015-10-16
EP2082738B1 (en) 2015-09-16
RU2008129605A (ru) 2010-01-27
CA2632262C (en) 2015-04-07
EP1968564A2 (en) 2008-09-17
NZ593182A (en) 2012-09-28
NZ568611A (en) 2011-11-25
CR10085A (es) 2008-08-06
RU2011133891A (ru) 2013-02-20

Similar Documents

Publication Publication Date Title
ECSP088539A (es) MÉTODO DE UTILIZACIÓN DE b-HIDROXI-b-METILBUTIRATO
CY1121136T1 (el) Φυτικα εκχυλισματα που περιεχουν κανναβινοειδη ως νευροπροστατευτικους παραγοντες
MX2009009207A (es) Metodos y composiciones para normalizar las secreciones de glandulas meibomianas.
NO20071077L (no) Fosfonatanaloger til HIV-inhibitorforbindelser
CL2004002050A1 (es) Compuestos derivados de piridinonas sustituidas; su uso en el tratamiento de afecciones causadas o exacerbadas por actividad p38 map kinasa y/o tnf no regulada, tales como inflamaciones, tumores, sida y otros.
BRPI0518228A (pt) inibidores de cinesina mitótica e métodos de uso destes
ECSP045004A (es) Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades andrógeno dependientes
UY31073A1 (es) Inhibidores de la proteína activadora de la 5-lipoxigenasa (flap)
NO20070866L (no) Antivirale forbindelser.
PA8493701A1 (es) Compuestos para tratar la obesidad
NO20080462L (no) Krystallformer av astaxantin
ECSP067093A (es) Derivados de sulfamato y sulfamida para el tratamiento de epilepsia y trastornos relacionados
CL2009000803A1 (es) Uso de una variante de igf-1 pegilada para tratar, prevenir un trastorno neuromuscular; metodo para el tratamiento, prevencion y/o demora de un trastorno neuromuscular; composicion que comprende la variante de igf-1 modificada
AR048135A1 (es) Uso de gen de amiloide a serico en el diagnostico y tratamiento del glaucoma y en la identificacion de agentes anti-glaucoma.
BRPI0416812A (pt) métodos e reagentes para o tratamento de desordens inflamatórias
ATE551333T1 (de) Biphenylderivate als modulatoren von spannungsabhängigen ionenkanälen
MX2024002913A (es) Anticuerpos anti-siglec-6 y metodos de uso de los mismos.
AR058308A1 (es) Fragmentos vip y metodos de uso de los mismos
PA8597501A1 (es) Derivados azabiciclicos de piridiloximetilo y bencisoxazol
ATE393796T1 (de) Härtbare zusammensetzungen auf basis von epoxidharzen und 3(4)-(aminomethyl)-cyclohexan- propanamin und 1,4(5)-cyclooctandimethanamin
NO20055612L (no) Anti-inflammatoriske fosfonatforbindelser
ECSP066722A (es)
UY30557A1 (es) Tratamiento y prevencion de la fibrosis intestinal
UY29417A1 (es) Agentes endoparasiticidas
AR045013A1 (es) Metodo para tratar o prevenir trastornos del sistema nervioso central con compuestos que tienen selectividad por la subunidad alfa -3 del receptor de benzodiazepinas