ECSP088540A - PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES - Google Patents

PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES

Info

Publication number
ECSP088540A
ECSP088540A EC2008008540A ECSP088540A ECSP088540A EC SP088540 A ECSP088540 A EC SP088540A EC 2008008540 A EC2008008540 A EC 2008008540A EC SP088540 A ECSP088540 A EC SP088540A EC SP088540 A ECSP088540 A EC SP088540A
Authority
EC
Ecuador
Prior art keywords
pirrol
janus kinases
piridines
heteroarilo
pyrimidins
Prior art date
Application number
EC2008008540A
Other languages
Spanish (es)
Inventor
James D Rodgers
Stacey Shepard
Thomas P Maduskuie
Haisheng Wang
Nikoo Falahatpisheh
Maria Rafalski
Argyrios G Arvanitis
Louis Storace
Ravi Kumar Jalluri
Jordan S Fridman
Krishna Vaddi
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37903501&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP088540(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of ECSP088540A publication Critical patent/ECSP088540A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Pirrol[2,3-b]piridinas y pirrol[2,3-b]pirimidinas sustituidas con heteroarilo que modulan la actividad de las quinasas Janus y son útiles para el tratamiento de enfermedades relacionadas con la actividad de las quinasas Janus que incluyen, por ejemplo, las enfermedades relacionadas con el sistema inmune, trastornos dermatológicos, trastornos proliferativos mieloides, cáncer y otras enfermedadesPyrrol [2,3-b] pyridines and pyrrol [2,3-b] heteroaryl substituted pyrimidines that modulate the activity of Janus kinases and are useful for the treatment of diseases related to the activity of Janus kinases which include, by For example, diseases related to the immune system, dermatological disorders, myeloid proliferative disorders, cancer and other diseases

EC2008008540A 2005-12-13 2008-06-13 PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES ECSP088540A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US74990505P 2005-12-13 2005-12-13
US81023106P 2006-06-02 2006-06-02
US85062506P 2006-10-10 2006-10-10
US85687206P 2006-11-03 2006-11-03
US85940406P 2006-11-16 2006-11-16

Publications (1)

Publication Number Publication Date
ECSP088540A true ECSP088540A (en) 2008-07-30

Family

ID=37903501

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2008008540A ECSP088540A (en) 2005-12-13 2008-06-13 PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES
ECSP12008540 ECSP12008540A (en) 2005-12-13 2012-03-08 PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES

Family Applications After (1)

Application Number Title Priority Date Filing Date
ECSP12008540 ECSP12008540A (en) 2005-12-13 2012-03-08 PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES

Country Status (36)

Country Link
US (16) US7598257B2 (en)
EP (10) EP3838903B1 (en)
JP (4) JP5017278B2 (en)
KR (4) KR101324737B1 (en)
CN (4) CN103214484B (en)
AR (1) AR057995A1 (en)
AT (1) ATE525374T1 (en)
AU (1) AU2006326548B2 (en)
BE (1) BE2013C014I2 (en)
BR (1) BRPI0619817B8 (en)
CA (1) CA2632466C (en)
CR (2) CR10065A (en)
CY (8) CY1112762T1 (en)
DK (7) DK2426129T3 (en)
EA (3) EA035795B1 (en)
EC (2) ECSP088540A (en)
ES (10) ES2970354T3 (en)
FR (2) FR13C0007I2 (en)
HR (7) HRP20110903T1 (en)
HU (7) HUE025173T2 (en)
IL (3) IL192019A (en)
LT (6) LT3184526T (en)
LU (1) LU92137I2 (en)
ME (1) ME01312B (en)
MX (1) MX346183B (en)
MY (2) MY159449A (en)
NZ (2) NZ778831A (en)
PL (7) PL2348023T3 (en)
PT (7) PT1966202E (en)
RS (7) RS54683B1 (en)
SG (3) SG10202003901UA (en)
SI (7) SI2474545T1 (en)
TW (6) TWI630207B (en)
UA (2) UA98449C2 (en)
WO (1) WO2007070514A1 (en)
ZA (1) ZA200805165B (en)

Families Citing this family (444)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005105814A1 (en) * 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
AR054416A1 (en) 2004-12-22 2007-06-27 Incyte Corp PIRROLO [2,3-B] PIRIDIN-4-IL-AMINAS AND PIRROLO [2,3-B] PIRIMIDIN-4-IL-AMINAS AS INHIBITORS OF THE JANUS KINASES. PHARMACEUTICAL COMPOSITIONS.
JP2009508832A (en) * 2005-09-16 2009-03-05 アストラゼネカ アクチボラグ Heterobicyclic compounds as glucokinase activators
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
US7528143B2 (en) * 2005-11-01 2009-05-05 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8604042B2 (en) * 2005-11-01 2013-12-10 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
US8133900B2 (en) * 2005-11-01 2012-03-13 Targegen, Inc. Use of bi-aryl meta-pyrimidine inhibitors of kinases
CN103214484B (en) 2005-12-13 2016-07-06 因塞特控股公司 Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine
ES2408318T3 (en) * 2005-12-23 2013-06-20 Glaxosmithkline Llc Aurora kinase azaindole inhibitors
MX2008012738A (en) * 2006-04-03 2009-02-06 Astellas Pharma Inc Hetero compound.
CA2648250A1 (en) * 2006-04-05 2007-10-18 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
EP2101819B1 (en) 2006-11-20 2013-01-09 President and Fellows of Harvard College Methods, compositions, and kits for treating pain and pruritis
ES2415863T3 (en) 2006-12-22 2013-07-29 Incyte Corporation Substituted heterocycles as Janus Kinase inhibitors
CL2008001709A1 (en) 2007-06-13 2008-11-03 Incyte Corp Compounds derived from pyrrolo [2,3-b] pyrimidine, jak kinase modulators; pharmaceutical composition; and use in the treatment of diseases such as cancer, psoriasis, rheumatoid arthritis, among others.
HUE029236T2 (en) * 2007-06-13 2017-02-28 Incyte Holdings Corp Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
WO2009003998A2 (en) * 2007-07-02 2009-01-08 Boehringer Ingelheim International Gmbh Antiproliferative compounds based on 5-membered heterocycles
WO2009032338A1 (en) * 2007-09-09 2009-03-12 University Of Florida Research Foundation Apratoxin therapeutic agents: mechanism and methods of treatment
WO2009049028A1 (en) * 2007-10-09 2009-04-16 Targegen Inc. Pyrrolopyrimidine compounds and their use as janus kinase modulators
US8183245B2 (en) * 2007-10-25 2012-05-22 Merck Sharp & Dohme Corp. Pyrazine substituted pyrrolopyridines as inhibitors of JAK and PDK1
MX2010005300A (en) * 2007-11-16 2010-06-25 Incyte Corp 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroaryl pyrimidin-2-amines as janus kinase inhibitors.
BRPI0908433A2 (en) * 2008-02-06 2019-09-24 Novartis Ag pyrrolo [2,3-d] pyridines and their use as tyrosine kinase inhibitors
WO2009114552A1 (en) * 2008-03-10 2009-09-17 The Board Of Trustees Of The Leland Stanford Junior University Heteroaryl compounds, compositions, and methods of use in cancer treatment
TWI444382B (en) * 2008-03-11 2014-07-11 Incyte Corp Azetidine and cyclobutane derivatives as jak inhibitors
EP2278969B1 (en) * 2008-04-21 2013-02-13 Merck Sharp & Dohme Corp. Inhibitors of Janus kinases
CA2722326A1 (en) * 2008-04-24 2009-10-29 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
AR071717A1 (en) 2008-05-13 2010-07-07 Array Biopharma Inc PIRROLO [2,3-B] CHK1 AND CHK2 QUINASE INHIBITING PIRIDINS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCESS TO PREPARE THEM AND USE OF THE SAME IN THE TREATMENT AND PREVENTION OF CANCER.
EP2299816B1 (en) * 2008-06-18 2013-11-13 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
US20100035875A1 (en) * 2008-06-20 2010-02-11 Bing-Yan Zhu Triazolopyridine jak inhibitor compounds and methods
KR20110033223A (en) * 2008-06-20 2011-03-30 제넨테크, 인크. Triazolopyridine JAP inhibitor compounds and methods
CL2009001884A1 (en) * 2008-10-02 2010-05-14 Incyte Holdings Corp Use of 3-cyclopentyl-3- [4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl) -1h-pyrazol-1-yl) propanonitrile, janus kinase inhibitor, and use of a composition that understands it for the treatment of dry eye.
AT507187B1 (en) 2008-10-23 2010-03-15 Helmut Dr Buchberger INHALER
PE20211639A1 (en) * 2009-01-15 2021-08-24 Incyte Holdings Corp PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIARY COMPOUNDS
US8765727B2 (en) * 2009-01-23 2014-07-01 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
EP2432472B1 (en) * 2009-05-22 2019-10-02 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
MY156727A (en) * 2009-05-22 2016-03-15 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
JP5719840B2 (en) 2009-06-08 2015-05-20 武田薬品工業株式会社 Dihydropyrrolonaphthylidinone compounds as inhibitors of JAK
EP2845856A1 (en) 2009-06-29 2015-03-11 Incyte Corporation Pyrimidinones as PI3K inhibitors
EP2995303A1 (en) 2009-07-10 2016-03-16 President and Fellows of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
TWI466885B (en) 2009-07-31 2015-01-01 Japan Tobacco Inc Nitrogen-containing spiro compound and its medical use
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
WO2011029043A1 (en) * 2009-09-04 2011-03-10 Biogen Idec Ma Inc. Heteroaryl btk inhibitors
CA2773182A1 (en) 2009-09-10 2011-03-17 F. Hoffmann-La Roche Ag Inhibitors of jak
JP6012468B2 (en) 2009-10-02 2016-10-25 アヴェクシン エーエス Anti-inflammatory 2-oxothiazole and 2-oxooxazole
MX2012004180A (en) * 2009-10-09 2012-07-17 Incyte Corp Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclo pentylpropanenitrile.
US8389728B2 (en) * 2009-11-06 2013-03-05 The Arizona Board Of Regents Pollen tube stimulants from Arabidopsis pistils
CA2790070C (en) * 2010-02-18 2018-03-06 Incyte Corporation Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
WO2011109217A2 (en) * 2010-03-02 2011-09-09 Immunodiagnostics, Inc. Methods of treating or preventing rna polymerase dependent viral disorders by administration of jak2 kinase inhibitors
EP3354652B1 (en) * 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
AU2015205858B2 (en) * 2010-03-10 2017-04-13 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
JP2013523884A (en) * 2010-04-14 2013-06-17 アレイ バイオファーマ、インコーポレイテッド 5,7-substituted imidazo [1,2-c] pyrimidines as inhibitors of JAK kinase
AR081626A1 (en) 2010-04-23 2012-10-10 Cytokinetics Inc AMINO-PYRIDAZINIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND USE OF THE SAME TO TREAT CARDIAC AND SKELETIC MUSCULAR DISORDERS
EP2560488B1 (en) 2010-04-23 2015-10-28 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (en) 2010-04-23 2012-08-08 Cytokinetics Inc AMINO- PYRIMIDINES COMPOSITIONS OF THE SAME AND METHODS FOR THE USE OF THE SAME
AR084691A1 (en) * 2010-05-21 2013-06-05 Incyte Corp TOPICAL USE FORMULATION FOR A JAK INHIBITOR AND METHOD TO TREAT SKIN DISORDER
JP5749341B2 (en) * 2010-08-20 2015-07-15 ハチソン メディファーマ リミテッド Pyrrolopyrimidine compounds and uses thereof
WO2012040527A2 (en) * 2010-09-24 2012-03-29 The Regents Of The University Of Michigan Deubiquitinase inhibitors and methods for use of the same
CA2816088A1 (en) 2010-10-28 2012-05-03 Viamet Pharmaceuticals, Inc. Metalloenzyme inhibitor compounds
WO2012060847A1 (en) 2010-11-07 2012-05-10 Targegen, Inc. Compositions and methods for treating myelofibrosis
EA036970B1 (en) * 2010-11-19 2021-01-21 Инсайт Холдингс Корпорейшн USE OF {1-{1-[3-FLUORO-2-(TRIFLUOROMETHYL)ISONICOTINOYL]PIPERIDINE-4-YL}-3-[4-(7H-PYRROLO[2,3-d]PYRIMIDINE-4-YL)-1H-PYRAZOL-1-YL]AZETIDINE-3-YL}ACETONITRILE IN TREATING JAK1-ASSOCIATED DISEASES
CA2818542A1 (en) * 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
WO2012068440A1 (en) * 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
EP2651930B1 (en) * 2010-12-16 2015-10-28 Boehringer Ingelheim International GmbH Biarylamide inhibitors of leukotriene production
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
JP5681819B2 (en) 2011-02-11 2015-03-11 バットマーク・リミテッド Inhaler components
WO2012112847A1 (en) 2011-02-18 2012-08-23 Novartis Pharma Ag mTOR/JAK INHIBITOR COMBINATION THERAPY
AU2012220601B2 (en) 2011-02-24 2017-03-09 Cephalon, Inc. Vinyl -aryl - sulfones for use in peritoneal carcinomatosis
CN103547580B (en) 2011-03-22 2016-12-07 阿迪维纳斯疗法有限公司 Substituted fused tricyclic compounds, their composition and medical use
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
MX2013013331A (en) * 2011-05-17 2014-10-17 Principia Biopharma Inc Azaindole derivatives as tyrosine kinase inhibitors.
CA2844407A1 (en) 2011-06-14 2012-12-20 Novartis Ag Combination of panobinostat and ruxolitinib in the treatment of cancer such as a myeloproliferative neoplasm
MY165963A (en) * 2011-06-20 2018-05-18 Incyte Holdings Corp Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
KR20140058543A (en) 2011-07-08 2014-05-14 노파르티스 아게 Novel pyrrolo pyrimidine derivatives
CA2844507A1 (en) 2011-08-10 2013-02-14 Novartis Pharma Ag Jak pi3k/mtor combination therapy
TW201313721A (en) 2011-08-18 2013-04-01 Incyte Corp Cyclohexyl azetidine derivatives as JAK inhibitors
UA121539C2 (en) 2011-09-02 2020-06-25 Інсайт Холдинґс Корпорейшн HETEROCYCLYLAMINE AS RI3K INHIBITORS
UA111854C2 (en) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS
EP2758389B1 (en) * 2011-09-22 2017-06-07 Merck Sharp & Dohme Corp. Pyrazole carboxamides as janus kinase inhibitors
WO2013055645A1 (en) * 2011-10-12 2013-04-18 Array Biopharma Inc. 5,7-substituted-imidazo[1,2-c]pyrimidines
CA3131037A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
US10821111B2 (en) 2011-11-30 2020-11-03 Emory University Antiviral JAK inhibitors useful in treating or preventing retroviral and other viral infections
WO2013085802A1 (en) * 2011-12-06 2013-06-13 Merck Sharp & Dohme Corp. Pyrrolopyrimidines as janus kinase inhibitors
AR090548A1 (en) 2012-04-02 2014-11-19 Incyte Corp BICYCLIC AZAHETEROCICLOBENCILAMINS AS PI3K INHIBITORS
WO2013173506A2 (en) 2012-05-16 2013-11-21 Rigel Pharmaceuticals, Inc. Method of treating muscular degradation
TW201406761A (en) 2012-05-18 2014-02-16 Incyte Corp Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
DK3882249T3 (en) * 2012-06-15 2025-08-25 Sun Pharmaceutical Ind Inc DEUTERIZED DERIVATIVES OF RUXOLITINIB
SG10201610869TA (en) 2012-06-26 2017-02-27 Del Mar Pharmaceuticals Methods for treating tyrosine-kinase-inhibitor-resistant malignancies in patients with genetic polymorphisms or ahi1 dysregulations or mutations employing dianhydrogalactitol, diacetyldianhydrogalacti
CA2879603A1 (en) 2012-07-27 2014-01-30 Ratiopharm Gmbh Oral dosage forms for modified release comprising ruxolitinib
DK2880025T3 (en) 2012-08-02 2019-03-18 Nerviano Medical Sciences Srl SUBSTITUTED PYROLES ACTIVE AS KINase INHIBITORS
IN2015DN02008A (en) 2012-09-21 2015-08-14 Advinus Therapeutics Ltd
JP6139690B2 (en) * 2012-10-26 2017-05-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Bruton tyrosine kinase inhibitor
JP6359546B2 (en) 2012-11-01 2018-07-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Tricyclic fused thiophene derivatives as JAK inhibitors
TWI761825B (en) 2012-11-15 2022-04-21 美商英塞特控股公司 Sustained-release dosage forms of ruxolitinib
US9310374B2 (en) * 2012-11-16 2016-04-12 Redwood Bioscience, Inc. Hydrazinyl-indole compounds and methods for producing a conjugate
WO2014085154A1 (en) 2012-11-27 2014-06-05 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
AU2013355220B2 (en) * 2012-12-06 2018-08-02 Baruch S. Blumberg Institute Functionalized benzamide derivatives as antiviral agents against HBV infection
US9260426B2 (en) 2012-12-14 2016-02-16 Arrien Pharmaceuticals Llc Substituted 1H-pyrrolo [2, 3-b] pyridine and 1H-pyrazolo [3, 4-b] pyridine derivatives as salt inducible kinase 2 (SIK2) inhibitors
CN105102438B (en) 2013-01-29 2019-04-30 埃维克辛公司 Anti-inflammatory and antitumor 2-oxothiazoles and 2-oxothiophenes
US10126301B2 (en) 2013-02-08 2018-11-13 Institute For Myeloma & Bone Cancer Research Diagnostic, prognostic, and monitoring methods for multiple myeloma, chronic lymphocytic leukemia, and B-cell non-hodgkin lymphoma
JP6274199B2 (en) * 2013-02-12 2018-02-07 コニカミノルタ株式会社 ORGANIC ELECTROLUMINESCENT ELEMENT AND LIGHTING DEVICE
MX384910B (en) 2013-03-06 2025-03-14 Incyte Holdings Corp PROCESSES AND INTERMEDIATE FOR MAKING A JAK INHIBITOR.
US20140343034A1 (en) 2013-04-25 2014-11-20 Japan Tobacco Inc. Skin barrier function improving agent
PE20200527A1 (en) 2013-05-17 2020-03-09 Incyte Corp DERIVATIVES OF BIPIRAZOLE AS JAK INHIBITORS
SG11201600815WA (en) 2013-08-07 2016-03-30 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
WO2015026818A1 (en) * 2013-08-20 2015-02-26 Incyte Corporation Survival benefit in patients with solid tumors with elevated c-reactive protein levels
EP3757130A1 (en) 2013-09-26 2020-12-30 Costim Pharmaceuticals Inc. Methods for treating hematologic cancers
WO2015054283A1 (en) * 2013-10-08 2015-04-16 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP3057972A4 (en) * 2013-10-15 2017-03-22 V Jin Novel compositions, uses and methods for their preparation
MX2016006894A (en) 2013-11-27 2016-08-17 Novartis Ag Combination therapy comprising an inhibitor of jak, cdk and pim.
ES2654051T3 (en) 2013-12-05 2018-02-12 Pfizer Inc. Pyrrolo [2,3-d] pyrimidinyl, pyrrolo [2,3-b] pyrazinyl and pyrrolo [2,3-d] pyridinyl acrylamides
JP6367545B2 (en) * 2013-12-17 2018-08-01 コンサート ファーマシューティカルズ インコーポレイテッド Deuterated derivatives of ruxolitinib
KR102261733B1 (en) * 2013-12-18 2021-06-04 콘서트 파마슈티컬즈, 인크. Deuterated derivatives of ruxolitinib
CN104725380B (en) * 2013-12-18 2019-06-28 康塞特医药品有限公司 Deuterated derivatives of ruxolitinib
CA2935423C (en) 2014-01-24 2023-11-07 Dana-Farber Cancer Institute, Inc. Antibody molecules to pd-1 and uses thereof
AU2015210750B2 (en) 2014-01-31 2020-08-20 Children's Medical Center Corporation Antibody molecules to TIM-3 and uses thereof
SG10201807952PA (en) 2014-02-28 2018-10-30 Incyte Corp Jak1 inhibitors for the treatment of myelodysplastic syndromes
EP4019518A1 (en) 2014-02-28 2022-06-29 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
WO2015138920A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
CN106413716B (en) 2014-04-08 2020-03-27 因赛特公司 Treatment of B cell malignancies by combination of JAK and PI3K inhibitors
BR112016025427A2 (en) 2014-04-30 2017-08-15 Incyte Corp processes for preparing a jak1 inhibitor and forms thereof
RU2564891C1 (en) * 2014-05-27 2015-10-10 Александр Александрович Кролевец Method of producing nanocapsules of cytokinins
WO2015184087A2 (en) * 2014-05-28 2015-12-03 Institute For Myeloma & Bone Cancer Research Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
CN105218548A (en) * 2014-06-09 2016-01-06 上海海和药物研究开发有限公司 A kind of novel heterocyclic compounds and preparation method thereof and the purposes as kinase inhibitor
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
EA201790189A1 (en) * 2014-07-14 2017-11-30 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи METHODS OF TREATING MALIGNANT NUMER FORMATION USING SUBSTITUTED PYRROPYRYMIDIN COMPOUNDS, COMPOSITIONS ON THEIR BASIS
NZ629796A (en) * 2014-07-14 2015-12-24 Signal Pharm Llc Amorphous form of 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d]oxazol-6-yl)-7h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
GB201413695D0 (en) 2014-08-01 2014-09-17 Avexxin As Compound
US20170224819A1 (en) 2014-08-11 2017-08-10 Acerta Pharma B.V. Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor
RS62713B1 (en) 2014-08-11 2022-01-31 Acerta Pharma Bv Therapeutic combinations of a btk inhibitor and a bcl-2 inhibitor
HRP20220738T1 (en) 2014-08-11 2022-08-19 Acerta Pharma B.V. Therapeutic combinations of a btk inhibitor, a pi3k inhibitor, a jak-2 inhibitor, a pd-1 inhibitor and/or a pd-l1 inhibitor
CN117164657A (en) 2014-08-12 2023-12-05 莫纳什大学 Prodrugs of directed lymphatics
EP3183252B1 (en) * 2014-08-21 2021-05-12 ratiopharm GmbH Oxalate salt of ruxolitinib
WO2016040882A1 (en) 2014-09-13 2016-03-17 Novartis Ag Combination therapies of egfr inhibitors
CN105524067A (en) * 2014-09-28 2016-04-27 江苏柯菲平医药股份有限公司 4-substituted pyrrolo[2,3-d]pyrimidine compound and uses thereof
KR20170066546A (en) 2014-10-03 2017-06-14 노파르티스 아게 Combination therapies
MA41044A (en) 2014-10-08 2017-08-15 Novartis Ag COMPOSITIONS AND METHODS OF USE FOR INCREASED IMMUNE RESPONSE AND CANCER TREATMENT
WO2016061142A1 (en) 2014-10-14 2016-04-21 Novartis Ag Antibody molecules to pd-l1 and uses thereof
WO2016063294A2 (en) * 2014-10-20 2016-04-28 Msn Laboratories Private Limited Process for the preparation of (r)-3-(4-(7h-pyrrolo[2,3-d], pyrimidin-4-yl)-1 h-pyrazol-1-yl)-3-cyclopentylpropanenitrile phosphate and its polymorphs thereof
KR102754019B1 (en) 2014-10-29 2025-01-14 바이시클러드 리미티드 Bicyclic peptide ligands specific for mt1-mmp
GB2535427A (en) 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
CZ2014773A3 (en) 2014-11-10 2016-05-18 Zentiva, K.S. Salts of (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile
CN105777754B (en) * 2014-12-16 2019-07-26 北京赛林泰医药技术有限公司 Pyrrolopyrimidine compounds
ES2930585T3 (en) 2015-02-27 2022-12-19 Nimbus Lakshmi Inc TYK2 inhibitors and uses thereof
UA122332C2 (en) 2015-02-27 2020-10-26 Інсайт Корпорейшн Salts of pi3k inhibitor and processes for their preparation
JO3746B1 (en) 2015-03-10 2021-01-31 Aduro Biotech Inc Compositions and methods for activating “stimulator of interferon gene”-dependent signalling
KR101859170B1 (en) * 2015-04-17 2018-05-17 광주과학기술원 Triazol compounds and Use thereof
UA119701C2 (en) * 2015-04-29 2019-07-25 Вуксі Фортуне Фармасьютікал Ко., Лтд Jak inhibitors
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
US9840503B2 (en) 2015-05-11 2017-12-12 Incyte Corporation Heterocyclic compounds and uses thereof
WO2016183060A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
WO2017004134A1 (en) 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
CZ2015496A3 (en) 2015-07-14 2017-01-25 Zentiva, K.S. The crystalline salt forms of (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-pyrazol-1-yl] of propanenitrile and their preparation
WO2017011720A1 (en) * 2015-07-16 2017-01-19 Signal Pharmaceuticals, Llc Solod forms 4-((4-(cyclopentyloxy)-5-(2-methylbenzo[d] oxazol-6-yl)17h-pyrrolo[2,3-d]pyrimidin-2-yl)amino)-3-methoxy-n-methylbenzamide, compositions thereof and methods of their use
ES2878188T3 (en) 2015-07-29 2021-11-18 Novartis Ag Combination therapies comprising antibody molecules against LAG-3
EP4378957A3 (en) 2015-07-29 2024-08-07 Novartis AG Combination therapies comprising antibody molecules to pd-1
WO2017019897A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to tim-3
WO2017024037A1 (en) 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
WO2017027717A1 (en) 2015-08-12 2017-02-16 Incyte Corporation Bicyclic fused pyrimidine compounds as tam inhibitors
US10053465B2 (en) 2015-08-26 2018-08-21 Incyte Corporation Pyrrolopyrimidine derivatives as TAM inhibitors
JP6802263B2 (en) 2015-09-02 2020-12-16 ニンバス ラクシュミ， インコーポレイテッド TYK2 inhibitor and its use
EP3347340A4 (en) 2015-09-08 2019-01-23 Monash University PROMOTERS TARGETING THE LYMPH
US10683308B2 (en) 2015-09-11 2020-06-16 Navitor Pharmaceuticals, Inc. Rapamycin analogs and uses thereof
GB2542838B (en) 2015-10-01 2022-01-12 Nicoventures Trading Ltd Aerosol provision system
AU2016342027B2 (en) 2015-10-23 2021-05-13 Navitor Pharmaceuticals, Inc. Modulators of Sestrin-GATOR2 interaction and uses thereof
KR20250099459A (en) 2015-11-03 2025-07-01 얀센 바이오테크 인코포레이티드 Antibodies specifically binding pd-1 and their uses
TWI744256B (en) 2015-11-06 2021-11-01 美商英塞特公司 HETEROCYCLIC COMPOUNDS AS PI3K-γ INHIBITORS
ES2908470T3 (en) 2015-11-09 2022-04-29 Scherer Technologies Llc R P Anti-CD22-maytansine antibody conjugates and methods of using the same
RU2601410C1 (en) * 2015-11-13 2016-11-10 ЗАО "Р-Фарм" {3-[(7H-PYRROLO[2,3-d]PYRIMIDIN-4-YL)AZOLYL]AZETIDIN-3-YL} ACETONITRILES AS JANUS KINASE INHIBITORS
EP3389664A4 (en) 2015-12-14 2020-01-08 Raze Therapeutics Inc. MTHFD2 CAFFEIN INHIBITORS AND USES THEREOF
WO2017101777A1 (en) * 2015-12-15 2017-06-22 北京赛林泰医药技术有限公司 Pyrrolopyrimidine compound salt
RU2018125603A (en) 2015-12-17 2020-01-21 Новартис Аг COMBINATION OF C-MET INHIBITOR WITH ANTIBODY MOLECULE TO PD-1 AND ITS APPLICATIONS
EP3389712B1 (en) 2015-12-17 2024-04-10 Novartis AG Antibody molecules to pd-1 and uses thereof
US9630968B1 (en) 2015-12-23 2017-04-25 Arqule, Inc. Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof
JP6921087B2 (en) * 2015-12-31 2021-08-18 チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッドChia Tai Tianqing Pharmaceutical Group Co., Ltd. Ruxolitinib synthesis process
ES2898329T3 (en) 2016-01-12 2022-03-07 Oncotracker Inc Improved methods for monitoring the immune status of a subject
CZ201629A3 (en) 2016-01-22 2017-08-02 Zentiva, K.S. Crystalline modifications of the (3R)-3-cyclopentyl-3- [4-(7H-pyrrolo [2,3-d] pyrimidin-4yl) pyrazol-1yl] propanenitrile salts and the method of their preparation
CN106905322B (en) * 2016-01-26 2019-10-15 杭州华东医药集团新药研究院有限公司 Pyrropyrimidine five-membered nitrogen heterocyclic derivatives and applications thereof
CN105541891B (en) * 2016-02-04 2017-11-28 东南大学 Ba Rui prepares methods of the Ba Rui for Buddhist nun for intermediate of Buddhist nun and preparation method thereof and by the intermediate
PT3426243T (en) 2016-03-09 2021-08-19 Raze Therapeutics Inc 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
EP3426244B1 (en) 2016-03-09 2023-06-07 Raze Therapeutics, Inc. 3-phosphoglycerate dehydrogenase inhibitors and uses thereof
GB201604318D0 (en) 2016-03-14 2016-04-27 Avexxin As Combination therapy
CN114456176B (en) 2016-03-28 2024-08-30 因赛特公司 Pyrrolotriazine compounds as TAM inhibitors
WO2017177230A1 (en) 2016-04-08 2017-10-12 X4 Pharmaceuticals, Inc. Methods for treating cancer
LT3452039T (en) 2016-05-04 2024-10-25 Sun Pharmaceutical Industries, Inc. TREATMENT OF HAIR LOSS DISORDER WITH DEUTERONATED JAK INHIBITORS
UA124237C2 (en) 2016-06-01 2021-08-11 Байєр Енімал Хелс Гмбх Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
CN107513069A (en) * 2016-06-16 2017-12-26 正大天晴药业集团股份有限公司 The preparation method of chiral Pyrrolopyrimidine compounds
CN107759600A (en) * 2016-06-16 2018-03-06 正大天晴药业集团股份有限公司 Crystallization as the Pyrrolopyrimidine compounds of JAK inhibitor
CN107513067A (en) * 2016-06-16 2017-12-26 北京赛林泰医药技术有限公司 Pyrrolopyrimidine compounds containing substituted cyclopenta
WO2017223229A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
CA3027500A1 (en) 2016-06-21 2017-12-28 X4 Pharmaceuticals, Inc. Cxcr4 inhibitors and uses thereof
JP7054529B2 (en) 2016-06-21 2022-04-14 エックス４ ファーマシューティカルズ， インコーポレイテッド CXCR4 inhibitor and its use
KR102329162B1 (en) 2016-06-30 2021-11-22 주식회사 대웅제약 pyrazolopyrimidine derivatives as kinase inhibitor
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
WO2018019223A1 (en) 2016-07-26 2018-02-01 张文燕 Compound as selective jak inhibitor, and salt and therapeutic use thereof
SG11201901197PA (en) 2016-08-24 2019-03-28 Arqule Inc Amino-pyrrolopyrimidinone compounds and methods of use thereof
JOP20190024A1 (en) 2016-08-26 2019-02-19 Gilead Sciences Inc Substituted pyrrolizine compounds and uses thereof
IT201600092051A1 (en) * 2016-09-13 2018-03-13 Alessandro Antonelli MEDICAL COMPOUND FOR TREATMENT OF THYROID CANCER
CN115448916B (en) 2016-10-14 2026-04-28 武田药品工业株式会社 TYK2 inhibitors and their uses
JP7082120B2 (en) 2016-10-21 2022-06-07 ニンバス ラクシュミ， インコーポレイテッド TYK2 inhibitors and their use
WO2018089499A1 (en) 2016-11-08 2018-05-17 Navitor Pharmaceuticals, Inc. PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF
AU2017368050A1 (en) 2016-11-29 2019-06-20 Puretech Lyt, Inc. Exosomes for delivery of therapeutic agents
US11091451B2 (en) 2016-12-05 2021-08-17 Raze Therapeutics, Inc. SHMT inhibitors and uses thereof
RU2644155C1 (en) * 2016-12-12 2018-02-08 Закрытое акционерное общество "Р-Фарм" (ЗАО "Р-Фарм") 2-(3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile heminaphthyldisulfonate as janus kinase inhibitor
US11730819B2 (en) 2016-12-23 2023-08-22 Bicycletx Limited Peptide derivatives having novel linkage structures
WO2018127699A1 (en) 2017-01-06 2018-07-12 Bicyclerd Limited Compounds for treating cancer
EA039344B1 (en) * 2017-01-19 2022-01-17 Сучжоу Лонгбайотек Фармасьютикалз Ко., Лтд. Heterocyclic compound as jak inhibitor and salts and therapeutic use thereof
TWI868528B (en) 2017-03-08 2025-01-01 日商武田藥品工業股份有限公司 Methods for production of tyk2 inhibitors
EP3375784A1 (en) 2017-03-14 2018-09-19 Artax Biopharma Inc. Aza-dihydro-acridone derivatives
EP3375778A1 (en) 2017-03-14 2018-09-19 Artax Biopharma Inc. Aryl-piperidine derivatives
WO2018191146A1 (en) 2017-04-10 2018-10-18 Navitor Pharmaceuticals, Inc. Heteroaryl rheb inhibitors and uses thereof
JOP20180036A1 (en) 2017-04-18 2019-01-30 Vifor Int Ag Salts for new fruortin inhibitors
TWI776886B (en) 2017-04-26 2022-09-11 美商奈維特製藥公司 Modulators of sestrin-gator2 interaction and uses thereof
US10857196B2 (en) 2017-04-27 2020-12-08 Bicycletx Limited Bicyclic peptide ligands and uses thereof
UY37695A (en) 2017-04-28 2018-11-30 Novartis Ag BIS 2’-5’-RR- (3’F-A) (3’F-A) CYCLE DINUCLEOTIDE COMPOUND AND USES OF THE SAME
JP2020520955A (en) 2017-05-23 2020-07-16 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー Glucuronide prodrugs of Janus kinase inhibitors
WO2018231944A1 (en) 2017-06-13 2018-12-20 Berenson James R Diagnostic, prognostic, and monitoring methods for solid tumor cancers
WO2018237173A1 (en) 2017-06-22 2018-12-27 Novartis Ag Antibody molecules to cd73 and uses thereof
US11312783B2 (en) 2017-06-22 2022-04-26 Novartis Ag Antibody molecules to CD73 and uses thereof
CN111032678A (en) 2017-06-26 2020-04-17 拜西克尔德有限公司 Bicyclic peptide ligands with detectable moieties and uses thereof
CN107298680A (en) * 2017-07-12 2017-10-27 海门华祥医药科技有限公司 A kind of production technology of 4-chloro-7-azaindole
WO2019023468A1 (en) 2017-07-28 2019-01-31 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
ES2926195T3 (en) 2017-08-04 2022-10-24 Bicycletx Ltd CD137-specific bicyclic peptide ligands
EP3668550A1 (en) 2017-08-14 2020-06-24 Bicyclerd Limited Bicyclic peptide ligand prr-a conjugates and uses thereof
WO2019034866A1 (en) 2017-08-14 2019-02-21 Bicyclerd Limited Bicyclic peptide ligand sting conjugates and uses thereof
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
WO2019046491A1 (en) 2017-08-29 2019-03-07 Ariya Therapeutics, Inc. Lymphatic system-directing lipid prodrugs
WO2019060693A1 (en) 2017-09-22 2019-03-28 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
JP7366031B2 (en) 2017-09-22 2023-10-20 カイメラ セラピューティクス， インコーポレイテッド Proteolytic agents and their use
KR102739325B1 (en) 2017-09-27 2024-12-09 인사이트 코포레이션 Salts of pyrrolotriazine derivatives useful as TAM inhibitors
CN109651424B (en) * 2017-10-11 2021-01-22 新发药业有限公司 Synthesis method of 7-protecting group-4- (1-hydrogen-pyrazol-4-yl) pyrrole [2,3-d ] pyrimidine
US10800775B2 (en) 2017-11-03 2020-10-13 Aclaris Therapeutics, Inc. Pyrazolyl pyrrolo[2,3-b]pyrmidine-5-carboxylate analogs and methods of making the same
KR102821964B1 (en) 2017-11-03 2025-06-19 어클라리스 쎄라퓨틱스, 인코포레이티드 Substituted pyrrolopyrimidine JAK inhibitors and methods for their manufacture and use
KR102034538B1 (en) 2017-11-28 2019-10-21 주식회사한국파마 Jak inhibitor compounds, and method of preparing the same
US10596161B2 (en) 2017-12-08 2020-03-24 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
GB201721265D0 (en) 2017-12-19 2018-01-31 Bicyclerd Ltd Bicyclic peptide ligands specific for EphA2
WO2019126378A1 (en) 2017-12-19 2019-06-27 Ariya Therapeutics, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
TWI825046B (en) 2017-12-19 2023-12-11 英商拜西可泰克斯有限公司 Bicyclic peptide ligands specific for epha2
IL315310A (en) 2017-12-26 2024-10-01 Kymera Therapeutics Inc IRAK joints and used in them
US11512080B2 (en) 2018-01-12 2022-11-29 Kymera Therapeutics, Inc. CRBN ligands and uses thereof
EP3737666A4 (en) 2018-01-12 2022-01-05 Kymera Therapeutics, Inc. Protein degraders and uses thereof
US12398209B2 (en) 2018-01-22 2025-08-26 Janssen Biotech, Inc. Methods of treating cancers with antagonistic anti-PD-1 antibodies
JP7377207B2 (en) 2018-01-29 2023-11-09 メルク パテント ゲーエムベーハー GCN2 inhibitors and their uses
EP4616913A3 (en) 2018-01-29 2025-12-10 Merck Patent GmbH Gcn2 inhibitors and uses thereof
JP7393348B2 (en) 2018-01-30 2023-12-06 インサイト・コーポレイション Process and intermediates for producing (1-(3-fluoro-2(trifluoromethyl)isonicotinyl)piperidin-4-one)
UA127519C2 (en) 2018-02-16 2023-09-20 Інсайт Корпорейшн Jak1 pathway inhibitors for the treatment of cytokine-related disorders
AU2019224659A1 (en) 2018-02-23 2020-10-15 Bicycletx Limited Multimeric bicyclic peptide ligands
KR102526964B1 (en) 2018-02-26 2023-04-28 길리애드 사이언시즈, 인코포레이티드 Substituted pyrrolizine compounds as HBV replication inhibitors
EP3759086A1 (en) 2018-02-27 2021-01-06 Artax Biopharma Inc. Chromene derivatives as inhibitors of tcr-nck interaction
EP3762424A1 (en) 2018-03-08 2021-01-13 Novartis AG Use of an anti-p-selectin antibody
CN110357887B (en) * 2018-03-26 2022-09-16 武汉誉祥医药科技有限公司 Substituted 7H-pyrrolo [2,3-d ] pyrimidine derivatives, preparation method and use thereof
CN113768934A (en) 2018-03-30 2021-12-10 因赛特公司 Treatment of hidradenitis suppurativa with JAK inhibitors
JP7565798B2 (en) 2018-03-30 2024-10-11 インサイト・コーポレイション Biomarkers for Inflammatory Skin Disease
MX2020010815A (en) 2018-04-13 2020-12-11 Incyte Corp Biomarkers for graft-versus-host disease.
HUE067936T2 (en) 2018-04-24 2024-11-28 Merck Patent Gmbh Antiproliferation compounds and uses thereof
WO2019209757A1 (en) 2018-04-24 2019-10-31 Vertex Pharmaceuticals Incorporated Pteridinone compounds and uses thereof
UY38247A (en) 2018-05-30 2019-12-31 Novartis Ag ANTIBODIES AGAINST ENTPD2, COMBINATION THERAPIES AND METHODS OF USE OF ANTIBODIES AND COMBINATION THERAPIES
US20210214459A1 (en) 2018-05-31 2021-07-15 Novartis Ag Antibody molecules to cd73 and uses thereof
MX2020012826A (en) 2018-06-01 2021-03-09 Incyte Corp DOSAGE REGIMEN FOR THE TREATMENT OF DISORDERS RELATED TO PHOSPHATIDYLINOSITOL 3-KINASES (PI3K).
WO2019233434A1 (en) * 2018-06-06 2019-12-12 杭州澳津生物医药技术有限公司 Pyrazolopyrimidine derivative, use thereof and pharmaceutical composition
IL314362A (en) 2018-06-15 2024-09-01 Janssen Pharmaceutica Nv Rapamycin analogs and uses thereof
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
GB201810316D0 (en) 2018-06-22 2018-08-08 Bicyclerd Ltd Peptide ligands for binding to EphA2
US11241438B2 (en) 2018-06-29 2022-02-08 Incyte Corporation Formulations of an AXL/MER inhibitor
JP6830460B2 (en) * 2018-07-05 2021-02-17 コンサート ファーマシューティカルズ インコーポレイテッド Deuterated derivative of ruxolitinib
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
EP3817822A4 (en) 2018-07-06 2022-07-27 Kymera Therapeutics, Inc. PROTEIN DEGRADING AGENTS AND THEIR USES
CA3224985C (en) 2018-07-31 2025-11-18 Loxo Oncology, Inc. Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1h-pyrazole-4-carboxamide
EP3833350A4 (en) 2018-08-10 2022-05-18 Aclaris Therapeutics, Inc. PYRROLOPYRIMIDINE ITC INHIBITORS
WO2020039401A1 (en) 2018-08-24 2020-02-27 Novartis Ag Treatment comprising il-1βeta binding antibodies and combinations thereof
US10548889B1 (en) 2018-08-31 2020-02-04 X4 Pharmaceuticals, Inc. Compositions of CXCR4 inhibitors and methods of preparation and use
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
CA3115088A1 (en) 2018-10-15 2020-04-23 Nimbus Lakshmi, Inc. Tyk2 inhibitors and uses thereof
US10919937B2 (en) 2018-10-23 2021-02-16 Bicycletx Limited Bicyclic peptide ligands and uses thereof
JP7644002B2 (en) 2018-10-24 2025-03-11 ナビター ファーマシューティカルズ， インコーポレイテッド Polymorphic Compounds and Uses Thereof
EA202191170A1 (en) 2018-10-31 2021-07-27 Инсайт Корпорейшн COMBINED THERAPY FOR TREATMENT OF HEMATOLOGICAL DISEASES
CN113271938A (en) 2018-11-30 2021-08-17 林伯士拉克许米公司 TYK2 inhibitors and uses thereof
JP7623943B2 (en) 2018-11-30 2025-01-29 カイメラ セラピューティクス， インコーポレイテッド IRAK degraders and their uses
CN109394768B (en) * 2018-12-10 2019-08-23 牡丹江医学院 A kind of medicine for treating eczema and preparation method thereof
GB201820325D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for psma
GB201820295D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for MT1-MMP
GB201820288D0 (en) 2018-12-13 2019-01-30 Bicycle Tx Ltd Bicycle peptide ligaands specific for MT1-MMP
CN111320633B (en) * 2018-12-14 2022-09-27 中国医药研究开发中心有限公司 Pyrrole/imidazo six-membered heteroaromatic ring compound and preparation method and medical application thereof
CN113474337A (en) 2018-12-19 2021-10-01 奥瑞生物药品公司 7- ((3, 5-dimethoxyphenyl) amino) quinoxaline derivatives as FGFR inhibitors for the treatment of cancer
EP3898626A1 (en) 2018-12-19 2021-10-27 Array Biopharma, Inc. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases
EP3670659A1 (en) 2018-12-20 2020-06-24 Abivax Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
CA3124330A1 (en) 2018-12-21 2020-06-25 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate and kinase inhibitor
CN113474045A (en) 2018-12-21 2021-10-01 拜斯科技术开发有限公司 PD-L1 specific bicyclic peptide ligands
US12551567B2 (en) 2018-12-21 2026-02-17 Bicyclerd Limited Bicyclic peptide ligands specific for PD-L1
AU2020212001A1 (en) 2019-01-23 2021-07-22 Takeda Pharmaceutical Company Limited TYK2 inhibitors and uses thereof
WO2020165600A1 (en) 2019-02-14 2020-08-20 Bicycletx Limited Bicyclic peptide ligand sting conjugates and uses thereof
CN111620873B (en) * 2019-02-28 2021-12-28 沈阳药科大学 Pyrrolo [2,3-d ] pyrimidine derivatives containing piperidine and preparation and application thereof
PH12021552130A1 (en) 2019-03-05 2022-08-31 Incyte Corp Jak1 pathway inhibitors for the treatment of chronic lung allograft dysfunction
EP3937945A4 (en) 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
BR112021017809A2 (en) 2019-03-11 2021-11-23 Nocion Therapeutics Inc Ester-substituted ion channel blockers and methods for use
MA55307A (en) 2019-03-11 2022-01-19 Nocion Therapeutics Inc CHARGED ION CHANNEL BLOCKERS AND METHODS OF USE
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
TW202102222A (en) 2019-03-19 2021-01-16 美商英塞特公司 Biomarkers for vitiligo
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
JP2022528887A (en) 2019-04-02 2022-06-16 バイスクルテクス・リミテッド Bicycle toxin conjugates and their use
US11485750B1 (en) 2019-04-05 2022-11-01 Kymera Therapeutics, Inc. STAT degraders and uses thereof
AR118750A1 (en) 2019-04-24 2021-10-27 Elanco Us Inc A PROCESS TO PREPARE A CRYSTALLINE FORM OF 2- (3- (4- (7H-PIRROLO [2,3-d] PYRIMIDIN-4-IL) -1H-PIRAZOL-1-IL) -1- (CYCLOPROPYLSULFONYL) AZETIDIN- 3-IL) ACETONITRILE POSSESSING JAK INHIBITING ACTIVITY
US11420966B2 (en) 2019-05-02 2022-08-23 Aclaris Therapeutics, Inc. Substituted pyrrolopyridines as JAK inhibitors
CN110028509B (en) * 2019-05-27 2020-10-09 上海勋和医药科技有限公司 Pyrrolopyrimidines as selective JAK2 inhibitors, their synthesis methods and uses
KR102286372B1 (en) 2019-05-27 2021-08-05 주식회사한국파마 Jak inhibitor compounds, and pharmaceutical composition comprising the same
WO2020240586A1 (en) * 2019-05-28 2020-12-03 Mankind Pharma Ltd. Novel compounds for inhibition of janus kinase 1
WO2020243423A1 (en) 2019-05-31 2020-12-03 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2020251971A1 (en) 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
JP7532511B2 (en) * 2019-06-10 2024-08-13 インサイト・コーポレイション Topical treatment of vitiligo vulgaris with JAK inhibitors
WO2020251972A1 (en) 2019-06-10 2020-12-17 Kymera Therapeutics, Inc. Smarca degraders and uses thereof
KR20220026586A (en) 2019-06-27 2022-03-04 크리스퍼 테라퓨틱스 아게 Use of chimeric antigen receptor T cell and NK cell inhibitors for the treatment of cancer
BR112021026517A2 (en) 2019-06-28 2022-05-10 Kymera Therapeutics Inc Irak degraders and uses thereof
WO2021011868A1 (en) 2019-07-17 2021-01-21 Kymera Therapeutics, Inc. Irak degraders and uses thereof
TWI860386B (en) 2019-07-30 2024-11-01 英商拜西可泰克斯有限公司 Heterotandem bicyclic peptide complex
CN110305140B (en) 2019-07-30 2020-08-04 上海勋和医药科技有限公司 Dihydropyrrolopyrimidines selective JAK2 inhibitors
WO2021022178A1 (en) * 2019-07-31 2021-02-04 Aclaris Therapeutics, Inc. Substituted sulfonamide pyrrolopyridines as jak inhibitors
US12624038B2 (en) 2019-08-01 2026-05-12 St. Jude Children's Research Hospital, Inc. Molecules and methods related to treatment of uncontrolled cellular proliferation
CN115038688A (en) 2019-09-11 2022-09-09 文森雷生物科学股份有限公司 USP30 inhibitors and uses thereof
PH12022550605A1 (en) 2019-09-13 2023-09-25 Nimbus Saturn Inc Hpk1 antagonists and uses thereof
JP2022548627A (en) 2019-09-16 2022-11-21 ノバルティス アーゲー Use of high-affinity ligand-blocking humanized anti-T cell immunoglobulin domain and mucin domain 3 (TIM-3) IGG4 antibodies for the treatment of myelofibrosis
WO2021053489A1 (en) 2019-09-16 2021-03-25 Novartis Ag Use of an mdm2 inhibitor for the treatment of myelofibrosis
JP2022548881A (en) 2019-09-18 2022-11-22 ノバルティス アーゲー ENTPD2 Antibodies, Combination Therapy and Methods of Using Antibodies and Combination Therapy
JP2022549506A (en) 2019-09-27 2022-11-25 ディスク・メディシン・インコーポレイテッド Methods for treating myelofibrosis and related conditions
CN110538183B (en) * 2019-10-09 2021-05-04 吉林大学 A composition for preventing and treating infantile eczema and preparation method thereof
EP4041204A1 (en) 2019-10-10 2022-08-17 Incyte Corporation Biomarkers for graft-versus-host disease
US12360120B2 (en) 2019-10-10 2025-07-15 Incyte Corporation Biomarkers for graft-versus-host disease
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
JP7518900B2 (en) 2019-10-16 2024-07-18 インサイト・コーポレイション Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and lichen planus (LP) - Patent Application 20070233334
EP4051259A4 (en) 2019-11-01 2023-11-22 Navitor Pharmaceuticals, Inc. Methods of treatment using an mtorc1 modulator
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
BR112022009710A2 (en) 2019-11-22 2022-08-09 Incyte Corp COMBINATION THERAPY COMPRISING AN ALK2 INHIBITOR AND A JAK2 INHIBITOR
BR112022010754A2 (en) 2019-12-05 2022-08-23 Anakuria Therapeutics Inc RAPAMICIN ANALOGS AND USES THEREOF
EP4072591A4 (en) 2019-12-10 2024-06-05 Kymera Therapeutics, Inc. IRAQ DEGRADATION AGENTS AND THEIR USES
JP2023509366A (en) 2019-12-17 2023-03-08 カイメラ セラピューティクス， インコーポレイテッド IRAK dissolving agents and their uses
WO2021127283A2 (en) 2019-12-17 2021-06-24 Kymera Therapeutics, Inc. Irak degraders and uses thereof
US12569485B2 (en) 2019-12-23 2026-03-10 Kymera Therapeutics, Inc. SMARCA inhibitors and uses thereof
CN115297931A (en) 2019-12-23 2022-11-04 凯麦拉医疗公司 SMARCA degrading agents and uses thereof
AU2020417293A1 (en) 2020-01-03 2022-09-01 Berg Llc Polycyclic amides as UBE2K modulators for treating cancer
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
AU2021217172A1 (en) 2020-02-05 2022-09-22 Monash University Lipid prodrugs of neurosteroids
CN111728975A (en) * 2020-02-25 2020-10-02 广东省检迅检测科技有限公司 Composition for reducing athletic injuries and promoting repair of athletic injuries
MX2022010944A (en) 2020-03-03 2022-11-09 Pic Therapeutics Inc Eif4e inhibitors and uses thereof.
PH12022552347A1 (en) 2020-03-06 2024-01-29 Incyte Corp Combination therapy comprising axl/mer and pd-1/pd-l1 inhibitors
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7708777B2 (en) 2020-03-11 2025-07-15 ノシオン セラピューティクス，インコーポレイテッド Charged ion channel blockers and methods of use - Patents.com
IL296451B2 (en) 2020-03-19 2026-05-01 Kymera Therapeutics Inc Mdm2 degraders and uses thereof
EP3892280A3 (en) 2020-04-09 2022-01-12 Children's Hospital Medical Center Sars-cov-2 infection biomarkers and uses thereof
US11324750B2 (en) 2020-04-09 2022-05-10 Children's Hospital Medical Center Compositions and methods for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
WO2021206766A1 (en) 2020-04-09 2021-10-14 Children's Hospital Medical Center Sars-cov-2 infection biomarkers and uses thereof
US20230218644A1 (en) 2020-04-16 2023-07-13 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
KR20230012539A (en) 2020-05-13 2023-01-26 디스크 메디슨, 인크. Anti-hemojuvelin (HJV) antibodies to treat myelofibrosis
WO2021236139A1 (en) 2020-05-21 2021-11-25 Concert Pharmaceuticals, Inc. Novel deuterated jak inhibitor and uses thereof
JP7802696B2 (en) 2020-06-02 2026-01-20 インサイト・コーポレイション Preparation process of JAK1 inhibitors
TW202210483A (en) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Crystalline forms of irak degraders
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
WO2021247897A1 (en) 2020-06-03 2021-12-09 Kymera Therapeutics, Inc. Deuterated irak degraders and uses thereof
HRP20251457T1 (en) 2020-06-03 2026-01-02 Incyte Corporation COMBINATION OF RUXOLITINIB WITH INCB057643 FOR USE IN THE TREATMENT OF MYELOPLOLIFERATIVE NEOPLASMS
JP2023529867A (en) 2020-06-05 2023-07-12 キネート バイオファーマ インク． Inhibitor of fibroblast growth factor receptor kinase
US20220023344A1 (en) 2020-06-26 2022-01-27 Crispr Therapeutics Ag Allogeneic cell therapy of acute lymphoblastic leukemia using genetically engineered t cells targeting cd19
EP3944859A1 (en) 2020-07-30 2022-02-02 Assistance Publique Hôpitaux de Paris Method for treating immune toxicities induced by immune checkpoint inhibitors
CA3189761A1 (en) 2020-08-03 2022-02-10 Gemma Mudd Peptide-based linkers
US11751108B2 (en) * 2020-08-05 2023-09-05 Qualcomm Incorporated Execution of reduced signaling handover
CN116348467A (en) * 2020-08-12 2023-06-27 康塞特医药品有限公司 Methods for preparing enantiomerically enriched JAK inhibitors
KR20230074721A (en) 2020-08-17 2023-05-31 바이사이클티엑스 리미티드 NECTIN-4 Specific Bicyclic Conjugates and Uses Thereof
WO2022040172A1 (en) 2020-08-18 2022-02-24 Incyte Corporation Process and intermediates for preparing a jak1 inhibitor
CR20230129A (en) 2020-08-18 2023-07-13 Incyte Corp Process and intermediates for preparing a jak inhibitor
US12590098B2 (en) * 2020-09-16 2026-03-31 Axceso Biopharma Co., Ltd. Pyrimido pyrimidinone compound and pharmaceutical composition comprising the same
US20230364095A1 (en) 2020-09-16 2023-11-16 Incyte Corporation Topical treatment of vitiligo
CA3197645A1 (en) 2020-10-02 2022-04-07 Incyte Corporation Topical ruxolitinib for treating lichen planus
US20240000777A1 (en) 2020-10-08 2024-01-04 Novartis Ag Use of an erk inhibitor for the treatment of myelofibrosis
EP4225316A1 (en) 2020-10-08 2023-08-16 Novartis AG Use of an erk inhibitor for the treatment of myelofibrosis
JP2023546996A (en) 2020-10-23 2023-11-08 ニンバス クロソー， インコーポレイテッド CTPS1 inhibitors and their uses
CN114437079B (en) * 2020-10-30 2024-11-01 杭州邦顺制药有限公司 Crystalline forms of pyrrolopyrimidine five-membered nitrogen heterocyclic compounds
KR102551758B1 (en) 2020-11-30 2023-07-05 주식회사한국파마 Novel jak specific inhibitor compounds, and method for the preparation thereof
WO2022120353A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
IL303376A (en) 2020-12-02 2023-08-01 Ikena Oncology Inc TEAD inhibitors and their uses
ES3025481T3 (en) 2020-12-04 2025-06-09 Incyte Corp Jak inhibitor with a vitamin d analog for treatment of skin diseases
JP2023552452A (en) 2020-12-08 2023-12-15 インサイト・コーポレイション JAK1 pathway inhibitor for vitiligo treatment
EP4259144A4 (en) 2020-12-09 2025-08-20 Kymera Therapeutics Inc SMARCA DECORATORS AND USES THEREOF
JP2023554665A (en) 2020-12-18 2023-12-28 ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド Boron-containing pyrazole compounds, compositions containing them, methods and uses thereof
WO2022147465A1 (en) 2020-12-30 2022-07-07 Kymera Therapeutics, Inc. Irak degraders and uses thereof
TW202237083A (en) 2021-01-11 2022-10-01 美商英塞特公司 Combination therapy comprising jak pathway inhibitor and rock inhibitor
US20240174662A1 (en) * 2021-02-01 2024-05-30 Janssen Biotech, Inc. Small molecule inhibitors of salt inducible kinases
KR20230153387A (en) 2021-02-02 2023-11-06 리미널 바이오사이언시스 리미티드 GPR84 antagonists and their uses
JP2024506858A (en) 2021-02-02 2024-02-15 リミナル・バイオサイエンシーズ・リミテッド GPR84 antagonists and their uses
WO2022166796A1 (en) * 2021-02-05 2022-08-11 上海齐鲁制药研究中心有限公司 Pyrimidine or pyridine and heterocyclic adenosine receptor inhibitor, preparation method therefor and use thereof
WO2022174253A1 (en) 2021-02-12 2022-08-18 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
TW202245788A (en) 2021-02-15 2022-12-01 美商凱麥拉醫療公司 Irak4 degraders and uses thereof
CN116867494A (en) 2021-02-15 2023-10-10 凯麦拉医疗公司 IRAK4 degraders and their uses
AU2022227673A1 (en) 2021-02-25 2023-08-17 Impact Biomedicines, Inc. Use of a bet inhibitor alone or in combination with fedratinib or ruxolitinib for treating a hematological malignancy such as myelofibrosis
CN117295737A (en) 2021-03-05 2023-12-26 林伯士萨顿公司 HPK1 antagonists and their uses
WO2022213062A1 (en) 2021-03-29 2022-10-06 Nimbus Saturn, Inc. Hpk1 antagonists and uses thereof
EP4319756A4 (en) 2021-04-09 2025-02-26 Nimbus Clio, Inc. CBL-B MODULATORS AND THEIR USES
WO2022221866A1 (en) 2021-04-16 2022-10-20 Ikena Oncology, Inc. Mek inhibitors and uses thereof
EP4696710A3 (en) 2021-05-03 2026-05-06 Incyte Corporation Jak1 pathway inhibitors for the treatment of prurigo nodularis
AU2022271290A1 (en) 2021-05-07 2023-11-23 Kymera Therapeutics, Inc. Cdk2 degraders and uses thereof
CA3226714A1 (en) 2021-07-12 2023-01-19 Incyte Corporation Process and intermediates for preparing baricitinib
CN118159272A (en) 2021-08-11 2024-06-07 太阳医药工业公司 Deuterated JAK inhibitors for treating hair loss disorders
JP2024532276A (en) 2021-08-25 2024-09-05 ピク セラピューティクス， インコーポレイテッド eIF4E inhibitors and uses thereof
TW202315621A (en) 2021-08-25 2023-04-16 美商皮克醫療公司 Eif4e inhibitors and uses thereof
KR102718345B1 (en) * 2021-09-16 2024-10-17 광주과학기술원 Novel triazolylpyrrolopyrimidine derivatives and use thereof
US20240376102A1 (en) * 2021-09-18 2024-11-14 Natco Pharma Limited An improved process for the preparation of ruxolitinib phosphate
EP4423086A1 (en) 2021-10-25 2024-09-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
EP4422635A4 (en) 2021-10-29 2025-11-26 Kymera Therapeutics Inc IRAQ-4 DEGRADER AND SYNTHESIS OF IT
CN118696059A (en) 2021-11-17 2024-09-24 美国全心医药生技股份有限公司 Methods for treating T cell-mediated inflammatory diseases or cancer using a combination of an anti-PSGL-1 antibody and a JAK inhibitor
WO2023102559A1 (en) 2021-12-03 2023-06-08 Incyte Corporation Topical formulations of ruxolitinib with an organic amine ph adjusting agent for treatment of skin diseases
WO2023114984A1 (en) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Tead inhibitors and uses thereof
CN114044777B (en) * 2022-01-10 2022-04-19 南京佰麦生物技术有限公司 Preparation method of tricitabinib phosphate
IL314437A (en) 2022-01-31 2024-09-01 Kymera Therapeutics Inc Irak degraders and uses thereof
CN114456181A (en) * 2022-02-21 2022-05-10 浙江乐普药业股份有限公司 Preparation method of luccotinib
WO2023173057A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023173053A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023211889A1 (en) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Polymorphic compounds and uses thereof
KR20250040894A (en) 2022-05-25 2025-03-25 이케나 온콜로지, 인코포레이티드 MEK inhibitors and uses thereof
EP4540252A1 (en) * 2022-06-14 2025-04-23 Incyte Corporation Solid forms of a jak inhibitor and process of preparing the same
CN117384163B (en) * 2022-07-05 2026-02-17 盛世泰科生物医药技术(苏州)股份有限公司 Compound containing gem difluoro group and preparation method and application thereof
JP2025527250A (en) 2022-08-02 2025-08-20 リミナル・バイオサイエンシーズ・リミテッド Heteroarylcarboxamides and related gpr84 antagonists and their uses
JP2025527247A (en) 2022-08-02 2025-08-20 リミナル・バイオサイエンシーズ・リミテッド Aryl-triazolyl and related gpr84 antagonists and their uses
JP2025527248A (en) 2022-08-02 2025-08-20 リミナル・バイオサイエンシーズ・リミテッド Substituted pyridone gpr84 antagonists and uses thereof
EP4565213A1 (en) 2022-08-03 2025-06-11 Medichem, S.A. Stable oral pharmaceutical formulation containing ruxolitinib hemifumarate
AU2023331168A1 (en) * 2022-08-22 2024-08-29 Granules India Limited An improved process for the preparation of ruxolitinib
CN119998286A (en) * 2022-10-28 2025-05-13 勃林格殷格翰国际有限公司 Heterocyclic compounds as STING antagonists
US20240166654A1 (en) * 2022-11-11 2024-05-23 Zhejiang Ausun Pharmaceutical Co., Ltd. Ruxolitinib crystal and pharmaceutical composition thereof
TW202430148A (en) 2022-11-22 2024-08-01 美商皮克醫療公司 Eif4e inhibitors and uses thereof
WO2024153148A1 (en) * 2023-01-18 2024-07-25 北京普祺医药科技股份有限公司 Heterocyclic compound, and pharmaceutical composition and use thereof
WO2024184926A1 (en) * 2023-03-08 2024-09-12 Aarti Pharmalabs Limited Process for preparation of chiral ruxolitinib and salts thereof
WO2024187416A1 (en) * 2023-03-15 2024-09-19 Zhejiang Qizheng Pharmaceutical Co., Ltd. Pharmaceutical composition comprising ruxolitinib
WO2024187415A1 (en) * 2023-03-15 2024-09-19 Zhejiang Qizheng Pharmaceutical Co., Ltd. Pharmaceutical composition comprising ruxolitinib
US20240398810A1 (en) 2023-05-21 2024-12-05 Incyte Corporation Topical ruxolitinib foam
EP4615455A2 (en) 2023-06-23 2025-09-17 Kymera Therapeutics, Inc. Irak degraders and uses thereof
EP4491175A1 (en) 2023-07-10 2025-01-15 Genepharm S.A. A solid oral composition of ruxolitinib
EP4540253A4 (en) 2023-09-04 2025-11-05 Granules India Ltd IMPROVED METHOD FOR PRODUCING RUXOLITINIB AND NOVEL CRYSTALLINE FORM OF IT
IT202300018879A1 (en) 2023-09-14 2025-03-14 Chemelectiva S R L ENZYMATIC PROCESS FOR THE PREPARATION OF (R)-3-(4-BROMO-1H-PYRAZOL-1-YL)-3-CYCLOPENTYLPROPANENITRILE, AS AN INTERMEDIATE IN THE SYNTHESIS OF RUXOLITINIB
AU2024344754A1 (en) 2023-09-21 2026-04-02 Takeda Pharmaceutical Company Limited Tyk2 inhibitors for use in the treatment of inflammatory bowel disease
US12364699B2 (en) 2023-10-10 2025-07-22 Sun Pharmaceuticals Industries, Inc. Method of treating hair loss disorders
WO2025117642A1 (en) 2023-12-01 2025-06-05 Incyte Corporation Ruxolitinib for treating hidradenitis suppurativa (hs)
EP4621803A1 (en) 2024-03-22 2025-09-24 Assistance Publique - Hôpitaux de Paris Method for identifying patients in need for ici-induced myotoxicity treatment
TW202547468A (en) * 2024-03-27 2025-12-16 美商基利科學股份有限公司 Small molecule modulators of stat6
US20250325664A1 (en) 2024-04-22 2025-10-23 Incyte Corporation Combination therapy with an anti-colony stimulating factor 1 receptor antibody and a jak inhibitor
AU2025271553A1 (en) 2024-08-26 2026-03-12 Incyte Corporation Topical skin formulations of a pharmaceutically acceptable salt of ruxolitinib

Family Cites Families (311)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985589A (en) 1957-05-22 1961-05-23 Universal Oil Prod Co Continuous sorption process employing fixed bed of sorbent and moving inlets and outlets
US3632836A (en) 1968-10-25 1972-01-04 Dow Chemical Co Solid curable polyepoxides modified with hydrolyzed liquid polyepoxides
US3832460A (en) * 1971-03-19 1974-08-27 C Kosti Anesthetic-vasoconstrictor-antihistamine composition for the treatment of hypertrophied oral tissue
US4140755A (en) * 1976-02-13 1979-02-20 Hoffmann-La Roche Inc. Sustained release tablet formulations
DE3036390A1 (en) 1980-09-26 1982-05-13 Troponwerke GmbH & Co KG, 5000 Köln Antiinflammatory intermediate 7H-pyrrolo-(2,3-D)-pyrimidine derivs. - prepd. by dealkylation of 7-phenyl:ethyl derivs. by reaction with hydrochloric, phosphoric or poly:phosphoric acid
DE3220113A1 (en) 1982-05-28 1983-12-01 Basf Ag, 6700 Ludwigshafen DIFLUORMETHOXIPHENYLTHIOPHOSPHORSAEUREESTER
US4402832A (en) 1982-08-12 1983-09-06 Uop Inc. High efficiency continuous separation process
US4404335A (en) 1982-08-16 1983-09-13 The Dow Chemical Company Hydrolyzing epoxy resins in absence of solvent and in presence of oxalic acid and a phosphonium compound
US4548990A (en) 1983-08-15 1985-10-22 Ciba-Geigy Corporation Crosslinked, porous polymers for controlled drug delivery
US4498991A (en) 1984-06-18 1985-02-12 Uop Inc. Serial flow continuous separation process
NL8403224A (en) * 1984-10-24 1986-05-16 Oce Andeno Bv DIOXAPHOSPHORINANS, THEIR PREPARATION AND THE USE FOR SPLITTING OF OPTICALLY ACTIVE COMPOUNDS.
CA1306260C (en) 1985-10-18 1992-08-11 Shionogi & Co., Ltd. Condensed imidazopyridine derivatives
US4921947A (en) 1986-03-31 1990-05-01 Eli Lilly And Company Process for preparing macrolide derivatives
JPH0710876Y2 (en) 1989-08-31 1995-03-15 石垣機工株式会社 Cleaning device for dehydration cylinder in screw press
EP0495982B1 (en) * 1989-10-11 1996-06-12 Teijin Limited Bicyclic pyrimidine derivative, method of producing the same, and pharmaceutical preparation containing the same as active ingredient
US5403593A (en) 1991-03-04 1995-04-04 Sandoz Ltd. Melt granulated compositions for preparing sustained release dosage forms
IT1258781B (en) 1992-01-16 1996-02-29 Zambon Spa OPHTHALMIC PHARMACEUTICAL COMPOSITION CONTAINING N-ACETYLCISTEIN AND POLYVINYL ALCOHOL
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
FR2695126B1 (en) 1992-08-27 1994-11-10 Sanofi Elf Thienyl or pyrrolyl carboxylic acid derivatives, their preparation and medicaments containing them.
AU671491B2 (en) 1992-12-18 1996-08-29 F. Hoffmann-La Roche Ag N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines
JPH0710876A (en) * 1993-06-24 1995-01-13 Teijin Ltd Pyrrolo [2,3-d] pyrimidine having a cyclic amino group at the 4-position
USH1439H (en) 1993-10-18 1995-05-02 The Dow Chemical Company Method to increase the level of α-glycol in liquid epoxy resin
EP0727217A3 (en) 1995-02-10 1997-01-15 Suntory Ltd Pharmaceutical and cosmetic compositions containing ellagitannin of the god type as active ingredient
IL117580A0 (en) 1995-03-29 1996-07-23 Merck & Co Inc Inhibitors of farnesyl-protein transferase and pharmaceutical compositions containing them
US5856326A (en) 1995-03-29 1999-01-05 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
DE69618959T2 (en) 1995-07-05 2002-08-29 E.I. Du Pont De Nemours And Co., Wilmington PYRIMIDONE AND THEIR USE AS FUNGICIDES
EP0836605B1 (en) 1995-07-06 2002-02-06 Novartis AG Pyrrolopyrimidines and processes for the preparation thereof
US5630943A (en) 1995-11-30 1997-05-20 Merck Patent Gesellschaft Mit Beschrankter Haftung Discontinuous countercurrent chromatographic process and apparatus
GB9604361D0 (en) 1996-02-29 1996-05-01 Pharmacia Spa 4-Substituted pyrrolopyrimidine compounds as tyrosine kinase inhibitors
JP2000504023A (en) 1996-04-03 2000-04-04 メルク エンド カンパニー インコーポレーテッド Cancer treatment methods
WO1997038664A2 (en) 1996-04-18 1997-10-23 Merck & Co., Inc. A method of treating cancer
US5795909A (en) * 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
EP0934270A1 (en) 1996-05-30 1999-08-11 Merck & Co., Inc. A method of treating cancer
US6624138B1 (en) * 2001-09-27 2003-09-23 Gp Medical Drug-loaded biological material chemically treated with genipin
EP0973396A4 (en) 1997-04-07 2001-02-07 Merck & Co Inc CANCER TREATMENT PROCESS
US6063284A (en) 1997-05-15 2000-05-16 Em Industries, Inc. Single column closed-loop recycling with periodic intra-profile injection
US6060038A (en) 1997-05-15 2000-05-09 Merck & Co., Inc. Radiolabeled farnesyl-protein transferase inhibitors
US5908841A (en) 1997-08-11 1999-06-01 Boehringer Ingelheim Pharmaceuticals, Inc. 5,11-dihydro-6H-dipyrido 3,2-b:2',3'-e!azepine-6-ones and their use in the prevention of treatment of HIV infection
US7153845B2 (en) 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6075056A (en) 1997-10-03 2000-06-13 Penederm, Inc. Antifungal/steroid topical compositions
SE9800729L (en) 1998-03-06 1999-09-07 Scotia Lipidteknik Ab New topical formulation I
US6025366A (en) 1998-04-02 2000-02-15 Merck & Co., Inc. Antagonists of gonadotropin releasing hormone
US6232320B1 (en) 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
KR20010052570A (en) 1998-06-04 2001-06-25 스티븐 에프. 웨인스톡 Cell adhesion-inhibiting antiinflammatory compounds
PA8474101A1 (en) 1998-06-19 2000-09-29 Pfizer Prod Inc PYROLEUM [2,3-D] PIRIMIDINE COMPOUNDS
PL198640B1 (en) 1998-06-19 2008-07-31 Pfizer Prod Inc PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS
EP1107964B8 (en) 1998-08-11 2010-04-07 Novartis AG Isoquinoline derivatives with angiogenesis inhibiting activity
JP2000119271A (en) 1998-08-12 2000-04-25 Hokuriku Seiyaku Co Ltd 1H-imidazopyridine derivative
ATE232382T1 (en) * 1998-09-10 2003-02-15 Nycomed Danmark As PHARMACEUTICAL COMPOSITIONS WITH RAPID RELEASE OF ACTIVE INGREDIENTS
US6413419B1 (en) 1998-10-29 2002-07-02 Institut Francais Du Petrole Process and device for separation with variable-length chromatographic
FR2785196B1 (en) 1998-10-29 2000-12-15 Inst Francais Du Petrole METHOD AND DEVICE FOR SEPARATION WITH VARIABLE LENGTH CHROMATOGRAPHIC AREAS
US6375839B1 (en) 1998-10-29 2002-04-23 Institut Francais Du Petrole Process and device for separation with variable-length chromatographic zones
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
WO2000051614A1 (en) 1999-03-03 2000-09-08 Merck & Co., Inc. Inhibitors of prenyl-protein transferases
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6239113B1 (en) 1999-03-31 2001-05-29 Insite Vision, Incorporated Topical treatment or prevention of ocular infections
WO2000063168A1 (en) 1999-04-16 2000-10-26 Coelacanth Chemical Corporation Synthesis of azetidine derivatives
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
ES2223588T3 (en) 1999-10-13 2005-03-01 Banyu Pharmaceutical Co., Ltd. IMIDAZOLIDINONA SUBSTITUTED DERIVATIVES.
US7235258B1 (en) 1999-10-19 2007-06-26 Nps Pharmaceuticals, Inc. Sustained-release formulations for treating CNS-mediated disorders
EA006227B1 (en) * 1999-12-10 2005-10-27 Пфайзер Продактс Инк. PIRROLO(2,3-d)PYRIMIDINE COMPOUNDS
EP1990343B1 (en) * 1999-12-24 2012-04-04 Aventis Pharma Limited Azaindoles
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
DE60100866T2 (en) 2000-04-07 2004-07-29 Laboratoire Medidom S.A. Ophthalmic medicinal product containing cyclosporine, hyaluronic acid and polysorbate
AU4878601A (en) 2000-04-20 2001-11-07 Mitsubishi Corporation Aromatic amide compounds
DK2223922T3 (en) * 2000-04-25 2016-06-06 Icos Corp Inhibitors of HUMANPHOSPHATIDYL-inositol 3-KINASEDELTA
US7498304B2 (en) 2000-06-16 2009-03-03 Curis, Inc. Angiogenesis-modulating compositions and uses
AU7549501A (en) 2000-06-16 2002-01-02 Biogen Inc Angiogenesis-modulating compositions and uses
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
CA2413313C (en) 2000-06-23 2011-06-14 Mitsubishi Pharma Corporation Antitumor effect potentiators
EA006153B1 (en) * 2000-06-26 2005-10-27 Пфайзер Продактс Инк. PYRROLO[2,3-d]PYRIMIDINE COMPOUNDS AS IMMUNOSUPPRESSIVE AGENTS
KR100786927B1 (en) 2000-06-28 2007-12-17 스미스클라인비이참피이엘시이 Wet Grinding Method
WO2002016370A1 (en) 2000-08-22 2002-02-28 Hokuriku Seiyaku Co., Ltd. 1h-imidazopyridine derivatives
US20020111353A1 (en) 2000-12-05 2002-08-15 Mark Ledeboer Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
GB0100622D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical compounds V111
JP2004520347A (en) 2001-01-15 2004-07-08 グラクソ　グループ　リミテッド Arylpiperidine and piperazine derivatives as inducers of LDL-receptor expression
EP1363702A4 (en) 2001-01-30 2007-08-22 Cytopia Pty Ltd Methods of inhibiting kinases
AU2002308748A1 (en) 2001-05-16 2002-11-25 Vertex Pharmaceuticals Incorporated Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases
US7301023B2 (en) 2001-05-31 2007-11-27 Pfizer Inc. Chiral salt resolution
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
GB0115393D0 (en) 2001-06-23 2001-08-15 Aventis Pharma Ltd Chemical compounds
AU2002355732B2 (en) 2001-08-01 2006-11-09 Merck Sharp & Dohme Corp. Benzimidazo[4,5-f]isoquinolinone derivatives
AU2002337142B2 (en) 2001-09-19 2007-10-11 Aventis Pharma S.A. Indolizines as kinase protein inhibitors
US6429231B1 (en) 2001-09-24 2002-08-06 Bradley Pharmaceuticals, Inc. Compositions containing antimicrobials and urea for the treatment of dermatological disorders and methods for their use
IL161156A0 (en) 2001-10-30 2004-08-31 Novartis Ag Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
JP2003155285A (en) 2001-11-19 2003-05-27 Toray Ind Inc Cyclic nitrogen-containing derivative
CN1582272A (en) 2001-11-30 2005-02-16 帝人株式会社 Process for preparing 5-(3-cyanophenyl)-3-formylbenzoic acid compound
PY0228255A (en) 2001-12-06 2004-06-01 Pfizer Prod Inc NOVEL CRYSTALLINE COMPOUNDS
US6995144B2 (en) 2002-03-14 2006-02-07 Eisai Co., Ltd. Nitrogen containing heterocyclic compounds and medicines containing the same
CN1655766B (en) 2002-04-15 2012-05-30 利洁时有限责任公司 Sustained release of guaifenesin combination drugs
TW200403058A (en) 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
AU2003237121A1 (en) 2002-04-26 2003-11-10 Vertex Pharmaceuticals Incorporated Pyrrole derivatives as inhibitors of erk2 and uses thereof
EP1503757B1 (en) 2002-05-02 2007-12-19 Merck & Co., Inc. Tyrosine kinase inhibitors
CN1658836A (en) 2002-05-07 2005-08-24 控制传输系统公司 Processes for forming a drug delivery device
NZ537155A (en) 2002-05-23 2006-09-29 Cytopia Pty Ltd Protein kinase inhibitors
TW200406374A (en) 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
US7385018B2 (en) * 2002-06-26 2008-06-10 Idemitsu Kosan Co., Ltd. Hydrogenated copolymer, process for producing the same, and hot-melt adhesive composition containing the same
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
GB0215844D0 (en) 2002-07-09 2002-08-14 Novartis Ag Organic compounds
AU2003252478A1 (en) 2002-07-10 2004-02-02 Ono Pharmaceutical Co., Ltd. Ccr4 antagonist and medicinal use thereof
BR0314603A (en) 2002-09-20 2005-07-26 Alcon Inc Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
US20040204404A1 (en) 2002-09-30 2004-10-14 Robert Zelle Human N-type calcium channel blockers
US7259161B2 (en) 2002-11-04 2007-08-21 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of JAK and other protein kinases
US8034831B2 (en) 2002-11-06 2011-10-11 Celgene Corporation Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies
AR042052A1 (en) 2002-11-15 2005-06-08 Vertex Pharma USEFUL DIAMINOTRIAZOLS AS INHIBITORS OF PROTEINQUINASES
US20040099204A1 (en) 2002-11-25 2004-05-27 Nestor John J. Sheet, page, line, position marker
AU2003276591A1 (en) 2002-11-26 2004-06-18 Pfizer Products Inc. Method of treatment of transplant rejection
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
TWI335819B (en) 2002-12-24 2011-01-11 Alcon Inc Use of oculosurface selective glucocorticoid in the treatment of dry eye
TW200418806A (en) 2003-01-13 2004-10-01 Fujisawa Pharmaceutical Co HDAC inhibitor
US7444183B2 (en) * 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
AU2004212421B2 (en) * 2003-02-07 2009-08-20 Vertex Pharmaceuticals Incorporated Heteroaryl substituted pyrolls useful as inhibitors of protein kinases
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
WO2004092154A1 (en) 2003-04-03 2004-10-28 Vertex Pharmaceuticals Incorporated Compositions useful as inhibitors of protein kinases
SE0301373D0 (en) 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
SE0301372D0 (en) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
FR2857454B1 (en) 2003-07-08 2006-08-11 Aventis Pasteur DOSAGE OF TECHIC ACIDS OF BACTERIA GRAM +
US20050043346A1 (en) * 2003-08-08 2005-02-24 Pharmacia Italia S.P.A. Pyridylpyrrole derivatives active as kinase inhibitors
WO2005020921A2 (en) 2003-08-29 2005-03-10 Exelixis, Inc. C-kit modulators and methods of use
EP1678147B1 (en) 2003-09-15 2012-08-08 Lead Discovery Center GmbH Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
AR045944A1 (en) 2003-09-24 2005-11-16 Novartis Ag ISOQUINOLINE DERIVATIVES 1.4-DISPOSED
WO2005039574A1 (en) 2003-10-24 2005-05-06 Santen Pharmaceutical Co., Ltd. Therapeutic agent for keratoconjunctive disorder
US7387793B2 (en) 2003-11-14 2008-06-17 Eurand, Inc. Modified release dosage forms of skeletal muscle relaxants
MY141220A (en) 2003-11-17 2010-03-31 Astrazeneca Ab Pyrazole derivatives as inhibitors of receptor tyrosine kinases
CA2545192A1 (en) 2003-11-25 2005-06-09 Pfizer Products Inc. Method of treatment of atherosclerosis
CA2549485A1 (en) 2003-12-17 2005-07-07 Pfizer Products Inc. Pyrrolo [2,3-d] pyrimidine compounds for treating transplant rejection
EP1694659B8 (en) 2003-12-19 2008-10-08 Schering Corporation Thiadiazoles as cxc- and cc- chemokine receptor ligands
PL1696920T3 (en) 2003-12-19 2015-03-31 Plexxikon Inc Compounds and methods for development of ret modulators
NZ547696A (en) 2003-12-23 2009-12-24 Astex Therapeutics Ltd Pyrazole derivatives as protein kinase modulators
US20050187389A1 (en) * 2004-01-13 2005-08-25 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
EP1744751A4 (en) 2004-03-18 2010-03-10 Brigham & Womens Hospital TREATMENT OF SYNUCLEINOPATHIES
US7507826B2 (en) 2004-03-30 2009-03-24 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of JAK and other protein kinases
WO2005117909A2 (en) 2004-04-23 2005-12-15 Exelixis, Inc. Kinase modulators and methods of use
WO2005105814A1 (en) 2004-04-28 2005-11-10 Incyte Corporation Tetracyclic inhibitors of janus kinases
WO2005105988A2 (en) 2004-04-28 2005-11-10 Vertex Pharmaceuticals Incorporated Crystal structure of human jak3 kinase domain complex and binding pockets thereof
MXPA06012663A (en) 2004-05-03 2007-01-16 Novartis Ag Combinations comprising a s1p receptor agonist and a jak3 kinase inhibitor.
JP2007537296A (en) 2004-05-14 2007-12-20 アボット・ラボラトリーズ Kinase inhibitors as therapeutic agents
PE20060426A1 (en) 2004-06-02 2006-06-28 Schering Corp TARTARIC ACID DERIVATIVES AS INHIBITORS OF MMPs, ADAMs, TACE AND TNF-alpha
ES2396135T3 (en) 2004-06-10 2013-02-19 Irm Llc Compounds and compositions as protein kinase inhibitors
JP5315611B2 (en) 2004-06-23 2013-10-16 小野薬品工業株式会社 Compound having S1P receptor binding ability and use thereof
WO2006004984A1 (en) 2004-06-30 2006-01-12 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of protein kinases
US7138423B2 (en) * 2004-07-20 2006-11-21 Bristol-Myers Squibb Company Arylpyrrolidine derivatives as NK-1 /SSRI antagonists
FR2873691B1 (en) 2004-07-29 2006-10-06 Sanofi Synthelabo AMINO-PIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
WO2006013114A1 (en) 2004-08-06 2006-02-09 Develogen Aktiengesellschaft Use of a timp-2 secreted protein product for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
WO2006022459A1 (en) 2004-08-23 2006-03-02 Mogam Biotechnology Institute Primer and probe for detection of sars coronavirus, kit comprising the primer and/or the probe, and detection method thereof
GB0421525D0 (en) 2004-09-28 2004-10-27 Novartis Ag Inhibitors of protein kineses
US20070054916A1 (en) 2004-10-01 2007-03-08 Amgen Inc. Aryl nitrogen-containing bicyclic compounds and methods of use
DK1802625T3 (en) 2004-10-13 2008-09-01 Hoffmann La Roche Disubstituted pyrazolobenzodiazepines useful as inhibitors of CDK2 and angiogenesis and in the treatment of breast, colon, lung and prostate cancer
MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
UY29177A1 (en) 2004-10-25 2006-05-31 Astex Therapeutics Ltd SUBSTITUTED DERIVATIVES OF PURINA, PURINONA AND DEAZAPURINA, COMPOSITIONS THAT CONTAIN METHODS FOR THEIR PREPARATION AND ITS USES
ES2354824T3 (en) 2004-11-04 2011-03-18 Vertex Pharmaceuticals, Inc. PIRAZOLO [1,5-A] USEFUL PYRIMIDINS AS INHIBITORS OF KINASE PROTEINS.
KR20070085433A (en) 2004-11-24 2007-08-27 노파르티스 아게 Combination of BAA inhibitors with one or more of BC-ALL, FLT-3, FA or RAF kinase inhibitors
US7517870B2 (en) 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
US20060128803A1 (en) 2004-12-14 2006-06-15 Alcon, Inc. Method of treating dry eye disorders using 13(S)-HODE and its analogs
AR054416A1 (en) 2004-12-22 2007-06-27 Incyte Corp PIRROLO [2,3-B] PIRIDIN-4-IL-AMINAS AND PIRROLO [2,3-B] PIRIMIDIN-4-IL-AMINAS AS INHIBITORS OF THE JANUS KINASES. PHARMACEUTICAL COMPOSITIONS.
AR053992A1 (en) 2004-12-22 2007-05-30 Astrazeneca Ab CHEMICAL COMPOUNDS WITH ANTI-TARGET ACTIVITY, A PROCEDURE FOR THEIR PREPARATION, ITS USE IN THE PREPARATION OF MEDICINES AND PHARMACEUTICAL COMPOSITION.
JP2008528477A (en) 2005-01-20 2008-07-31 ファイザー・リミテッド Compound
EP1844050B1 (en) 2005-02-03 2009-01-14 Vertex Pharmaceuticals, Inc. Pyrrolopyrimidines useful as inhibitors of protein kinase
US7683171B2 (en) 2005-02-04 2010-03-23 Bristol-Myers Squibb Company 1H-imidazo[4,5-d]thieno[3,2-b]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
AU2006227790B2 (en) 2005-03-15 2009-09-10 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2006108103A1 (en) 2005-04-05 2006-10-12 Pharmacopeia, Inc. Purine and imidazopyridine derivatives for immunosuppression
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
GB0510390D0 (en) 2005-05-20 2005-06-29 Novartis Ag Organic compounds
KR20080016659A (en) * 2005-05-20 2008-02-21 버텍스 파마슈티칼스 인코포레이티드 Pyrrolopyridines useful as inhibitors of protein kinase
EP1904457B1 (en) 2005-06-08 2017-09-06 Rigel Pharmaceuticals, Inc. Compositions and methods for inhibition of the jak pathway
WO2006136823A1 (en) 2005-06-21 2006-12-28 Astex Therapeutics Limited Heterocyclic containing amines as kinase b inhibitors
DK2395004T3 (en) 2005-06-22 2016-03-21 Plexxikon Inc Pyrrolo [2,3-b] pyridine derivatives as protein kinase inhibitors
CN102127078A (en) 2005-07-14 2011-07-20 安斯泰来制药株式会社 Heterocyclic janus kinase 3 inhibitors
FR2889662B1 (en) 2005-08-11 2011-01-14 Galderma Res & Dev OIL-IN-WATER EMULSION FOR TOPICAL APPLICATION IN DERMATOLOGY
US20070049591A1 (en) 2005-08-25 2007-03-01 Kalypsys, Inc. Inhibitors of MAPK/Erk Kinase
EP2270014A1 (en) 2005-09-22 2011-01-05 Incyte Corporation Azepine inhibitors of janus kinases
JP2009513571A (en) 2005-09-30 2009-04-02 バーテックス ファーマシューティカルズ インコーポレイテッド Deazapurine useful as a Janus kinase inhibitor
US20070128633A1 (en) 2005-10-11 2007-06-07 Chembridge Research Laboratories, Inc. Cell-free protein expression systems and methods of use thereof
PT1937664E (en) 2005-10-14 2011-07-07 Sumitomo Chemical Co Hydrazide compound and pesticidal use of the same
WO2007049041A1 (en) 2005-10-28 2007-05-03 Astrazeneca Ab 4- (3-aminopyrazole) pyrimidine derivatives for use as tyrosine kinase inhibitors in the treatment of cancer
US7528143B2 (en) 2005-11-01 2009-05-05 Targegen, Inc. Bi-aryl meta-pyrimidine inhibitors of kinases
WO2007062459A1 (en) 2005-11-29 2007-06-07 Cytopia Research Pty Ltd Selective kinase inhibitors based on pyridine scaffold
CN103214484B (en) 2005-12-13 2016-07-06 因塞特控股公司 Pyrrolo-[2,3-b] pyridine replaced as the heteroaryl of Janus inhibitors of kinases and pyrrolo-[2,3-b] pyrimidine
US20130137681A1 (en) * 2005-12-13 2013-05-30 Incyte Corporation HETEROARYL SUBSTITUTED PYRROLO[2,3-b]PYRIDINES AND PYRROLO[2,3-b]PYRIMIDINES AS JANUS KINASE INHIBITORS
EP1968568A4 (en) 2005-12-22 2011-04-13 Glaxosmithkline Llc INHIBITORS OF Akt ACTIVITY
ES2408318T3 (en) 2005-12-23 2013-06-20 Glaxosmithkline Llc Aurora kinase azaindole inhibitors
JP4643455B2 (en) 2006-01-12 2011-03-02 株式会社ユニバーサルエンターテインメント Game system
TW201412738A (en) 2006-01-17 2014-04-01 Vertex Pharma Azaindoles useful as inhibitors of janus kinases
JP2009523812A (en) 2006-01-19 2009-06-25 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド Fusion heterobicyclic kinase inhibitors
JP2009525350A (en) 2006-02-01 2009-07-09 スミスクライン ビーチャム コーポレーション Pyrrolo [2,3, B] pyridine derivatives useful as RAF kinase inhibitors
US7745477B2 (en) 2006-02-07 2010-06-29 Hoffman-La Roche Inc. Heteroaryl and benzyl amide compounds
US20070202172A1 (en) 2006-02-24 2007-08-30 Tomer Gold Metoprolol succinate E.R. tablets and methods for their preparation
WO2007105637A1 (en) 2006-03-10 2007-09-20 Ono Pharmaceutical Co., Ltd. Nitrogenated heterocyclic derivative, and pharmaceutical agent comprising the derivative as active ingredient
MX2008012738A (en) 2006-04-03 2009-02-06 Astellas Pharma Inc Hetero compound.
CA2648250A1 (en) 2006-04-05 2007-10-18 Vertex Pharmaceuticals Incorporated Deazapurines useful as inhibitors of janus kinases
US20090124636A1 (en) 2006-04-12 2009-05-14 Pfizer Inc. Chemical compounds
WO2007129195A2 (en) 2006-05-04 2007-11-15 Pfizer Products Inc. 4-pyrimidine-5-amino-pyrazole compounds
US20080051427A1 (en) 2006-05-18 2008-02-28 Fritz Schuckler Pharmaceutical Compositions and Methods of Using Same
US7691811B2 (en) 2006-05-25 2010-04-06 Bodor Nicholas S Transporter-enhanced corticosteroid activity and methods and compositions for treating dry eye
JO3235B1 (en) 2006-05-26 2018-03-08 Astex Therapeutics Ltd Pyrroloperimidine compounds and their uses
NZ573174A (en) 2006-06-01 2012-01-12 Msd Consumer Care Inc Sustained release pharmaceutical dosage form containing phenylephrine
CA2658764A1 (en) 2006-07-20 2008-01-24 Mehmet Kahraman Benzothiophene inhibitors of rho kinase
WO2008013622A2 (en) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Fungicidal azocyclic amides
US8492378B2 (en) 2006-08-03 2013-07-23 Takeda Pharmaceutical Company Limited GSK-3β inhibitor
JP5252404B2 (en) 2006-08-16 2013-07-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pyrazine compounds, their use and methods of preparation
CA2662091A1 (en) 2006-09-08 2008-03-13 Novartis Ag N-biaryl (hetero) arylsulphonamide derivatives useful in the treatment of diseases mediated by lymphocytes interactions
WO2008035376A2 (en) 2006-09-19 2008-03-27 Council Of Scientific & Industrial Research A novel bio-erodible insert for ophthalmic applications and a process for the preparation thereof
CL2007002866A1 (en) 2006-10-04 2008-07-04 Pharmacopeia Inc COMPOUNDS DERIVED FROM 6-SUBSTITUTES-2- (BENCIMIDAZOLIL) PURINA AND PURINONA; PHARMACEUTICAL COMPOSITION THAT INCLUDES SUCH COMPOUND; AND USE OF THE COMPOUND IN THE TREATMENT OF AUTOIMMUNE DISEASES, INFLAMMATORY DISEASE, DISEASE MEDIATED BY M
CL2007002867A1 (en) 2006-10-04 2008-06-27 Pharmacopeia Inc COMPOUNDS DERIVED FROM 2- (BENCIMIDAZOLIL) PURINA, INHIBITORS OF JANUS QUINASA 3; PHARMACEUTICAL COMPOSITION THAT CONTAINS THEM; AND ITS USE TO TREAT AUTOIMMUNE, INFLAMMATORY, CARDIOVASCULAR DISEASES, IMPLANT REJECTION, AMONG OTHERS.
US20120225057A1 (en) 2006-10-11 2012-09-06 Deciphera Pharmaceuticals, Llc Methods and compositions for the treatment of myeloproliferative diseases and other proliferative diseases
MY146474A (en) 2006-11-06 2012-08-15 Supergen Inc Imidazo[1,2-b]pyridazine and pyrazolo[1,5-a]pyrimidine derivatives and their use as protein kinase inhibitors
US20080119496A1 (en) 2006-11-16 2008-05-22 Pharmacopeia Drug Discovery, Inc. 7-Substituted Purine Derivatives for Immunosuppression
ES2560435T3 (en) 2006-11-22 2016-02-19 Incyte Holdings Corporation Imidazotriazines and imidazopyrimidines as kinase inhibitors
WO2008067119A2 (en) 2006-11-27 2008-06-05 Smithkline Beecham Corporation Novel compounds
CN101562977A (en) 2006-12-15 2009-10-21 艾博特公司 Novel oxadiazole compounds
WO2008079292A1 (en) 2006-12-20 2008-07-03 Amgen Inc. Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer
WO2008079291A2 (en) 2006-12-20 2008-07-03 Amgen Inc. Substituted heterocycles and methods of use
ES2415863T3 (en) 2006-12-22 2013-07-29 Incyte Corporation Substituted heterocycles as Janus Kinase inhibitors
WO2008077712A1 (en) 2006-12-22 2008-07-03 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Gel useful for the delivery of ophthalmic drugs
KR20080062876A (en) 2006-12-29 2008-07-03 주식회사 대웅제약 Novel Antifungal Triazole Derivatives
WO2008082840A1 (en) 2006-12-29 2008-07-10 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics
WO2008082839A2 (en) 2006-12-29 2008-07-10 Abbott Laboratories Pim kinase inhibitors as cancer chemotherapeutics
ES2431163T3 (en) 2007-03-01 2013-11-25 Novartis Ag PIM kinase inhibitors and methods for use
NZ580327A (en) 2007-04-03 2012-02-24 Array Biopharma Inc IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS RECEPTOR TYROSINE KINASE INHIBITORS
US8188178B2 (en) 2007-05-07 2012-05-29 3M Innovative Properties Company Cold shrinkable article including an epichlorohydrin composition
GB0709031D0 (en) 2007-05-10 2007-06-20 Sareum Ltd Pharmaceutical compounds
WO2008145681A2 (en) 2007-05-31 2008-12-04 Boehringer Ingelheim International Gmbh Ccr2 receptor antagonists and uses thereof
GB0710528D0 (en) 2007-06-01 2007-07-11 Glaxo Group Ltd Novel compounds
CL2008001709A1 (en) 2007-06-13 2008-11-03 Incyte Corp Compounds derived from pyrrolo [2,3-b] pyrimidine, jak kinase modulators; pharmaceutical composition; and use in the treatment of diseases such as cancer, psoriasis, rheumatoid arthritis, among others.
HUE029236T2 (en) 2007-06-13 2017-02-28 Incyte Holdings Corp Crystalline salts of the janus kinase inhibitor (r)-3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropanenitrile
CA2691914C (en) 2007-07-11 2012-06-26 Pfizer Inc. Pharmaceutical compositions and methods of treating dry eye disorders
KR20100038119A (en) 2007-08-01 2010-04-12 화이자 인코포레이티드 Pyrazole compounds and their use as raf inhibitors
WO2009049028A1 (en) 2007-10-09 2009-04-16 Targegen Inc. Pyrrolopyrimidine compounds and their use as janus kinase modulators
WO2009064486A2 (en) 2007-11-15 2009-05-22 Musc Foundation For Research Development Inhibitors of pim protein kinases, compositions, and methods for treating cancer
MX2010005300A (en) 2007-11-16 2010-06-25 Incyte Corp 4-pyrazolyl-n-arylpyrimidin-2-amines and 4-pyrazolyl-n-heteroaryl pyrimidin-2-amines as janus kinase inhibitors.
GB0723815D0 (en) 2007-12-05 2008-01-16 Glaxo Group Ltd Compounds
WO2009089804A1 (en) 2008-01-18 2009-07-23 Institute Of Organic Chemistry And Biochemistry As Cr, V.V.I. Novel cytostatic 7-deazapurine nucleosides
KR20100115789A (en) 2008-02-04 2010-10-28 머큐리 테라퓨틱스, 인코포레이티드 APM Controller
UY31679A1 (en) 2008-03-03 2009-09-30 PIM KINASE INHIBITORS AND METHODS FOR USE
TWI444382B (en) 2008-03-11 2014-07-11 Incyte Corp Azetidine and cyclobutane derivatives as jak inhibitors
BRPI0908906A2 (en) 2008-03-21 2019-09-24 Novartis Ag heterocyclic compounds and their uses
EP2299816B1 (en) 2008-06-18 2013-11-13 Merck Sharp & Dohme Corp. Inhibitors of janus kinases
KR102080429B1 (en) 2008-06-26 2020-02-21 안테리오스, 인코퍼레이티드 Dermal delivery
UY31952A (en) 2008-07-02 2010-01-29 Astrazeneca Ab 5-METHYLIDENE-1,3-THIAZOLIDINE-2,4-DIONAS REPLACED AS PIM QUINASE INHIBITORS
FR2933409B1 (en) 2008-07-03 2010-08-27 Centre Nat Rech Scient NEW PYRROLO ° 2,3-a! CARBAZOLES AND THEIR USE AS INHIBITORS OF PIM KINASES
TWI496779B (en) 2008-08-19 2015-08-21 Array Biopharma Inc Triazolopyridine compounds as pim kinase inhibitors
US8557809B2 (en) 2008-08-19 2013-10-15 Array Biopharma Inc. Triazolopyridine compounds as PIM kinase inhibitors
HRP20140395T1 (en) 2008-08-20 2014-06-06 Zoetis Llc PIROLO [2,3-d] PIRIMIDINE COMPOUNDS
WO2010026122A1 (en) 2008-09-02 2010-03-11 Novartis Ag Heterocyclic pim-kinase inhibitors
JP5564045B2 (en) 2008-09-02 2014-07-30 ノバルティス アーゲー Bicyclic kinase inhibitor
WO2010026124A1 (en) 2008-09-02 2010-03-11 Novartis Ag Picolinamide derivatives as kinase inhibitors
CL2009001884A1 (en) 2008-10-02 2010-05-14 Incyte Holdings Corp Use of 3-cyclopentyl-3- [4- (7h-pyrrolo [2,3-d] pyrimidin-4-yl) -1h-pyrazol-1-yl) propanonitrile, janus kinase inhibitor, and use of a composition that understands it for the treatment of dry eye.
EP2350054A4 (en) 2008-10-17 2012-03-28 Merck Canada Inc AZETIDINE DERIVATIVES AS DELTA-9 DEATURASE STÉAROYL-COENZYME INHIBITORS
PE20211639A1 (en) 2009-01-15 2021-08-24 Incyte Holdings Corp PROCESSES FOR PREPARING JAK INHIBITORS AND RELATED INTERMEDIARY COMPOUNDS
EP2210890A1 (en) 2009-01-19 2010-07-28 Almirall, S.A. Oxadiazole derivatives as S1P1 receptor agonists
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
EP2432472B1 (en) * 2009-05-22 2019-10-02 Incyte Holdings Corporation 3-[4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl]octane- or heptane-nitrile as jak inhibitors
MY156727A (en) 2009-05-22 2016-03-15 Incyte Corp N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
UA110324C2 (en) 2009-07-02 2015-12-25 Genentech Inc Jak inhibitory compounds based on pyrazolo pyrimidine
BR112012000422A2 (en) 2009-07-08 2017-05-09 Leo Pharma As compound, pharmaceutical composition, use of a compound, and method for preventing it from treating or ameliorating immune system disorders
US20120157500A1 (en) 2009-08-24 2012-06-21 Weikang Tao Jak inhibition blocks rna interference associated toxicities
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
ES2557316T3 (en) 2009-09-08 2016-01-25 F. Hoffmann-La Roche Ag 4-substituted pyridine-3-yl-carboxamide compounds and methods of use
EP2305660A1 (en) 2009-09-25 2011-04-06 Almirall, S.A. New thiadiazole derivatives
MX2012004180A (en) 2009-10-09 2012-07-17 Incyte Corp Hydroxyl, keto, and glucuronide derivatives of 3-(4-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclo pentylpropanenitrile.
NZ598907A (en) 2009-10-20 2014-03-28 Cellzome Ltd Heterocyclyl pyrazolopyrimidine analogues as jak inhibitors
US20110113416A1 (en) 2009-11-09 2011-05-12 Bank Of America Corporation Network-Enhanced Control Of Software Updates Received Via Removable Computer-Readable Medium
EP2332917B1 (en) 2009-11-11 2012-08-01 Sygnis Bioscience GmbH & Co. KG Compounds for PIM kinase inhibition and for treating malignancy
EP2504032A4 (en) 2009-11-24 2013-06-19 Alderbio Holdings Llc Antagonists of il-6 to prevent or treat thrombosis
US20130129675A1 (en) 2009-12-04 2013-05-23 Board Of Regents, The University Of Texas System Interferon therapies in combination with blockade of stat3 activation
ES2461967T3 (en) 2009-12-18 2014-05-21 Pfizer Inc. Pyrrolo [2,3-d] pyrimidine compounds
WO2011086053A1 (en) 2010-01-12 2011-07-21 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof
EP2531508A1 (en) 2010-02-05 2012-12-12 Pfizer Inc. Pyrrolo [ 2, 3 - d]pyrimidine urea compounds as jak inhibitors
SA111320200B1 (en) 2010-02-17 2014-02-16 ديبيوفارم اس ايه Bicyclic Compounds and their Uses as Dual C-SRC / JAK Inhibitors
CA2790070C (en) 2010-02-18 2018-03-06 Incyte Corporation Cyclobutane and methylcyclobutane derivatives as janus kinase inhibitors
EP3354652B1 (en) 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
JP2013523884A (en) 2010-04-14 2013-06-17 アレイ バイオファーマ、インコーポレイテッド 5,7-substituted imidazo [1,2-c] pyrimidines as inhibitors of JAK kinase
EP2390252A1 (en) 2010-05-19 2011-11-30 Almirall, S.A. New pyrazole derivatives
AR084691A1 (en) 2010-05-21 2013-06-05 Incyte Corp TOPICAL USE FORMULATION FOR A JAK INHIBITOR AND METHOD TO TREAT SKIN DISORDER
WO2011156698A2 (en) 2010-06-11 2011-12-15 Abbott Laboratories NOVEL PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS
US9351943B2 (en) 2010-07-01 2016-05-31 Matthew T. McLeay Anti-fibroblastic fluorochemical emulsion therapies
WO2012045010A1 (en) 2010-09-30 2012-04-05 Portola Pharmaceuticals, Inc. Combinations of 4-(3-(2h-1,2,3-triazo-2-yl) phenylamino)-2-((1r,2s)-2-aminocyclohexylamino) pyrimidine-5-carboxamide and fludarabine
WO2012068440A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as jak inhibitors
CA2818542A1 (en) 2010-11-19 2012-05-24 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as jak inhibitors
WO2012071612A1 (en) 2010-12-03 2012-06-07 Ym Biosciences Australia Pty Ltd Treatment of jak2-mediated conditions
WO2012112847A1 (en) 2011-02-18 2012-08-23 Novartis Pharma Ag mTOR/JAK INHIBITOR COMBINATION THERAPY
CN102247368B (en) 2011-05-19 2013-05-29 安徽永生堂药业有限责任公司 Compound acrivastine sustained release tablets, and preparation method thereof
CN102218042A (en) 2011-05-26 2011-10-19 青岛黄海制药有限责任公司 Sustained release tablet of quetiapine fumarate composition and preparation method of sustained release tablet
MY165963A (en) 2011-06-20 2018-05-18 Incyte Holdings Corp Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
WO2013007765A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Fused tricyclic compounds for use as inhibitors of janus kinases
WO2013007768A1 (en) 2011-07-13 2013-01-17 F. Hoffmann-La Roche Ag Tricyclic heterocyclic compounds, compositions and methods of use thereof as jak inhibitors
CA2844507A1 (en) 2011-08-10 2013-02-14 Novartis Pharma Ag Jak pi3k/mtor combination therapy
TW201313721A (en) 2011-08-18 2013-04-01 Incyte Corp Cyclohexyl azetidine derivatives as JAK inhibitors
UA111854C2 (en) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн METHODS AND INTERMEDIATE COMPOUNDS FOR JAK INHIBITORS
TW201406761A (en) 2012-05-18 2014-02-16 Incyte Corp Piperidinylcyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
US10155987B2 (en) 2012-06-12 2018-12-18 Dana-Farber Cancer Institute, Inc. Methods of predicting resistance to JAK inhibitor therapy
DK3882249T3 (en) 2012-06-15 2025-08-25 Sun Pharmaceutical Ind Inc DEUTERIZED DERIVATIVES OF RUXOLITINIB
CA2879603A1 (en) 2012-07-27 2014-01-30 Ratiopharm Gmbh Oral dosage forms for modified release comprising ruxolitinib
CN102772384A (en) 2012-08-07 2012-11-14 四川百利药业有限责任公司 Minocycline hydrochloride sustained release tablet and preparation method thereof
EP2890691B1 (en) 2012-08-31 2018-04-25 Principia Biopharma Inc. Benzimidazole derivatives as itk inhibitors
JP6359546B2 (en) 2012-11-01 2018-07-18 インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ Tricyclic fused thiophene derivatives as JAK inhibitors
TWI761825B (en) 2012-11-15 2022-04-21 美商英塞特控股公司 Sustained-release dosage forms of ruxolitinib
MX384910B (en) 2013-03-06 2025-03-14 Incyte Holdings Corp PROCESSES AND INTERMEDIATE FOR MAKING A JAK INHIBITOR.
PE20200527A1 (en) 2013-05-17 2020-03-09 Incyte Corp DERIVATIVES OF BIPIRAZOLE AS JAK INHIBITORS
SG11201600815WA (en) 2013-08-07 2016-03-30 Incyte Corp Sustained release dosage forms for a jak1 inhibitor
WO2015026818A1 (en) 2013-08-20 2015-02-26 Incyte Corporation Survival benefit in patients with solid tumors with elevated c-reactive protein levels
SG10201807952PA (en) 2014-02-28 2018-10-30 Incyte Corp Jak1 inhibitors for the treatment of myelodysplastic syndromes
CN106413716B (en) 2014-04-08 2020-03-27 因赛特公司 Treatment of B cell malignancies by combination of JAK and PI3K inhibitors
BR112016025427A2 (en) 2014-04-30 2017-08-15 Incyte Corp processes for preparing a jak1 inhibitor and forms thereof
WO2015184087A2 (en) 2014-05-28 2015-12-03 Institute For Myeloma & Bone Cancer Research Anti-cancer effects of jak2 inhibitors in combination with thalidomide derivatives and glucocorticoids
WO2015184305A1 (en) 2014-05-30 2015-12-03 Incyte Corporation TREATMENT OF CHRONIC NEUTROPHILIC LEUKEMIA (CNL) AND ATYPICAL CHRONIC MYELOID LEUKEMIA (aCML) BY INHIBITORS OF JAK1
US10766900B2 (en) 2017-12-29 2020-09-08 Formosa Laboratories, Inc. Baricitinib intermediate, method for forming Baricitinib intermediate, and method for preparing Baricitinib or pharmaceutically acceptable salt thereof
CA3129096A1 (en) 2019-02-06 2020-08-13 Concert Pharmaceuticals, Inc. Process for preparing enantiomerically enriched jak inhibitors

Also Published As

Publication number Publication date
PT1966202E (en) 2012-01-03
US11331320B2 (en) 2022-05-17
PT2474545T (en) 2017-02-14
AU2006326548B2 (en) 2012-04-05
CY1118607T1 (en) 2017-07-12
CN103254190A (en) 2013-08-21
US20160272648A1 (en) 2016-09-22
RS54181B1 (en) 2015-12-31
ES2700433T3 (en) 2019-02-15
TWI553008B (en) 2016-10-11
US20200338077A1 (en) 2020-10-29
JP5710430B2 (en) 2015-04-30
JP2015193641A (en) 2015-11-05
HUE032337T2 (en) 2017-09-28
CY2017015I2 (en) 2017-09-13
ECSP12008540A (en) 2012-04-30
CY1121202T1 (en) 2020-05-29
CA2632466C (en) 2013-09-24
US10639310B2 (en) 2020-05-05
EA201200132A8 (en) 2018-10-31
US8946245B2 (en) 2015-02-03
EA201691294A2 (en) 2018-11-30
US20110224157A1 (en) 2011-09-15
KR20120120462A (en) 2012-11-01
US10398699B2 (en) 2019-09-03
PL2426129T3 (en) 2017-04-28
CN103214484A (en) 2013-07-24
DK2348023T5 (en) 2017-05-15
DK2348023T3 (en) 2015-06-22
US11744832B2 (en) 2023-09-05
MY159449A (en) 2017-01-13
US9206187B2 (en) 2015-12-08
CR20130506A (en) 2013-10-30
EP2455382B1 (en) 2016-10-26
SI2426129T1 (en) 2017-02-28
EP2343298A1 (en) 2011-07-13
ES2611588T3 (en) 2017-05-09
EP3466953A1 (en) 2019-04-10
SI2343299T1 (en) 2016-06-30
KR101391900B1 (en) 2014-05-02
MY162590A (en) 2017-06-30
US20110223210A1 (en) 2011-09-15
HRP20150837T2 (en) 2017-04-07
RS54181B9 (en) 2020-01-31
US20150238492A1 (en) 2015-08-27
US7598257B2 (en) 2009-10-06
SI2455382T1 (en) 2017-03-31
PL2455382T3 (en) 2017-04-28
DK2426129T3 (en) 2017-01-16
EP3838903B1 (en) 2023-11-22
DK2343299T3 (en) 2016-01-18
LTPA2017012I1 (en) 2017-05-10
HK1171023A1 (en) 2013-03-15
US20220395506A1 (en) 2022-12-15
PL2348023T3 (en) 2015-11-30
US8415362B2 (en) 2013-04-09
TW201831490A (en) 2018-09-01
US20140243360A1 (en) 2014-08-28
US9974790B2 (en) 2018-05-22
HK1160137A1 (en) 2012-08-10
JP6138865B2 (en) 2017-05-31
HK1124840A1 (en) 2009-07-24
JP5876026B2 (en) 2016-03-02
CY1116574T1 (en) 2018-03-07
ME01312B (en) 2013-12-20
DK1966202T3 (en) 2012-01-16
BRPI0619817B1 (en) 2020-03-17
EA036785B1 (en) 2020-12-21
ES2561507T3 (en) 2016-02-26
KR20110137406A (en) 2011-12-22
KR101218214B1 (en) 2013-01-04
ES2543903T3 (en) 2015-08-25
HUE041382T2 (en) 2019-05-28
US9079912B2 (en) 2015-07-14
HUS1700017I1 (en) 2017-05-29
SG179430A1 (en) 2012-04-27
NZ778831A (en) 2022-12-23
NZ569015A (en) 2011-06-30
EA200870048A1 (en) 2009-02-27
EP3184526A1 (en) 2017-06-28
EP3838903A1 (en) 2021-06-23
PT2426129T (en) 2017-02-10
IL192019A (en) 2014-04-30
LU92137I9 (en) 2019-01-04
BE2013C014I2 (en) 2025-12-10
CY1118506T1 (en) 2017-07-12
HRP20181912T1 (en) 2019-03-22
CY1118724T1 (en) 2017-07-12
TWI468162B (en) 2015-01-11
ATE525374T1 (en) 2011-10-15
LTPA2013002I1 (en) 2013-02-25
LU92137I2 (en) 2014-01-18
RS55632B1 (en) 2017-06-30
CN103214484B (en) 2016-07-06
WO2007070514A1 (en) 2007-06-21
BRPI0619817A2 (en) 2011-11-22
US20170071947A1 (en) 2017-03-16
LT2455382T (en) 2017-02-10
TW200728275A (en) 2007-08-01
EP2455382A1 (en) 2012-05-23
DK2474545T3 (en) 2017-01-23
HRP20160112T1 (en) 2016-02-26
US8530485B2 (en) 2013-09-10
US20190125750A1 (en) 2019-05-02
RS55576B1 (en) 2017-05-31
ES2373688T3 (en) 2012-02-07
US20090181959A1 (en) 2009-07-16
EP1966202B1 (en) 2011-09-21
EP2343298B9 (en) 2020-05-06
CA2632466A1 (en) 2007-06-21
LT2474545T (en) 2017-02-27
ES2867505T3 (en) 2021-10-20
US9662335B2 (en) 2017-05-30
CN103254190B (en) 2016-12-07
EP3184526B1 (en) 2018-10-03
UA116187C2 (en) 2018-02-26
US20140005210A1 (en) 2014-01-02
SI1966202T1 (en) 2012-01-31
EA201200132A1 (en) 2017-01-30
US20180338978A1 (en) 2018-11-29
RS52101B (en) 2012-06-30
FR13C0007I1 (en) 2013-01-03
AR057995A1 (en) 2008-01-09
EP2474545A1 (en) 2012-07-11
HUE028588T2 (en) 2016-12-28
HK1160111A1 (en) 2012-08-10
KR20080079677A (en) 2008-09-01
TW201704235A (en) 2017-02-01
IL248938A0 (en) 2017-01-31
IL192019A0 (en) 2008-12-29
EP2426129A1 (en) 2012-03-07
ES2543904T3 (en) 2015-08-25
CN101448826A (en) 2009-06-03
SG10202003901UA (en) 2020-05-28
PT2455382T (en) 2017-01-31
CY2013006I1 (en) 2015-10-07
TWI410407B (en) 2013-10-01
EP2348023B9 (en) 2017-03-08
ES2612196T3 (en) 2017-05-12
HRP20150837T1 (en) 2015-09-11
EP1966202A1 (en) 2008-09-10
PL2343299T3 (en) 2016-09-30
BRPI0619817B8 (en) 2021-05-25
KR20120120463A (en) 2012-11-01
IL231992A (en) 2016-11-30
EP3466953B1 (en) 2021-02-03
EA019504B1 (en) 2014-04-30
PT3184526T (en) 2018-12-19
EP2343299A1 (en) 2011-07-13
US20160346286A1 (en) 2016-12-01
EP2426129B1 (en) 2016-11-02
HK1160115A1 (en) 2012-08-10
AU2006326548A1 (en) 2007-06-21
HRP20110903T1 (en) 2012-01-31
JP5017278B2 (en) 2012-09-05
SI2474545T1 (en) 2017-03-31
HUE030235T2 (en) 2017-04-28
TWI664182B (en) 2019-07-01
PL2474545T3 (en) 2017-04-28
SI2348023T1 (en) 2015-10-30
SG10201506912RA (en) 2015-10-29
DK3184526T3 (en) 2019-01-14
US20070135461A1 (en) 2007-06-14
TW201240663A (en) 2012-10-16
JP2009519340A (en) 2009-05-14
HRP20170200T1 (en) 2017-04-07
HUE030418T2 (en) 2017-05-29
EP2474545B1 (en) 2016-11-09
PL1966202T3 (en) 2012-02-29
EP2343298B1 (en) 2015-05-06
MX346183B (en) 2017-03-10
TW201434835A (en) 2014-09-16
CY2017015I1 (en) 2017-09-13
CY2013006I2 (en) 2015-10-07
KR101324737B1 (en) 2013-11-05
LT2426129T (en) 2017-02-10
US8933086B2 (en) 2015-01-13
FR17C1013I1 (en) 2017-06-02
US9814722B2 (en) 2017-11-14
PL3184526T3 (en) 2019-04-30
EP2343299B9 (en) 2017-03-08
ES2970354T3 (en) 2024-05-28
FR13C0007I2 (en) 2014-03-07
EP2348023B1 (en) 2015-05-06
EA035795B1 (en) 2020-08-11
HUE025173T2 (en) 2016-01-28
JP2014051531A (en) 2014-03-20
SI3184526T1 (en) 2019-03-29
PT2343299E (en) 2016-02-26
RS58113B1 (en) 2019-02-28
UA98449C2 (en) 2012-05-25
EP2343299B1 (en) 2015-11-04
TW201522344A (en) 2015-06-16
LT3184526T (en) 2019-02-25
ZA200805165B (en) 2012-05-30
FR17C1013I2 (en) 2018-05-04
CN103214483A (en) 2013-07-24
EP2348023A1 (en) 2011-07-27
CY1112762T1 (en) 2015-10-07
HRP20170090T1 (en) 2017-03-24
US8541425B2 (en) 2013-09-24
RS55634B1 (en) 2017-06-30
PT2348023E (en) 2015-09-15
ES2543904T9 (en) 2017-05-29
IL231992A0 (en) 2014-05-28
RS54683B1 (en) 2016-08-31
US20100022522A1 (en) 2010-01-28
US20140018374A1 (en) 2014-01-16
CR10065A (en) 2008-07-10
ES2612489T3 (en) 2017-05-17
CN103214483B (en) 2014-12-17
DK2455382T3 (en) 2017-01-02
BRPI0619817A8 (en) 2018-01-23
HRP20170162T1 (en) 2017-03-24
JP2011252024A (en) 2011-12-15
KR101216055B1 (en) 2012-12-27
TWI630207B (en) 2018-07-21

Similar Documents

Publication Publication Date Title
ECSP12008540A (en) PIRROL [2,3-b] PIRIDINES AND PIRROL [2,3-b] HETEROARILO PYRIMIDINS REPLACED AS INHIBITORS OF JANUS KINASES
ECSP10010263A (en) 4-PIRAZOLIL-N-ARILPIRIMIDIN-2-AMINAS AND 4-PIRAZOLIL-N-HETEROARILPIRIMIDIN-2-AMINAS AS INHIBITORS OF JANUS KINASES
BR0318383A (en) pyrazoloisoquinoline derivatives as kinase inhibitors
ECSP088121A (en) PIRROLO DERIVATIVES [2,3-B] PYRIDINE AS PROTEIN KINASE INHIBITORS
BRPI0811617A2 (en) primidine derivatives and compositions as c-kit and pdgfr kinase inhibitors.
EA201400707A1 (en) DESIGNED BY BENZOTHENYL-PYRROLOTRIASINES AND THEIR APPLICATION AS RFIN KINASE INHIBITORS
CR11149A (en) METABOLITES OF THE JANUS QUINASA INHIBITOR (R) -3- (4- (7H-PIRROLO [2,3-d] PIRIMIDIN-4-IL) -1H-PIRAZOL-1-IL) -3-CYCLOPENTILPROPANONITRILE
MX2019005232A (en) Piperidin-4-yl azetidine derivatives as jak1 inhibitors.
EA201171454A1 (en) N- (GETERO) ARYLPYRROLIDINE DERIVATIVES PYRAZOL-4-ILPYRROLO [2,3-d] PYRIMIDINES AND PYRROL-3-ILPYRROLO [2,3-d] PYRIMIDINES AS AN INITIATORS YANUS-I-I-I-I-I-I-I-I-I-I-I-IU-ZY-3-d)
MX2009006162A (en) Pyrrolo [2, 3-b] pyridine derivatives as kinase modulators.
CR10358A (en) PIRIDO [3,2-E] PIRAZINAS, ITS USE AS PHOSPHODESTERASE 10 INHIBITORS, AND PROCESSES TO PREPARE THEM
CR10560A (en) THYROSINE KINASE INHIBITORS
NI200700318A (en) BENZOCICLOHEPTAPIRIDINAS AS INHIBITORS OF MET TREOSINE KINASE RECEPTOR
EA202091616A2 (en) HETEROARYL SUBSTITUTED PYRROLO [2,3-b] PYRIDINES AND PYRROLO [2,3-b] PYRIMIDINES AS INHIBITORS OF JANUS KINASE
CY1117389T1 (en) HYDROSYL-SUBSTITUTED PYROLID [2,3-b] PYRIDINES AND PYROLID [2,3-b] PYRAMIDINES AS JANUS MOVEMENTS
CU20100174A7 (en) HETEROCYCLIC OR HIPERBYCLIC BICYCLIC DERIVATIVES LINKED PYRAZOL [1,5-A] PYRIMIDINES, PROCEDURE FOR PREPARATION AND USES OF THE SAME
UA110978C2 (en) Azetidinylphenyl, pyridyl or pyrazinylcarboxamide derivatives as JAK inhibitors