ECSP088589A - Formas trihidrocloruro de un derivado de dihidropteridinona y procedimientos de preparación - Google Patents

Formas trihidrocloruro de un derivado de dihidropteridinona y procedimientos de preparación

Info

Publication number
ECSP088589A
ECSP088589A EC2008008589A ECSP088589A ECSP088589A EC SP088589 A ECSP088589 A EC SP088589A EC 2008008589 A EC2008008589 A EC 2008008589A EC SP088589 A ECSP088589 A EC SP088589A EC SP088589 A ECSP088589 A EC SP088589A
Authority
EC
Ecuador
Prior art keywords
trihydrocloride
forms
preparation procedures
derivative
dihydropteridinone
Prior art date
Application number
EC2008008589A
Other languages
English (en)
Inventor
Peter Sieger
Guenter Linz
Matthias Grauert
Rolf Schmid
Original Assignee
Boehringer Ingelheim International Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of ECSP088589A publication Critical patent/ECSP088589A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a una sal específica de un derivado de dihidropteridiona, a saber, la sal de trihidrocloruro del compuesto N-[trans-4-[4-(ciclopropilmetil)-1-piperazinil]ciclohexil]-4-[[(7R)-7-etil-5,6,7,8-tetrahidro-5-metil-8-(1-metiletil)-6-oxo-2-pteridinil]amino]-3-metoxi-benzamida, a su cristalización en la forma de un hidrato con agua, a un procedimiento para su fabricación y su uso en una composición farmacéutica.
EC2008008589A 2006-02-08 2008-06-27 Formas trihidrocloruro de un derivado de dihidropteridinona y procedimientos de preparación ECSP088589A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06101414 2006-02-08

Publications (1)

Publication Number Publication Date
ECSP088589A true ECSP088589A (es) 2008-07-30

Family

ID=38008126

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008589A ECSP088589A (es) 2006-02-08 2008-06-27 Formas trihidrocloruro de un derivado de dihidropteridinona y procedimientos de preparación

Country Status (21)

Country Link
US (3) US7439358B2 (es)
EP (2) EP2543669A3 (es)
JP (1) JP5134552B2 (es)
KR (2) KR101462879B1 (es)
CN (2) CN101379064B (es)
AR (1) AR059349A1 (es)
AU (1) AU2007213752B2 (es)
BR (1) BRPI0707604A8 (es)
CA (1) CA2635834C (es)
EA (2) EA015389B1 (es)
EC (1) ECSP088589A (es)
IL (2) IL193217A (es)
NO (1) NO20082610L (es)
NZ (2) NZ606264A (es)
PE (2) PE20071248A1 (es)
SG (2) SG169397A1 (es)
TW (1) TW200738716A (es)
UA (2) UA101060C2 (es)
UY (1) UY30136A1 (es)
WO (1) WO2007090844A1 (es)
ZA (1) ZA200804587B (es)

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US9358233B2 (en) 2010-11-29 2016-06-07 Boehringer Ingelheim International Gmbh Method for treating acute myeloid leukemia
US20130131069A1 (en) 2011-05-13 2013-05-23 Boehringer Ingelheim International Gmbh Method for treatment of solid malignancies including advanced or metastatic solid malignancies
US9370535B2 (en) * 2011-05-17 2016-06-21 Boehringer Ingelheim International Gmbh Method for treatment of advanced solid tumors
US20140154304A1 (en) 2012-11-30 2014-06-05 Boehringer Ingelheim International Gmbh Combination therapy with volasertib
EP3024464A1 (en) 2013-07-26 2016-06-01 Boehringer Ingelheim International GmbH Treatment of myelodysplastic syndrome
CA2919294A1 (en) * 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Volasertib in combination with decitabine for the treatment of acute myeloid leukemia and myelodysplastic syndrome ii
CN104003989B (zh) * 2014-05-26 2015-11-11 苏州明锐医药科技有限公司 伏拉塞替及其中间体的制备方法
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Also Published As

Publication number Publication date
KR101462879B1 (ko) 2014-11-18
EA015389B1 (ru) 2011-08-30
HK1127772A1 (en) 2009-10-09
JP5134552B2 (ja) 2013-01-30
UY30136A1 (es) 2007-09-28
CN101379064B (zh) 2012-01-25
CN102093360B (zh) 2014-11-05
WO2007090844A1 (en) 2007-08-16
US20070203146A1 (en) 2007-08-30
KR20140082837A (ko) 2014-07-02
AU2007213752A1 (en) 2007-08-16
KR20080093068A (ko) 2008-10-17
ZA200804587B (en) 2009-04-29
PE20110100A1 (es) 2011-02-18
UA95625C2 (ru) 2011-08-25
SG169397A1 (en) 2011-03-30
HK1158628A1 (en) 2012-07-20
EP1984367A1 (en) 2008-10-29
EP2543669A2 (en) 2013-01-09
BRPI0707604A8 (pt) 2017-12-26
WO2007090844A8 (en) 2007-10-11
US7439358B2 (en) 2008-10-21
AR059349A1 (es) 2008-03-26
SG10201404755SA (en) 2014-10-30
NO20082610L (no) 2008-08-26
US8188086B2 (en) 2012-05-29
NZ570987A (en) 2011-09-30
CA2635834C (en) 2014-10-21
US20120214995A1 (en) 2012-08-23
EA018663B1 (ru) 2013-09-30
EP2543669A3 (en) 2013-05-15
EA200801769A1 (ru) 2009-02-27
US8664222B2 (en) 2014-03-04
KR101445114B1 (ko) 2014-09-29
CN102093360A (zh) 2011-06-15
CN101379064A (zh) 2009-03-04
IL193217A0 (en) 2009-02-11
JP2009526017A (ja) 2009-07-16
AU2007213752B2 (en) 2013-01-17
EA201100638A1 (ru) 2011-10-31
NZ606264A (en) 2014-08-29
UA101060C2 (ru) 2013-02-25
TW200738716A (en) 2007-10-16
PE20071248A1 (es) 2008-01-15
BRPI0707604A2 (pt) 2011-05-10
US20090030004A1 (en) 2009-01-29
IL193217A (en) 2017-06-29
CA2635834A1 (en) 2007-08-16
IL236736A0 (en) 2015-02-26

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