ECSP088593A - 5-(arilsulfonil)-pirazolopiperidinas - Google Patents

5-(arilsulfonil)-pirazolopiperidinas

Info

Publication number
ECSP088593A
ECSP088593A EC2008008593A ECSP088593A ECSP088593A EC SP088593 A ECSP088593 A EC SP088593A EC 2008008593 A EC2008008593 A EC 2008008593A EC SP088593 A ECSP088593 A EC SP088593A EC SP088593 A ECSP088593 A EC SP088593A
Authority
EC
Ecuador
Prior art keywords
formula
compounds
pirazolopiperidins
arilsulfonil
alzheimer
Prior art date
Application number
EC2008008593A
Other languages
English (en)
Inventor
Andrei Konradi
Christopher M Semko
Ying-Zi Xu
Jenifer Smith
Xiacong Michael Ye
Albert W Garofalo
Jacek J Jagodzinski
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of ECSP088593A publication Critical patent/ECSP088593A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La invención proporciona compuestos de sulfonamido N-cíclicos de la Fórmula (I) en donde A, B, R1, R1a, R2, R2a, R3 y R3a son como se describen en la especificación. Los compuestos de la fórmula (I) son útiles en el tratamiento o prevención de los trastornos cognoscitivos, tal como enfermedad de Alzheimer. La invención también abarca composiciones farmacéuticas que comprenden los compuestos de la Fórmula (I), métodos para preparar los compuestos de la Fórmula (I), y métodos para el tratamiento de trastornos cognoscitivos, tal como enfermedad de Alzheimer
EC2008008593A 2005-12-01 2008-07-01 5-(arilsulfonil)-pirazolopiperidinas ECSP088593A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74136605P 2005-12-01 2005-12-01

Publications (1)

Publication Number Publication Date
ECSP088593A true ECSP088593A (es) 2008-08-29

Family

ID=38092841

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2008008593A ECSP088593A (es) 2005-12-01 2008-07-01 5-(arilsulfonil)-pirazolopiperidinas

Country Status (18)

Country Link
US (2) US7732609B2 (es)
EP (1) EP1957458A2 (es)
JP (1) JP2009518301A (es)
KR (1) KR20080073359A (es)
CN (1) CN101370776A (es)
AR (1) AR057959A1 (es)
AU (1) AU2006320423B2 (es)
BR (1) BRPI0619633A2 (es)
CA (1) CA2632227A1 (es)
EA (1) EA014906B1 (es)
EC (1) ECSP088593A (es)
IL (1) IL190608A0 (es)
MA (1) MA30089B1 (es)
MY (1) MY149422A (es)
NZ (1) NZ568109A (es)
PE (1) PE20071090A1 (es)
TW (1) TW200736255A (es)
WO (1) WO2007064914A2 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2029602E (pt) * 2006-05-31 2010-07-08 Galapagos Nv Compostos de triazolopirazina uteis para o tratamento de doenãas degenerativas e inflamatërias
AU2008256940A1 (en) * 2007-05-25 2008-12-04 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
EP2527328A1 (en) 2008-04-01 2012-11-28 Abbott GmbH & Co. KG Tetrahydroisoquinolines, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
TW201038569A (en) * 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
CA2756064A1 (en) * 2009-03-25 2010-09-30 Elan Pharmaceuticals, Inc. Process for the production of fused, tricyclic sulfonamides
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8853196B2 (en) 2011-08-05 2014-10-07 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
CN104011028A (zh) 2011-11-18 2014-08-27 艾伯维德国有限责任两合公司 N-取代的氨基苯并环庚烯、氨基四氢化萘、氨基茚满和苯烷基胺衍生物、包含所述衍生物的药物组合物及其在治疗中的用途
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
WO2015055770A1 (en) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Aminochromane, aminothiochromane and amino-1,2,3,4-tetrahydroquinoline derivatives, pharmaceutical compositions containing them, and their use in therapy
SG11201602935PA (en) 2013-10-17 2016-05-30 Abbvie Deutschland Aminotetraline and aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
CN104059063A (zh) * 2014-04-03 2014-09-24 丽水绿氟科技有限公司 7,7-二氟-4,5,6,7-四氢吡唑并[4,3-c]吡啶及其衍生物的制备方法
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970707124A (ko) * 1994-10-20 1997-12-01 스피겔 알렌 제이 비사이클릭 테트라하이드로 피라졸로피리딘 및 약제로서 이의 용도(bicyclic tetrahydro pyrazolopyridines and their use as medicaments)
DK1320531T3 (da) * 2000-08-10 2011-01-03 Pfizer Italia Srl Bicyclo-pyrazoler, der er aktive som kinase inhibitorer, fremgangsmåde til fremstilling deraf og farmaceutiske sammensætninger, der indeholder disse
EP1443046B1 (en) * 2001-10-09 2008-12-17 Kyorin Pharmaceutical Co., Ltd. Novel 4-(2furoyl)aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
AU2003292724A1 (en) * 2002-12-27 2004-07-29 Japan Tobacco Inc. Fused n-containing heterocyclic compounds and medicinal use thereof
US20060035884A1 (en) * 2004-05-20 2006-02-16 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
KR20070074638A (ko) * 2004-10-27 2007-07-12 얀센 파마슈티카 엔.브이. 테트라하이드로 피리디닐 피라졸 카나비노이드 모듈레이터
DE102005002500A1 (de) * 2005-01-19 2006-07-27 Sanofi-Aventis Deutschland Gmbh Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
WO2006101434A1 (en) * 2005-03-22 2006-09-28 Astrazeneca Ab NOVEL TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE DERIVATIVES AS CB1’ RECEPTOR LIGANDS
DE102005016170A1 (de) * 2005-04-07 2006-10-12 Grünenthal GmbH 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
AU2006279312A1 (en) * 2005-08-19 2007-02-22 Elan Pharmaceuticals, Inc. Bridged N-cyclic sulfonamido inhibitors of gamma secretase

Also Published As

Publication number Publication date
KR20080073359A (ko) 2008-08-08
AU2006320423A1 (en) 2007-06-07
PE20071090A1 (es) 2007-10-24
US20070155753A1 (en) 2007-07-05
EP1957458A2 (en) 2008-08-20
AU2006320423B2 (en) 2012-06-21
IL190608A0 (en) 2008-11-03
BRPI0619633A2 (pt) 2011-10-04
WO2007064914A2 (en) 2007-06-07
US20100267747A1 (en) 2010-10-21
EA200801481A1 (ru) 2009-02-27
AR057959A1 (es) 2007-12-26
WO2007064914A8 (en) 2008-05-15
WO2007064914A3 (en) 2007-12-27
NZ568109A (en) 2011-07-29
MY149422A (en) 2013-08-30
US7732609B2 (en) 2010-06-08
MA30089B1 (fr) 2008-12-01
TW200736255A (en) 2007-10-01
CN101370776A (zh) 2009-02-18
JP2009518301A (ja) 2009-05-07
CA2632227A1 (en) 2007-06-07
EA014906B1 (ru) 2011-02-28

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