MA30089B1 - (arylsulfonyl)-pyrasolopiperidines - Google Patents

(arylsulfonyl)-pyrasolopiperidines

Info

Publication number
MA30089B1
MA30089B1 MA31080A MA31080A MA30089B1 MA 30089 B1 MA30089 B1 MA 30089B1 MA 31080 A MA31080 A MA 31080A MA 31080 A MA31080 A MA 31080A MA 30089 B1 MA30089 B1 MA 30089B1
Authority
MA
Morocco
Prior art keywords
formula
compounds
pyrasolopiperidines
arylsulfonyl
alzheimer
Prior art date
Application number
MA31080A
Other languages
English (en)
Inventor
Albert W Garofalo
Jacek J Jagodzinski
Andrei W Konradi
Christopher M Semko
Jenifer L Smith
Ying-Zi Xu
Xiaocong Michael Ye
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of MA30089B1 publication Critical patent/MA30089B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La présente invention concerne des composés de sulfonamido N-cycliques de formule I dans laquelle A, B, R1, R1a, R2, R2a, R3 et R3a sont tels que décrits dans le mémoire descriptif. Les composés de formule I sont utiles pour le traitement ou la prévention de troubles de la cognition tels que la maladie d'Alzheimer. L'invention concerne également des compositions pharmaceutiques qui comprennent des composés de formule I, des procédés de préparation de composés de formule I et de procédés de traitement de troubles de la cognition tels que la maladie d'Alzheimer.
MA31080A 2005-12-01 2008-06-26 (arylsulfonyl)-pyrasolopiperidines MA30089B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74136605P 2005-12-01 2005-12-01

Publications (1)

Publication Number Publication Date
MA30089B1 true MA30089B1 (fr) 2008-12-01

Family

ID=38092841

Family Applications (1)

Application Number Title Priority Date Filing Date
MA31080A MA30089B1 (fr) 2005-12-01 2008-06-26 (arylsulfonyl)-pyrasolopiperidines

Country Status (18)

Country Link
US (2) US7732609B2 (fr)
EP (1) EP1957458A2 (fr)
JP (1) JP2009518301A (fr)
KR (1) KR20080073359A (fr)
CN (1) CN101370776A (fr)
AR (1) AR057959A1 (fr)
AU (1) AU2006320423B2 (fr)
BR (1) BRPI0619633A2 (fr)
CA (1) CA2632227A1 (fr)
EA (1) EA014906B1 (fr)
EC (1) ECSP088593A (fr)
IL (1) IL190608A0 (fr)
MA (1) MA30089B1 (fr)
MY (1) MY149422A (fr)
NZ (1) NZ568109A (fr)
PE (1) PE20071090A1 (fr)
TW (1) TW200736255A (fr)
WO (1) WO2007064914A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20100378T1 (hr) * 2006-05-31 2010-08-31 Galapagos N.V. Spojevi triazolopirazina učinkoviti za tretman degenerativnih i upalnih bolesti
MX2009012525A (es) * 2007-05-25 2009-12-09 Elan Pharm Inc Pirazol-pirrolidinas como inhibidores de gamma secretasa.
EP2271625B1 (fr) 2008-04-01 2012-09-12 Abbott GmbH & Co. KG Tétrahydroisoquinoléines, compositions pharmaceutiques les contenant et leur utilisation en thérapie
TW201038569A (en) * 2009-02-16 2010-11-01 Abbott Gmbh & Co Kg Heterocyclic compounds, pharmaceutical compositions containing them, and their use in therapy
AR075442A1 (es) 2009-02-16 2011-03-30 Abbott Gmbh & Co Kg Derivados de aminotetralina, composiciones farmaceuticas que las contienen y sus usos en terapia
US20110034691A1 (en) * 2009-03-25 2011-02-10 Elan Pharmaceuticals, Inc. Process for the Production of Fused, Tricyclic Sulfonamides
US8883839B2 (en) 2010-08-13 2014-11-11 Abbott Laboratories Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US8877794B2 (en) 2010-08-13 2014-11-04 Abbott Laboratories Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9045459B2 (en) 2010-08-13 2015-06-02 AbbVie Deutschland GmbH & Co. KG Phenalkylamine derivatives, pharmaceutical compositions containing them, and their use in therapy
US8846743B2 (en) 2010-08-13 2014-09-30 Abbott Laboratories Aminoindane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9051280B2 (en) 2010-08-13 2015-06-09 AbbVie Deutschland GmbH & Co. KG Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy
US9309200B2 (en) 2011-05-12 2016-04-12 AbbVie Deutschland GmbH & Co. KG Benzazepine derivatives, pharmaceutical compositions containing them, and their use in therapy
MX2014001457A (es) 2011-08-05 2014-08-21 Abbvie Deutschland Derivados de aminocromano, de aminotiocromano y de amino-1,2,3,4-tetrahidroquinolina composiciones farmaceuticas que los contienen, y su uso en terapia.
WO2013072520A1 (fr) 2011-11-18 2013-05-23 AbbVie Deutschland GmbH & Co. KG Dérivés aminobenzocycloheptène, aminotétraline, aminoindane et phénalkylamine n-substitués, composition pharmaceutiques les contenant, et leur application thérapeutique
US9365512B2 (en) 2012-02-13 2016-06-14 AbbVie Deutschland GmbH & Co. KG Isoindoline derivatives, pharmaceutical compositions containing them, and their use in therapy
US9656955B2 (en) 2013-03-15 2017-05-23 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
US9650334B2 (en) 2013-03-15 2017-05-16 Abbvie Inc. Pyrrolidine derivatives, pharmaceutical compositions containing them, and their use in therapy
JP2016533375A (ja) 2013-10-17 2016-10-27 アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー アミノテトラリン誘導体およびアミノインダン誘導体、これらを含有する医薬組成物、および治療におけるこれらの使用
CA2924689A1 (fr) 2013-10-17 2015-04-23 AbbVie Deutschland GmbH & Co. KG Derives d'aminochromane, d'aminothiochromane et d'amino-1,2,3,4-tetrahydroquinoleine, compositions pharmaceutiques contenant ceux-ci et leur utilisation therapeutique
CN104059063A (zh) * 2014-04-03 2014-09-24 丽水绿氟科技有限公司 7,7-二氟-4,5,6,7-四氢吡唑并[4,3-c]吡啶及其衍生物的制备方法
CR20200464A (es) 2018-03-08 2021-04-14 Incyte Corp Compuestos diólicos de aminopirazina como inhibidores de pi3k-y
WO2020010003A1 (fr) 2018-07-02 2020-01-09 Incyte Corporation DÉRIVÉS D'AMINOPYRAZINE UTILISÉS EN TANT QU'INHIBITEURS DE PI3K-γ

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL319758A1 (en) 1994-10-20 1997-08-18 Pfizer Bicyclic tetrahydropyrasole pyridines and their application as medicines
CA2416527C (fr) * 2000-08-10 2009-12-22 Pharmacia Italia S.P.A. Bicyclo-pyrazoles actifs en tant qu'inhibiteurs de kinase, leur procede de preparation et compositions pharmaceutiques les contenant
US7375115B2 (en) * 2001-10-09 2008-05-20 Kyorin Pharmaceutical Co., Ltd. 4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same
AU2003292724A1 (en) * 2002-12-27 2004-07-29 Japan Tobacco Inc. Fused n-containing heterocyclic compounds and medicinal use thereof
WO2005113542A2 (fr) * 2004-05-20 2005-12-01 Elan Pharmaceuticals, Inc. Inhibiteurs sulfonamido n-cycliques de gamma-secretase
US20060089378A1 (en) * 2004-10-27 2006-04-27 Mingde Xia Tetrahydro-pyridinyl pyrazole cannabinoid modulators
DE102005002500A1 (de) * 2005-01-19 2006-07-27 Sanofi-Aventis Deutschland Gmbh Tetrahydrofuranderivate als Inhibitoren von Matrix-Metalloproteinasen
EP1863810A4 (fr) * 2005-03-22 2010-03-31 Astrazeneca Ab NOUVEAUX DERIVES DE TETRAHYDRO-1H-PYRIDO [4,3-b] INDOLE UTILISES COMME LIGANDS DU RECEPTEUR CB1'
DE102005016170A1 (de) * 2005-04-07 2006-10-12 Grünenthal GmbH 4,5,6,7- Tetrahydro-isoxazolo(4,5c)pyridin-Verbindungen und deren Verwendung zur Herstellung von Arzneimitteln
JP2009504773A (ja) * 2005-08-19 2009-02-05 エラン ファーマシューティカルズ，インコーポレイテッド ガンマセクレターゼの架橋ｎ−二環式スルホンアミド阻害剤

Also Published As

Publication number Publication date
PE20071090A1 (es) 2007-10-24
MY149422A (en) 2013-08-30
IL190608A0 (en) 2008-11-03
EA014906B1 (ru) 2011-02-28
WO2007064914A2 (fr) 2007-06-07
US20070155753A1 (en) 2007-07-05
AR057959A1 (es) 2007-12-26
WO2007064914A8 (fr) 2008-05-15
JP2009518301A (ja) 2009-05-07
CN101370776A (zh) 2009-02-18
AU2006320423B2 (en) 2012-06-21
US20100267747A1 (en) 2010-10-21
CA2632227A1 (fr) 2007-06-07
US7732609B2 (en) 2010-06-08
TW200736255A (en) 2007-10-01
EA200801481A1 (ru) 2009-02-27
EP1957458A2 (fr) 2008-08-20
AU2006320423A1 (en) 2007-06-07
WO2007064914A3 (fr) 2007-12-27
ECSP088593A (es) 2008-08-29
KR20080073359A (ko) 2008-08-08
BRPI0619633A2 (pt) 2011-10-04
NZ568109A (en) 2011-07-29

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