ECSP088704A - Derivados de tieno-piridina como inhibidores de mek - Google Patents

Derivados de tieno-piridina como inhibidores de mek

Info

Publication number: ECSP088704A
Authority: EC; Ecuador
Prior art keywords: pyridine derivatives; tieno; mek inhibitors; substituted; mapkk
Prior art date: 2006-01-31

Application number

EC2008008704A

Other languages

English (en)

Spanish (es)

Inventor

Daniel Christopher Brookings

Jeremy Martin Davis

Barry John Langham

James A Johnson

Martin Clive Hutchings

Sarah Catherine Archibald

Judi Charlotte Neuss

Original Assignee

Ucb Pharma Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-01-31

Filing date

2008-08-28

Publication date

2008-09-29

2008-08-28 Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa

2008-09-29 Publication of ECSP088704A publication Critical patent/ECSP088704A/es

Links

239000002829 mitogen activated protein kinase inhibitor Substances 0.000 title 1
102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 abstract 2
108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 abstract 2
229940124639 Selective inhibitor Drugs 0.000 abstract 1
125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
230000001363 autoimmune Effects 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
230000003040 nociceptive effect Effects 0.000 abstract 1
230000000771 oncological effect Effects 0.000 abstract 1
230000002062 proliferating effect Effects 0.000 abstract 1
SMZMHUCIDGHERP-UHFFFAOYSA-N thieno[2,3-b]pyridine Chemical class C1=CN=C2SC=CC2=C1 SMZMHUCIDGHERP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Transplantation (AREA)
Cardiology (AREA)
Oncology (AREA)
Rheumatology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

EC2008008704A 2006-01-31 2008-08-28 Derivados de tieno-piridina como inhibidores de mek ECSP088704A (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0601962.4A GB0601962D0 (en)	2006-01-31	2006-01-31	Therapeutic agents

Publications (1)

Publication Number	Publication Date
ECSP088704A true ECSP088704A (es)	2008-09-29

Family

ID=36100789

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EC2008008704A ECSP088704A (es)	2006-01-31	2008-08-28	Derivados de tieno-piridina como inhibidores de mek

Country Status (26)

Country	Link
US (3)	US8283359B2 (pt)
EP (1)	EP1981892B1 (pt)
JP (1)	JP5249787B2 (pt)
KR (1)	KR101446919B1 (pt)
CN (1)	CN101379067B (pt)
AU (1)	AU2007211377B2 (pt)
BR (1)	BRPI0708016B1 (pt)
CA (1)	CA2640594C (pt)
CY (1)	CY1115404T1 (pt)
DK (1)	DK1981892T3 (pt)
EA (1)	EA016128B1 (pt)
EC (1)	ECSP088704A (pt)
ES (1)	ES2471970T3 (pt)
GB (1)	GB0601962D0 (pt)
HR (1)	HRP20140503T1 (pt)
IL (1)	IL192603A (pt)
MY (1)	MY146387A (pt)
NO (1)	NO341064B1 (pt)
NZ (1)	NZ569638A (pt)
PL (1)	PL1981892T3 (pt)
PT (1)	PT1981892E (pt)
RS (1)	RS53342B (pt)
SI (1)	SI1981892T1 (pt)
UA (1)	UA95939C2 (pt)
WO (1)	WO2007088345A1 (pt)
ZA (1)	ZA200807447B (pt)

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WO2014130932A2 (en)	2013-02-25	2014-08-28	Novartis Ag	Novel androgen receptor mutation
EP3008073B1 (en)	2013-06-11	2020-01-01	Latvian Institute Of Organic Synthesis	Thieno[2,3-b]pyridines as multidrug resistance modulators
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JP6661554B2 (ja)	2014-06-10	2020-03-11	バイオマトリカ，インク．	周囲温度における血小板の安定化
CN105384754B (zh) *	2014-09-02	2018-04-20	上海科州药物研发有限公司	作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
WO2017033113A1 (en)	2015-08-21	2017-03-02	Acerta Pharma B.V.	Therapeutic combinations of a mek inhibitor and a btk inhibitor
JP6827048B2 (ja)	2015-12-08	2021-02-10	バイオマトリカ，インク．	赤血球沈降速度の低下
ES3030506T3 (en)	2017-05-19	2025-06-30	Nflection Therapeutics Inc	Pyrrolopyridine-aniline compounds for treatment of dermal disorders
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CN109836434B (zh) *	2017-11-27	2020-09-25	上海宇耀生物科技有限公司	噻吩并环类化合物及其合成方法和应用
CA3120337A1 (en)	2018-11-20	2020-05-28	Nflection Therapeutics, Inc.	Naphthyridinone-aniline compounds for treatment of dermal disorders
MA55141A (fr)	2018-11-20	2021-09-29	Nflection Therapeutics Inc	Composés cyanoaryl-aniline pour le traitement d'affections de la peau
CA3120351A1 (en) *	2018-11-20	2020-05-28	Nflection Therapeutics, Inc.	Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
JP7546297B2 (ja) *	2018-11-20	2024-09-06	エヌフレクションセラピューティクスインコーポレイテッド	皮膚障害の処置のためのチエニル－アニリン化合物
BR112021018168B1 (pt)	2019-03-21	2023-11-28	Onxeo	Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CA3159348A1 (en)	2019-11-08	2021-05-14	Inserm (Institut National De La Sante Et De La Recherche Medicale)	Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
CN111138449B (zh) *	2020-01-15	2022-11-29	四川大学华西医院	双靶向erk1和erk5抑制剂的制备及其抗肿瘤应用
WO2021148581A1 (en)	2020-01-22	2021-07-29	Onxeo	Novel dbait molecule and its use
US12280055B2 (en)	2021-05-27	2025-04-22	Mirati Therapeutics, Inc.	Combination therapies
EP4436570A4 (en)	2021-11-23	2025-10-22	Nflection Therapeutics Inc	FORMULATIONS OF PYRROLOPYRIDINE-ANILINE COMPOUNDS
GB202205203D0 (en)	2022-04-08	2022-05-25	UCB Biopharma SRL	Combination with inhibitor
WO2025073765A1 (en)	2023-10-03	2025-04-10	Institut National de la Santé et de la Recherche Médicale	Methods of prognosis and treatment of patients suffering from melanoma

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GB0601962D0 (en)	2006-01-31	2006-03-15	Ucb Sa	Therapeutic agents
TW200808769A (en)	2006-04-18	2008-02-16	Astrazeneca Ab	Therapeutic compounds
GB0616214D0 (en)	2006-08-15	2006-09-27	Ucb Sa	Therapeutic Agents
JP2010500994A (ja)	2006-08-16	2010-01-14	エグゼリクシス，インコーポレイテッド	Ｐｉ３ｋおよびｍｅｋモジュレーターを使用する方法
JP5311673B2 (ja)	2006-12-14	2013-10-09	エグゼリクシス，インコーポレイテッド	Ｍｅｋ阻害剤の使用方法
GB0714384D0 (en)	2007-07-23	2007-09-05	Ucb Pharma Sa	theraputic agents
EP2240494B1 (en)	2008-01-21	2016-03-30	UCB Biopharma SPRL	Thieno-pyridine derivatives as mek inhibitors
GB0811304D0 (en)	2008-06-19	2008-07-30	Ucb Pharma Sa	Therapeutic agents

2006
- 2006-01-31 GB GBGB0601962.4A patent/GB0601962D0/en not_active Ceased
2007
- 2007-01-30 EP EP07705076.3A patent/EP1981892B1/en active Active
- 2007-01-30 DK DK07705076.3T patent/DK1981892T3/da active
- 2007-01-30 SI SI200731467T patent/SI1981892T1/sl unknown
- 2007-01-30 EA EA200801684A patent/EA016128B1/ru not_active IP Right Cessation
- 2007-01-30 KR KR1020087018972A patent/KR101446919B1/ko not_active Expired - Fee Related
- 2007-01-30 PT PT77050763T patent/PT1981892E/pt unknown
- 2007-01-30 CA CA2640594A patent/CA2640594C/en active Active
- 2007-01-30 ZA ZA200807447A patent/ZA200807447B/xx unknown
- 2007-01-30 CN CN2007800040774A patent/CN101379067B/zh not_active Expired - Fee Related
- 2007-01-30 RS RS20140304A patent/RS53342B/sr unknown
- 2007-01-30 ES ES07705076.3T patent/ES2471970T3/es active Active
- 2007-01-30 WO PCT/GB2007/000310 patent/WO2007088345A1/en not_active Ceased
- 2007-01-30 AU AU2007211377A patent/AU2007211377B2/en not_active Ceased
- 2007-01-30 NZ NZ569638A patent/NZ569638A/en not_active IP Right Cessation
- 2007-01-30 MY MYPI20082765A patent/MY146387A/en unknown
- 2007-01-30 UA UAA200809945A patent/UA95939C2/ru unknown
- 2007-01-30 HR HRP20140503TT patent/HRP20140503T1/hr unknown
- 2007-01-30 BR BRPI0708016-6A patent/BRPI0708016B1/pt not_active IP Right Cessation
- 2007-01-30 PL PL07705076T patent/PL1981892T3/pl unknown
- 2007-01-30 JP JP2008552878A patent/JP5249787B2/ja active Active
2008
- 2008-07-03 IL IL192603A patent/IL192603A/en active IP Right Grant
- 2008-07-30 US US12/182,931 patent/US8283359B2/en active Active
- 2008-08-28 EC EC2008008704A patent/ECSP088704A/es unknown
- 2008-08-29 NO NO20083739A patent/NO341064B1/no unknown
2012
- 2012-09-05 US US13/604,282 patent/US8394822B2/en active Active
2013
- 2013-02-06 US US13/760,788 patent/US8604051B2/en active Active
2014
- 2014-06-11 CY CY20141100415T patent/CY1115404T1/el unknown

Also Published As

Publication number	Publication date
HK1125924A1 (en)	2009-08-21
PT1981892E (pt)	2014-06-23
JP2009525317A (ja)	2009-07-09
BRPI0708016A2 (pt)	2011-05-17
US8604051B2 (en)	2013-12-10
EA200801684A1 (ru)	2009-04-28
GB0601962D0 (en)	2006-03-15
RS53342B (sr)	2014-10-31
NZ569638A (en)	2010-08-27
PL1981892T3 (pl)	2014-08-29
CA2640594A1 (en)	2007-08-09
SI1981892T1 (sl)	2014-07-31
NO341064B1 (no)	2017-08-14
DK1981892T3 (da)	2014-06-23
CA2640594C (en)	2014-12-23
CN101379067B (zh)	2011-03-23
US20130150573A1 (en)	2013-06-13
HRP20140503T1 (hr)	2014-07-04
KR101446919B1 (ko)	2014-10-07
EP1981892B1 (en)	2014-03-12
US8394822B2 (en)	2013-03-12
US20120329774A1 (en)	2012-12-27
US8283359B2 (en)	2012-10-09
WO2007088345A1 (en)	2007-08-09
JP5249787B2 (ja)	2013-07-31
NO20083739L (no)	2008-08-29
MY146387A (en)	2012-08-15
CY1115404T1 (el)	2017-01-04
IL192603A (en)	2013-12-31
CN101379067A (zh)	2009-03-04
ZA200807447B (en)	2009-11-25
UA95939C2 (en)	2011-09-26
IL192603A0 (en)	2009-02-11
AU2007211377B2 (en)	2012-03-01
AU2007211377A1 (en)	2007-08-09
ES2471970T3 (es)	2014-06-27
US20090149437A1 (en)	2009-06-11
EP1981892A1 (en)	2008-10-22
EA016128B1 (ru)	2012-02-28
BRPI0708016B1 (pt)	2021-07-06
KR20080095870A (ko)	2008-10-29

Publication	Publication Date	Title
ECSP088704A (es)	2008-09-29	Derivados de tieno-piridina como inhibidores de mek
NO20060279L (no)	2006-03-20	Thienopyridonderivater som kinaseinhibitorer
WO2008020206A3 (en)	2008-04-24	Fused thiophene derivatives as mek inhibitors
MX356086B (es)	2018-05-11	Produccion de acidos grasos y derivados de los mismos.
CR20110261A (es)	2011-06-09	COMPUESTOS PIRAZOLO[1,5-a]PIRIMIDINA SUSTITUIDA COMO IHNIBIDORES DE TRK CINASA
ECSP066927A (es)	2006-12-20	Sintesis regioespecífica de los derivados de 42 - ester de rapamicina
CY1114419T1 (el)	2016-08-31	Παραγωγα συντηγμενου θειαζολιου ως αναστολεις κινασης
CY1120304T1 (el)	2019-07-10	Ενωσεις microrna και μεθοδοι για τη διαμορφωση της mir-21 δραστικοτητας
MX2009009371A (es)	2009-09-21	Produccion mejorada de derivados de acidos grasos.
AR081515A1 (es)	2012-10-03	Agente de sustentacion de un material vitroceramico
DK2021577T3 (da)	2013-12-02	Konfigurerbart borehulszoneisolationssystem og tilhørende fremgangsmåder
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