ECSP099342A - Purinas como inhibidores de la pkc theta - Google Patents

Purinas como inhibidores de la pkc theta

Info

Publication number
ECSP099342A
ECSP099342A EC2009009342A ECSP099342A ECSP099342A EC SP099342 A ECSP099342 A EC SP099342A EC 2009009342 A EC2009009342 A EC 2009009342A EC SP099342 A ECSP099342 A EC SP099342A EC SP099342 A ECSP099342 A EC SP099342A
Authority
EC
Ecuador
Prior art keywords
inhibitors
purins
pkc theta
pkc
theta
Prior art date
Application number
EC2009009342A
Other languages
English (en)
Inventor
Neeltje Miranda Teerhuis
Johannes Petrus Maria Lommerse
Jui-Hsiang Chan
Michael Ohlmeyer
Irina Neagu
Celia Kingsbury
Andrew Roughton
Koc-Kan Ho
David Diller
Jacobus Cornelis Henricus Maria Wijkmans
Original Assignee
Organon Nv
Pharmacopeia Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Nv, Pharmacopeia Llc filed Critical Organon Nv
Publication of ECSP099342A publication Critical patent/ECSP099342A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

La presente invención se refiere a géneros químicos de purinas que son útiles como inhibidores ? PKC. El género es representado por la fórmula (I); un ejemplo representativo es: (II)
EC2009009342A 2006-10-20 2009-05-18 Purinas como inhibidores de la pkc theta ECSP099342A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US85339606P 2006-10-20 2006-10-20

Publications (1)

Publication Number Publication Date
ECSP099342A true ECSP099342A (es) 2009-06-30

Family

ID=39111415

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009342A ECSP099342A (es) 2006-10-20 2009-05-18 Purinas como inhibidores de la pkc theta

Country Status (17)

Country Link
US (1) US20110046131A1 (es)
EP (1) EP2078019A2 (es)
JP (1) JP2010507581A (es)
KR (1) KR20090075854A (es)
CN (1) CN101657453B (es)
AU (1) AU2007309167A1 (es)
BR (1) BRPI0717435A2 (es)
CA (1) CA2666940A1 (es)
CO (1) CO6160294A2 (es)
EC (1) ECSP099342A (es)
IL (1) IL198080A0 (es)
IN (1) IN2009CN02154A (es)
MX (1) MX2009004154A (es)
NO (1) NO20091597L (es)
RU (1) RU2009118963A (es)
WO (1) WO2008051826A2 (es)
ZA (1) ZA200902640B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989459B2 (en) * 2006-02-17 2011-08-02 Pharmacopeia, Llc Purinones and 1H-imidazopyridinones as PKC-theta inhibitors
US20090281075A1 (en) * 2006-02-17 2009-11-12 Pharmacopeia, Inc. Isomeric purinones and 1h-imidazopyridinones as pkc-theta inhibitors
KR20080107466A (ko) * 2006-03-09 2008-12-10 파마코페이아, 인코포레이티드 대사 장애 치료용 8-헤테로아릴퓨린 ｍｎｋ2 억제제
JP2009541332A (ja) * 2006-06-23 2009-11-26 パラテック ファーマシューティカルズ インコーポレイテッド 転写因子調節化合物およびその使用法
WO2011066211A1 (en) * 2009-11-24 2011-06-03 Glaxosmithkline Llc Azabenzimidazoles as fatty acid synthase inhibitors
JP2013518114A (ja) * 2010-01-27 2013-05-20 バーテックス ファーマシューティカルズ インコーポレイテッド ピラゾロピリミジンキナーゼ阻害剤
KR20130051507A (ko) 2010-09-15 2013-05-20 에프. 호프만-라 로슈 아게 아자벤조티아졸 화합물, 조성물 및 사용 방법
RU2014113236A (ru) * 2011-09-20 2015-10-27 Ф. Хоффманн-Ля Рош Аг Соединения имидазопиридина, композиции и способы применения
AU2015309686B2 (en) * 2014-08-25 2020-05-14 Epiaxis Therapeutics Pty Ltd Compositions for modulating cancer stem cells and uses therefor
US11986480B2 (en) 2017-02-03 2024-05-21 Tohoku University Heterocyclic compound
CA3082055A1 (en) * 2017-11-08 2019-05-16 Epiaxis Therapeutics Pty Ltd Immunogenic compositions and uses therefor

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0470543A1 (de) * 1990-08-10 1992-02-12 Dr. Karl Thomae GmbH Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung
CA2309350C (en) * 1997-11-12 2007-04-03 Mitsubishi Chemical Corporation Purine derivatives and medicaments comprising the same as active ingredient
US20050165232A1 (en) * 2002-05-13 2005-07-28 Richard Beresis Phenyl substituted imidaopyridines and phenyl substituted benzimidazoles
JP2004217582A (ja) * 2003-01-16 2004-08-05 Abbott Japan Co Ltd ９ｈ−プリン誘導体
US8153640B2 (en) * 2004-10-29 2012-04-10 Tibotec Pharmaceuticals Ltd. HIV inhibiting bicyclic pyrimdine derivatives
US7723340B2 (en) * 2005-01-13 2010-05-25 Signal Pharmaceuticals, Llc Haloaryl substituted aminopurines, compositions thereof, and methods of treatment therewith
PT1853588E (pt) * 2005-02-16 2008-08-25 Astrazeneca Ab Compostos químicos
WO2006091737A1 (en) * 2005-02-24 2006-08-31 Kemia, Inc. Modulators of gsk-3 activity
KR20080107466A (ko) * 2006-03-09 2008-12-10 파마코페이아, 인코포레이티드 대사 장애 치료용 8-헤테로아릴퓨린 ｍｎｋ2 억제제

Also Published As

Publication number Publication date
JP2010507581A (ja) 2010-03-11
IN2009CN02154A (es) 2015-08-07
CA2666940A1 (en) 2008-05-02
WO2008051826A2 (en) 2008-05-02
IL198080A0 (en) 2009-12-24
WO2008051826A3 (en) 2008-10-02
NO20091597L (no) 2009-07-14
ZA200902640B (en) 2010-05-26
MX2009004154A (es) 2009-09-09
RU2009118963A (ru) 2010-11-27
AU2007309167A1 (en) 2008-05-02
BRPI0717435A2 (pt) 2014-03-18
CN101657453A (zh) 2010-02-24
KR20090075854A (ko) 2009-07-09
CO6160294A2 (es) 2010-05-20
EP2078019A2 (en) 2009-07-15
CN101657453B (zh) 2013-06-12
US20110046131A1 (en) 2011-02-24

Similar Documents

Publication Publication Date Title
PE20120495A1 (es) 3-ciclopentilamino-2,2-difluor-propanoato de etilo como intermediario en la preparacion de pirimidodiazepinas
CY1113131T1 (el) Τα παραγωγα ινδολης ως αγωνιστες υποδοχεων s1p1
ECSP12011573A (es) Compuestos tetracíclicos
CR10662A (es) Compuestos de metilpiridopirimidinona
CO6150142A2 (es) Bezoxazoles y oxazolopiridinas que son utiles como inhibidores de las cinasas janus
CR20110046A (es) Amidofenoxiindazoles utiles como inhibidores de c-met
GT200500103A (es) 4-fenilamino-quinazolin-6-il-amidas
MX2009003834A (es) Derivados de pirrolidina como inhibidores de iap.
GT200600306A (es) Inhibidores de glutamato agrecanasa
GT200800170A (es) Compuestos de n-formil-hidroxilamina
SV2011003831A (es) Compuestos organicos
ECSP11010889A (es) INHIBIDORES DE cMET
UY32074A (es) Compuestos de pirrol
DOP2010000183A (es) Derivados de itazol usados como inhibidores de pi 3-cinasa
BRPI0610859A2 (pt) compostos para dispositivos eletrÈnicos orgánicos
BRPI0702269A (pt) alcanolamidas e uso do mesmo como aditivos de combustìvel
MX2009004154A (es) Purinas como inhibidores de pkc-theta.
UY32481A (es) Derivados de benzofurano
EA200900945A1 (ru) Новый способ синтеза агомелатина
UY31925A (es) Isoquinolinas e isoquinolinonas sustituidas
EA200900946A1 (ru) Новый способ синтеза агомелатина
CU23757B7 (es) Bencilaminas, un proceso para su producción y su uso como agentes anti-inflamatorios
MX2009012612A (es) Purinonas e inhibidores 1h-imidazopiridinonas como pkc-theta.
CO6310998A2 (es) Composiciones anfifilicas que comprenden un grupo hidrofilo y un grupo hidrofobo y proceso para su produccion
BR112023017834A2 (pt) Inibidores de lrrk2 cinase macrocíclicos