ECSP099702A - Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2 - Google Patents

Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2

Info

Publication number
ECSP099702A
ECSP099702A EC2009009702A ECSP099702A ECSP099702A EC SP099702 A ECSP099702 A EC SP099702A EC 2009009702 A EC2009009702 A EC 2009009702A EC SP099702 A ECSP099702 A EC SP099702A EC SP099702 A ECSP099702 A EC SP099702A
Authority
EC
Ecuador
Prior art keywords
piperazinas
pirimidinil
legands
receiver
useful
Prior art date
Application number
EC2009009702A
Other languages
English (en)
Inventor
Szalai Gizella Bartane
Csongor Eva Againe
Gyoergy Domany
Istvan Gyertyan
Bela Kiss
Judit Laszy
Katalin Saghy
Eva Schmidt
Sandor Farkas
Zsolt Komlodi
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of ECSP099702A publication Critical patent/ECSP099702A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se relaciona con nuevos ligandos de dopamina D3 y D2 de fórmula (I): en donde R1, R2 y Q son como se describe aquí, y/o isómeros geométricos y/o estereoisómeros y/o diastereómeros y/o sales y/o hidratos y/o solvatos y/o polimorfos de los mismos. La invención también se relaciona con procesos para preparar los mismos, con composiciones que contienen los mismos y con su uso en el tratamiento y/o prevención de afecciones que requieren modulación de receptores de dopamina.
EC2009009702A 2007-04-11 2009-10-23 Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2 ECSP099702A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0700269A HUP0700269A2 (en) 2007-04-11 2007-04-11 Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use

Publications (1)

Publication Number Publication Date
ECSP099702A true ECSP099702A (es) 2009-11-30

Family

ID=38336883

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009702A ECSP099702A (es) 2007-04-11 2009-10-23 Pirimidinil-piperazinas útiles como ligandos del receptor d3/d2

Country Status (35)

Country Link
EP (1) EP2132185B1 (es)
JP (1) JP4580464B2 (es)
KR (1) KR101540821B1 (es)
CN (1) CN101652351B (es)
AP (1) AP2460A (es)
AT (1) ATE518843T1 (es)
AU (1) AU2008237696B2 (es)
BR (1) BRPI0809641A2 (es)
CA (1) CA2682817C (es)
CO (1) CO6241116A2 (es)
CR (1) CR11071A (es)
CU (1) CU23853B1 (es)
CY (1) CY1111962T1 (es)
DK (1) DK2132185T3 (es)
EA (1) EA016174B1 (es)
EC (1) ECSP099702A (es)
ES (1) ES2370748T3 (es)
GE (1) GEP20115272B (es)
HR (1) HRP20110785T8 (es)
HU (1) HUP0700269A2 (es)
IL (1) IL200801A0 (es)
MA (1) MA31359B1 (es)
MX (1) MX2009010896A (es)
MY (1) MY148384A (es)
NI (1) NI200900179A (es)
NZ (1) NZ579754A (es)
PL (1) PL2132185T3 (es)
PT (1) PT2132185E (es)
RS (1) RS51979B (es)
SI (1) SI2132185T1 (es)
TN (1) TN2009000386A1 (es)
TW (1) TWI445534B (es)
UA (1) UA103748C2 (es)
WO (1) WO2008125891A2 (es)
ZA (1) ZA200906543B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9091489B2 (en) 2010-05-14 2015-07-28 Paragon Space Development Corporation Radiator systems
ES2612471T3 (es) * 2010-06-18 2017-05-17 Altos Therapeutics, LLC Antagonistas D2, métodos de síntesis y métodos de uso
US9376396B2 (en) * 2012-10-22 2016-06-28 AbbVie Deutschland GmbH & Co. KG Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
HU229987B1 (en) * 2012-11-21 2015-04-28 Richter Gedeon Nyrt Process for the preparation of pyrimidinyl-piperazines
US10870660B2 (en) 2016-07-28 2020-12-22 Shionogi & Co., Ltd. Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect
KR20200112910A (ko) 2018-01-26 2020-10-05 시오노기 앤드 컴파니, 리미티드 도파민 d3 수용체 길항 작용을 갖는 축환 화합물
JP7250405B2 (ja) * 2018-01-26 2023-04-03 塩野義製薬株式会社 ドーパミンｄ３受容体拮抗作用を有する環式化合物
CN111770754B (zh) * 2019-01-30 2023-09-19 江苏豪森药业集团有限公司 一种多环类衍生物调节剂、其制备方法和应用
WO2024072930A1 (en) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2311776A1 (fr) * 1975-05-23 1976-12-17 Sogeras Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) * 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
EP1870405A1 (en) * 2006-06-22 2007-12-26 Bioprojet Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands

Also Published As

Publication number Publication date
HK1134491A1 (en) 2010-04-30
MA31359B1 (fr) 2010-05-03
AP2009004970A0 (en) 2009-10-31
GEP20115272B (en) 2011-08-25
PT2132185E (pt) 2011-11-21
NI200900179A (es) 2010-06-30
RS51979B (en) 2012-02-29
MX2009010896A (es) 2009-12-14
KR101540821B1 (ko) 2015-07-30
TWI445534B (zh) 2014-07-21
TW201002328A (en) 2010-01-16
CY1111962T1 (el) 2015-11-04
ZA200906543B (en) 2010-06-30
MY148384A (en) 2013-04-15
HUP0700269A2 (en) 2009-04-28
CA2682817A1 (en) 2008-10-23
CN101652351A (zh) 2010-02-17
HU0700269D0 (en) 2007-05-29
PL2132185T3 (pl) 2011-12-30
WO2008125891A2 (en) 2008-10-23
KR20100082713A (ko) 2010-07-19
EP2132185B1 (en) 2011-08-03
AU2008237696B2 (en) 2013-03-14
UA103748C2 (uk) 2013-11-25
AP2460A (en) 2012-09-13
NZ579754A (en) 2011-11-25
WO2008125891A3 (en) 2009-01-08
CN101652351B (zh) 2012-07-04
EP2132185A2 (en) 2009-12-16
BRPI0809641A2 (pt) 2014-11-11
HRP20110785T8 (en) 2012-04-30
DK2132185T3 (da) 2011-10-03
CA2682817C (en) 2015-11-24
CU20090161A7 (es) 2011-09-21
CO6241116A2 (es) 2011-01-20
ATE518843T1 (de) 2011-08-15
AU2008237696A1 (en) 2008-10-23
IL200801A0 (en) 2010-05-17
JP2010523642A (ja) 2010-07-15
ES2370748T3 (es) 2011-12-22
TN2009000386A1 (en) 2010-12-31
CU23853B1 (es) 2012-10-15
EA016174B1 (ru) 2012-02-28
HRP20110785T1 (hr) 2011-11-30
SI2132185T1 (sl) 2011-11-30
JP4580464B2 (ja) 2010-11-10
CR11071A (es) 2009-11-20
EA200901391A1 (ru) 2010-02-26

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