DK2132185T3 - Pyrimidinyl-piperaziner nyttige som dopamin-D3/D2-receptorligander - Google Patents

Pyrimidinyl-piperaziner nyttige som dopamin-D3/D2-receptorligander

Info

Publication number: DK2132185T3
Authority: DK; Denmark
Prior art keywords: dopamine; pyrimidinyl; receptor ligands; piperazines useful; piperazines
Prior art date: 2007-04-11

Application number

DK08737283.5T

Other languages

English (en)

Inventor

Szalai Gizella Bartane

Csongor Eva Againe

Gyoergy Domany

Istvan Gyertyan

Bela Kiss

Judit Laszy

Katalin Saghy

Sandor Farkas

Zsolt Komlodi

Eva Schmidt

Original Assignee

Richter Gedeon Nyrt

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-11

Filing date

2008-04-10

Publication date

2011-10-03

2008-04-10 Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt

2011-10-03 Application granted granted Critical

2011-10-03 Publication of DK2132185T3 publication Critical patent/DK2132185T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B53/00—Asymmetric syntheses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/09—Geometrical isomers

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DK08737283.5T 2007-04-11 2008-04-10 Pyrimidinyl-piperaziner nyttige som dopamin-D3/D2-receptorligander DK2132185T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0700269A HUP0700269A2 (en)	2007-04-11	2007-04-11	Pyrimidinyl-piperazines useful as d3/d2 receptor ligands, pharmaceutical compositions containing them and their use
PCT/HU2008/000032 WO2008125891A2 (en)	2007-04-11	2008-04-10	Pyrimidinyl-piperazines useful as dopamine d3 /d2 receptor ligands

Publications (1)

Publication Number	Publication Date
DK2132185T3 true DK2132185T3 (da)	2011-10-03

Family

ID=38336883

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08737283.5T DK2132185T3 (da)	2007-04-11	2008-04-10	Pyrimidinyl-piperaziner nyttige som dopamin-D3/D2-receptorligander

Country Status (35)

Country	Link
EP (1)	EP2132185B1 (da)
JP (1)	JP4580464B2 (da)
KR (1)	KR101540821B1 (da)
CN (1)	CN101652351B (da)
AP (1)	AP2460A (da)
AT (1)	ATE518843T1 (da)
AU (1)	AU2008237696B2 (da)
BR (1)	BRPI0809641A2 (da)
CA (1)	CA2682817C (da)
CO (1)	CO6241116A2 (da)
CR (1)	CR11071A (da)
CU (1)	CU23853B1 (da)
CY (1)	CY1111962T1 (da)
DK (1)	DK2132185T3 (da)
EA (1)	EA016174B1 (da)
EC (1)	ECSP099702A (da)
ES (1)	ES2370748T3 (da)
GE (1)	GEP20115272B (da)
HR (1)	HRP20110785T8 (da)
HU (1)	HUP0700269A2 (da)
IL (1)	IL200801A0 (da)
MA (1)	MA31359B1 (da)
MX (1)	MX2009010896A (da)
MY (1)	MY148384A (da)
NI (1)	NI200900179A (da)
NZ (1)	NZ579754A (da)
PL (1)	PL2132185T3 (da)
PT (1)	PT2132185E (da)
RS (1)	RS51979B (da)
SI (1)	SI2132185T1 (da)
TN (1)	TN2009000386A1 (da)
TW (1)	TWI445534B (da)
UA (1)	UA103748C2 (da)
WO (1)	WO2008125891A2 (da)
ZA (1)	ZA200906543B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9091489B2 (en)	2010-05-14	2015-07-28	Paragon Space Development Corporation	Radiator systems
WO2011160084A1 (en) *	2010-06-18	2011-12-22	Altos Therapeutics, LLC	D2 antagonists, methods of synthesis and methods of use
US9376396B2 (en)	2012-10-22	2016-06-28	AbbVie Deutschland GmbH & Co. KG	Acylaminocycloalkyl compounds suitable for treating disorders that respond to modulation of dopamine D3 receptor
HU229987B1 (en) *	2012-11-21	2015-04-28	Richter Gedeon Nyrt	Process for the preparation of pyrimidinyl-piperazines
WO2018021447A1 (ja)	2016-07-28	2018-02-01	塩野義製薬株式会社	ドーパミンｄ３受容体拮抗作用を有する含窒素縮環化合物
BR112020014875A2 (pt)	2018-01-26	2020-12-08	Shionogi & Co., Ltd.	Composto cíclico condensado tendo antagonismo de receptor de dopamina d3
WO2019146740A1 (ja) *	2018-01-26	2019-08-01	塩野義製薬株式会社	ドーパミンｄ３受容体拮抗作用を有する環式化合物
WO2020156312A1 (zh) *	2019-01-30	2020-08-06	江苏豪森药业集团有限公司	一种多环类衍生物调节剂、其制备方法和应用
AU2023353560A1 (en) *	2022-09-30	2025-04-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Dopamine d3/d2 receptor partial agonists for the treatment of neuropsychiatric disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2311776A1 (fr) *	1975-05-23	1976-12-17	Sogeras	Diamino-2,4 bromo-5 chloro-6 pyrimidines et procede pour leur preparation
US5047406A (en) *	1989-12-06	1991-09-10	Warner-Lambert Co.	Substituted cyclohexanols as central nervous system agents
US4957921A (en)	1989-12-06	1990-09-18	Warner-Lambert Company	Substituted cyclohexanols as central nervous system agents
SE9802208D0 (sv)	1998-06-22	1998-06-22	Astra Pharma Inc	Novel compounds
US6919342B2 (en)	2003-06-05	2005-07-19	Abbott Gmbh & Co. Kg	Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) *	2003-08-04	2011-08-29	Richter Gedeon Nyrt	(thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
EP1870405A1 (en) *	2006-06-22	2007-12-26	Bioprojet	Carbonylated (Aza)cyclohexanes as dopamine D3 receptor ligands

2007
- 2007-04-11 HU HU0700269A patent/HUP0700269A2/hu unknown
2008
- 2008-04-10 RS RS20110478A patent/RS51979B/en unknown
- 2008-04-10 AT AT08737283T patent/ATE518843T1/de active
- 2008-04-10 AP AP2009004970A patent/AP2460A/xx active
- 2008-04-10 JP JP2010502585A patent/JP4580464B2/ja active Active
- 2008-04-10 CN CN2008800116439A patent/CN101652351B/zh active Active
- 2008-04-10 UA UAA200911488A patent/UA103748C2/uk unknown
- 2008-04-10 NZ NZ579754A patent/NZ579754A/en not_active IP Right Cessation
- 2008-04-10 GE GEAP200811554A patent/GEP20115272B/en unknown
- 2008-04-10 AU AU2008237696A patent/AU2008237696B2/en not_active Ceased
- 2008-04-10 CA CA2682817A patent/CA2682817C/en not_active Expired - Fee Related
- 2008-04-10 BR BRPI0809641-4A2A patent/BRPI0809641A2/pt not_active IP Right Cessation
- 2008-04-10 WO PCT/HU2008/000032 patent/WO2008125891A2/en not_active Ceased
- 2008-04-10 KR KR1020097020486A patent/KR101540821B1/ko not_active Expired - Fee Related
- 2008-04-10 EP EP08737283A patent/EP2132185B1/en active Active
- 2008-04-10 DK DK08737283.5T patent/DK2132185T3/da active
- 2008-04-10 MX MX2009010896A patent/MX2009010896A/es active IP Right Grant
- 2008-04-10 HR HR20110785T patent/HRP20110785T8/xx unknown
- 2008-04-10 EA EA200901391A patent/EA016174B1/ru not_active IP Right Cessation
- 2008-04-10 MY MYPI20094131A patent/MY148384A/en unknown
- 2008-04-10 PT PT08737283T patent/PT2132185E/pt unknown
- 2008-04-10 PL PL08737283T patent/PL2132185T3/pl unknown
- 2008-04-10 ES ES08737283T patent/ES2370748T3/es active Active
- 2008-04-10 SI SI200830405T patent/SI2132185T1/sl unknown
- 2008-07-08 TW TW097125706A patent/TWI445534B/zh not_active IP Right Cessation
2009
- 2009-09-08 IL IL200801A patent/IL200801A0/en not_active IP Right Cessation
- 2009-09-18 ZA ZA200906543A patent/ZA200906543B/xx unknown
- 2009-09-18 TN TNP2009000386A patent/TN2009000386A1/fr unknown
- 2009-09-25 CU CU2009000161A patent/CU23853B1/es active IP Right Grant
- 2009-10-07 NI NI200900179A patent/NI200900179A/es unknown
- 2009-10-21 CR CR11071A patent/CR11071A/es unknown
- 2009-10-23 EC EC2009009702A patent/ECSP099702A/es unknown
- 2009-11-02 MA MA32320A patent/MA31359B1/fr unknown
- 2009-11-06 CO CO09126013A patent/CO6241116A2/es active IP Right Grant
2011
- 2011-10-21 CY CY20111101000T patent/CY1111962T1/el unknown

Also Published As

Publication number	Publication date
EA200901391A1 (ru)	2010-02-26
ECSP099702A (es)	2009-11-30
CY1111962T1 (el)	2015-11-04
KR101540821B1 (ko)	2015-07-30
WO2008125891A3 (en)	2009-01-08
CN101652351B (zh)	2012-07-04
MX2009010896A (es)	2009-12-14
JP4580464B2 (ja)	2010-11-10
CN101652351A (zh)	2010-02-17
EA016174B1 (ru)	2012-02-28
GEP20115272B (en)	2011-08-25
TW201002328A (en)	2010-01-16
CO6241116A2 (es)	2011-01-20
AP2009004970A0 (en)	2009-10-31
ZA200906543B (en)	2010-06-30
CR11071A (es)	2009-11-20
KR20100082713A (ko)	2010-07-19
EP2132185A2 (en)	2009-12-16
WO2008125891A2 (en)	2008-10-23
CU20090161A7 (es)	2011-09-21
SI2132185T1 (sl)	2011-11-30
TWI445534B (zh)	2014-07-21
RS51979B (en)	2012-02-29
NZ579754A (en)	2011-11-25
CU23853B1 (es)	2012-10-15
BRPI0809641A2 (pt)	2014-11-11
PT2132185E (pt)	2011-11-21
MA31359B1 (fr)	2010-05-03
HU0700269D0 (en)	2007-05-29
ATE518843T1 (de)	2011-08-15
UA103748C2 (uk)	2013-11-25
IL200801A0 (en)	2010-05-17
ES2370748T3 (es)	2011-12-22
MY148384A (en)	2013-04-15
TN2009000386A1 (en)	2010-12-31
NI200900179A (es)	2010-06-30
CA2682817C (en)	2015-11-24
AU2008237696A1 (en)	2008-10-23
AU2008237696B2 (en)	2013-03-14
HRP20110785T8 (en)	2012-04-30
HUP0700269A2 (en)	2009-04-28
CA2682817A1 (en)	2008-10-23
JP2010523642A (ja)	2010-07-15
HK1134491A1 (en)	2010-04-30
EP2132185B1 (en)	2011-08-03
PL2132185T3 (pl)	2011-12-30
HRP20110785T1 (hr)	2011-11-30
AP2460A (en)	2012-09-13

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