ECSP099704A - Estabilizacion de soluciones liquidas de proteina recombinante para el almacenamiento congelado - Google Patents

Estabilizacion de soluciones liquidas de proteina recombinante para el almacenamiento congelado

Info

Publication number
ECSP099704A
ECSP099704A EC2009009704A ECSP099704A ECSP099704A EC SP099704 A ECSP099704 A EC SP099704A EC 2009009704 A EC2009009704 A EC 2009009704A EC SP099704 A ECSP099704 A EC SP099704A EC SP099704 A ECSP099704 A EC SP099704A
Authority
EC
Ecuador
Prior art keywords
recombinant protein
frozen storage
stabilization
liquid solutions
solution
Prior art date
Application number
EC2009009704A
Other languages
English (en)
Inventor
Nelly Tsvetkova
Omkar Joshi
Paul Wu
Deqian Wang
Arnaud Desponds
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Publication of ECSP099704A publication Critical patent/ECSP099704A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La invención se refiere a un método para estabilizar una solución a granel de proteína recombinante para el almacenamiento congelado, que comprende la provisión de una solución parcialmente purificada de la proteína recombinante que tiene una concentración de sal monovalente de al menos 100 mM, y la adición de un carbohidrato a dicha solución en una cantidad suficiente de modo que, después del congelamiento, la solución tiene una temperatura de transición vítrea de -56ºC o mayor.
EC2009009704A 2007-04-26 2009-10-23 Estabilizacion de soluciones liquidas de proteina recombinante para el almacenamiento congelado ECSP099704A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92669807P 2007-04-26 2007-04-26

Publications (1)

Publication Number Publication Date
ECSP099704A true ECSP099704A (es) 2009-11-30

Family

ID=39926041

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2009009704A ECSP099704A (es) 2007-04-26 2009-10-23 Estabilizacion de soluciones liquidas de proteina recombinante para el almacenamiento congelado

Country Status (15)

Country Link
US (2) US8187799B2 (es)
EP (1) EP2150264A4 (es)
JP (1) JP5401446B2 (es)
KR (2) KR101578561B1 (es)
CN (2) CN101678066B (es)
AU (1) AU2008245821B2 (es)
BR (1) BRPI0810500A2 (es)
CA (1) CA2683317C (es)
EC (1) ECSP099704A (es)
HK (1) HK1198815A1 (es)
IL (1) IL201508A0 (es)
MX (1) MX2009011367A (es)
RU (1) RU2469739C2 (es)
WO (1) WO2008134310A1 (es)
ZA (1) ZA200907247B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US11197916B2 (en) 2007-12-28 2021-12-14 Takeda Pharmaceutical Company Limited Lyophilized recombinant VWF formulations
SG187410A1 (en) 2007-12-28 2013-02-28 Baxter Int Recombinant vwf formulations
EP2349314B1 (en) 2008-10-21 2013-02-27 Baxter International Inc. Lyophilized recombinant vwf formulations
US20100278822A1 (en) * 2009-05-04 2010-11-04 Abbott Biotechnology, Ltd. Stable high protein concentration formulations of human anti-tnf-alpha-antibodies
US8821865B2 (en) 2010-11-11 2014-09-02 Abbvie Biotechnology Ltd. High concentration anti-TNFα antibody liquid formulations
RU2695428C2 (ru) 2014-01-20 2019-07-23 Октафарма Аг СПОСОБ ПРОИЗВОДСТВА ФАКТОРА VIII, ИМЕЮЩЕГО УЛУЧШЕННОЕ СООТНОШЕНИЕ FVIII:C/FVIII:Ag
JP5892303B1 (ja) 2014-06-13 2016-03-23 凸版印刷株式会社 針状体の製造方法

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US4457916A (en) 1982-08-31 1984-07-03 Asahi Kasei Kogyo Kabushiki Kaisha Method for stabilizing Tumor Necrosis Factor and a stable aqueous solution or powder containing the same
JPS59134730A (ja) * 1983-01-20 1984-08-02 Green Cross Corp:The 血液凝固第８因子の加熱処理法
US5576194A (en) 1986-07-11 1996-11-19 Bayer Corporation Recombinant protein production
CA1329760C (en) * 1987-10-29 1994-05-24 Ted C. K. Lee Plasma and recombinant protein formulations in high ionic strength media
US5605884A (en) 1987-10-29 1997-02-25 Rhone-Poulenc Rorer Pharmaceuticals Inc. Factor VIII formulations in high ionic strength media
US4877608A (en) 1987-11-09 1989-10-31 Rorer Pharmaceutical Corporation Pharmaceutical plasma protein formulations in low ionic strength media
DE4111393A1 (de) 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
US5278289A (en) * 1991-11-12 1994-01-11 Johnson Alan J Antihemophilic factor stabilization
CA2124690C (en) 1992-10-02 2007-09-11 Thomas Osterberg Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
US5576291A (en) * 1993-09-13 1996-11-19 Baxter International Inc. Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency
IL113010A (en) 1994-03-31 1999-10-28 Pharmacia & Upjohn Ab Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration
US6818439B1 (en) * 1994-12-30 2004-11-16 Chiron Corporation Methods for administration of recombinant gene delivery vehicles for treatment of hemophilia and other disorders
US6790439B1 (en) 1995-06-07 2004-09-14 Zymogenetics, Inc. Thrombopoietin compositions
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US5770700A (en) 1996-01-25 1998-06-23 Genetics Institute, Inc. Liquid factor IX formulations
US5763401A (en) 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
US5804420A (en) 1997-04-18 1998-09-08 Bayer Corporation Preparation of recombinant Factor VIII in a protein free medium
AT407255B (de) 1997-06-20 2001-02-26 Immuno Ag Rekombinanter zellklon mit erhöhter stabilität in serum- und proteinfreiem medium und verfahren zur gewinnung des stabilen zellklons
DK1820516T3 (da) 1999-02-22 2013-10-28 Univ Connecticut Nye albuminfrie faktor VIII-præparater
MXPA02000525A (es) 1999-07-15 2005-07-01 Inst Genetics Llc Formulaciones de il-11.
US7147876B2 (en) 2001-08-13 2006-12-12 Michael Hargreaves Riley Compositions for removal of toxins
DE10149030A1 (de) 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
CN1671410B (zh) * 2002-06-21 2010-05-12 诺和诺德医疗保健公司 因子ⅶ多肽的稳定化固体组合物
KR100560697B1 (ko) 2003-08-06 2006-03-16 씨제이 주식회사 알부민을 함유하지 않는 에리스로포이에틴 제제

Also Published As

Publication number Publication date
US8187799B2 (en) 2012-05-29
ZA200907247B (en) 2010-08-25
CN101678066B (zh) 2014-09-24
RU2009143493A (ru) 2011-06-10
CN101678066A (zh) 2010-03-24
US20100113744A1 (en) 2010-05-06
WO2008134310A1 (en) 2008-11-06
AU2008245821A1 (en) 2008-11-06
CA2683317C (en) 2014-12-16
US8536125B2 (en) 2013-09-17
HK1198815A1 (en) 2015-06-12
EP2150264A4 (en) 2014-09-24
KR20100017354A (ko) 2010-02-16
AU2008245821B2 (en) 2013-07-04
JP5401446B2 (ja) 2014-01-29
JP2010525071A (ja) 2010-07-22
US20120211698A1 (en) 2012-08-23
EP2150264A1 (en) 2010-02-10
CA2683317A1 (en) 2008-11-06
KR20150103333A (ko) 2015-09-09
IL201508A0 (en) 2010-05-31
MX2009011367A (es) 2010-03-22
RU2469739C2 (ru) 2012-12-20
WO2008134310A8 (en) 2009-12-10
KR101578561B1 (ko) 2015-12-17
BRPI0810500A2 (pt) 2014-10-14
CN103990116A (zh) 2014-08-20

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