ES2572267T3 - Composiciones de insulina de acción súper rápida - Google Patents

Composiciones de insulina de acción súper rápida

Info

Publication number
ES2572267T3
ES2572267T3 ES13193463T ES13193463T ES2572267T3 ES 2572267 T3 ES2572267 T3 ES 2572267T3 ES 13193463 T ES13193463 T ES 13193463T ES 13193463 T ES13193463 T ES 13193463T ES 2572267 T3 ES2572267 T3 ES 2572267T3
Authority
ES
Spain
Prior art keywords
acting insulin
fast
insulin
super
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES13193463T
Other languages
English (en)
Inventor
Gregory Frost
Igor Bilinsky
Daniel Vaughn
Barry Sugarman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Halozyme Inc
Original Assignee
Halozyme Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41037892&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2572267(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Halozyme Inc filed Critical Halozyme Inc
Application granted granted Critical
Publication of ES2572267T3 publication Critical patent/ES2572267T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Una composición de insulina de acción súper rápida para uso para administración a un sujeto diabético para controlar los niveles de glucosa en sangre post-prandial en el sujeto, donde la composición de insulina de acción súper rápida comprende: una concentración terapéuticamente eficaz de un análogo de insulina de acción rápida para mantener los niveles de glucosa en sangre normales, donde un análogo de insulina de acción rápida es una insulina que comprende uno o más cambios de aminoácidos en insulina que reducen la autoasociación de la molécula de insulina, por lo que el análogo de insulina de acción rápida muestra una disociación más rápida de forma hexamérica a monomérica tras la administración subcutánea; y una concentración de una enzima degradante de hialuronano suficiente para convertir el análogo de insulina de acción rápida en una composición de insulina de acción súper rápida tras la administración, donde la composición de insulina de acción súper rápida tiene un inicio de acción que se asemeja estrechamente a la liberación de insulina postprandial endógena de un sujeto no diabético.
ES13193463T 2008-04-28 2009-04-28 Composiciones de insulina de acción súper rápida Active ES2572267T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12583508P 2008-04-28 2008-04-28
US12704408P 2008-05-09 2008-05-09

Publications (1)

Publication Number Publication Date
ES2572267T3 true ES2572267T3 (es) 2016-05-31

Family

ID=41037892

Family Applications (2)

Application Number Title Priority Date Filing Date
ES09739183.3T Active ES2531630T3 (es) 2008-04-28 2009-04-28 Composiciones de insulina de acción súper rápida
ES13193463T Active ES2572267T3 (es) 2008-04-28 2009-04-28 Composiciones de insulina de acción súper rápida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES09739183.3T Active ES2531630T3 (es) 2008-04-28 2009-04-28 Composiciones de insulina de acción súper rápida

Country Status (28)

Country Link
US (3) US8318154B2 (es)
EP (2) EP2300046B1 (es)
JP (3) JP2011523940A (es)
KR (2) KR101516534B1 (es)
CN (1) CN102083458B (es)
AR (1) AR072250A1 (es)
AU (1) AU2009241795B2 (es)
BR (1) BRPI0911782A2 (es)
CA (1) CA2722628C (es)
CL (1) CL2009001014A1 (es)
CY (1) CY1116311T1 (es)
DK (1) DK2300046T3 (es)
EA (1) EA029502B1 (es)
ES (2) ES2531630T3 (es)
HR (1) HRP20150313T1 (es)
IL (1) IL208554A0 (es)
MX (2) MX348276B (es)
NZ (1) NZ588748A (es)
PE (2) PE20141384A1 (es)
PL (1) PL2300046T3 (es)
PT (1) PT2300046E (es)
RS (1) RS53945B1 (es)
SG (1) SG10201404218VA (es)
SI (1) SI2300046T1 (es)
TW (1) TWI394580B (es)
UY (1) UY31789A1 (es)
WO (1) WO2009134380A2 (es)
ZA (1) ZA201007403B (es)

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* Cited by examiner, † Cited by third party
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EA201001698A1 (ru) 2011-08-30
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CN102083458A (zh) 2011-06-01
MX348276B (es) 2017-06-02
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US8568713B2 (en) 2013-10-29
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