ECSP099769A - Anticuerpos anti-cd44 hibridos y humanizados que median la citotoxicidad de celulas de cancer - Google Patents

Anticuerpos anti-cd44 hibridos y humanizados que median la citotoxicidad de celulas de cancer

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Publication number
ECSP099769A
ECSP099769A EC2009009769A ECSP099769A ECSP099769A EC SP099769 A ECSP099769 A EC SP099769A EC 2009009769 A EC2009009769 A EC 2009009769A EC SP099769 A ECSP099769 A EC SP099769A EC SP099769 A ECSP099769 A EC SP099769A
Authority
EC
Ecuador
Prior art keywords
cancer
monoclonal antibody
cells
hybrid
antibody
Prior art date
Application number
EC2009009769A
Other languages
English (en)
Inventor
Lisa M Cechetto
Helen P Findlay
Susan E Hahn
Fortunata Mcconkey
David S F Young
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP099769A publication Critical patent/ECSP099769A/es

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57545—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the ovaries
    • A—HUMAN NECESSITIES
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
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    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
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    • G01N33/57555—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the prostate
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70585—CD44

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  • Health & Medical Sciences (AREA)
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Abstract

El CD44, una glicoproteína de unión a ácido hialurónico (HA) de cadena individual, se expresa en una variedad de tejidos normales, todas las células hepatopoyéticas y varios tejidos de cáncer. Un anticuerpo monoclonal contra CD44 del hibridoma H460-16-2, depositado con la ATCC como PTA-4621, se mostró anteriormente que es un anticuerpo modificador de enfermedad cancerosa (CDMAB), que impide el crecimiento del tumor y que reduce la carga tumoral en modelos de cáncer incluyendo cáncer de próstata y mama por citotoxicidad. Las regiones variables de este anticuerpo monoclonal también se aislaron y se secuenciaron para generar un anticuerpo híbrido que tiene actividad anti-cáncer mejorada con respecto al anticuerpo monoclonal. Ahora, se generan anticuerpos humanizados que tienen actividad similar de unión a CD44 como el anticuerpo monoclonal PTA-4621 de origen. Los anticuerpos monoclonales, híbridos y humanizados se pueden conjugar a toxinas, enzimas, compuestos radioactivos, citocinas, interferones, porciones objetivo o indicadoras y células hematogenas para tratar cáncer. Estos anticuerpos también se usan en ensayos de unión para determinar la expresión de CD44 en células.
EC2009009769A 2007-05-30 2009-11-27 Anticuerpos anti-cd44 hibridos y humanizados que median la citotoxicidad de celulas de cancer ECSP099769A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11/807,887 US8071072B2 (en) 1999-10-08 2007-05-30 Cytotoxicity mediation of cells evidencing surface expression of CD44

Publications (1)

Publication Number Publication Date
ECSP099769A true ECSP099769A (es) 2009-12-28

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EC2009009769A ECSP099769A (es) 2007-05-30 2009-11-27 Anticuerpos anti-cd44 hibridos y humanizados que median la citotoxicidad de celulas de cancer

Country Status (21)

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US (2) US8071072B2 (es)
EP (1) EP2164874A4 (es)
JP (2) JP5363464B2 (es)
KR (1) KR101131401B1 (es)
CN (2) CN101687930A (es)
AU (1) AU2008255527B2 (es)
BR (1) BRPI0812488A2 (es)
CA (1) CA2687583C (es)
CO (1) CO6241160A2 (es)
CR (1) CR11125A (es)
EC (1) ECSP099769A (es)
IL (1) IL202097A0 (es)
MA (1) MA31662B1 (es)
MX (1) MX2009012672A (es)
NZ (2) NZ581507A (es)
PH (1) PH12014500679A1 (es)
RU (2) RU2487723C2 (es)
SG (1) SG188795A1 (es)
UA (1) UA98332C2 (es)
WO (1) WO2008144890A1 (es)
ZA (1) ZA200908344B (es)

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US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
DK2531527T3 (da) * 2010-02-04 2014-05-05 Hoffmann La Roche Monoklonalt antistof til cd44 til anvendelse i behandlingen af hoved-hals-pladeepitelcarcinom
JP2015527869A (ja) 2011-08-26 2015-09-24 メリマック ファーマシューティカルズ インコーポレーティッド タンデムＦｃ二重特異性抗体
KR20140090997A (ko) * 2011-10-26 2014-07-18 더 리전트 오브 더 유니버시티 오브 캘리포니아 B-세포 만성 림프구성 백혈병 및 다른 혈액학적 악성종양의 치료를 위한 cd44 단일클론 항체
US20140335084A1 (en) 2011-12-06 2014-11-13 Hoffmann-La Roche Inc. Antibody formulation
KR20150143458A (ko) 2013-03-06 2015-12-23 메리맥 파마슈티컬즈, 인크. 항-C-MET 탠덤 Fc 이중특이적 항체
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