ECSP10010327A - Péptidos del fviii y su uso para hemofílicos tolerantes - Google Patents
Péptidos del fviii y su uso para hemofílicos tolerantesInfo
- Publication number
- ECSP10010327A ECSP10010327A EC2010010327A ECSP10010327A ECSP10010327A EC SP10010327 A ECSP10010327 A EC SP10010327A EC 2010010327 A EC2010010327 A EC 2010010327A EC SP10010327 A ECSP10010327 A EC SP10010327A EC SP10010327 A ECSP10010327 A EC SP10010327A
- Authority
- EC
- Ecuador
- Prior art keywords
- peptides
- fviii
- hemophylics
- tolerant
- peptide
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 title abstract 3
- 102100026735 Coagulation factor VIII Human genes 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 201000003542 Factor VIII deficiency Diseases 0.000 abstract 1
- 208000009292 Hemophilia A Diseases 0.000 abstract 1
- 208000013633 acquired hemophilia Diseases 0.000 abstract 1
- 230000030741 antigen processing and presentation Effects 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 102000057593 human F8 Human genes 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención provee un péptido que comprende una secuencia residual central derivable del FVIII humano, este péptido es capaz de unirse a una molécula de MHC de clase II sin un procesamiento de antígeno adicional. La presente invención también se refiere al uso de dichos péptidos para la prevención o supresión de la formación de anticuerpos inhibidores en la hemofilia A y/o hemofilia adquirida.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0723712.6A GB0723712D0 (en) | 2007-12-04 | 2007-12-04 | Peptides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP10010327A true ECSP10010327A (es) | 2010-09-30 |
Family
ID=38982965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2010010327A ECSP10010327A (es) | 2007-12-04 | 2010-07-02 | Péptidos del fviii y su uso para hemofílicos tolerantes |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US8445448B2 (es) |
| EP (1) | EP2227488B3 (es) |
| JP (2) | JP5501245B2 (es) |
| KR (1) | KR101519840B1 (es) |
| CN (2) | CN103709234B (es) |
| AU (1) | AU2008332968B2 (es) |
| BR (1) | BRPI0820143A2 (es) |
| CA (2) | CA3005013C (es) |
| CY (1) | CY1115168T1 (es) |
| DK (1) | DK2227488T6 (es) |
| EA (1) | EA019370B1 (es) |
| EC (1) | ECSP10010327A (es) |
| ES (1) | ES2458315T7 (es) |
| GB (1) | GB0723712D0 (es) |
| HR (1) | HRP20140344T4 (es) |
| IL (1) | IL205780A (es) |
| MX (1) | MX2010006084A (es) |
| MY (1) | MY150995A (es) |
| NZ (1) | NZ585217A (es) |
| PL (1) | PL2227488T6 (es) |
| PT (1) | PT2227488E (es) |
| SI (1) | SI2227488T1 (es) |
| UA (1) | UA101003C2 (es) |
| WO (1) | WO2009071886A1 (es) |
| ZA (1) | ZA201002997B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1918298T3 (da) | 2000-08-21 | 2010-11-29 | Apitope Technology Bristol Ltd | Peptid |
| GB0801513D0 (en) * | 2008-01-28 | 2008-03-05 | Circassia Ltd | Peptides from factor VIII |
| PL2300497T3 (pl) * | 2008-06-24 | 2013-02-28 | Octapharma Ag | Sposób oczyszczania czynnika krzepnięcia VIII |
| GB0908515D0 (en) * | 2009-05-18 | 2009-06-24 | Apitope Technology Bristol Ltd | Peptide |
| US20120135917A1 (en) * | 2009-06-16 | 2012-05-31 | Eisaku Yoshihara | Anti-Gram Negative Bacteria Agent |
| US8969524B2 (en) | 2010-10-27 | 2015-03-03 | Baxter International Inc. | FVIII peptides for immune tolerance induction and immunodiagnostics |
| SMT201800586T1 (it) | 2012-01-12 | 2019-01-11 | Bioverativ Therapeutics Inc | Riduzione dell'immunogenicita' contro il fattore viii negli individui che si sottopongono alla terapia con fattore viii |
| PL2917232T3 (pl) * | 2012-11-12 | 2017-09-29 | Apitope International Nv | Pochodzące od czynnika VIII peptydy do zastosowania w leczeniu hemofilii A |
| GB201314052D0 (en) * | 2013-08-06 | 2013-09-18 | Apitope Int Nv | Peptides |
| CN108884140B (zh) | 2015-12-03 | 2022-10-25 | 朱诺治疗学股份有限公司 | 修饰的嵌合受体及相关组合物和方法 |
| JP2019536794A (ja) | 2016-12-02 | 2019-12-19 | バイオベラティブ セラピューティクス インコーポレイテッド | 凝固因子に対する免疫寛容を誘導する方法 |
| US12077607B2 (en) * | 2021-09-23 | 2024-09-03 | University Of Utah Research Foundation | Functional and therapeutic effects of PAR4 cleavage by cathepsin G |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5930890A (en) * | 1989-06-20 | 1991-01-08 | Scripps Clinic And Research Foundation | The phospholipid binding domain of factor viii |
| ATE244579T1 (de) * | 1997-01-22 | 2003-07-15 | Univ Texas | Verfahren und zusammensetzungen des gewebefaktors zur koagulation und behandlung von tumoren |
| DK1918298T3 (da) * | 2000-08-21 | 2010-11-29 | Apitope Technology Bristol Ltd | Peptid |
| WO2002060917A2 (en) * | 2000-12-01 | 2002-08-08 | Regents Of The University Of Minnesota | Method to treat hemophilia |
| PL362324A1 (en) * | 2001-02-19 | 2004-10-18 | Merck Patent Gmbh | Artificial fusion proteins with reduced immunogenicity |
| WO2002098454A2 (en) * | 2001-05-31 | 2002-12-12 | D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
| WO2003087161A1 (en) * | 2002-04-18 | 2003-10-23 | Merck Patent Gmbh | Modified factor viii |
| JP5010923B2 (ja) * | 2004-02-09 | 2012-08-29 | ヒューマン ジノーム サイエンシーズ， インコーポレイテッド | アルブミン融合蛋白質 |
| WO2006003183A1 (de) | 2004-07-02 | 2006-01-12 | Alois Jungbauer | Peptide zur blockierung von fviii-inhibitoren |
| IL229645A0 (en) * | 2013-11-26 | 2014-03-31 | Omrix Biopharmaceuticals Ltd | A dry bandage containing thrombin and pectin |
-
2007
- 2007-12-04 GB GBGB0723712.6A patent/GB0723712D0/en not_active Ceased
-
2008
- 2008-03-12 UA UAA201008194A patent/UA101003C2/uk unknown
- 2008-12-03 WO PCT/GB2008/003996 patent/WO2009071886A1/en not_active Ceased
- 2008-12-03 JP JP2010536523A patent/JP5501245B2/ja not_active Expired - Fee Related
- 2008-12-03 AU AU2008332968A patent/AU2008332968B2/en not_active Ceased
- 2008-12-03 EA EA201070681A patent/EA019370B1/ru not_active IP Right Cessation
- 2008-12-03 DK DK08855772.3T patent/DK2227488T6/en active
- 2008-12-03 ES ES08855772.3T patent/ES2458315T7/es active Active
- 2008-12-03 SI SI200831186T patent/SI2227488T1/sl unknown
- 2008-12-03 MY MYPI20102567 patent/MY150995A/en unknown
- 2008-12-03 PL PL08855772T patent/PL2227488T6/pl unknown
- 2008-12-03 HR HRP20140344TT patent/HRP20140344T4/hr unknown
- 2008-12-03 BR BRPI0820143 patent/BRPI0820143A2/pt not_active Application Discontinuation
- 2008-12-03 MX MX2010006084A patent/MX2010006084A/es active IP Right Grant
- 2008-12-03 NZ NZ585217A patent/NZ585217A/xx not_active IP Right Cessation
- 2008-12-03 EP EP08855772.3A patent/EP2227488B3/en active Active
- 2008-12-03 PT PT88557723T patent/PT2227488E/pt unknown
- 2008-12-03 CA CA3005013A patent/CA3005013C/en active Active
- 2008-12-03 US US12/746,141 patent/US8445448B2/en not_active Expired - Fee Related
- 2008-12-03 CN CN201310392152.6A patent/CN103709234B/zh not_active Expired - Fee Related
- 2008-12-03 KR KR1020107011743A patent/KR101519840B1/ko not_active Expired - Fee Related
- 2008-12-03 CN CN200880119313.1A patent/CN101889024B/zh not_active Expired - Fee Related
- 2008-12-03 CA CA2707559A patent/CA2707559C/en active Active
-
2010
- 2010-04-29 ZA ZA2010/02997A patent/ZA201002997B/en unknown
- 2010-05-13 IL IL205780A patent/IL205780A/en active IP Right Grant
- 2010-07-02 EC EC2010010327A patent/ECSP10010327A/es unknown
-
2014
- 2014-02-10 JP JP2014023217A patent/JP6063402B2/ja not_active Expired - Fee Related
- 2014-04-15 CY CY20141100281T patent/CY1115168T1/el unknown
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