ECSP11010773A - Cristal de derivados de espirocetal, y procedimiento para la preparacion de derivados de espirocetal - Google Patents

Cristal de derivados de espirocetal, y procedimiento para la preparacion de derivados de espirocetal

Info

Publication number
ECSP11010773A
ECSP11010773A EC2011010773A ECSP11010773A ECSP11010773A EC SP11010773 A ECSP11010773 A EC SP11010773A EC 2011010773 A EC2011010773 A EC 2011010773A EC SP11010773 A ECSP11010773 A EC SP11010773A EC SP11010773 A ECSP11010773 A EC SP11010773A
Authority
EC
Ecuador
Prior art keywords
spirocetal
derivatives
crystal
procedure
preparation
Prior art date
Application number
EC2011010773A
Other languages
English (en)
Inventor
Masatoshi Murakata
Takuma Ikeda
Nobuaki Kimura
Akira Kawase
Masahiro Nagase
Keisuke Yamamoto
Noriyuki Takata
Shinichi Yoshizaki
Koji Takano
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41434188&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11010773(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of ECSP11010773A publication Critical patent/ECSP11010773A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención provee un procedimiento para preparar un derivado de espirocetal, por medio de un intermediario representado por la fórmula (VI):(VI)en donde los grupos y números variables son como se definen en la especificación, y el cual puede producirse de derivados de dihalobenceno en una reacción en un recipiente.
EC2011010773A 2008-06-20 2011-01-20 Cristal de derivados de espirocetal, y procedimiento para la preparacion de derivados de espirocetal ECSP11010773A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2008162073 2008-06-20

Publications (1)

Publication Number Publication Date
ECSP11010773A true ECSP11010773A (es) 2011-02-28

Family

ID=41434188

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010773A ECSP11010773A (es) 2008-06-20 2011-01-20 Cristal de derivados de espirocetal, y procedimiento para la preparacion de derivados de espirocetal

Country Status (24)

Country Link
US (2) US8569520B2 (es)
EP (3) EP4036100A1 (es)
JP (2) JP4823385B2 (es)
KR (1) KR101856784B1 (es)
CN (1) CN102046645B (es)
AR (1) AR072211A1 (es)
AU (1) AU2009261129A1 (es)
CA (1) CA2727923A1 (es)
CL (1) CL2010001485A1 (es)
CO (1) CO6351798A2 (es)
CR (1) CR20110033A (es)
EC (1) ECSP11010773A (es)
ES (1) ES2907611T3 (es)
IL (1) IL210098A0 (es)
MA (1) MA32530B1 (es)
MX (1) MX2010014023A (es)
NZ (1) NZ589961A (es)
PE (1) PE20110115A1 (es)
PL (1) PL3170834T3 (es)
RU (1) RU2011101972A (es)
SG (1) SG193795A1 (es)
TW (1) TW201011043A (es)
WO (1) WO2009154276A1 (es)
ZA (1) ZA201100016B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5711669B2 (ja) * 2009-12-18 2015-05-07 中外製薬株式会社 スピロケタール誘導体の製造方法
JP6294665B2 (ja) * 2011-02-25 2018-03-14 中外製薬株式会社 スピロケタール誘導体の結晶
MX355016B (es) * 2011-10-06 2018-04-02 Bayer Ip Gmbh Heterociclilpiri(mi)dinilpirazoles como fungicidas.
US10231930B2 (en) * 2013-12-27 2019-03-19 Chugai Seiyaku Kabushiki Kaisha Solid preparations containing tofogliflozin and process of producing the same
CN106188190B (zh) * 2016-07-28 2020-08-25 迪嘉药业集团有限公司 一种托格列净一水合物的制备方法
US20210212968A1 (en) 2016-10-19 2021-07-15 Boehringer Ingelheim International Gmbh Combinations comprising an ssao/vap-1 inhibitor and a sglt2 inhibitor, uses thereof
CN108640958B (zh) * 2017-05-05 2021-03-30 镇江圣安医药有限公司 异苯并呋喃衍生物、其药物组合物和制剂以及用途
CN111989103A (zh) 2018-04-17 2020-11-24 勃林格殷格翰国际有限公司 药物组合物、其治疗方法和用途
KR102812426B1 (ko) 2018-10-29 2025-05-26 베링거 인겔하임 인터내셔날 게엠베하 피리디닐 설폰아미드 유도체, 약제학적 조성물 및 이의 용도
US12213970B2 (en) 2018-10-29 2025-02-04 Boehringer Ingelheim International Gmbh Pyridinyl sulfonamide derivatives, pharmaceutical compositions and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL63968A (en) * 1980-10-01 1985-10-31 Glaxo Group Ltd Form 2 ranitidine hydrochloride,its preparation and pharmaceutical compositions containing it
HU196775B (en) 1986-08-05 1989-01-30 Richter Gedeon Vegyeszet Process for production of morfologically unique new modifications of famotidin and medical compositions containing such substances
PT98344B (pt) 1991-07-17 1999-04-30 Lneti Lab Nac De Eng Tec Ind D Processo para a obtencao de espirocetais labdanicos do tipo ambar cinzento
GB9426103D0 (en) 1994-12-23 1995-02-22 Merck Sharp & Dohme Therapeutic agents
JP2000044534A (ja) 1998-07-28 2000-02-15 Mitsui Chemicals Inc Ｎ保護基アミノ酸の製造法
WO2001057046A1 (en) 2000-02-02 2001-08-09 Banyu Pharmaceutical Co., Ltd. Method of converting functional group through halogen-metal exchange reaction
JP3849024B2 (ja) 2003-03-26 2006-11-22 国立大学法人 東京大学 有機亜鉛錯体およびその製造方法
TW200637869A (en) * 2005-01-28 2006-11-01 Chugai Pharmaceutical Co Ltd The spiroketal derivatives and the use as therapeutical agent for diabetes of the same
CA2634468C (en) 2005-12-23 2014-10-07 Ecobiotics Limited Spiroketals
US7803778B2 (en) 2006-05-23 2010-09-28 Theracos, Inc. Glucose transport inhibitors and methods of use
TWI403516B (zh) 2006-07-27 2013-08-01 Chugai Pharmaceutical Co Ltd To replace spirocyclic alcohol derivatives, and its use as a therapeutic agent for diabetes

Also Published As

Publication number Publication date
US20110306778A1 (en) 2011-12-15
IL210098A0 (en) 2011-02-28
CA2727923A1 (en) 2009-12-23
HK1154589A1 (en) 2012-04-27
US20140024817A1 (en) 2014-01-23
CR20110033A (es) 2011-02-16
KR20110020909A (ko) 2011-03-03
CN102046645A (zh) 2011-05-04
RU2011101972A (ru) 2012-07-27
MX2010014023A (es) 2011-02-15
WO2009154276A1 (ja) 2009-12-23
CN102046645B (zh) 2015-04-01
ES2907611T3 (es) 2022-04-25
EP4036100A1 (en) 2022-08-03
CO6351798A2 (es) 2011-12-20
US9163051B2 (en) 2015-10-20
JPWO2009154276A1 (ja) 2011-12-01
EP3170834B1 (en) 2022-02-09
PL3170834T3 (pl) 2022-05-02
AR072211A1 (es) 2010-08-11
EP2308886B1 (en) 2016-12-07
ZA201100016B (en) 2012-03-28
EP3170834A1 (en) 2017-05-24
JP5485237B2 (ja) 2014-05-07
EP3170834B8 (en) 2022-03-23
JP2012001554A (ja) 2012-01-05
EP2308886A4 (en) 2013-04-03
PE20110115A1 (es) 2011-02-14
TW201011043A (en) 2010-03-16
JP4823385B2 (ja) 2011-11-24
AU2009261129A1 (en) 2009-12-23
MA32530B1 (fr) 2011-08-01
NZ589961A (en) 2012-12-21
SG193795A1 (en) 2013-10-30
EP2308886A1 (en) 2011-04-13
US8569520B2 (en) 2013-10-29
KR101856784B1 (ko) 2018-05-10
CL2010001485A1 (es) 2011-09-16

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