ECSP14013245A - Nuevos derivados dihidroquinolina-2-ona - Google Patents
Nuevos derivados dihidroquinolina-2-onaInfo
- Publication number
- ECSP14013245A ECSP14013245A ECSP14013245A ECSP14013245A EC SP14013245 A ECSP14013245 A EC SP14013245A EC SP14013245 A ECSP14013245 A EC SP14013245A EC SP14013245 A ECSP14013245 A EC SP14013245A
- Authority
- EC
- Ecuador
- Prior art keywords
- dihydroquinoline
- new
- ona
- derivatives
- ona derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La invención proporciona nuevos compuestos que presentan la fórmula general (I): (I)en la que R1, R2, R3, R4¸ R5, R6, R7, A1, A2 y A3 son tal como se indica en la presente memoria, composiciones que incluyen los compuestos, y métodos de utilización de los compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011079673 | 2011-09-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP14013245A true ECSP14013245A (es) | 2014-07-31 |
Family
ID=46829775
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP14013245 ECSP14013245A (es) | 2011-09-15 | 2014-03-14 | Nuevos derivados dihidroquinolina-2-ona |
Country Status (33)
| Country | Link |
|---|---|
| US (1) | US9260408B2 (es) |
| EP (2) | EP3653618B1 (es) |
| JP (1) | JP6012735B2 (es) |
| KR (1) | KR101785143B1 (es) |
| CN (1) | CN103814021B (es) |
| AR (1) | AR087901A1 (es) |
| AU (1) | AU2012307509B2 (es) |
| BR (1) | BR112014006283B1 (es) |
| CA (1) | CA2846785C (es) |
| CL (1) | CL2014000604A1 (es) |
| CO (1) | CO6890099A2 (es) |
| CR (1) | CR20140091A (es) |
| DK (1) | DK2755963T3 (es) |
| EA (1) | EA035757B1 (es) |
| EC (1) | ECSP14013245A (es) |
| ES (2) | ES2763332T3 (es) |
| HR (1) | HRP20192323T1 (es) |
| HU (1) | HUE047771T2 (es) |
| IL (1) | IL231229A0 (es) |
| LT (1) | LT2755963T (es) |
| MX (1) | MX358376B (es) |
| MY (1) | MY169043A (es) |
| PE (1) | PE20141372A1 (es) |
| PH (1) | PH12014500434A1 (es) |
| PL (1) | PL2755963T3 (es) |
| PT (1) | PT2755963T (es) |
| RS (1) | RS59737B1 (es) |
| SG (1) | SG11201400679WA (es) |
| SI (1) | SI2755963T1 (es) |
| TW (1) | TWI462914B (es) |
| UA (1) | UA111626C2 (es) |
| WO (1) | WO2013037779A1 (es) |
| ZA (1) | ZA201401884B (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014135561A1 (en) * | 2013-03-08 | 2014-09-12 | F. Hoffmann-La Roche Ag | New dihydroquinoline-2-one derivatives as aldosterone synthase (cyp1 1 b2 or cyp1 1 b1 ) inhibitors |
| MX2015011005A (es) * | 2013-03-14 | 2015-10-22 | Hoffmann La Roche | Derivados de dihidorquinolin-2-ona para usarse como inhibidores de aldoesterona sintasa. |
| CN105073732B (zh) * | 2013-03-14 | 2017-07-21 | 豪夫迈·罗氏有限公司 | 用作醛固酮合酶抑制剂的二氢喹啉‑2‑酮衍生物 |
| US9682983B2 (en) | 2013-03-14 | 2017-06-20 | The Brigham And Women's Hospital, Inc. | BMP inhibitors and methods of use thereof |
| JP6067181B2 (ja) * | 2013-04-30 | 2017-01-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | アルドステロンシンターゼ阻害薬 |
| RU2693698C2 (ru) * | 2013-05-27 | 2019-07-04 | Ф. Хоффманн-Ля Рош Аг | Новые соединения 3,4-дигидро-2н-изохинолин-1-она и 2,3-дигидроизоиндол-1-она |
| CN105143205B (zh) * | 2013-05-27 | 2018-02-02 | 豪夫迈·罗氏有限公司 | 新的3,4‑二氢‑2h‑异喹啉‑1‑酮和2,3‑二氢‑异吲哚‑1‑酮化合物 |
| TWI651317B (zh) | 2013-05-27 | 2019-02-21 | 赫孚孟拉羅股份公司 | 新穎３，４－二氫－２ｈ－異喹啉－１－酮及２，３－二氫異吲哚－１－酮化合物 |
| JP6581970B2 (ja) * | 2013-05-27 | 2019-09-25 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 新規３，４−ジヒドロ−２ｈ−イソキノリン−１−オン及び２，３−ジヒドロ−イソインドール−１−オン化合物 |
| WO2015125858A1 (ja) * | 2014-02-24 | 2015-08-27 | 日本曹達株式会社 | ヘテロアリール化合物およびその用途 |
| EP3122355A4 (en) * | 2014-03-26 | 2017-08-09 | The Brigham and Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| MY176401A (en) | 2014-04-24 | 2020-08-05 | Mitsubishi Tanabe Pharma Corp | Novel disubstituted 1,2,4-triazine compound |
| WO2016011019A1 (en) | 2014-07-15 | 2016-01-21 | The Brigham And Women's Hospital, Inc. | Compositions and methods for inhibiting bmp |
| PE20171057A1 (es) * | 2014-10-08 | 2017-07-21 | Hoffmann La Roche | Derivados espirodiamina como inhibidores de la aldosterona sintasa |
| WO2016066597A1 (en) * | 2014-10-31 | 2016-05-06 | F. Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds |
| EP3212631B1 (en) | 2014-10-31 | 2020-02-12 | F.Hoffmann-La Roche Ag | Pyrazolyl-3,4-dihydroquinolin-2-one aldosterone synthase inhibitors |
| EP3212638B1 (en) * | 2014-10-31 | 2019-11-20 | F.Hoffmann-La Roche Ag | New dihydroquinoline pyrazolyl compounds as aldosterone synthase inhibitors |
| EP3344613B1 (en) | 2015-08-31 | 2020-03-04 | Dong-A Socio Holdings Co., Ltd. | Heteroaryl compounds and their use as therapeutic drugs |
| JP6314196B2 (ja) * | 2015-10-22 | 2018-04-18 | 田辺三菱製薬株式会社 | 医薬組成物 |
| JP6545275B2 (ja) | 2015-10-23 | 2019-07-17 | 田辺三菱製薬株式会社 | 新規含窒素芳香族複素環化合物 |
| US10913730B2 (en) | 2016-10-10 | 2021-02-09 | Dong-A Socio Holdings Co., Ltd. | Heteroaryl compounds and their use as Mer inhibitors |
| CR20190268A (es) * | 2016-12-08 | 2019-07-11 | Hoffmann La Roche | Nuevos deribados de isoxazolil éter como pam de gaba a alfa5 |
| JP7530384B2 (ja) | 2019-05-01 | 2024-08-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | （ｒ）－（２－メチルオキシラン－２－イル）メチル ４－ブロモベンゼンスルホネート |
| WO2023063851A1 (en) * | 2021-10-13 | 2023-04-20 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| TW202339719A (zh) | 2021-12-14 | 2023-10-16 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療慢性腎臟病之醛固酮合成酶抑制劑 |
| EP4615843A1 (en) * | 2022-11-10 | 2025-09-17 | «Target Medicals» Limited Liability Company | Inhibitors of human aldosterone synthase (cyp11b2) |
| WO2024109885A1 (zh) * | 2022-11-23 | 2024-05-30 | 上海翰森生物医药科技有限公司 | 吡啶多环类化合物抑制剂、及其制备方法和应用 |
| WO2024235165A1 (zh) * | 2023-05-12 | 2024-11-21 | 南京明德新药研发有限公司 | 含氮杂环类化合物及其应用 |
| WO2025131022A1 (zh) * | 2023-12-22 | 2025-06-26 | 上海翊石医药科技有限公司 | 一类芳杂环化合物及其制备方法和应用 |
| CN121135736A (zh) * | 2024-03-01 | 2025-12-16 | 浙江扬厉医药技术有限公司 | 吡喃并吡啶类化合物、其制备方法、药物组合物及应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT79699B (en) * | 1983-12-22 | 1986-12-10 | Pfizer | Process for preparing quinolone inotropic agents |
| GB8334282D0 (en) * | 1983-12-22 | 1984-02-01 | Pfizer Ltd | Quinolone inotropic agents |
| CN85100796A (zh) * | 1985-04-01 | 1986-10-01 | 辉瑞公司 | 喹啉酮衍生物的制备方法 |
| FR2580646A1 (fr) * | 1985-04-19 | 1986-10-24 | Synthelabo | Derives de 2(1h)-quinolinone, leur preparation et leur application en therapeutique |
| WO2006113432A2 (en) | 2005-04-14 | 2006-10-26 | Smithkline Beecham Corporation | Compounds, compositions and methods |
| DE102008022221A1 (de) * | 2008-05-06 | 2009-11-12 | Universität des Saarlandes | Inhibitoren der humanen Aldosteronsynthase CYP11B2 |
| US8455522B2 (en) | 2009-05-15 | 2013-06-04 | Novartis Ag | Benzoxazolone derivatives as aldosterone synthase inhibitors |
| JP5659224B2 (ja) | 2009-05-15 | 2015-01-28 | ノバルティス アーゲー | アルドステロンシンターゼ阻害剤としてのアリールピリジン |
| US8541404B2 (en) | 2009-11-09 | 2013-09-24 | Elexopharm Gmbh | Inhibitors of the human aldosterone synthase CYP11B2 |
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2012
- 2012-09-12 JP JP2014530184A patent/JP6012735B2/ja active Active
- 2012-09-12 MY MYPI2014700616A patent/MY169043A/en unknown
- 2012-09-12 ES ES12756741T patent/ES2763332T3/es active Active
- 2012-09-12 LT LTEP12756741.0T patent/LT2755963T/lt unknown
- 2012-09-12 BR BR112014006283-8A patent/BR112014006283B1/pt active IP Right Grant
- 2012-09-12 CA CA2846785A patent/CA2846785C/en active Active
- 2012-09-12 SG SG11201400679WA patent/SG11201400679WA/en unknown
- 2012-09-12 MX MX2014002770A patent/MX358376B/es active IP Right Grant
- 2012-09-12 PL PL12756741T patent/PL2755963T3/pl unknown
- 2012-09-12 AU AU2012307509A patent/AU2012307509B2/en active Active
- 2012-09-12 WO PCT/EP2012/067744 patent/WO2013037779A1/en not_active Ceased
- 2012-09-12 HU HUE12756741A patent/HUE047771T2/hu unknown
- 2012-09-12 DK DK12756741.0T patent/DK2755963T3/da active
- 2012-09-12 ES ES19204552T patent/ES3016782T3/es active Active
- 2012-09-12 EA EA201490596A patent/EA035757B1/ru not_active IP Right Cessation
- 2012-09-12 PT PT127567410T patent/PT2755963T/pt unknown
- 2012-09-12 PH PH1/2014/500434A patent/PH12014500434A1/en unknown
- 2012-09-12 EP EP19204552.4A patent/EP3653618B1/en active Active
- 2012-09-12 HR HRP20192323TT patent/HRP20192323T1/hr unknown
- 2012-09-12 RS RS20191655A patent/RS59737B1/sr unknown
- 2012-09-12 EP EP12756741.0A patent/EP2755963B1/en active Active
- 2012-09-12 KR KR1020147009761A patent/KR101785143B1/ko active Active
- 2012-09-12 PE PE2014000328A patent/PE20141372A1/es active IP Right Grant
- 2012-09-12 CN CN201280045041.1A patent/CN103814021B/zh active Active
- 2012-09-12 TW TW101133381A patent/TWI462914B/zh active
- 2012-09-12 SI SI201231713T patent/SI2755963T1/sl unknown
- 2012-09-13 US US13/612,956 patent/US9260408B2/en active Active
- 2012-09-17 AR ARP120103420A patent/AR087901A1/es active IP Right Grant
- 2012-12-09 UA UAA201404030A patent/UA111626C2/uk unknown
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2014
- 2014-02-25 CR CR20140091A patent/CR20140091A/es unknown
- 2014-02-26 CO CO14040934A patent/CO6890099A2/es unknown
- 2014-02-27 IL IL231229A patent/IL231229A0/en active IP Right Grant
- 2014-03-13 CL CL2014000604A patent/CL2014000604A1/es unknown
- 2014-03-14 EC ECSP14013245 patent/ECSP14013245A/es unknown
- 2014-03-14 ZA ZA201401884A patent/ZA201401884B/en unknown
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