ECSP11010878A - Formas cristalinas de un derivado de 2-tiazolil-4-quinolinil-oxi, un potente inhibidor de hcv. - Google Patents

Formas cristalinas de un derivado de 2-tiazolil-4-quinolinil-oxi, un potente inhibidor de hcv.

Info

Publication number
ECSP11010878A
ECSP11010878A EC2011010878A ECSP11010878A ECSP11010878A EC SP11010878 A ECSP11010878 A EC SP11010878A EC 2011010878 A EC2011010878 A EC 2011010878A EC SP11010878 A ECSP11010878 A EC SP11010878A EC SP11010878 A ECSP11010878 A EC SP11010878A
Authority
EC
Ecuador
Prior art keywords
quinolinil
tiazolil
oxi
powerful
derivative
Prior art date
Application number
EC2011010878A
Other languages
English (en)
Inventor
Carl A Busacca
Richard J Varsolona
Thilo Berkenbusch
Burkhard Jaeger
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41268627&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11010878(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP11010878A publication Critical patent/ECSP11010878A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Esta invención se refiere a nuevas formas cristalinas del siguiente Compuesto (1), y sus sales de sodio, y a métodos para su preparación, a sus composiciones farmacéuticas, y a su uso en el tratamiento de la infección por Hepatitis C Viral (HCV):
EC2011010878A 2008-09-16 2011-03-09 Formas cristalinas de un derivado de 2-tiazolil-4-quinolinil-oxi, un potente inhibidor de hcv. ECSP11010878A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9729108P 2008-09-16 2008-09-16
US15082609P 2009-03-09 2009-03-09

Publications (1)

Publication Number Publication Date
ECSP11010878A true ECSP11010878A (es) 2011-07-29

Family

ID=41268627

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2011010878A ECSP11010878A (es) 2008-09-16 2011-03-09 Formas cristalinas de un derivado de 2-tiazolil-4-quinolinil-oxi, un potente inhibidor de hcv.

Country Status (33)

Country Link
US (2) US8232293B2 (es)
EP (2) EP2331538B1 (es)
JP (2) JP5520301B2 (es)
KR (1) KR101653550B1 (es)
CN (1) CN102159571B (es)
AR (1) AR073298A1 (es)
AU (1) AU2009293494B2 (es)
BR (1) BRPI0918513A2 (es)
CA (1) CA2737055C (es)
CL (1) CL2011000558A1 (es)
CO (1) CO6351741A2 (es)
CY (1) CY1115253T1 (es)
DK (1) DK2331538T3 (es)
EA (1) EA018603B1 (es)
EC (1) ECSP11010878A (es)
ES (1) ES2474992T3 (es)
HR (1) HRP20140666T1 (es)
IL (1) IL210345A (es)
MA (1) MA32633B1 (es)
ME (1) ME01831B (es)
MX (1) MX2011002828A (es)
MY (1) MY153093A (es)
NZ (2) NZ602163A (es)
PE (2) PE20110388A1 (es)
PL (1) PL2331538T3 (es)
PT (1) PT2331538E (es)
RS (1) RS53292B (es)
SG (1) SG189740A1 (es)
SI (1) SI2331538T1 (es)
TW (1) TWI471323B (es)
UY (1) UY32119A (es)
WO (1) WO2010033444A1 (es)
ZA (1) ZA201100096B (es)

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UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
AU2009293494B2 (en) * 2008-09-16 2014-04-24 Boehringer Ingelheim International Gmbh Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent HCV inhibitor
EP2337583A1 (en) 2008-09-17 2011-06-29 Boehringer Ingelheim International GmbH Combination of hcv ns3 protease inhibitor with interferon and ribavirin
EP2408382A4 (en) * 2009-03-13 2013-06-19 Univ Toledo MINIMALLY INVASIVE COLLABBABLE CAGE
WO2010107965A1 (en) * 2009-03-19 2010-09-23 Boehringer Ingelheim International Gmbh Process for preparing sulfonyl quinolines
EP2427434B1 (en) 2009-05-05 2017-05-31 Boehringer Ingelheim International GmbH Process for preparing bromo-substituted quinolines
WO2011005646A2 (en) 2009-07-07 2011-01-13 Boehringer Ingelheim International Gmbh Pharmaceutical composition for a hepatitis c viral protease inhibitor
BR112012010110A2 (pt) 2009-10-30 2019-09-24 Boehringer Ingelheim Int regimes de dosagem para terapia combinada para hcv compreendendo bi201335, interferon alfa e ribavirina
US8530497B2 (en) 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor
AP2013006734A0 (en) 2010-09-30 2013-02-28 Boehringer Ingelheim Int Combination therapy for treating HCV infection
CN103534256B (zh) 2010-12-30 2016-08-10 益安药业 大环丙型肝炎丝氨酸蛋白酶抑制剂
WO2012092411A2 (en) 2010-12-30 2012-07-05 Enanta Pharmaceuticals, Inc. Phenanthridine macrocyclic hepatitis c serine protease inhibitors
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
CA2811203C (en) 2011-10-21 2015-05-05 Abbvie Inc. Methods for treating hcv
CN104023726A (zh) 2011-10-21 2014-09-03 艾伯维公司 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333)
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
MX2014008205A (es) 2012-01-12 2014-08-08 Boehringer Ingelheim Int Formulaciones farmaceuticas estabilizadas de un potente inhibidor de hcv.
JP2015509980A (ja) 2012-03-14 2015-04-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｈｃｖ−ｈｉｖ同時感染患者集団のｈｃｖ感染症を治療するための併用療法
WO2013147750A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
WO2013147749A1 (en) 2012-03-27 2013-10-03 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient subgenotype populations
WO2013143581A1 (en) 2012-03-28 2013-10-03 Boehringer Ingelheim International Gmbh Combination therapy for treating hcv infection in specific patient subgenotype sub-population
UA119315C2 (uk) 2012-07-03 2019-06-10 Гіліад Фармассет Елелсі Інгібітори вірусу гепатиту с
WO2014138374A1 (en) 2013-03-08 2014-09-12 Boehringer Ingelheim International Gmbh Oral combination therapy for treating hcv infection in specific patient sub-population
SG11201507223TA (en) 2013-03-15 2015-10-29 Gilead Sciences Inc Macrocyclic and bicyclic inhibitors of hepatitis c virus
CN105228593B (zh) * 2013-03-15 2018-08-28 勃林格殷格翰国际有限公司 呈无定形状态的hcv抑制剂的固体口服剂型
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
JP7129703B2 (ja) 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
WO2022107182A1 (en) * 2020-11-18 2022-05-27 University Of Petra A composition of fentanyl and fatty acids, and a method of preparation thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308955T5 (es) 1993-09-28 2012-04-03 R.P. Scherer Gmbh Fabricación de cápsulas de gelatina blanda
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
AR022061A1 (es) 1998-08-10 2002-09-04 Boehringer Ingelheim Ca Ltd Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos.
US6608027B1 (en) 1999-04-06 2003-08-19 Boehringer Ingelheim (Canada) Ltd Macrocyclic peptides active against the hepatitis C virus
UA74546C2 (en) 1999-04-06 2006-01-16 Boehringer Ingelheim Ca Ltd Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition
SK9742002A3 (en) * 2000-01-07 2003-02-04 Transform Pharmaceuticals Inc High-throughput formation, identification, and analysis of diverse solid-forms
UY28240A1 (es) * 2003-03-27 2004-11-08 Boehringer Ingelheim Pharma Fases cristalinas de un potente inhibidor de la hcv
HRP20080014T3 (en) * 2003-05-21 2008-02-29 Boehringer Ingelheim International Gmbh Hepatitis c inhibitor compounds
WO2005116054A1 (en) * 2004-05-25 2005-12-08 Boehringer Ingelheim International, Gmbh Process for preparing acyclic hcv protease inhibitors
AU2009293494B2 (en) * 2008-09-16 2014-04-24 Boehringer Ingelheim International Gmbh Crystalline forms of a 2-thiazolyl- 4-quinolinyl-oxy derivative, a potent HCV inhibitor
US8530497B2 (en) * 2010-03-11 2013-09-10 Boehringer Ingelheim International Gmbh Crystalline salts of a potent HCV inhibitor

Also Published As

Publication number Publication date
HRP20140666T1 (hr) 2014-10-10
SG189740A1 (en) 2013-05-31
NZ602163A (en) 2013-06-28
TW201024292A (en) 2010-07-01
MA32633B1 (fr) 2011-09-01
AR073298A1 (es) 2010-10-28
DK2331538T3 (da) 2014-06-02
KR20110059841A (ko) 2011-06-07
AU2009293494A1 (en) 2010-03-25
WO2010033444A1 (en) 2010-03-25
JP2014062116A (ja) 2014-04-10
CL2011000558A1 (es) 2011-07-15
NZ591013A (en) 2012-09-28
HK1156624A1 (en) 2012-06-15
WO2010033444A8 (en) 2010-06-17
UY32119A (es) 2010-04-30
IL210345A (en) 2015-06-30
EP2687526A1 (en) 2014-01-22
PL2331538T3 (pl) 2014-09-30
US20120270775A1 (en) 2012-10-25
RS53292B (sr) 2014-08-29
AU2009293494B2 (en) 2014-04-24
IL210345A0 (en) 2011-03-31
EA201100482A1 (ru) 2011-10-31
CA2737055C (en) 2016-08-30
US8232293B2 (en) 2012-07-31
US20100093792A1 (en) 2010-04-15
TWI471323B (zh) 2015-02-01
MX2011002828A (es) 2011-04-05
PE20110388A1 (es) 2011-07-01
EP2331538B1 (en) 2014-04-16
JP5520301B2 (ja) 2014-06-11
US8362035B2 (en) 2013-01-29
JP2012502910A (ja) 2012-02-02
SI2331538T1 (sl) 2014-06-30
EP2331538A1 (en) 2011-06-15
ES2474992T3 (es) 2014-07-10
CA2737055A1 (en) 2010-03-25
PT2331538E (pt) 2014-05-12
PE20130307A1 (es) 2013-03-22
BRPI0918513A2 (pt) 2015-12-01
CN102159571A (zh) 2011-08-17
CN102159571B (zh) 2014-10-01
ME01831B (me) 2014-12-20
CY1115253T1 (el) 2017-01-04
KR101653550B1 (ko) 2016-09-02
EA018603B1 (ru) 2013-09-30
CO6351741A2 (es) 2011-12-20
MY153093A (en) 2014-12-31
ZA201100096B (en) 2011-09-28

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