ECSP11011163A - Pirimidin-4-carboxamidas cíclicas en calidad de antagonistas del receptor CCR2 para el tratamiento de inflamación, asma y EPOC - Google Patents

Pirimidin-4-carboxamidas cíclicas en calidad de antagonistas del receptor CCR2 para el tratamiento de inflamación, asma y EPOC

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Publication number
ECSP11011163A
ECSP11011163A EC2011011163A ECSP11011163A ECSP11011163A EC SP11011163 A ECSP11011163 A EC SP11011163A EC 2011011163 A EC2011011163 A EC 2011011163A EC SP11011163 A ECSP11011163 A EC SP11011163A EC SP11011163 A ECSP11011163 A EC SP11011163A
Authority
EC
Ecuador
Prior art keywords
copd
asthma
carboxamides
inflammation
treatment
Prior art date
Application number
EC2011011163A
Other languages
English (en)
Inventor
Christoph Hoenke
Thomas Trieselmann
Heiner Ebel
Riccardo Giovannini
Patrick Tielmann
Stefan Scheuerer
Silke Hobbie
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42049604&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP11011163(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of ECSP11011163A publication Critical patent/ECSP11011163A/es

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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Abstract

La presente invención se refiere a antagonistas novedosos para el CCR2 (receptor 2 de quimioquina CC) y a su uso para proporcionar medicamentos para tratar afecciones y enfermedades, en especial enfermedades pulmonares tales como asma y EPOC.
EC2011011163A 2008-12-19 2011-06-24 Pirimidin-4-carboxamidas cíclicas en calidad de antagonistas del receptor CCR2 para el tratamiento de inflamación, asma y EPOC ECSP11011163A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08172336 2008-12-19
EP09160416 2009-05-15

Publications (1)

Publication Number Publication Date
ECSP11011163A true ECSP11011163A (es) 2011-07-29

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EC2011011163A ECSP11011163A (es) 2008-12-19 2011-06-24 Pirimidin-4-carboxamidas cíclicas en calidad de antagonistas del receptor CCR2 para el tratamiento de inflamación, asma y EPOC

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US (3) US20120053164A1 (es)
EP (2) EP2379525B1 (es)
JP (2) JP2012512834A (es)
KR (1) KR101754698B1 (es)
CN (2) CN103724328B (es)
AR (1) AR074814A1 (es)
AU (1) AU2009327127C1 (es)
BR (1) BRPI0923051B1 (es)
CA (1) CA2747677C (es)
CL (1) CL2011001322A1 (es)
CO (1) CO6382124A2 (es)
DK (1) DK2379525T3 (es)
EA (1) EA020548B1 (es)
EC (1) ECSP11011163A (es)
ES (1) ES2551557T3 (es)
HU (1) HUE025547T2 (es)
IL (1) IL212605A (es)
MA (1) MA33085B1 (es)
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CA2711558C (en) 2008-01-04 2016-12-13 Intellikine, Inc. Phosphatidyl inositol-3 kinase inhibiting compounds
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
JP5731978B2 (ja) 2008-09-26 2015-06-10 インテリカイン， エルエルシー 複素環キナーゼ阻害剤
DK2379525T3 (en) 2008-12-19 2015-10-19 Boehringer Ingelheim Int Cyclic pyrimidin-4-carboxamides, as CCR2 receptor antagonists for the treatment of inflammation, asthma and COPD
RU2011143740A (ru) * 2009-03-30 2013-05-10 Астеллас Фарма Инк. Соединение пиримидина
EP2427195B1 (en) 2009-05-07 2019-05-01 Intellikine, LLC Heterocyclic compounds and uses thereof
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
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JP5786258B2 (ja) * 2011-07-15 2015-09-30 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規かつ選択的なｃｃｒ２拮抗薬

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