ECSP14013282A - 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il) ureas como inhibidores de proteínas cinasas activadas por mitógeno p38 - Google Patents

1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il) ureas como inhibidores de proteínas cinasas activadas por mitógeno p38

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Publication number
ECSP14013282A
ECSP14013282A ECSP14013282A ECSP14013282A EC SP14013282 A ECSP14013282 A EC SP14013282A EC SP14013282 A ECSP14013282 A EC SP14013282A EC SP14013282 A ECSP14013282 A EC SP14013282A
Authority
EC
Ecuador
Prior art keywords
mitogen
anilinopirimidin
pirazolil
naftalen
oxi
Prior art date
Application number
Other languages
English (en)
Inventor
Alex Herman Copmans
Stuart Thomas Onions
Catherine Charron
John King-Underwood
Kazuhiro Ito
Alistair Ian Longshaw
Rudy Broeckx
Walter Filliers
Original Assignee
Respivert Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47018247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP14013282(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP11183688.8A external-priority patent/EP2578582A1/en
Application filed by Respivert Ltd filed Critical Respivert Ltd
Publication of ECSP14013282A publication Critical patent/ECSP14013282A/es

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Se proporciona un compuesto de la fórmula (I) que es un inhibidor de la familia de enzimas cinasas de la proteína activada por el mitógeno p38, y su uso en terapia, incluido en combinaciones farmacéuticas, especialmente en el tratamiento de enfermedades inflamatorias, incluyendo enfermedades inflamatorias del pulmón, tales como asma y COPD.
ECSP14013282 2011-10-03 2014-04-03 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il) ureas como inhibidores de proteínas cinasas activadas por mitógeno p38 ECSP14013282A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP11183682 2011-10-03
EP11183688.8A EP2578582A1 (en) 2011-10-03 2011-10-03 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
EP12168395 2012-05-16
EP12168396 2012-05-16

Publications (1)

Publication Number Publication Date
ECSP14013282A true ECSP14013282A (es) 2014-05-31

Family

ID=47018247

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP14013282 ECSP14013282A (es) 2011-10-03 2014-04-03 1-pirazolil-3-(4-((2-anilinopirimidin-4-il)oxi)naftalen-1-il) ureas como inhibidores de proteínas cinasas activadas por mitógeno p38

Country Status (25)

Country Link
US (5) US9108950B2 (es)
EP (1) EP2763984B1 (es)
JP (2) JP2014528404A (es)
KR (2) KR102057058B1 (es)
CN (1) CN103917536B (es)
AU (1) AU2012320300C1 (es)
BR (1) BR112014007694B1 (es)
CA (1) CA2846222C (es)
CL (1) CL2014000813A1 (es)
CO (1) CO6910202A2 (es)
EA (1) EA023650B1 (es)
EC (1) ECSP14013282A (es)
ES (1) ES2583853T3 (es)
GT (1) GT201400054A (es)
IL (1) IL231025A (es)
MX (1) MX342168B (es)
MY (1) MY167798A (es)
NI (1) NI201400027A (es)
PE (1) PE20142355A1 (es)
PH (1) PH12014500547A1 (es)
PL (1) PL2763984T3 (es)
PT (1) PT2763984T (es)
SG (1) SG11201400226UA (es)
WO (1) WO2013050757A1 (es)
ZA (1) ZA201403204B (es)

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EP2578582A1 (en) 2011-10-03 2013-04-10 Respivert Limited 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors
JP2014528404A (ja) * 2011-10-03 2014-10-27 レスピバート・リミテツド ｐ３８ＭＡＰキナーゼ阻害剤としての１−ピラゾリル−３−（４−（（２−アニリノピリミジン−４−イル）オキシ）ナフタレン−１−イル）尿素
GB201214750D0 (en) 2012-08-17 2012-10-03 Respivert Ltd Compounds
US9783556B2 (en) 2012-08-29 2017-10-10 Respivert Limited Kinase inhibitors
EP2890695A2 (en) 2012-08-29 2015-07-08 Respivert Limited Kinase inhibitors
EP2890460B1 (en) 2012-08-29 2017-02-22 Respivert Limited Kinase inhibitors
GB201215357D0 (en) 2012-08-29 2012-10-10 Respivert Ltd Compounds
EP2925742B1 (en) 2012-11-16 2016-10-26 Respivert Limited Kinase inhibitors
WO2014140582A1 (en) 2013-03-14 2014-09-18 Respivert Limited Kinase inhibitors
MX363949B (es) 2013-04-02 2019-04-08 Topivert Pharma Ltd Inhibidor de quinasa.
US9771353B2 (en) 2013-04-02 2017-09-26 Topivert Pharma Limited Kinase inhibitors based upon N-alkyl pyrazoles
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
WO2015092423A1 (en) 2013-12-20 2015-06-25 Respivert Limited Urea derivatives useful as kinase inhibitors
EP3105222B1 (en) 2014-02-14 2018-04-11 Respivert Limited Aromatic heterocyclic compounds as antiinflammatory compounds
MA40774A (fr) 2014-10-01 2017-08-08 Respivert Ltd Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
CA3015978A1 (en) 2016-04-06 2017-10-12 Topivert Pharma Limited Kinase inhibitors
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