ECSP11011241A - Sistemas basados en conjugados para entrega farmacológica controlada - Google Patents
Sistemas basados en conjugados para entrega farmacológica controladaInfo
- Publication number
- ECSP11011241A ECSP11011241A EC2011011241A ECSP11011241A ECSP11011241A EC SP11011241 A ECSP11011241 A EC SP11011241A EC 2011011241 A EC2011011241 A EC 2011011241A EC SP11011241 A ECSP11011241 A EC SP11011241A EC SP11011241 A ECSP11011241 A EC SP11011241A
- Authority
- EC
- Ecuador
- Prior art keywords
- certain embodiments
- saccharide
- glucose
- ligands
- conjugates
- Prior art date
Links
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 10
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 5
- 239000008103 glucose Substances 0.000 abstract 5
- 239000003446 ligand Substances 0.000 abstract 5
- 102000004877 Insulin Human genes 0.000 abstract 4
- 108090001061 Insulin Proteins 0.000 abstract 4
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 229940125396 insulin Drugs 0.000 abstract 4
- 238000000034 method Methods 0.000 abstract 4
- 230000003285 pharmacodynamic effect Effects 0.000 abstract 3
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 abstract 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 2
- 108010062580 Concanavalin A Proteins 0.000 abstract 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 abstract 1
- 101000976075 Homo sapiens Insulin Proteins 0.000 abstract 1
- SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 abstract 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 abstract 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract 1
- 230000005923 long-lasting effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002459 sustained effect Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
En un aspecto, la divulgación proporciona métodos para controlar los perfiles farmacocinéticos (PK) y/o farmacodinámicos (PD) de insulina en una forma que es sensible a las concentraciones sistémicas de un sacárido tal como la glucosa. Como se discutió en los Ejemplos, se descubrió que cuando la insulina fuera conjugada con ligandos sacáridos de alta afinidad, pudo hacerse exhibir perfiles PK/PD que respondieran a cambios de concentración sacárida aún en ausencia de una molécula multivalente y exógena fijadora de sacáridos tal como Con A. Este hallazgo fue inesperado y proporciona una oportunidad sin precedentes para generar sistemas simples de insulina sensibles a sacáridos libres de lectina. En otro aspecto, la divulgación proporciona conjugados y métodos de ejemplo para la fabricación de los mismos. En general, estos conjugados incluyen un fármaco y uno o más ligandos separados en donde cada uno incluye un sacárido. En ciertas realizaciones, los ligandos son capaces de competir con un sacárido (por ejemplo, glucosa o manosa) para unirse a una molécula fijadora de sacáridos endógenos. En ciertas realizaciones, los ligandos son capaces de competir con la glucosa o manosa por la unión a Con A. Como se explica en detalle más adelante, en ciertas realizaciones, los ligandos y el fármaco pueden estar covalente o no covalentemente unidos a una estructura de conjugado. En ciertas realizaciones, la estructura es no polimérica. En ciertas realizaciones, un conjugado puede tener un índice de polidispersidad de uno y un peso molecular de menos de 20.000 Da aproximadamente. En ciertas realizaciones, el conjugado es de larga duración (es decir, presenta un perfil farmacocinético que es más sostenido que la insulina humana recombinante soluble o RHI).Como está discutido en detalle más adelante, se debe entender que los métodos, conjugados y formulaciones que se describen en este documento no están limitados de ninguna manera a solamente la entrega de insulina y se debe entender que pueden ser utilizados para liberar cualquier medicamento. También se debe entender que los métodos se pueden utilizar para liberar fármacos en respuesta a sacáridos diferentes de la glucosa. En particular, como se indica en los ejemplos, se ha demostrado que los conjugados de ejemplo responden a sacáridos exógenos como el alfa- metil manosa y L- fucosa. En ciertas realizaciones, esto puede utilizarse para preparar conjugados que pueden ser controlados por la administración de uno de estos sacáridos exógenos (es decir, en lugar de o además de ser controlados por las fluctuaciones en la glucosa endógena).
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14787809P | 2009-01-28 | 2009-01-28 | |
| US15964309P | 2009-03-12 | 2009-03-12 | |
| US16210709P | 2009-03-20 | 2009-03-20 | |
| US16308409P | 2009-03-25 | 2009-03-25 | |
| US21989609P | 2009-06-24 | 2009-06-24 | |
| US21989709P | 2009-06-24 | 2009-06-24 | |
| US22357209P | 2009-07-07 | 2009-07-07 | |
| US25285709P | 2009-10-19 | 2009-10-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP11011241A true ECSP11011241A (es) | 2011-11-30 |
Family
ID=42395990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2011011241A ECSP11011241A (es) | 2009-01-28 | 2011-07-28 | Sistemas basados en conjugados para entrega farmacológica controlada |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US8906850B2 (es) |
| EP (1) | EP2391646B1 (es) |
| JP (1) | JP2012516342A (es) |
| KR (2) | KR20140054404A (es) |
| CN (1) | CN102341409A (es) |
| AU (1) | AU2010208319A1 (es) |
| BR (1) | BRPI1007466A2 (es) |
| CA (1) | CA2750269A1 (es) |
| CO (1) | CO6400230A2 (es) |
| EC (1) | ECSP11011241A (es) |
| IL (1) | IL214126A0 (es) |
| MX (1) | MX2011007930A (es) |
| PE (1) | PE20120582A1 (es) |
| RU (1) | RU2011135730A (es) |
| SG (1) | SG173117A1 (es) |
| WO (1) | WO2010088300A1 (es) |
| ZA (1) | ZA201105462B (es) |
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| CA2750223A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Exogenously triggered controlled release materials and uses thereof |
| WO2010088286A1 (en) | 2009-01-28 | 2010-08-05 | Smartcells, Inc. | Synthetic conjugates and uses thereof |
| BRPI1007457A2 (pt) | 2009-01-28 | 2015-08-25 | Smartcells Inc | Conjungado, formulação de liberação prolongada, e, sistema de distribuição de bomba. |
| US9095623B2 (en) | 2009-03-20 | 2015-08-04 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
| CA2754950A1 (en) | 2009-03-20 | 2010-09-23 | Smartcells, Inc. | Terminally-functionalized conjugates and uses thereof |
| US9068013B2 (en) | 2010-07-28 | 2015-06-30 | Smart Cells, Inc. | Recombinant lectins, binding-site modified lectins and uses thereof |
| EP2598170A4 (en) * | 2010-07-28 | 2016-07-06 | Smartcells Inc | MEDICINAL LIGANDEN CONJUGATES, THEIR SYNTHESIS AND INTERMEDIATE PRODUCTS THEREOF |
| US9074015B2 (en) | 2010-07-28 | 2015-07-07 | Smartcells, Inc. | Recombinantly expressed insulin polypeptides and uses thereof |
| EP2598171A2 (en) * | 2010-07-28 | 2013-06-05 | Smartcells, Inc. | Drug-ligand conjugates, synthesis thereof, and intermediates thereto |
| CN102188367B (zh) * | 2011-01-05 | 2012-11-07 | 山东新时代药业有限公司 | 一种甘精胰岛素注射液及其制备方法 |
| US9457096B2 (en) | 2012-07-06 | 2016-10-04 | Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Concet) | Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery |
| AU2014329567B2 (en) * | 2013-10-04 | 2019-07-25 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| WO2016007935A2 (en) | 2014-07-10 | 2016-01-14 | Companion Medical, Inc. | Medicine administering system including injection pen and companion device |
| US20180110863A1 (en) * | 2015-04-08 | 2018-04-26 | Merck Sharp & Dohme Corp. | Glucose-responsive insulin conjugates |
| CN113350489A (zh) | 2015-04-21 | 2021-09-07 | 北卡罗来纳州立大学 | 使用缺氧敏感性纳米复合材料的葡萄糖响应性胰岛素递送系统 |
| CN108778318B (zh) | 2016-01-14 | 2022-05-03 | 北卡罗莱纳州立大学 | 葡萄糖响应性胰岛素递送组合物和方法 |
| WO2017132577A1 (en) | 2016-01-29 | 2017-08-03 | Companion Medical, Inc. | Automatic medication delivery tracking |
| RU2018147235A (ru) * | 2016-06-02 | 2020-07-10 | Санофи | Конъюгаты фармацевтического средства и фрагмента, способного связываться с глюкозочувствительным белком |
| WO2018085809A1 (en) | 2016-11-07 | 2018-05-11 | North Carolina State University | Patch loaded with dual-sensitive vesicles for enhanced glucose-responsive insulin delivery |
| WO2018227163A1 (en) | 2017-06-09 | 2018-12-13 | Companion Medical, Inc. | Intelligent medication delivery systems and methods |
| EP3694583B1 (en) | 2017-10-12 | 2026-05-06 | Medtronic MiniMed, Inc. | Intelligent medication delivery systems and methods for dose recommendation and management |
| CN111433193A (zh) | 2017-12-01 | 2020-07-17 | 赛诺菲 | 药剂和能够结合至葡萄糖传感蛋白的部分的新型缀合物 |
| US11083852B2 (en) | 2017-12-12 | 2021-08-10 | Bigfoot Biomedical, Inc. | Insulin injection assistance systems, methods, and devices |
| US11464459B2 (en) | 2017-12-12 | 2022-10-11 | Bigfoot Biomedical, Inc. | User interface for diabetes management systems including flash glucose monitor |
| US11116899B2 (en) | 2017-12-12 | 2021-09-14 | Bigfoot Biomedical, Inc. | User interface for diabetes management systems and devices |
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-
2010
- 2010-01-27 JP JP2011548261A patent/JP2012516342A/ja active Pending
- 2010-01-27 CN CN201080009857XA patent/CN102341409A/zh active Pending
- 2010-01-27 SG SG2011053378A patent/SG173117A1/en unknown
- 2010-01-27 RU RU2011135730/04A patent/RU2011135730A/ru not_active Application Discontinuation
- 2010-01-27 WO PCT/US2010/022277 patent/WO2010088300A1/en not_active Ceased
- 2010-01-27 US US13/145,525 patent/US8906850B2/en active Active
- 2010-01-27 EP EP10736359.0A patent/EP2391646B1/en active Active
- 2010-01-27 CA CA2750269A patent/CA2750269A1/en not_active Abandoned
- 2010-01-27 PE PE2011001412A patent/PE20120582A1/es not_active Application Discontinuation
- 2010-01-27 MX MX2011007930A patent/MX2011007930A/es not_active Application Discontinuation
- 2010-01-27 KR KR1020147008437A patent/KR20140054404A/ko not_active Withdrawn
- 2010-01-27 AU AU2010208319A patent/AU2010208319A1/en not_active Abandoned
- 2010-01-27 KR KR1020117017642A patent/KR20110110253A/ko not_active Abandoned
- 2010-01-27 BR BRPI1007466A patent/BRPI1007466A2/pt not_active IP Right Cessation
-
2011
- 2011-07-17 IL IL214126A patent/IL214126A0/en unknown
- 2011-07-25 ZA ZA2011/05462A patent/ZA201105462B/en unknown
- 2011-07-28 CO CO11095151A patent/CO6400230A2/es active IP Right Grant
- 2011-07-28 EC EC2011011241A patent/ECSP11011241A/es unknown
-
2014
- 2014-05-19 US US14/280,793 patent/US9463249B2/en active Active
-
2016
- 2016-10-07 US US15/288,362 patent/US20170022262A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI1007466A2 (pt) | 2018-06-12 |
| ZA201105462B (en) | 2015-01-28 |
| EP2391646A4 (en) | 2012-06-27 |
| KR20110110253A (ko) | 2011-10-06 |
| RU2011135730A (ru) | 2013-03-10 |
| US20110281791A1 (en) | 2011-11-17 |
| CO6400230A2 (es) | 2012-03-15 |
| AU2010208319A1 (en) | 2011-08-11 |
| US9463249B2 (en) | 2016-10-11 |
| US20170022262A1 (en) | 2017-01-26 |
| WO2010088300A1 (en) | 2010-08-05 |
| IL214126A0 (en) | 2011-08-31 |
| US8906850B2 (en) | 2014-12-09 |
| MX2011007930A (es) | 2011-09-06 |
| US20140275476A1 (en) | 2014-09-18 |
| PE20120582A1 (es) | 2012-05-26 |
| CA2750269A1 (en) | 2010-08-05 |
| EP2391646B1 (en) | 2016-08-10 |
| JP2012516342A (ja) | 2012-07-19 |
| CN102341409A (zh) | 2012-02-01 |
| EP2391646A1 (en) | 2011-12-07 |
| SG173117A1 (en) | 2011-08-29 |
| KR20140054404A (ko) | 2014-05-08 |
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