ECSP12011878A - Derivados de sulfonamida heterocíclicos útiles como inhibidores de mek - Google Patents

Derivados de sulfonamida heterocíclicos útiles como inhibidores de mek

Info

Publication number
ECSP12011878A
ECSP12011878A ECSP12011878A ECSP12011878A EC SP12011878 A ECSP12011878 A EC SP12011878A EC SP12011878 A ECSP12011878 A EC SP12011878A EC SP12011878 A ECSP12011878 A EC SP12011878A
Authority
EC
Ecuador
Prior art keywords
mek inhibitors
sulfonamide derivatives
heterocyclic sulfonamide
useful heterocyclic
useful
Prior art date
Application number
Other languages
English (en)
Inventor
Chetan Pandit
Mark G Bock
Henrik Moebitz
Dinesh Chikkanna
Clive Mccarthy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43416908&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP12011878(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP12011878A publication Critical patent/ECSP12011878A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a los compuestos de la fórmula (IA):(IA)en donde R1a, R1b, X, R2a, R2b, W, R3, R4, y R5 son como se definen en la presente, así como a las sales farmacéuticamente aceptables de los mismos. Se ha demostrado que los compuestos actúan como inhibidores de MEK, lo cual puede ser útil en el tratamiento de enfermedades hiperproliferativas, como cáncer e inflamación.
ECSP12011878 2009-11-04 2012-05-10 Derivados de sulfonamida heterocíclicos útiles como inhibidores de mek ECSP12011878A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IN2678CH2009 2009-11-04

Publications (1)

Publication Number Publication Date
ECSP12011878A true ECSP12011878A (es) 2012-07-31

Family

ID=43416908

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP12011878 ECSP12011878A (es) 2009-11-04 2012-05-10 Derivados de sulfonamida heterocíclicos útiles como inhibidores de mek

Country Status (30)

Country Link
US (1) US8466289B2 (es)
EP (1) EP2496575B1 (es)
JP (1) JP5466767B2 (es)
KR (1) KR101398772B1 (es)
CN (1) CN102596951B (es)
AR (1) AR078900A1 (es)
AU (1) AU2010317167B2 (es)
BR (1) BR112012010519A2 (es)
CA (1) CA2779935A1 (es)
CL (1) CL2012001027A1 (es)
CO (1) CO6541547A2 (es)
CR (1) CR20120234A (es)
DO (1) DOP2012000127A (es)
EA (1) EA201200651A1 (es)
EC (1) ECSP12011878A (es)
ES (1) ES2487628T3 (es)
GT (1) GT201200138A (es)
IL (1) IL219113A0 (es)
MA (1) MA33721B1 (es)
MX (1) MX2012005293A (es)
MY (1) MY156209A (es)
NI (1) NI201200084A (es)
NZ (1) NZ599565A (es)
PE (1) PE20121471A1 (es)
PH (1) PH12012500823A1 (es)
TN (1) TN2012000153A1 (es)
TW (1) TW201139449A (es)
UY (1) UY33000A (es)
WO (1) WO2011054828A1 (es)
ZA (1) ZA201202530B (es)

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EA201391820A1 (ru) * 2011-06-09 2014-12-30 Новартис Аг Гетероциклические сульфонамидные производные
WO2014142660A1 (en) 2013-03-12 2014-09-18 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Combinations of inhibitors of mek, egfr and erbb2 in the treatment of kras-mutant lung cancer and kras-mutant colon cancer
US9227969B2 (en) 2013-08-14 2016-01-05 Novartis Ag Compounds and compositions as inhibitors of MEK
US9629851B2 (en) 2013-09-20 2017-04-25 Stitching Het Nederlands Kanker Institut—Antoni Van Leeuwenhoek Ziekenhuis ROCK in combination with MAPK pathway
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
WO2015156674A2 (en) 2014-04-10 2015-10-15 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (en) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions for cancer treatment
EP3018131A1 (en) 2014-11-07 2016-05-11 Bayer Pharma Aktiengesellschaft Synthesis of copanlisib and its dihydrochloride salt
WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
CN106518885B (zh) * 2016-10-26 2018-10-16 云南大学 1,3-二氮杂环并吡啶季铵盐类化合物及其中间体化合物、制备方法和应用
KR20200110452A (ko) * 2018-02-12 2020-09-23 어레이 바이오파마 인크. 담도암을 치료하기 위한 방법 및 조합 요법
WO2019197605A2 (en) 2018-04-12 2019-10-17 Umc Utrecht Holding B.V. Drug combinations for use in the treatment of ras-mutant cancer
EA202192575A1 (ru) 2019-03-21 2022-01-14 Онксео Соединения dbait в сочетании с ингибиторами киназ для лечения рака
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
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CN111548344B (zh) * 2020-06-10 2025-01-28 北京深度制耀科技有限公司 Stat3小分子抑制剂及其应用
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WO2025073765A1 (en) 2023-10-03 2025-04-10 Institut National de la Santé et de la Recherche Médicale Methods of prognosis and treatment of patients suffering from melanoma
CN119528775A (zh) * 2024-08-05 2025-02-28 瑞博(苏州)制药有限公司 一种含环丁基的丙酸甲酯及丙二醇衍生物的合成方法

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Also Published As

Publication number Publication date
MY156209A (en) 2016-01-29
CN102596951B (zh) 2015-04-15
JP2013510118A (ja) 2013-03-21
EP2496575A1 (en) 2012-09-12
NI201200084A (es) 2012-08-13
ES2487628T3 (es) 2014-08-22
JP5466767B2 (ja) 2014-04-09
IL219113A0 (en) 2012-06-28
CN102596951A (zh) 2012-07-18
EA201200651A1 (ru) 2012-12-28
GT201200138A (es) 2014-03-27
NZ599565A (en) 2013-05-31
WO2011054828A1 (en) 2011-05-12
MA33721B1 (fr) 2012-11-01
US8466289B2 (en) 2013-06-18
AU2010317167A1 (en) 2012-05-03
UY33000A (es) 2011-06-30
ZA201202530B (en) 2013-01-30
CO6541547A2 (es) 2012-10-16
TW201139449A (en) 2011-11-16
PE20121471A1 (es) 2012-11-01
MX2012005293A (es) 2012-06-19
KR101398772B1 (ko) 2014-05-27
CL2012001027A1 (es) 2012-08-03
AU2010317167B2 (en) 2012-11-29
DOP2012000127A (es) 2012-08-31
CA2779935A1 (en) 2011-05-12
KR20120090078A (ko) 2012-08-16
US20110190334A1 (en) 2011-08-04
AR078900A1 (es) 2011-12-14
TN2012000153A1 (en) 2013-12-12
PH12012500823A1 (en) 2013-01-07
BR112012010519A2 (pt) 2017-12-05
CR20120234A (es) 2012-06-28
EP2496575B1 (en) 2014-04-30

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