ECSP12012155A - Hidrato del hidrocloruro de agomelatina y - Google Patents
Hidrato del hidrocloruro de agomelatina yInfo
- Publication number
- ECSP12012155A ECSP12012155A ECSP12012155A ECSP12012155A EC SP12012155 A ECSP12012155 A EC SP12012155A EC SP12012155 A ECSP12012155 A EC SP12012155A EC SP12012155 A ECSP12012155 A EC SP12012155A
- Authority
- EC
- Ecuador
- Prior art keywords
- hydrochloride
- present method
- agomelatine
- hydrate
- formula
- Prior art date
Links
- XEKAUTDWPYQNFU-UHFFFAOYSA-N chlorane Chemical compound Cl.Cl.Cl XEKAUTDWPYQNFU-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 abstract 1
- 229960002629 agomelatine Drugs 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- ZJVMEXOLMFNQPX-UHFFFAOYSA-N n-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide;hydrochloride Chemical compound Cl.C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 ZJVMEXOLMFNQPX-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
Se proporciona un hidrato del hidrocloruro de agomelatina de fórmula (I), en la que X es Cl, preparación, uso y composición farmacéutica del mismo. Dicho hidrato obtenido mediante el presente método tiene una solubilidad significativamente aumentada que la agomelatina, y por ello es más adecuada para fabricar formulaciones farmacéuticas. Usando el presente método, se puede obtener una pureza elevada mediante de un proceso simple, sin ninguna etapa complicada.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010126254XA CN102190594A (zh) | 2010-03-17 | 2010-03-17 | 阿戈美拉汀氯化氢水合物及其制备方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP12012155A true ECSP12012155A (es) | 2012-12-28 |
Family
ID=44599556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP12012155 ECSP12012155A (es) | 2010-03-17 | 2012-09-14 | Hidrato del hidrocloruro de agomelatina y |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8729131B2 (es) |
| EP (1) | EP2547649B1 (es) |
| JP (1) | JP5634532B2 (es) |
| KR (1) | KR101406727B1 (es) |
| CN (2) | CN102190594A (es) |
| AP (1) | AP2012006492A0 (es) |
| AU (1) | AU2011229618B2 (es) |
| BR (1) | BR112012023317B1 (es) |
| CA (1) | CA2792417C (es) |
| CL (1) | CL2012002540A1 (es) |
| CR (1) | CR20120462A (es) |
| CU (1) | CU20120137A7 (es) |
| CY (1) | CY1116086T1 (es) |
| DK (1) | DK2547649T3 (es) |
| EA (1) | EA022067B1 (es) |
| EC (1) | ECSP12012155A (es) |
| ES (1) | ES2530772T3 (es) |
| GE (1) | GEP20156231B (es) |
| GT (1) | GT201200259A (es) |
| HR (1) | HRP20150071T1 (es) |
| IL (1) | IL221782A (es) |
| MA (1) | MA34055B1 (es) |
| ME (1) | ME02054B (es) |
| MX (1) | MX2012010541A (es) |
| NI (1) | NI201200140A (es) |
| NZ (1) | NZ602450A (es) |
| PE (1) | PE20130013A1 (es) |
| PH (1) | PH12012501757A1 (es) |
| PL (1) | PL2547649T3 (es) |
| PT (1) | PT2547649E (es) |
| RS (1) | RS53815B1 (es) |
| SG (1) | SG183868A1 (es) |
| SI (1) | SI2547649T1 (es) |
| TN (1) | TN2012000435A1 (es) |
| UA (1) | UA105425C2 (es) |
| WO (1) | WO2011113362A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2551257A1 (en) * | 2011-07-28 | 2013-01-30 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of agomelatine with co-crystal-formers |
| FR2978916B1 (fr) | 2011-08-10 | 2013-07-26 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
| CN102718675B (zh) * | 2012-06-07 | 2015-03-25 | 上海右手医药科技开发有限公司 | 阿戈美拉汀甲磺酸复合物及其制备方法 |
| CN102702041B (zh) * | 2012-05-14 | 2013-08-14 | 上海右手医药科技开发有限公司 | 阿戈美拉汀苯磺酸类复合物及其制备方法 |
| EP2851363B1 (en) * | 2012-05-14 | 2018-01-03 | Shanghai Righthand Pharmtech. Co., Ltd. | Agomelatine acid radical composite, and preparation method and application thereof |
| CN102718676B (zh) * | 2012-06-26 | 2014-04-09 | 福建广生堂药业股份有限公司 | 阿戈美拉汀硫酸盐及其制备方法 |
| WO2014096373A1 (en) | 2012-12-21 | 2014-06-26 | Laboratorios Lesvi, S. L. | Process for prepararing n-(2-(7-methoxy-1-naphthalenyl)ethyl) acetamide and solid forms thereof |
| FR3001894A1 (fr) | 2013-02-08 | 2014-08-15 | Servier Lab | Composition pharmaceutique solide pour administration buccale d'agomelatine |
| WO2015013865A1 (en) * | 2013-07-29 | 2015-02-05 | Les Laboratoires Servier | Agomelatine sulfonic acids complexes and preparation thereof |
| KR101470794B1 (ko) | 2014-06-30 | 2014-12-08 | 순천향대학교 산학협력단 | 아고멜라틴 공결정의 제조 방법 및 이를 포함하는 조성물 |
| RU2018103913A (ru) * | 2015-07-02 | 2019-08-02 | Асерта Фарма Б.В. | Твердые формы и композиции (s)-4-(8-амино-3-(1-(бут-2- иноил)пирролидин-2-ил)имидазо[1,5-a]пиразин-1-ил)-n-(пиридин-2-ил)бензамида |
| US10484302B2 (en) * | 2016-08-27 | 2019-11-19 | Nicira, Inc. | Managed forwarding element executing in public cloud data compute node with different internal and external network addresses |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2658818B1 (fr) * | 1990-02-27 | 1993-12-31 | Adir Cie | Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| ES2204358T1 (es) * | 2000-10-30 | 2004-05-01 | Teva Pharmaceutical Industries Ltd. | Nuevas formas de cristal y de disolvente de hidrocloruro de ondasetron y procedimientos para su preparacion. |
| FR2890562B1 (fr) * | 2005-09-09 | 2012-10-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement des troubles du sommeil chez le patient deprime |
| FR2899472B1 (fr) * | 2006-04-07 | 2008-09-12 | Servier Lab | Utilisation de l'agomelatine pour l'obtention de medicaments destines au traitement du trouble anxiete generalisee |
| FR2934859B1 (fr) | 2008-08-05 | 2010-08-13 | Servier Lab | Nouveau procede de synthese de l'agomelatine |
| CN101481321B (zh) * | 2009-02-27 | 2012-04-18 | 上海医药工业研究院 | 阿戈美拉汀卤化氢复合物及其制备方法 |
| WO2012046253A2 (en) * | 2010-10-08 | 2012-04-12 | Msn Laboratories Limited | Process for the preparation of n-[2- (7-methoxy-l-naphthyl) ethyl] acetamide and its novel crystalline forms |
-
2010
- 2010-03-17 CN CN201010126254XA patent/CN102190594A/zh active Pending
-
2011
- 2011-03-17 CN CN201180024357.8A patent/CN102958911B/zh not_active Expired - Fee Related
- 2011-03-17 BR BR112012023317-3A patent/BR112012023317B1/pt not_active IP Right Cessation
- 2011-03-17 EA EA201201294A patent/EA022067B1/ru unknown
- 2011-03-17 MX MX2012010541A patent/MX2012010541A/es active IP Right Grant
- 2011-03-17 WO PCT/CN2011/071910 patent/WO2011113362A1/en not_active Ceased
- 2011-03-17 EP EP11755679.5A patent/EP2547649B1/en active Active
- 2011-03-17 DK DK11755679.5T patent/DK2547649T3/en active
- 2011-03-17 ES ES11755679T patent/ES2530772T3/es active Active
- 2011-03-17 RS RS20150041A patent/RS53815B1/sr unknown
- 2011-03-17 AP AP2012006492A patent/AP2012006492A0/xx unknown
- 2011-03-17 US US13/635,063 patent/US8729131B2/en active Active
- 2011-03-17 UA UAA201211720A patent/UA105425C2/ru unknown
- 2011-03-17 PE PE2012001448A patent/PE20130013A1/es active IP Right Grant
- 2011-03-17 AU AU2011229618A patent/AU2011229618B2/en not_active Ceased
- 2011-03-17 KR KR1020127026895A patent/KR101406727B1/ko not_active Expired - Fee Related
- 2011-03-17 NZ NZ602450A patent/NZ602450A/en not_active IP Right Cessation
- 2011-03-17 SG SG2012065009A patent/SG183868A1/en unknown
- 2011-03-17 GE GEAP201112869A patent/GEP20156231B/en unknown
- 2011-03-17 SI SI201130403T patent/SI2547649T1/sl unknown
- 2011-03-17 ME MEP-2015-23A patent/ME02054B/me unknown
- 2011-03-17 PL PL11755679T patent/PL2547649T3/pl unknown
- 2011-03-17 MA MA35192A patent/MA34055B1/fr unknown
- 2011-03-17 HR HRP20150071AT patent/HRP20150071T1/hr unknown
- 2011-03-17 JP JP2012557392A patent/JP5634532B2/ja not_active Expired - Fee Related
- 2011-03-17 CA CA2792417A patent/CA2792417C/en active Active
- 2011-03-17 PT PT117556795T patent/PT2547649E/pt unknown
- 2011-03-17 PH PH1/2012/501757A patent/PH12012501757A1/en unknown
-
2012
- 2012-08-31 TN TNP2012000435A patent/TN2012000435A1/en unknown
- 2012-09-04 IL IL221782A patent/IL221782A/en not_active IP Right Cessation
- 2012-09-11 CR CR20120462A patent/CR20120462A/es unknown
- 2012-09-12 NI NI201200140A patent/NI201200140A/es unknown
- 2012-09-13 CL CL2012002540A patent/CL2012002540A1/es unknown
- 2012-09-14 EC ECSP12012155 patent/ECSP12012155A/es unknown
- 2012-09-17 GT GT201200259A patent/GT201200259A/es unknown
- 2012-09-17 CU CU2012000137A patent/CU20120137A7/es unknown
-
2015
- 2015-01-22 CY CY20151100071T patent/CY1116086T1/el unknown
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