ECSP13012535A - Compuesto heterocíclico y sus usos - Google Patents

Compuesto heterocíclico y sus usos

Info

Publication number
ECSP13012535A
ECSP13012535A ECSP13012535A ECSP13012535A EC SP13012535 A ECSP13012535 A EC SP13012535A EC SP13012535 A ECSP13012535 A EC SP13012535A EC SP13012535 A ECSP13012535 A EC SP13012535A
Authority
EC
Ecuador
Prior art keywords
heterocyclic compound
activity
secretase
superior
symbol
Prior art date
Application number
Other languages
English (en)
Inventor
Tatsuki Koike
Takafumi Takai
Yasutaka Hoashi
Tetsuya Tsukamoto
Makoto Kamata
Minoru Nakamura
Yoshihide Tomata
Yuichi Kajita
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012535(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of ECSP13012535A publication Critical patent/ECSP13012535A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un derivado heterociclo que tiene una actividad inhibidora de la producción de amiloide superior y/o una actividad de modulación de -secretasa superior, y el uso del mismo. Un compuesto representado por la fórmula (I):donde cada símbolo es como se define en la presente memoria descriptiva, o una sal del mismo.
ECSP13012535 2010-09-02 2013-03-28 Compuesto heterocíclico y sus usos ECSP13012535A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010197064 2010-09-02
JP2011143548 2011-06-28

Publications (1)

Publication Number Publication Date
ECSP13012535A true ECSP13012535A (es) 2013-06-28

Family

ID=45094181

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012535 ECSP13012535A (es) 2010-09-02 2013-03-28 Compuesto heterocíclico y sus usos

Country Status (22)

Country Link
US (3) US8822699B2 (es)
EP (1) EP2611805A1 (es)
JP (1) JP5871909B2 (es)
KR (1) KR20130139895A (es)
CN (1) CN103249733A (es)
AR (1) AR082865A1 (es)
AU (1) AU2011296887A1 (es)
BR (1) BR112013004746A2 (es)
CA (1) CA2809779A1 (es)
CL (1) CL2013000575A1 (es)
DO (1) DOP2013000051A (es)
EA (1) EA201390333A1 (es)
EC (1) ECSP13012535A (es)
MA (1) MA34556B1 (es)
MX (1) MX2013002511A (es)
PE (1) PE20131305A1 (es)
PH (1) PH12013500403A1 (es)
SG (1) SG187917A1 (es)
TW (1) TW201213327A (es)
UY (1) UY33586A (es)
WO (1) WO2012029991A1 (es)
ZA (1) ZA201301929B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120142672A1 (en) * 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
UY33586A (es) * 2010-09-02 2012-03-30 Takeda Pharmaceutical Compuesto heterocíclico y sus usos
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
RU2750293C2 (ru) * 2015-05-12 2021-06-25 ЭфЭмСи Корпорейшн Арилзамещенные бициклические соединения в качестве гербицидов
MY202326A (en) * 2017-09-14 2024-04-24 Daiichi Sankyo Co Ltd Compound having cyclic structure
US20210079182A1 (en) * 2019-09-12 2021-03-18 Dupont Electronics, Inc. Polyimide films and electronic devices
IL313039A (en) * 2021-12-17 2024-07-01 Athira Pharma Inc Uses of bicyclic compounds for the treatment of diseases
CN118047687A (zh) * 2024-01-29 2024-05-17 湖州澄博生物科技有限公司 一种用于对20（s）喜树碱结构进行修饰的化合物及其合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1261610A2 (en) 2000-02-17 2002-12-04 Bristol-Myers Squibb Pharma Company Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
CN102584813B (zh) 2003-05-14 2016-07-06 Ngc药物公司 化合物及其在调节淀粉样蛋白β中的用途
CA2539811A1 (en) * 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
EP2261218B1 (en) 2004-05-26 2013-04-03 Eisai R&D Management Co., Ltd. Imidazole compound for use as an intermediate in the production of cinnamide compounds
KR20070083781A (ko) 2004-10-26 2007-08-24 에자이 알앤드디 매니지먼트 가부시키가이샤 신나미드 화합물의 비정질체
JP2009523170A (ja) 2006-01-11 2009-06-18 メルク エンド カムパニー インコーポレーテッド 縮合トリアゾールタキキニン受容体アンダニスト
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
GEP20115139B (en) 2006-03-09 2011-01-10 Eisai R&D Man Co Ltd Polycyclic cinnamide derivative
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
TW200835502A (en) 2006-12-26 2008-09-01 Daiichi Sankyo Co Ltd Thiazepine derivatives
US8143394B2 (en) 2006-12-26 2012-03-27 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infections
WO2008097538A1 (en) 2007-02-08 2008-08-14 Merck & Co., Inc. Therapeutic agents
MX2010006243A (es) 2007-12-06 2010-08-31 Schering Corp Moduladores de gamma secretasa.
TW201030002A (en) * 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2010197064A (ja) 2009-02-23 2010-09-09 Chugoku Electric Power Co Inc:The 直下位置測定装置
JP2012051806A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
RU2515976C2 (ru) 2009-02-26 2014-05-20 Эйсай Ар Энд Ди Менеджмент Ко., Лтд. Азотсодержащие конденсированные гетероциклические соединения и их применение в качестве ингибиторов продукции бета-амилоида
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
WO2011002067A1 (ja) 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
US20120142672A1 (en) * 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
WO2011006903A1 (en) 2009-07-15 2011-01-20 Ortho-Mcneil-Janssen Pharmaceuticals, Inc Substituted triazole and imidazole derivatives as gamma secretase modulators
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
WO2011016559A1 (ja) 2009-08-07 2011-02-10 武田薬品工業株式会社 複素環化合物およびその用途
JP2011143548A (ja) 2010-01-12 2011-07-28 Panasonic Corp スクリーン印刷機及びスクリーン印刷方法
PH12012501381A1 (en) 2010-01-15 2012-10-22 Janssen Pharmaceuticals Inc Novel substituted bicyclic triazole derivatives as gamma secretase modulators
UY33586A (es) * 2010-09-02 2012-03-30 Takeda Pharmaceutical Compuesto heterocíclico y sus usos

Also Published As

Publication number Publication date
CN103249733A (zh) 2013-08-14
MX2013002511A (es) 2013-07-29
PE20131305A1 (es) 2013-10-31
WO2012029991A1 (en) 2012-03-08
SG187917A1 (en) 2013-04-30
CA2809779A1 (en) 2012-03-08
UY33586A (es) 2012-03-30
CL2013000575A1 (es) 2013-08-23
EP2611805A1 (en) 2013-07-10
EA201390333A1 (ru) 2013-08-30
US20130178497A1 (en) 2013-07-11
AU2011296887A1 (en) 2013-04-11
AR082865A1 (es) 2013-01-16
US8822699B2 (en) 2014-09-02
US20120059030A1 (en) 2012-03-08
JP5871909B2 (ja) 2016-03-01
DOP2013000051A (es) 2013-04-30
TW201213327A (en) 2012-04-01
PH12013500403A1 (en) 2013-03-25
JP2013536798A (ja) 2013-09-26
MA34556B1 (fr) 2013-09-02
US20140350260A1 (en) 2014-11-27
KR20130139895A (ko) 2013-12-23
BR112013004746A2 (pt) 2016-06-07
US8901309B2 (en) 2014-12-02
ZA201301929B (en) 2013-11-27

Similar Documents

Publication Publication Date Title
UY33586A (es) Compuesto heterocíclico y sus usos
UY36199A (es) Compuesto heterocíclico
CR20150509A (es) Derivados de naftiridina utiles como antagonistas de la alfa-v-beta-6 integrina
MX368392B (es) Compuesto heterociclico fusionado.
UY36489A (es) Uso de compuestos de picolinamida con actividad fuingicida
CU24408B1 (es) Compuestos de dihidroisoquinolinona sustituida
MX2016003199A (es) Compuestos de azapiridona y usos de los mismos.
UY33943A (es) Derivados espirocíclicos de isoxazolina como agentes antiparasitarios.
CO2017001178A2 (es) Derivado de piridona que tiene un grupo tetrahidropiranil metilo
BR112016014020A8 (pt) moduladores de tetra-hidropiridopirazinas de gpr6.
MX372736B (es) Inhibidores de azaquinazolina de la proteina quinasa c atipica.
MX2013006113A (es) Compuestos biciclico.
BR112017013062A2 (pt) compostos picolinamida macrocíclicos com atividade fungicida.
BR112016006076A2 (pt) compostos de picolinamida macrocíclica com atividade fungicida
CO2019012125A2 (es) Inhibidores ip6k
MX2017002312A (es) Compuestos heterobiciclicos y su uso para el tratamiento de tuberculosis.
UY36263A (es) Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso
CO2017001528A2 (es) Compuestos novedosos de pirimidina sustituidos
CO2017001506A2 (es) Compuestos novedosos de pirimidina sustituidos
MX2016003892A (es) Uso de dihidrooxindolilsulfonamidas sustituidas, o sus sales, para aumentar la tolerancia de plantas al estres.
BR112015029348A2 (pt) inibidores da bace
CO6491037A2 (es) Derivados de pirazinooxazepina
CR20140495A (es) 5-amino[1,4]thiazines como inhibidores de bace1
CL2017001467A1 (es) Compuestos de dihidropirimidin - 2 - ona y sus usos médicos
BR112016028022A2 (pt) compostos de sulfonamida e seus usos como inibidores de stat5