ECSP13012535A - Compuesto heterocíclico y sus usos - Google Patents

Compuesto heterocíclico y sus usos

Info

Publication number
ECSP13012535A
ECSP13012535A ECSP13012535A ECSP13012535A EC SP13012535 A ECSP13012535 A EC SP13012535A EC SP13012535 A ECSP13012535 A EC SP13012535A EC SP13012535 A ECSP13012535 A EC SP13012535A
Authority
EC
Ecuador
Prior art keywords
heterocyclic compound
activity
secretase
superior
symbol
Prior art date
Application number
Other languages
English (en)
Inventor
Tatsuki Koike
Takafumi Takai
Yasutaka Hoashi
Tetsuya Tsukamoto
Makoto Kamata
Minoru Nakamura
Yoshihide Tomata
Yuichi Kajita
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45094181&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP13012535(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of ECSP13012535A publication Critical patent/ECSP13012535A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un derivado heterociclo que tiene una actividad inhibidora de la producción de amiloide superior y/o una actividad de modulación de -secretasa superior, y el uso del mismo. Un compuesto representado por la fórmula (I):donde cada símbolo es como se define en la presente memoria descriptiva, o una sal del mismo.
ECSP13012535 2010-09-02 2013-03-28 Compuesto heterocíclico y sus usos ECSP13012535A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2010197064 2010-09-02
JP2011143548 2011-06-28

Publications (1)

Publication Number Publication Date
ECSP13012535A true ECSP13012535A (es) 2013-06-28

Family

ID=45094181

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012535 ECSP13012535A (es) 2010-09-02 2013-03-28 Compuesto heterocíclico y sus usos

Country Status (22)

Country Link
US (3) US8822699B2 (es)
EP (1) EP2611805A1 (es)
JP (1) JP5871909B2 (es)
KR (1) KR20130139895A (es)
CN (1) CN103249733A (es)
AR (1) AR082865A1 (es)
AU (1) AU2011296887A1 (es)
BR (1) BR112013004746A2 (es)
CA (1) CA2809779A1 (es)
CL (1) CL2013000575A1 (es)
DO (1) DOP2013000051A (es)
EA (1) EA201390333A1 (es)
EC (1) ECSP13012535A (es)
MA (1) MA34556B1 (es)
MX (1) MX2013002511A (es)
PE (1) PE20131305A1 (es)
PH (1) PH12013500403A1 (es)
SG (1) SG187917A1 (es)
TW (1) TW201213327A (es)
UY (1) UY33586A (es)
WO (1) WO2012029991A1 (es)
ZA (1) ZA201301929B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120142672A1 (en) * 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
EP2611805A1 (en) * 2010-09-02 2013-07-10 Takeda Pharmaceutical Company Limited Fused triazoles for the treatment or prophylaxis of mild cognitive impairment
EP2687528A1 (en) * 2012-07-17 2014-01-22 Ares Trading S.A. Fused triazole derivatives as gamma secretase modulators
RU2563254C2 (ru) * 2013-07-08 2015-09-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) Способ получения производных 7-(гетеро)арил-4,5,6,7-тетрагидро[1,2,3]триазоло[1,5-a]пиридина
CA2980643C (en) * 2015-05-12 2023-10-17 E I Du Pont De Nemours And Company Aryl substituted bicyclic compounds as herbicides
DK3682881T3 (da) * 2017-09-14 2026-05-11 Daiichi Sankyo Co Limited Forbindelse med cyklisk struktur
US20210079182A1 (en) * 2019-09-12 2021-03-18 Dupont Electronics, Inc. Polyimide films and electronic devices
KR20240121239A (ko) * 2021-12-17 2024-08-08 아티라 파마, 인코포레이티드 질환 치료를 위한 이환식 화합물의 용도

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003523345A (ja) 2000-02-17 2003-08-05 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
EP1628666B1 (en) 2003-05-14 2015-09-23 NeuroGenetic Pharmaceuticals, Inc. Compouds and uses thereof in modulating amyloid beta
EP1678172B1 (en) * 2003-10-15 2009-12-09 Targacept, Inc. Azabicyclic compounds for relieving pain and treating central nervous system disorders
BRPI0511504A (pt) 2004-05-26 2008-01-22 Eisai R&D Man Co Ltd composto ou um sal farmaceuticamente aceitável do mesmo, e, agente preventivo ou terapêutico para uma doença resultante de beta-amilóides
ATE458729T1 (de) 2004-10-26 2010-03-15 Eisai R&D Man Co Ltd Amorphe form einer zimtsäureamidverbindung
CA2636946A1 (en) 2006-01-11 2007-07-19 Merck And Co., Inc. Fused triazole tachykinin receptor antagonists
PL1992618T3 (pl) 2006-03-09 2012-06-29 Eisai R&D Man Co Ltd Policykliczna pochodna cynamidowa
TWI378091B (en) 2006-03-09 2012-12-01 Eisai R&D Man Co Ltd Multi-cyclic cinnamide derivatives
TW200808800A (en) 2006-05-05 2008-02-16 Astrazeneca Ab MGluR5 modulators V
EP2119719A1 (en) 2006-12-26 2009-11-18 Daiichi Sankyo Company, Limited Thiazepine derivative
WO2008077649A1 (en) 2006-12-26 2008-07-03 Gilead Sciences, Inc. Pyrido(3,2-d)pyrimidines useful for treating viral infectons
JP2010518080A (ja) 2007-02-08 2010-05-27 メルク・シャープ・エンド・ドーム・コーポレイション 治療薬
JP2011506335A (ja) 2007-12-06 2011-03-03 シェーリング コーポレイション γ−セクレターゼ調節剤
TW201030002A (en) 2009-01-16 2010-08-16 Bristol Myers Squibb Co Bicyclic compounds for the reduction of beta-amyloid production
JP2010197064A (ja) 2009-02-23 2010-09-09 Chugoku Electric Power Co Inc:The 直下位置測定装置
JP2012051806A (ja) * 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd イミダゾリルピラジン誘導体
TW201035101A (en) 2009-02-26 2010-10-01 Eisai R&D Man Co Ltd Nitrogen-containing fused heterocyclic compound
JP2012051807A (ja) 2009-02-26 2012-03-15 Eisai R & D Management Co Ltd アリールイミダゾール化合物
WO2011002067A1 (ja) 2009-07-02 2011-01-06 武田薬品工業株式会社 複素環化合物およびその用途
US20120142672A1 (en) * 2009-07-13 2012-06-07 Tatsuki Koike Heterocyclic compound and use thereof
BR112012000915A2 (pt) 2009-07-15 2019-09-24 Janssen Pharmaceuticals Inc derivados de triazol e imidazol substituídos como moduladores de gama secretase.
TWI468402B (zh) 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
WO2011016559A1 (ja) 2009-08-07 2011-02-10 武田薬品工業株式会社 複素環化合物およびその用途
JP2011143548A (ja) 2010-01-12 2011-07-28 Panasonic Corp スクリーン印刷機及びスクリーン印刷方法
AU2011206635B2 (en) 2010-01-15 2015-01-22 Cellzome Limited Novel substituted triazole derivatives as gamma secretase modulators
EP2611805A1 (en) * 2010-09-02 2013-07-10 Takeda Pharmaceutical Company Limited Fused triazoles for the treatment or prophylaxis of mild cognitive impairment

Also Published As

Publication number Publication date
ZA201301929B (en) 2013-11-27
WO2012029991A1 (en) 2012-03-08
JP5871909B2 (ja) 2016-03-01
TW201213327A (en) 2012-04-01
KR20130139895A (ko) 2013-12-23
US8901309B2 (en) 2014-12-02
BR112013004746A2 (pt) 2016-06-07
CA2809779A1 (en) 2012-03-08
EP2611805A1 (en) 2013-07-10
US8822699B2 (en) 2014-09-02
CN103249733A (zh) 2013-08-14
US20120059030A1 (en) 2012-03-08
US20140350260A1 (en) 2014-11-27
AR082865A1 (es) 2013-01-16
MX2013002511A (es) 2013-07-29
AU2011296887A1 (en) 2013-04-11
CL2013000575A1 (es) 2013-08-23
EA201390333A1 (ru) 2013-08-30
PE20131305A1 (es) 2013-10-31
MA34556B1 (fr) 2013-09-02
SG187917A1 (en) 2013-04-30
PH12013500403A1 (en) 2013-03-25
DOP2013000051A (es) 2013-04-30
UY33586A (es) 2012-03-30
US20130178497A1 (en) 2013-07-11
JP2013536798A (ja) 2013-09-26

Similar Documents

Publication Publication Date Title
UY36199A (es) Compuesto heterocíclico
CR20150509A (es) Derivados de naftiridina utiles como antagonistas de la alfa-v-beta-6 integrina
UY33586A (es) Compuesto heterocíclico y sus usos
MX368392B (es) Compuesto heterociclico fusionado.
UY36489A (es) Uso de compuestos de picolinamida con actividad fuingicida
CU24408B1 (es) Compuestos de dihidroisoquinolinona sustituida
MX2016003199A (es) Compuestos de azapiridona y usos de los mismos.
UY33943A (es) Derivados espirocíclicos de isoxazolina como agentes antiparasitarios.
CO2017001178A2 (es) Derivado de piridona que tiene un grupo tetrahidropiranil metilo
BR112016014020A8 (pt) moduladores de tetra-hidropiridopirazinas de gpr6.
MX372736B (es) Inhibidores de azaquinazolina de la proteina quinasa c atipica.
MX2013006113A (es) Compuestos biciclico.
BR112017013062A2 (pt) compostos picolinamida macrocíclicos com atividade fungicida.
BR112016006076A2 (pt) compostos de picolinamida macrocíclica com atividade fungicida
CO2019012125A2 (es) Inhibidores ip6k
MX2017002312A (es) Compuestos heterobiciclicos y su uso para el tratamiento de tuberculosis.
UY36263A (es) Compuestos de tiazin-2-amina fusionados con ciclopropilo como inhibidores de beta-secretasa y métodos de uso
CO2017001528A2 (es) Compuestos novedosos de pirimidina sustituidos
CO2017001506A2 (es) Compuestos novedosos de pirimidina sustituidos
MX2016003892A (es) Uso de dihidrooxindolilsulfonamidas sustituidas, o sus sales, para aumentar la tolerancia de plantas al estres.
BR112015029348A2 (pt) inibidores da bace
CO6491037A2 (es) Derivados de pirazinooxazepina
CR20140495A (es) 5-amino[1,4]thiazines como inhibidores de bace1
CL2017001467A1 (es) Compuestos de dihidropirimidin - 2 - ona y sus usos médicos
BR112016028022A2 (pt) compostos de sulfonamida e seus usos como inibidores de stat5