ECSP13012554A - Compuestos de furo[3,2-d]pirimidina - Google Patents

Compuestos de furo[3,2-d]pirimidina

Info

Publication number
ECSP13012554A
ECSP13012554A ECSP13012554A ECSP13012554A EC SP13012554 A ECSP13012554 A EC SP13012554A EC SP13012554 A ECSP13012554 A EC SP13012554A EC SP13012554 A ECSP13012554 A EC SP13012554A
Authority
EC
Ecuador
Prior art keywords
compounds
formula
furo
pyrimidine
diseases
Prior art date
Application number
Other languages
English (en)
Inventor
Clara I Villamil
David Calderwood
Noel S Wilson
Kelly D Mullen
Gagandeep Somal
Michael Z Hoemann
Bing Li
Philip Cox
Bruce Clapham
Anil Vasudevan
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of ECSP13012554A publication Critical patent/ECSP13012554A/es

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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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Abstract

Compuestos novedosos de fórmula (I)Fórmula (I),sales, metabolitos con actividad biológica, prodrogas, racematos, enantiómeros, diastereómeros, solvatos e hidratos farmacéuticamente aceptables de éstos, donde las variables son como se las define en la presente. Los compuestos de fórmula (I) son útiles como inhibidores de quinasas, por lo que han de resultar de utilidad para tratar determinadas afecciones y enfermedades, especialmente afecciones y enfermedades inflamatorias y afecciones y trastornos proliferativos, por ejemplo, cánceres.
ECSP13012554 2010-10-08 2013-04-16 Compuestos de furo[3,2-d]pirimidina ECSP13012554A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39115710P 2010-10-08 2010-10-08
US201161503368P 2011-06-30 2011-06-30

Publications (1)

Publication Number Publication Date
ECSP13012554A true ECSP13012554A (es) 2013-06-28

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ID=45928140

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP13012554 ECSP13012554A (es) 2010-10-08 2013-04-16 Compuestos de furo[3,2-d]pirimidina

Country Status (23)

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US (1) US8551981B2 (es)
EP (1) EP2624698A4 (es)
JP (1) JP2013539762A (es)
KR (1) KR20140005882A (es)
CN (1) CN103442568A (es)
AR (1) AR083358A1 (es)
AU (1) AU2011311867A1 (es)
BR (1) BR112013008240A2 (es)
CA (1) CA2813437A1 (es)
CL (1) CL2013000933A1 (es)
CO (1) CO6731080A2 (es)
CR (1) CR20130206A (es)
EC (1) ECSP13012554A (es)
GT (1) GT201300091A (es)
IL (1) IL225622A0 (es)
MX (1) MX2013003913A (es)
PE (1) PE20140245A1 (es)
PH (1) PH12013500661A1 (es)
RU (1) RU2013120966A (es)
SG (1) SG189837A1 (es)
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