ECSP13012665A - Nueva forma de administracion de inhibidor de encefalinasa - Google Patents
Nueva forma de administracion de inhibidor de encefalinasaInfo
- Publication number
- ECSP13012665A ECSP13012665A ECSP13012665A ECSP13012665A EC SP13012665 A ECSP13012665 A EC SP13012665A EC SP13012665 A ECSP13012665 A EC SP13012665A EC SP13012665 A ECSP13012665 A EC SP13012665A
- Authority
- EC
- Ecuador
- Prior art keywords
- new
- encephalinasa
- administration form
- inhibitor administration
- inhibitor
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- ODUOJXZPIYUATO-UHFFFAOYSA-N 2-[[2-[(acetylthio)methyl]-1-oxo-3-phenylpropyl]amino]acetic acid (phenylmethyl) ester Chemical compound C=1C=CC=CC=1COC(=O)CNC(=O)C(CSC(=O)C)CC1=CC=CC=C1 ODUOJXZPIYUATO-UHFFFAOYSA-N 0.000 abstract 1
- 206010012735 Diarrhoea Diseases 0.000 abstract 1
- 229940122586 Enkephalinase inhibitor Drugs 0.000 abstract 1
- ODUOJXZPIYUATO-IBGZPJMESA-N benzyl 2-[[(2r)-2-(acetylsulfanylmethyl)-3-phenylpropanoyl]amino]acetate Chemical compound C([C@@H](CSC(=O)C)C(=O)NCC(=O)OCC=1C=CC=CC=1)C1=CC=CC=C1 ODUOJXZPIYUATO-IBGZPJMESA-N 0.000 abstract 1
- 108700010883 dexecadotril Proteins 0.000 abstract 1
- 229950008996 dexecadotril Drugs 0.000 abstract 1
- 239000002792 enkephalinase inhibitor Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108700040249 racecadotril Proteins 0.000 abstract 1
- 229960002281 racecadotril Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/223—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of alpha-aminoacids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/265—Esters, e.g. nitroglycerine, selenocyanates of carbonic, thiocarbonic, or thiocarboxylic acids, e.g. thioacetic acid, xanthogenic acid, trithiocarbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se relaciona con una nueva formulación de un inhibidor de encefalinasa, tal como racecadotril o dexecadotril, con el proceso para la preparación del mismo y con el uso del mismo en el tratamiento de diarrea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10306397A EP2462922A1 (en) | 2010-12-10 | 2010-12-10 | New form of administration of enkephalinase inhibitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP13012665A true ECSP13012665A (es) | 2013-08-30 |
Family
ID=45092498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP13012665 ECSP13012665A (es) | 2010-12-10 | 2013-06-06 | Nueva forma de administracion de inhibidor de encefalinasa |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9439853B2 (es) |
| EP (2) | EP2462922A1 (es) |
| JP (1) | JP5847192B2 (es) |
| KR (1) | KR101837685B1 (es) |
| CN (1) | CN103338749B (es) |
| AP (1) | AP3787A (es) |
| AU (1) | AU2011340500B2 (es) |
| BR (1) | BR112013014388A2 (es) |
| CA (1) | CA2820835C (es) |
| CO (1) | CO6731092A2 (es) |
| CY (1) | CY1123056T1 (es) |
| DK (1) | DK2648696T3 (es) |
| EA (1) | EA022730B1 (es) |
| EC (1) | ECSP13012665A (es) |
| ES (1) | ES2791710T3 (es) |
| HR (1) | HRP20200555T1 (es) |
| HU (1) | HUE049273T2 (es) |
| IL (1) | IL226775A (es) |
| LT (1) | LT2648696T (es) |
| MA (1) | MA34724B1 (es) |
| ME (1) | ME03769B (es) |
| MX (1) | MX354858B (es) |
| NZ (1) | NZ611597A (es) |
| PL (1) | PL2648696T3 (es) |
| PT (1) | PT2648696T (es) |
| RS (1) | RS60197B1 (es) |
| SG (1) | SG191068A1 (es) |
| SI (1) | SI2648696T1 (es) |
| SM (1) | SMT202000229T1 (es) |
| TN (1) | TN2013000239A1 (es) |
| UA (1) | UA111835C2 (es) |
| WO (1) | WO2012076691A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2987268B1 (fr) | 2012-02-28 | 2014-07-11 | Ammtek | Formulations liquides de sulfamides hypoglycemiants |
| EP2866789B1 (en) | 2012-06-28 | 2018-08-01 | Johnson & Johnson Consumer Inc. | Racecadotril lipid compositions |
| US9114171B2 (en) * | 2012-06-28 | 2015-08-25 | Mcneil-Ppc, Inc. | Racecadotril liquid compositions |
| US9801819B2 (en) | 2012-06-28 | 2017-10-31 | Johnson & Johnson Consumer Inc. | Racecadotril compositions |
| PT2866802T (pt) * | 2012-06-28 | 2016-09-05 | Johnson & Johnson Consumer Inc | Composições líquidas racecadotril |
| CN105848643A (zh) * | 2013-12-23 | 2016-08-10 | 强生消费者公司 | 消旋卡多曲组合物 |
| EP2918268A1 (en) | 2014-03-10 | 2015-09-16 | Galenicum Health S.L. | Pharmaceutical compositions comprising an active agent |
| ES2555484T1 (es) | 2014-05-26 | 2016-01-04 | Galenicum Health S.L. | Composiciones farmacéuticas que contienen un agente activo |
| MA40859A (fr) | 2014-10-29 | 2017-09-05 | Johnson & Johnson Consumer Inc | Particules de cadotril |
| CN105125477A (zh) * | 2015-08-19 | 2015-12-09 | 黑龙江佰彤儿童药物研究有限公司 | 一种含消旋卡多曲的药物制剂及制备方法 |
| IT201700099690A1 (it) | 2017-09-06 | 2019-03-06 | Abiogen Pharma Spa | Composizione per l’integrazione di calcio |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2480747A1 (fr) | 1980-04-17 | 1981-10-23 | Roques Bernard | Derives d'acides amines et leur application therapeutique |
| GB0015490D0 (en) * | 2000-06-23 | 2000-08-16 | Smithkline Beecham Lab | Novel formulations |
| DK1294372T3 (da) | 2000-06-23 | 2005-09-19 | Bioprojet Soc Civ | Törpulverformulering der omdanner racecadotril |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| EP1563848A1 (en) * | 2004-02-12 | 2005-08-17 | Bioprojet | New combinations of an anti-emetic agent and an enkephalinase inhibitor |
| WO2007102171A2 (en) * | 2006-03-07 | 2007-09-13 | Panacea Biotec Ltd | Novel salts of 1h-1-benzazepine-1-acetic acid, their preparation and pharmaceutical composition |
| CN101103960B (zh) * | 2006-07-14 | 2010-12-08 | 海南盛科生命科学研究院 | 一种含有消旋卡多曲的干混悬剂及其制备方法 |
| TW201014830A (en) | 2008-09-30 | 2010-04-16 | Theravance Inc | Crystalline form of an alkoxyimidazol-1-ylmethyl biphenyl carboxylic acid |
-
2010
- 2010-12-10 EP EP10306397A patent/EP2462922A1/en not_active Withdrawn
-
2011
- 2011-09-12 UA UAA201308676A patent/UA111835C2/uk unknown
- 2011-12-09 CA CA2820835A patent/CA2820835C/en active Active
- 2011-12-09 BR BR112013014388A patent/BR112013014388A2/pt not_active Application Discontinuation
- 2011-12-09 NZ NZ611597A patent/NZ611597A/en unknown
- 2011-12-09 ME MEP-2020-71A patent/ME03769B/me unknown
- 2011-12-09 AP AP2013006971A patent/AP3787A/en active
- 2011-12-09 SI SI201131867T patent/SI2648696T1/sl unknown
- 2011-12-09 PT PT117972166T patent/PT2648696T/pt unknown
- 2011-12-09 KR KR1020137015290A patent/KR101837685B1/ko active Active
- 2011-12-09 LT LTEP11797216.6T patent/LT2648696T/lt unknown
- 2011-12-09 DK DK11797216.6T patent/DK2648696T3/da active
- 2011-12-09 EP EP11797216.6A patent/EP2648696B1/en active Active
- 2011-12-09 US US13/992,577 patent/US9439853B2/en active Active
- 2011-12-09 WO PCT/EP2011/072315 patent/WO2012076691A1/en not_active Ceased
- 2011-12-09 HR HRP20200555TT patent/HRP20200555T1/hr unknown
- 2011-12-09 CN CN201180064672.3A patent/CN103338749B/zh active Active
- 2011-12-09 MX MX2013006492A patent/MX354858B/es active IP Right Grant
- 2011-12-09 SM SM20200229T patent/SMT202000229T1/it unknown
- 2011-12-09 SG SG2013044250A patent/SG191068A1/en unknown
- 2011-12-09 EA EA201300688A patent/EA022730B1/ru unknown
- 2011-12-09 RS RS20200446A patent/RS60197B1/sr unknown
- 2011-12-09 AU AU2011340500A patent/AU2011340500B2/en active Active
- 2011-12-09 HU HUE11797216A patent/HUE049273T2/hu unknown
- 2011-12-09 ES ES11797216T patent/ES2791710T3/es active Active
- 2011-12-09 PL PL11797216T patent/PL2648696T3/pl unknown
- 2011-12-09 JP JP2013542560A patent/JP5847192B2/ja active Active
-
2013
- 2013-06-03 TN TNP2013000239A patent/TN2013000239A1/fr unknown
- 2013-06-06 MA MA35980A patent/MA34724B1/fr unknown
- 2013-06-06 EC ECSP13012665 patent/ECSP13012665A/es unknown
- 2013-06-06 IL IL226775A patent/IL226775A/en active IP Right Grant
- 2013-06-11 CO CO13139839A patent/CO6731092A2/es unknown
-
2020
- 2020-04-24 CY CY20201100374T patent/CY1123056T1/el unknown
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