ECSP14013199A - Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio - Google Patents

Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio

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Publication number
ECSP14013199A
ECSP14013199A ECSP14013199A ECSP14013199A EC SP14013199 A ECSP14013199 A EC SP14013199A EC SP14013199 A ECSP14013199 A EC SP14013199A EC SP14013199 A ECSP14013199 A EC SP14013199A
Authority
EC
Ecuador
Prior art keywords
sincicial
prophylaxis
respiratory
compounds
treatment
Prior art date
Application number
Other languages
English (en)
Inventor
Li Chen
Hong Ying Yun
Tao Guo
Yongfu Liu
Lichun Feng
Song Feng
Lu Gao
Mengwei Huang
Chungen Liang
Lisha Wang
Jason Christopher Wong
Jim Zhen Wu
Xihan Wu
Xiufang Zheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP14013199A publication Critical patent/ECSP14013199A/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de la fórmula (I) (I)y sus sales farmacéuticamente aceptables, en la que de R1 a R10, A, Q, X e Y tienen los significados definidos en la descripción y en las reivindicaciones, pueden utilizarse como medicamentos.
ECSP14013199 2011-08-11 2014-02-11 Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio ECSP14013199A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011078258 2011-08-11
CN2012078439 2012-07-10

Publications (1)

Publication Number Publication Date
ECSP14013199A true ECSP14013199A (es) 2014-03-31

Family

ID=46651492

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP14013199 ECSP14013199A (es) 2011-08-11 2014-02-11 Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio

Country Status (21)

Country Link
US (2) US8871756B2 (es)
EP (1) EP2742039B1 (es)
JP (1) JP5746793B2 (es)
KR (1) KR101570627B1 (es)
CN (1) CN103717589B (es)
AU (1) AU2012293644B2 (es)
BR (1) BR112014003198B1 (es)
CA (1) CA2842123C (es)
CL (1) CL2014000311A1 (es)
CO (1) CO6852080A2 (es)
CR (1) CR20140026A (es)
EA (1) EA023262B1 (es)
EC (1) ECSP14013199A (es)
ES (1) ES2552016T3 (es)
IL (1) IL230458A (es)
MA (1) MA35432B1 (es)
MX (1) MX349881B (es)
MY (1) MY184306A (es)
PE (1) PE20142148A1 (es)
PH (1) PH12014500164A1 (es)
WO (1) WO2013020993A1 (es)

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US9464055B2 (en) * 2014-02-27 2016-10-11 Janssen Pharmaceutica Nv Quinoline derivatives useful as CB-1 inverse agonists
US9266835B2 (en) * 2014-02-27 2016-02-23 Janssen Pharmaceutica Nv Quinoline derivatives useful as CB-1 inverse agonists
CN105726488B (zh) * 2014-12-08 2020-10-20 上海爱科百发生物医药技术有限公司 含有呼吸道合胞病毒抑制剂的肠溶微丸及其制备方法
CN104529802A (zh) * 2014-12-13 2015-04-22 西安近代化学研究所 一种合成n,n′-双取代氟代丙二酰胺化合物的方法
CN104860954B (zh) * 2015-04-20 2018-05-04 南京天印健华医药科技有限公司 一种苯酯螺吡咯烷类化合物及其制备方法
JP6749343B2 (ja) 2015-05-20 2020-09-02 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 脊髄性筋萎縮症を処置するための化合物
CN108290882B (zh) * 2015-07-16 2021-07-06 豪夫迈·罗氏有限公司 用于治疗呼吸道合胞病毒感染的4-喹唑啉胺衍生物的晶形
JP6659841B2 (ja) 2015-11-12 2020-03-04 エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft 脊髄性筋萎縮症を処置するための組成物
CN110946865B (zh) 2015-12-10 2024-01-26 Ptc医疗公司 用于治疗亨廷顿病的方法
EP3386978B1 (en) 2015-12-10 2021-01-27 H. Hoffnabb-La Roche Ag Bridged piperidine derivatives
SMT202200465T1 (it) 2016-07-14 2023-01-13 Crinetics Pharmaceuticals Inc Modulatori della somatostatina e loro usi
EP3634953B1 (en) 2017-06-05 2024-01-03 PTC Therapeutics, Inc. Compounds for treating huntington's disease
MX2019015578A (es) 2017-06-28 2020-07-28 Ptc Therapeutics Inc Metodos para tratar la enfermedad de huntington.
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
JP7399870B2 (ja) 2018-03-27 2023-12-18 ピーティーシー セラピューティクス, インコーポレイテッド ハンチントン病を処置するための化合物
KR20210038845A (ko) 2018-06-27 2021-04-08 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료를 위한 헤테로아릴 화합물
PL3814357T3 (pl) 2018-06-27 2024-09-16 Ptc Therapeutics, Inc. Związki heterocykliczne i heteroarylowe do leczenia choroby huntingtona
EP3814360B8 (en) 2018-06-27 2024-11-06 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
MX2021002569A (es) 2018-09-06 2021-06-08 Cidara Therapeutics Inc Composiciones y metodos para el tratamiento de infecciones virales.
CN116023365B (zh) 2019-01-29 2025-02-14 轩竹生物科技股份有限公司 己酮糖激酶抑制剂及其用途
CN114245794B (zh) 2019-05-13 2024-09-13 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
TWI861205B (zh) 2019-09-06 2024-11-11 美商席達拉醫療有限公司 用於治療病毒感染之組合物及方法
CN114728937A (zh) * 2019-09-09 2022-07-08 奇达拉治疗公司 用于治疗呼吸道合胞病毒的组合物及方法
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
WO2021083290A1 (en) * 2019-10-31 2021-05-06 Shanghai Ark Biopharmaceutical Co. Ltd. Respiratory syncytial virus fusion protein inhibitor compositions and methods for the treatment and prophylaxis of rsv diseases using the same
GB201915932D0 (en) * 2019-11-01 2019-12-18 Reviral Ltd Pharmaceutical compounds
CN113149977A (zh) * 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
CN116615189A (zh) * 2020-07-06 2023-08-18 新月生物科学 新型细胞代谢调节化合物及其用于治疗病毒疾病的用途
CN116456968B (zh) 2020-09-09 2026-03-20 克林提克斯医药股份有限公司 生长抑素调节剂的制剂
CN113234085A (zh) * 2021-04-26 2021-08-10 无锡合全药业有限公司 一种2-氧杂-6-氮杂螺[3.4]辛烷-8-基氨基甲酸叔丁酯的合成方法
WO2024131886A1 (zh) * 2022-12-22 2024-06-27 甫康(上海)健康科技有限责任公司 一种苯并硫氮杂卓类化合物及其制备方法与用途
CN119285628A (zh) * 2023-07-10 2025-01-10 石药集团中奇制药技术(石家庄)有限公司 用于治疗和预防呼吸道合胞病毒感染疾病的化合物
WO2025190151A1 (zh) * 2024-03-13 2025-09-18 甫康(上海)健康科技有限责任公司 一种苯并硒氮杂*类化合物及其制备方法与用途
CN120794971A (zh) * 2024-04-10 2025-10-17 广州医科大学 二氨基嘧啶化合物及其用途
WO2025252264A1 (zh) * 2024-06-07 2025-12-11 武汉武药科技有限公司 用于治疗或预防呼吸道合胞病毒疾病的化合物

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MA35432B1 (fr) 2014-09-01
ES2552016T3 (es) 2015-11-25
BR112014003198A2 (pt) 2017-04-04
CN103717589B (zh) 2016-08-17
CO6852080A2 (es) 2014-01-30
MX349881B (es) 2017-08-16
US20130196974A1 (en) 2013-08-01
EA023262B1 (ru) 2016-05-31
PH12014500164A1 (en) 2016-10-19
CL2014000311A1 (es) 2014-10-17
JP5746793B2 (ja) 2015-07-08
MX2014001481A (es) 2014-04-30
BR112014003198B1 (pt) 2020-10-13
AU2012293644B2 (en) 2017-05-25
HK1196131A1 (zh) 2014-12-05
JP2014521709A (ja) 2014-08-28
PE20142148A1 (es) 2015-01-03
EA201490419A1 (ru) 2014-05-30
IL230458A (en) 2015-11-30
KR101570627B1 (ko) 2015-11-19
CA2842123A1 (en) 2013-02-14
US8871756B2 (en) 2014-10-28
IL230458A0 (en) 2014-03-31
EP2742039B1 (en) 2015-09-16
CA2842123C (en) 2020-10-06
EP2742039A1 (en) 2014-06-18
MY184306A (en) 2021-03-31
CR20140026A (es) 2014-05-12
AU2012293644A1 (en) 2014-01-30
USRE49481E1 (en) 2023-04-04
NZ620079A (en) 2016-06-24
KR20140045590A (ko) 2014-04-16
WO2013020993A1 (en) 2013-02-14
CN103717589A (zh) 2014-04-09

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