ECSP14013199A - Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio - Google Patents

Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio

Info

Publication number
ECSP14013199A
ECSP14013199A ECSP14013199A ECSP14013199A EC SP14013199 A ECSP14013199 A EC SP14013199A EC SP14013199 A ECSP14013199 A EC SP14013199A EC SP14013199 A ECSP14013199 A EC SP14013199A
Authority
EC
Ecuador
Prior art keywords
sincicial
prophylaxis
respiratory
compounds
treatment
Prior art date
Application number
Other languages
English (en)
Inventor
Li Chen
Hong Ying Yun
Tao Guo
Yongfu Liu
Lichun Feng
Song Feng
Lu Gao
Mengwei Huang
Chungen Liang
Lisha Wang
Jason Christopher Wong
Jim Zhen Wu
Xihan Wu
Xiufang Zheng
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ECSP14013199A publication Critical patent/ECSP14013199A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)

Abstract

Un compuesto de la fórmula (I) (I)y sus sales farmacéuticamente aceptables, en la que de R1 a R10, A, Q, X e Y tienen los significados definidos en la descripción y en las reivindicaciones, pueden utilizarse como medicamentos.
ECSP14013199 2011-08-11 2014-02-11 Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio ECSP14013199A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011078258 2011-08-11
CN2012078439 2012-07-10

Publications (1)

Publication Number Publication Date
ECSP14013199A true ECSP14013199A (es) 2014-03-31

Family

ID=46651492

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSP14013199 ECSP14013199A (es) 2011-08-11 2014-02-11 Compuestos para el tratamiento y profilaxis de la enfermedad del virus sincicial respiratorio

Country Status (21)

Country Link
US (2) US8871756B2 (es)
EP (1) EP2742039B1 (es)
JP (1) JP5746793B2 (es)
KR (1) KR101570627B1 (es)
CN (1) CN103717589B (es)
AU (1) AU2012293644B2 (es)
BR (1) BR112014003198B1 (es)
CA (1) CA2842123C (es)
CL (1) CL2014000311A1 (es)
CO (1) CO6852080A2 (es)
CR (1) CR20140026A (es)
EA (1) EA023262B1 (es)
EC (1) ECSP14013199A (es)
ES (1) ES2552016T3 (es)
IL (1) IL230458A (es)
MA (1) MA35432B1 (es)
MX (1) MX349881B (es)
MY (1) MY184306A (es)
PE (1) PE20142148A1 (es)
PH (1) PH12014500164A1 (es)
WO (1) WO2013020993A1 (es)

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WO2015130445A1 (en) * 2014-02-27 2015-09-03 Janssen Pharmaceutica Nv Quinoline derivatives useful as cb-1 inverse agonists
WO2015130444A1 (en) * 2014-02-27 2015-09-03 Janssen Pharmaceutica Nv Quinoline derivatives useful as cb-1 inverse agonists
CN105726488B (zh) * 2014-12-08 2020-10-20 上海爱科百发生物医药技术有限公司 含有呼吸道合胞病毒抑制剂的肠溶微丸及其制备方法
CN104529802A (zh) * 2014-12-13 2015-04-22 西安近代化学研究所 一种合成n,n′-双取代氟代丙二酰胺化合物的方法
CN104860954B (zh) * 2015-04-20 2018-05-04 南京天印健华医药科技有限公司 一种苯酯螺吡咯烷类化合物及其制备方法
JP6749343B2 (ja) 2015-05-20 2020-09-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 脊髄性筋萎縮症を処置するための化合物
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AU2020214064B2 (en) * 2019-01-29 2022-10-20 Shandong Xuanzhu Pharma Co., Ltd. Hexone glucokinase inhibitor and use thereof
CN114245794B (zh) 2019-05-13 2024-09-13 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
US12617767B2 (en) 2019-07-17 2026-05-05 Crinetics Pharmaceuticals, Inc. Crystalline forms of somatostatin modulators
TWI861205B (zh) 2019-09-06 2024-11-11 美商席達拉醫療有限公司 用於治療病毒感染之組合物及方法
CA3153626A1 (en) * 2019-09-09 2021-03-18 Cidara Therapeutics, Inc. Compositions and methods for the treatment of respiratory syncytial virus
GB201915273D0 (en) * 2019-10-22 2019-12-04 Reviral Ltd Pharmaceutical compounds
JP7357157B2 (ja) * 2019-10-31 2023-10-05 シャンハイ アーク バイオファーマスゥ－ティカル カンパニー リミテッド 呼吸器合胞体ウイルス融合タンパク質阻害剤組成物及びそれを用いてｒｓｖ感染を治療及び予防する方法
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CN111620838A (zh) * 2020-05-16 2020-09-04 西安都创医药科技有限公司 一种氯代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111548325A (zh) * 2020-05-16 2020-08-18 西安都创医药科技有限公司 一种卤代苯并硫氮杂卓化合物的制备方法及其制备的产品及其应用
CN111518055A (zh) * 2020-05-16 2020-08-11 西安都创医药科技有限公司 一种苯并硫氮杂卓氧化物的制备方法及其制备的产品及其应用
CN111574475B (zh) * 2020-06-03 2022-09-20 西安都创医药科技有限公司 卤代苯并硫杂卓氧化物的制备方法及其制备的产品及其应用
JP2023532998A (ja) * 2020-07-06 2023-08-01 クレセンタ バイオサイエンシズ 新規細胞代謝調節化合物およびそのウイルス性疾患の治療のための使用
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CN118239945A (zh) * 2022-12-22 2024-06-25 甫康（上海）健康科技有限责任公司 一种苯并硫氮杂卓类化合物及其制备方法与用途
KR20260021067A (ko) 2023-07-10 2026-02-12 씨에스피씨 종콰이 팔마씨우티컬 테크놀로지 (스자좡) 컴퍼니 리미티드 호흡기세포융합바이러스 감염 질환의 치료 및 예방을 위한 화합물
WO2025190151A1 (zh) * 2024-03-13 2025-09-18 甫康（上海）健康科技有限责任公司 一种苯并硒氮杂*类化合物及其制备方法与用途
CN120794971A (zh) * 2024-04-10 2025-10-17 广州医科大学 二氨基嘧啶化合物及其用途
WO2025252264A1 (zh) * 2024-06-07 2025-12-11 武汉武药科技有限公司 用于治疗或预防呼吸道合胞病毒疾病的化合物

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Also Published As

Publication number Publication date
CL2014000311A1 (es) 2014-10-17
MX349881B (es) 2017-08-16
IL230458A (en) 2015-11-30
CR20140026A (es) 2014-05-12
KR20140045590A (ko) 2014-04-16
EA201490419A1 (ru) 2014-05-30
BR112014003198A2 (pt) 2017-04-04
ES2552016T3 (es) 2015-11-25
CN103717589A (zh) 2014-04-09
EP2742039B1 (en) 2015-09-16
HK1196131A1 (zh) 2014-12-05
MY184306A (en) 2021-03-31
US8871756B2 (en) 2014-10-28
MX2014001481A (es) 2014-04-30
JP5746793B2 (ja) 2015-07-08
PH12014500164A1 (en) 2016-10-19
US20130196974A1 (en) 2013-08-01
MA35432B1 (fr) 2014-09-01
BR112014003198B1 (pt) 2020-10-13
AU2012293644A1 (en) 2014-01-30
CA2842123C (en) 2020-10-06
CA2842123A1 (en) 2013-02-14
JP2014521709A (ja) 2014-08-28
IL230458A0 (en) 2014-03-31
EA023262B1 (ru) 2016-05-31
AU2012293644B2 (en) 2017-05-25
CN103717589B (zh) 2016-08-17
NZ620079A (en) 2016-06-24
WO2013020993A1 (en) 2013-02-14
PE20142148A1 (es) 2015-01-03
USRE49481E1 (en) 2023-04-04
KR101570627B1 (ko) 2015-11-19
CO6852080A2 (es) 2014-01-30
EP2742039A1 (en) 2014-06-18

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