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Application filed by Merck Sharp & DohmefiledCriticalMerck Sharp & Dohme
Publication of ECSP14013268ApublicationCriticalpatent/ECSP14013268A/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
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Abstract
La presente invención se refiere a compuestos de pirimidina que son útiles como agentes terapéuticos para el tratamiento de trastornos del sistema nervioso central asociados con la fosfodiesterasa 10 (PDE10). La presente invención también se refiere al uso de dichos compuestos para tratar trastornos neurológicos y psiquiátricos, tales como la esquizofrenia, la psicosis o la enfermedad de Huntington, y aquellos asociados con la hipofunción del cuerpo estriado o la disfunción de los ganglios basales.The present invention relates to pyrimidine compounds that are useful as therapeutic agents for the treatment of central nervous system disorders associated with phosphodiesterase 10 (PDE10). The present invention also relates to the use of said compounds to treat neurological and psychiatric disorders, such as schizophrenia, psychosis or Huntington's disease, and those associated with striated body hypofunction or basal ganglia dysfunction.
Compounds derived from 1,2,4-triazolo [4,3-a] pyridine, positive allosteric modulators of mglur2 receptors; pharmaceutical composition and its preparation process; pharmaceutical combination; and its use in the treatment or prevention of a central nervous system disorder such as anxiety and schizophrenia, among others.
Compounds derived from 1,2,4-triazolo [4,3-a] pyridine, positive allosteric modulators of mglur2 receptors; pharmaceutical composition; process to prepare it; and its use in the treatment or prevention of a central nervous system disorder such as anxiety, schizophrenia and migraine, among others.
Compounds derived from 1,2,4-triazolo [4,3-a] pyridine, allosteric modulators of mglur2 receptors; pharmaceutical composition; process to prepare it; and its use in the treatment or prevention of a selected central nervous system disorder of anxiety and schizophrenia, among others.
Compounds derived from pyrido [4,3-d] pyrimidin-5-one, their pharmaceutical compositions and their use as kinase inhibitors to treat asthma, COPD, ulcerative colitis, bronchitis, lupus, breast cancer, Alzheimer's disease, Alzheimer's disease parkinson's, osteoporosis, multiple sclerosis, diabetes, eye disorders, restenosis, inflammatory diseases.
compound, pharmaceutical composition, use of a compound or a pharmaceutically acceptable salt or solvate thereof, and method for treating a disease or condition