ECSP15006871A - 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos - Google Patents

4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos

Info

Publication number
ECSP15006871A
ECSP15006871A ECIEPI20156871A ECPI201506871A ECSP15006871A EC SP15006871 A ECSP15006871 A EC SP15006871A EC IEPI20156871 A ECIEPI20156871 A EC IEPI20156871A EC PI201506871 A ECPI201506871 A EC PI201506871A EC SP15006871 A ECSP15006871 A EC SP15006871A
Authority
EC
Ecuador
Prior art keywords
pentaaza
cyclopenta
methyl
naphthalenes
diseases
Prior art date
Application number
ECIEPI20156871A
Other languages
English (en)
Inventor
Barbara Bertani
Antonio Glustino Di
Hans Stange
Barbara Langen
Riccardo Giovannini
Ute Egerland
Christian Grunwald
Hans-Joachim Lankau
Sara Frattini
Norbert Hoefgen
Original Assignee
Gancia S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48906250&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP15006871(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gancia S P A filed Critical Gancia S P A
Publication of ECSP15006871A publication Critical patent/ECSP15006871A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a derivados de 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftaleno de la fórmula general (I) que son inhibidores de fosfodiesterasa 2 y/o 10, y que son útiles en el tratamiento de enfermedades del sistema nervioso central y otras enfermedades. En adición, la invención se refiere a procesos para preparar composiciones farmacéuticas así como también procesos para la elaboración de los compuestos de acuerdo con la invención.
ECIEPI20156871A 2012-07-31 2015-02-25 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos ECSP15006871A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12178713 2012-07-31

Publications (1)

Publication Number Publication Date
ECSP15006871A true ECSP15006871A (es) 2015-12-31

Family

ID=48906250

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI20156871A ECSP15006871A (es) 2012-07-31 2015-02-25 4-metil-2,3,5,9,9b-pentaaza-ciclopenta[a]naftalenos

Country Status (27)

Country Link
US (2) US20140045856A1 (es)
EP (1) EP2882749B1 (es)
JP (1) JP6356671B2 (es)
KR (1) KR20150037950A (es)
CN (1) CN104428302B (es)
AP (1) AP2015008202A0 (es)
AR (1) AR091939A1 (es)
AU (1) AU2013298621B2 (es)
BR (1) BR112015002118A2 (es)
CA (1) CA2880447A1 (es)
CL (1) CL2015000096A1 (es)
CO (1) CO7310531A2 (es)
EA (1) EA028958B1 (es)
EC (1) ECSP15006871A (es)
GE (1) GEP201706707B (es)
IL (1) IL236494A0 (es)
MA (1) MA37798B1 (es)
MX (1) MX2015000965A (es)
NZ (1) NZ703797A (es)
PE (1) PE20150706A1 (es)
PH (1) PH12015500211B1 (es)
SG (1) SG11201500772VA (es)
TN (1) TN2015000022A1 (es)
TW (1) TW201418255A (es)
UA (1) UA115561C2 (es)
UY (1) UY34955A (es)
WO (1) WO2014019979A1 (es)

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WO2016154081A1 (en) 2015-03-26 2016-09-29 Merck Sharp & Dohme Corp. Pyrazolyl pyrimidinone compounds as pde2 inhibitors
WO2016179059A1 (en) 2015-05-05 2016-11-10 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as pde2 inhibitors
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WO2016184313A1 (zh) * 2015-05-20 2016-11-24 南京明德新药研发股份有限公司 羟基嘌呤类化合物及其应用
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Also Published As

Publication number Publication date
UY34955A (es) 2014-01-31
KR20150037950A (ko) 2015-04-08
US20140045857A1 (en) 2014-02-13
MX2015000965A (es) 2015-04-10
TW201418255A (zh) 2014-05-16
WO2014019979A1 (en) 2014-02-06
EP2882749B1 (en) 2018-04-04
JP6356671B2 (ja) 2018-07-11
MA37798B1 (fr) 2018-11-30
CA2880447A1 (en) 2014-02-06
EA201500182A1 (ru) 2015-07-30
EP2882749A1 (en) 2015-06-17
PH12015500211A1 (en) 2015-03-16
PE20150706A1 (es) 2015-06-03
PH12015500211B1 (en) 2018-01-17
CN104428302A (zh) 2015-03-18
NZ703797A (en) 2017-09-29
BR112015002118A2 (pt) 2017-07-04
CL2015000096A1 (es) 2015-06-19
US20140045856A1 (en) 2014-02-13
CN104428302B (zh) 2017-03-22
AU2013298621B2 (en) 2017-12-21
UA115561C2 (uk) 2017-11-27
AR091939A1 (es) 2015-03-11
GEP201706707B (en) 2017-07-25
US9085584B2 (en) 2015-07-21
TN2015000022A1 (en) 2016-06-29
EA028958B1 (ru) 2018-01-31
SG11201500772VA (en) 2015-02-27
AP2015008202A0 (en) 2015-01-31
IL236494A0 (en) 2015-02-26
JP2015523406A (ja) 2015-08-13
CO7310531A2 (es) 2015-06-30
AU2013298621A1 (en) 2015-02-05
HK1208440A1 (en) 2016-03-04

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