ECSP15028696A - Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstos - Google Patents

Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstos

Info

Publication number
ECSP15028696A
ECSP15028696A ECIEPI201528696A ECPI201528696A ECSP15028696A EC SP15028696 A ECSP15028696 A EC SP15028696A EC IEPI201528696 A ECIEPI201528696 A EC IEPI201528696A EC PI201528696 A ECPI201528696 A EC PI201528696A EC SP15028696 A ECSP15028696 A EC SP15028696A
Authority
EC
Ecuador
Prior art keywords
lamp1
antibodies
cancer
gain
patient
Prior art date
Application number
ECIEPI201528696A
Other languages
English (en)
Inventor
Tarik Dabdoubi
Yves Baudat
Anne Marie Lefebvre
Francis Blanche
Manoel Nunes
Trigo Ana Merino
Magali Mathieu
Beatrice Cameron
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of ECSP15028696A publication Critical patent/ECSP15028696A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/68033—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a maytansine
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  • Chemical Kinetics & Catalysis (AREA)

Abstract

Se proporcionan anticuerpos que se unen específicamente a las proteínas proteína asociada a la membrana lisosomal 1 (LAMP1) humana y de Macaca fascicularis e inmunoconjugados que comprenden dichos anticuerpos conjugados o unidos a un agente inhibidor del crecimiento. También se proporcionan composiciones farmacéuticas que comprenden anticuerpos o inmunoconjugados de la invención y uso de los anticuerpos o inmunoconjugados para el tratamiento del cáncer., así como anticuerpos LAMP1, ácidos nucleicos aislados, vectores y células huésped que comprenden una secuencia que codifica dichos anticuerpos y el uso de dicho anticuerpo como una herramienta de diagnóstico. La solicitud proporciona además la detección de la amplificación o ganancia del gen LAMP1 en células cancerosas que da lugar a la determinación de si es probable que los pacientes con cáncer respondan a terapia anti-LAMP1. Por lo tanto, se propone un método in vitro para seleccionar pacientes con cáncer que comprende determinar, en una muestra biológica de un paciente con cáncer que incluye células cancerosas, si dicho paciente porta una ganancia en el número de copias del gen LAMP1; y seleccionar al paciente tomando como base la presencia de la ganancia en el número de copias del gen LAMP1. Además se proporciona un agente terapéutico anti-LAMP1 para uso para tratar cáncer en un paciente que porta una ganancia en el número de copias del gen LAMP1 en células cancerosas.
ECIEPI201528696A 2012-12-27 2015-07-03 Anticuerpos anti-lamp1 y conjugados anticuerpo fármaco, y usos de éstos ECSP15028696A (es)

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PCT/EP2013/078017 WO2014102299A2 (en) 2012-12-27 2013-12-26 Anti-lamp1 antibodies and antibody drug conjugates, and uses thereof

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AU2013369339B2 (en) 2018-11-15
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ZA201504538B (en) 2016-11-30
CN105007941A (zh) 2015-10-28
ES2871816T3 (es) 2021-11-02
TW201441260A (zh) 2014-11-01
EP3400961B1 (en) 2021-02-24
TN2015000291A1 (en) 2016-10-03
US20160280793A1 (en) 2016-09-29
WO2014102299A2 (en) 2014-07-03
EP2938358A2 (en) 2015-11-04
EA201591219A1 (ru) 2015-12-30
UY35250A (es) 2014-07-31
CL2015001849A1 (es) 2016-01-08
PH12015501467A1 (en) 2015-09-21
KR20150100848A (ko) 2015-09-02
US20180142032A1 (en) 2018-05-24
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IL239578A0 (en) 2015-08-31
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AU2013369339A1 (en) 2015-07-16
PE20151603A1 (es) 2015-11-20
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