ATE340590T1 - Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper - Google Patents

Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper

Info

Publication number
ATE340590T1
ATE340590T1 AT95925116T AT95925116T ATE340590T1 AT E340590 T1 ATE340590 T1 AT E340590T1 AT 95925116 T AT95925116 T AT 95925116T AT 95925116 T AT95925116 T AT 95925116T AT E340590 T1 ATE340590 T1 AT E340590T1
Authority
AT
Austria
Prior art keywords
human
chain
reconstituted
directed against
antibody directed
Prior art date
Application number
AT95925116T
Other languages
English (en)
Inventor
Kouji Matsushima
Yoshihiro Matsumoto
Yoshiki Yamada
Koh Sato
Masayuki Tsuchiya
Tatsumi Yamazaki
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE340590T1 publication Critical patent/ATE340590T1/de

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT95925116T 1994-07-13 1995-07-12 Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper ATE340590T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP16148194 1994-07-13
JP28995194 1994-11-24
JP31078594 1994-12-14

Publications (1)

Publication Number Publication Date
ATE340590T1 true ATE340590T1 (de) 2006-10-15

Family

ID=27321865

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95925116T ATE340590T1 (de) 1994-07-13 1995-07-12 Gegen menschliches interleukin-8 gerichteter, rekonstituierter menschlicher antikörper

Country Status (10)

Country Link
US (3) US5994524A (de)
EP (1) EP0770628B9 (de)
KR (1) KR100261941B1 (de)
AT (1) ATE340590T1 (de)
AU (1) AU701342B2 (de)
CA (1) CA2194907A1 (de)
DE (1) DE69535243T2 (de)
HU (1) HU221385B1 (de)
WO (1) WO1996002576A1 (de)
ZA (1) ZA955832B (de)

Families Citing this family (394)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
US7041871B1 (en) 1995-10-10 2006-05-09 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
CA2181787A1 (en) * 1994-03-03 1995-09-08 Claire M. Doerschuk Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
WO1997039772A1 (fr) * 1996-04-19 1997-10-30 Chugai Seiyaku Kabushiki Kaisha Remede contre l'arthrite rhumatoide contenant un anticorps anti-il-8 comme principe actif
WO1997040215A1 (fr) * 1996-04-23 1997-10-30 Chugai Seiyaku Kabushiki Kaisha Medicament contre l'infarctus du myocarde contenant comme principe actif un anticorps anti-il-8
EP1854481B1 (de) 1996-04-23 2014-07-16 Chugai Seiyaku Kabushiki Kaisha Präventivum oder Wirkstoff gegen Hirnschlag/cerebrales Ödem, mit il-8 Inhibitor als aktivem Inhaltsstoff
WO1997049426A1 (fr) * 1996-06-26 1997-12-31 Chugai Seiyaku Kabushiki Kaisha Medicaments destines aux lesions pulmonaires aigues dues a des causes indirectes, contenant un anticorps anti-il-8 comme principe actif
CA2268085A1 (en) * 1996-10-22 1998-04-30 Go Wakabayashi Sepsis remedy comprising anti-il-8 antibody as active ingredient
US7122636B1 (en) 1997-02-21 2006-10-17 Genentech, Inc. Antibody fragment-polymer conjugates and uses of same
US6133426A (en) * 1997-02-21 2000-10-17 Genentech, Inc. Humanized anti-IL-8 monoclonal antibodies
DK0968291T3 (da) 1997-02-21 2004-06-07 Genentech Inc Antistoffragment-polymerkonjugater
US6025158A (en) * 1997-02-21 2000-02-15 Genentech, Inc. Nucleic acids encoding humanized anti-IL-8 monoclonal antibodies
EP2011514B1 (de) 1997-03-21 2012-02-29 Chugai Seiyaku Kabushiki Kaisha Präventives oder therapeutisches Mittel mit einem IL-6-Antagonisten als Wirkstoff für durch sensibilisierte T-Zellen vermittelte Erkrankungen
CA2308007C (en) 1997-10-14 2011-05-17 Chugai Seiyaku Kabushiki Kaisha Enhancer for antibody to lymphocytic tumors
AU2559799A (en) * 1998-01-22 1999-08-09 Genentech Inc. Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies and uses of same
US6468532B1 (en) 1998-01-22 2002-10-22 Genentech, Inc. Methods of treating inflammatory diseases with anti-IL-8 antibody fragment-polymer conjugates
US6458355B1 (en) 1998-01-22 2002-10-01 Genentech, Inc. Methods of treating inflammatory disease with anti-IL-8 antibody fragment-polymer conjugates
US7005504B2 (en) 1998-01-22 2006-02-28 Genentech, Inc. Antibody fragment-peg conjugates
EP1105427A2 (de) * 1998-08-17 2001-06-13 Abgenix, Inc. Herstellung von modifizierten molekülen mit mit erhöhten halbwertszeiten
JP4228111B2 (ja) * 1998-08-24 2009-02-25 メディカル セラピーズ リミテッド 動脈硬化およびptca術後の血管再狭窄に対する予防・治療剤
WO2001013940A1 (en) 1999-08-23 2001-03-01 Chugai Seiyaku Kabushiki Kaisha Hm1.24 antigen expression potentiators
ATE498305T1 (de) 1999-10-01 2011-03-15 Chugai Pharmaceutical Co Ltd Vermeidung und behandlung von krankheiten, die mit der blutgerinnung in zusammenhang stehen
US8029793B2 (en) 2000-04-28 2011-10-04 Chugai Seiyaku Kabushiki Kaisha Methods for inhibiting cell proliferation
AU2001278742A1 (en) 2000-08-16 2002-02-25 Chugai Seiyaku Kabushiki Kaisha Agents for ameliorating symptoms caused by joint diseases
CA2430013C (en) 2000-11-30 2011-11-22 Medarex, Inc. Transgenic transchromosomal rodents for making human antibodies
WO2002052005A1 (fr) 2000-12-22 2002-07-04 Kazusa Dna Research Institute Foundation Genes et proteines codees par ceux-ci
US7931897B2 (en) 2001-02-07 2011-04-26 Chugai Seiyaku Kabushiki Kaisha Therapeutic agent for hematopoietic tumors
KR100583331B1 (ko) 2001-05-11 2006-05-26 기린 비루 가부시키가이샤 인간 항체 λ 경쇄 유전자를 포함하는 인간 인공 염색체 및 자손 전달 가능한 상기 인간 인공 염색체를 포함하는 비인간 동물
KR100453877B1 (ko) 2001-07-26 2004-10-20 메덱스젠 주식회사 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 TNFR/Fc 융합 단백질, 상기 단백질을 코딩하는 DNA, 상기 DNA를 포함하는벡터, 및 상기 벡터에 의한 형질전환체
PT1475101E (pt) 2002-02-14 2010-12-22 Chugai Pharmaceutical Co Ltd Fármacos em solução contendo anticorpos
US20070037769A1 (en) * 2003-03-14 2007-02-15 Multicell Immunotherapeutics, Inc. Compositions and methods to treat and control tumors by loading antigen presenting cells
JP2005526778A (ja) * 2002-03-15 2005-09-08 アストラル,インコーポレイテッド 免疫調節性非コードrnaモチーフを用いて抗体及び主要組織適合性クラスi拘束性又はクラスii拘束性t細胞の応答を開始或いは増強させるための組成物及び方法
EP2258712A3 (de) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Zusammensetzungen und Verfahren zur Einleitung bzw. Verstärkung von Antikörper- und Haupthistokompatibilität-Klasse-I- oder-Klasse-II-beschränkten T-Zell-Reaktionen unter Anwendung von Immunmodulierenden, nicht-codierenden RNA-Motiven
AU2003239966B9 (en) * 2002-06-03 2010-08-26 Genentech, Inc. Synthetic antibody phage libraries
WO2004019966A1 (ja) 2002-08-27 2004-03-11 Chugai Seiyaku Kabushiki Kaisha タンパク質溶液製剤の安定化方法
WO2004022595A1 (ja) 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha MRL/lprマウスを用いた抗体の作製
DK1561756T3 (en) 2002-09-11 2016-02-15 Chugai Pharmaceutical Co Ltd PROCEDURE FOR CLEANING PROTEIN.
EP1590364B1 (de) 2002-12-16 2011-10-05 Genmab A/S Humane monoklonale antikörper gegen interleukin 8 (il-8)
AU2004225480A1 (en) * 2003-03-26 2004-10-14 Multicell Immunotherapeutics, Inc. Selected RNA motifs to include cell death and/or apoptosis
JPWO2005017155A1 (ja) 2003-06-18 2006-10-12 中外製薬株式会社 フコーストランスポーター
CA2534055A1 (en) * 2003-08-01 2005-02-10 Genentech, Inc. Antibody cdr polypeptide sequences with restricted diversity
EP1652923B1 (de) 2003-08-08 2011-10-12 Perseus Proteomics Inc. Bei krebs überexprimiertes gen
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
WO2005035753A1 (ja) 2003-10-10 2005-04-21 Chugai Seiyaku Kabushiki Kaisha 機能蛋白質を代替する二重特異性抗体
US20080075712A1 (en) 2003-10-14 2008-03-27 Kunihiro Hattori Double Specific Antibodies Substituting For Functional Proteins
FI122368B (fi) * 2003-11-06 2011-12-30 Valtion Teknillinen Menetelmä huokoisen muovikalvon valmistamiseksi ja muovikalvo
CN101133083A (zh) 2003-11-11 2008-02-27 中外制药株式会社 人源化的抗cd47抗体
US9228008B2 (en) 2004-05-28 2016-01-05 Idexx Laboratories, Inc. Canine anti-CD20 antibodies
NZ579543A (en) 2004-07-09 2011-07-29 Chugai Pharmaceutical Co Ltd Anti-glypican 3 antibody
EP1829961A4 (de) 2004-12-22 2008-06-04 Chugai Pharmaceutical Co Ltd Verfahren zur herstellung eines antikörpers unter verwendung einer zelle mit gehemmter fucosetransporterfunktion
KR101564713B1 (ko) 2004-12-28 2015-11-06 이나뜨 파르마 Nkg2a에 대한 단클론 항체
TWI544076B (zh) 2005-03-31 2016-08-01 中外製藥股份有限公司 A method of manufacturing a polypeptide that controls assembly
ES2494921T3 (es) 2005-04-08 2014-09-16 Chugai Seiyaku Kabushiki Kaisha Anticuerpo que sustituye la función del factor VIII de coagulación sanguínea
CA2610987C (en) 2005-06-10 2013-09-10 Chugai Seiyaku Kabushiki Kaisha Stabilizer for protein preparation comprising meglumine and use thereof
US20090028854A1 (en) 2005-06-10 2009-01-29 Chugai Seiyaku Kabushiki Kaisha sc(Fv)2 SITE-DIRECTED MUTANT
JPWO2007046439A1 (ja) 2005-10-18 2009-04-23 独立行政法人農業生物資源研究所 抗体を産生するトランスジェニックカイコとその製造方法
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
EP2465870A1 (de) 2005-11-07 2012-06-20 Genentech, Inc. Bindepolypeptide mit verschiedenartigen und übereinstimmenden hypervariablen VH/VL-Sequenzen
EP1973951A2 (de) * 2005-12-02 2008-10-01 Genentech, Inc. Bindende polypeptide mit eingeschränkten diversitätssequenzen
US9084777B2 (en) 2005-12-28 2015-07-21 Chugai Seiyaku Kabushiki Kaisha Stabilized antibody-containing formulations
CA2647846C (en) 2006-03-31 2016-06-21 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
JP5144499B2 (ja) 2006-03-31 2013-02-13 中外製薬株式会社 二重特異性抗体を精製するための抗体改変方法
CA2638774C (en) 2006-03-31 2015-11-24 Medarex, Inc. Transgenic animals expressing chimeric antibodies for use in preparing human antibodies
EP2011513B1 (de) 2006-04-25 2016-10-19 The University of Tokyo Therapeutische mittel gegen alzheimer-krankheit und krebs
WO2007137300A2 (en) 2006-05-23 2007-11-29 Bellicum Pharmaceuticals, Inc. Modified dendritic cells having enhanced survival and immunogenicity and related compositions and methods
CN103272232B (zh) 2006-06-08 2018-07-24 中外制药株式会社 炎性疾病的预防或治疗药
MX2008015975A (es) 2006-06-14 2009-03-26 Chugai Pharmaceutical Co Ltd Agentes para promocionar el crecimiento de celulas de vastago hematopoyeticas.
CA2655289C (en) 2006-06-21 2016-08-23 Oncotherapy Science, Inc. Tumor-targeting monoclonal antibodies to fzd10 and uses thereof
RU2499001C2 (ru) 2006-06-30 2013-11-20 Ново Нордиск А/С Антитела к nkg2a и их применения
AU2007273507A1 (en) 2006-07-13 2008-01-17 Chugai Seiyaku Kabushiki Kaisha Cell death inducer
JP5175729B2 (ja) 2006-07-21 2013-04-03 中外製薬株式会社 腎疾患治療剤
ATE465179T1 (de) 2006-07-24 2010-05-15 Pasteur Institut Antikörper, antikörperfragmente und scfv die an posttranslational modifizierte neurotrophine binden
CA2658050A1 (en) 2006-08-14 2008-02-21 Forerunner Pharma Research Co., Ltd. Diagnosis and treatment of cancer using anti-desmoglein 3 antibodies
US9017684B2 (en) 2006-10-12 2015-04-28 Chugai Seiyaku Kabushiki Kaisha Diagnosis and treatment of cancer using anti-EREG antibody
JP5676849B2 (ja) 2006-10-20 2015-02-25 中外製薬株式会社 抗hb−egf抗体を有効成分として含む癌治療剤
CA2666559A1 (en) 2006-10-20 2008-04-24 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient
WO2008072723A1 (ja) 2006-12-14 2008-06-19 Forerunner Pharma Research Co., Ltd. 抗Claudin3モノクローナル抗体およびそれを用いる癌の治療および診断
EP2123676A4 (de) 2007-01-05 2011-01-05 Univ Tokyo Diagnose und behandlung von krebs unter verwendung von anti-prg-3-antikörpern
WO2008093688A1 (ja) 2007-01-30 2008-08-07 Forerunner Pharma Research Co., Ltd. キメラFcγレセプター及び該レセプターを用いたADCC活性測定方法
US8192740B2 (en) 2007-02-27 2012-06-05 Forerunner Pharma Research Co., Ltd. Pharmaceutical composition comprising anti-GRP78 antibody as active ingredient
CL2008000719A1 (es) 2007-03-12 2008-09-05 Univ Tokushima Chugai Seiyaku Agente terapeutico para cancer resistente a agentes quimioterapeuticos que comprende un anticuerpo que reconoce hla de clase i como ingrediente activo; composicion farmaceutica que comprende dicho anticuerpo; y metodo para tratar cancer resistente a
JP5117765B2 (ja) * 2007-05-28 2013-01-16 国立大学法人 東京大学 抗robo1抗体を含むpet用腫瘍診断剤
US8097422B2 (en) 2007-06-20 2012-01-17 Salk Institute For Biological Studies Kir channel modulators
US8722858B2 (en) 2007-06-25 2014-05-13 Chugai Seiyaku Kabushiki Kaisha Anti-Prominin-1 antibody having ADCC activity or CDC activity
US8536313B2 (en) 2007-07-10 2013-09-17 Shionogi & Co., Ltd. Monoclonal antibody having neutralizing activity against MMP13
RU2510400C9 (ru) 2007-09-26 2014-07-20 Чугаи Сейяку Кабусики Кайся Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr
EP2617736A1 (de) 2007-09-28 2013-07-24 Chugai Seiyaku Kabushiki Kaisha Anti-Glypican-3-Antikörper mit verbesserter Kinetik in Plasma
BRPI0818674B1 (pt) 2007-10-15 2023-01-17 Chugai Seiyaku Kabushiki Kaisha Métodos para produção de um anticorpo inteiro ou de um fragmento do mesmo e para preparação de fármacos, bem como vetor recombinante
WO2009063970A1 (ja) 2007-11-14 2009-05-22 Forerunner Pharma Research Co., Ltd. 抗gpr49抗体を用いる癌の診断および治療
BRPI0820543A2 (pt) 2007-11-15 2015-06-16 Chugai Pharmaceutical Co Ltd Anticorpo monoclonal capaz de ligar a anexelekto, e uso do mesmo
TWI548418B (zh) 2007-12-05 2016-09-11 中外製藥股份有限公司 Anti-NR10 / IL-31RA antibody and its use
CN101939025B (zh) 2007-12-05 2015-03-25 中外制药株式会社 搔痒症治疗药
PE20091174A1 (es) 2007-12-27 2009-08-03 Chugai Pharmaceutical Co Ltd Formulacion liquida con contenido de alta concentracion de anticuerpo
CN101918450A (zh) 2008-01-11 2010-12-15 国立大学法人东京大学 抗cldn6抗体
JP5774312B2 (ja) * 2008-01-24 2015-09-09 ノボ・ノルデイスク・エー/エス ヒト化抗ヒトnkg2aモノクローナル抗体
HUE032025T2 (en) 2008-01-31 2017-08-28 Inserm - Inst Nat De La Sante Et De La Rech Medicale Antibodies to human CD39 and their use to inhibit regulatory T cell activity
CL2009000647A1 (es) 2008-04-04 2010-06-04 Chugai Pharmaceutical Co Ltd Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.
TW201920257A (zh) 2008-04-11 2019-06-01 日商中外製藥股份有限公司 重複結合複數個抗原的抗原結合分子
EP2116261A1 (de) 2008-05-07 2009-11-11 Institut Pasteur Unterbereich eines Plasmodium-Proteins mit verbessertem Impfstoff-Potenzial und medizinische Verwendungen davon
US9226934B2 (en) 2008-06-02 2016-01-05 The University Of Tokyo Anti-cancer drug
PT2305300E (pt) 2008-07-10 2016-06-16 Toray Industries Composição farmacêutica para o tratamento e prevenção do cancro
BRPI0911926A2 (pt) 2008-08-05 2020-08-18 Toray Industries, Inc composições farmacêuticas, anticorpos e usos de um anticorpo ou um fragmento do mesmo.
EP2343087B1 (de) 2008-09-30 2018-07-18 Oriental Yeast Co., Ltd. Neuartiger induktor für chondrozytenproliferation und differenzierungs
WO2010040766A1 (en) 2008-10-07 2010-04-15 INSERM (Institut National de la Santé et de la Recherche Médicale) Neutralizing antibodies and fragments thereof directed against platelet factor-4 variant 1 (pf4v1)
US20110287036A1 (en) 2008-11-17 2011-11-24 Riken Novel cancer targeting therapy using complex of subtance capable of binding specifically to constituent factor of cancer stroma and anti-tumor compound
WO2010074049A1 (ja) 2008-12-22 2010-07-01 株式会社 未来創薬研究所 抗hs6st2抗体及びその用途
JP6009733B2 (ja) 2008-12-25 2016-10-19 国立大学法人 東京大学 抗tm4sf20抗体を用いた癌の診断と治療
KR20110099762A (ko) 2008-12-26 2011-09-08 고쿠리츠다이가쿠호우진 도쿄다이가쿠 항lgr7항체를 사용하는 암의 진단 및 치료
US8940501B2 (en) 2009-01-30 2015-01-27 Whitehead Institute For Biomedical Research Methods for ligation and uses thereof
JP2010210772A (ja) 2009-03-13 2010-09-24 Dainippon Screen Mfg Co Ltd 液晶表示装置の製造方法
EP3002296B1 (de) 2009-03-17 2020-04-29 Université d'Aix-Marseille Btla-antikörper und ihre verwendung
AU2010231575B2 (en) 2009-03-30 2013-09-12 Edimer Biotech S.A. Preparation of isolated agonist anti-EDAR monoclonal antibodies
EP2420515A4 (de) 2009-04-16 2013-08-28 Univ Tokyo Diagnose und behandlung von krebs mit anti-tmprss11e-antikörper
KR20120051603A (ko) 2009-05-01 2012-05-22 고쿠리츠다이가쿠호징 도쿄다이가쿠 항카드헤린 항체
TW201041595A (en) 2009-05-15 2010-12-01 Chugai Pharmaceutical Co Ltd Anti-axl antibody
WO2010137654A1 (ja) 2009-05-29 2010-12-02 株式会社未来創薬研究所 Egfファミリーリガンドのアンタゴニストを成分とする医薬組成物
WO2011021381A1 (ja) 2009-08-17 2011-02-24 株式会社未来創薬研究所 抗hb-egf抗体を有効成分として含む医薬組成物
TW201118166A (en) 2009-09-24 2011-06-01 Chugai Pharmaceutical Co Ltd HLA class I-recognizing antibodies
ES2701626T3 (es) 2009-12-28 2019-02-25 Oncotherapy Science Inc Anticuerpos anti-CDH3 y sus usos
TWI505838B (zh) 2010-01-20 2015-11-01 中外製藥股份有限公司 Stabilized antibody solution containing
EP2530109A4 (de) 2010-01-29 2013-08-28 Toray Industries Harzfolie auf polymilchsäurebasis
RS62387B1 (sr) 2010-01-29 2021-10-29 Chugai Pharmaceutical Co Ltd Anti-dll3 antitelo
JP5906739B2 (ja) 2010-02-04 2016-04-20 東レ株式会社 癌の治療及び/又は予防用医薬組成物
JP5845899B2 (ja) 2010-02-04 2016-01-20 東レ株式会社 癌の治療及び/又は予防用医薬組成物
KR101801667B1 (ko) 2010-02-04 2017-11-27 도레이 카부시키가이샤 암의 치료 및/또는 예방용 의약 조성물
BR112012018948B1 (pt) 2010-02-04 2021-12-14 Toray Industries, Inc Composições farmacêuticas, anticorpos, combinação farmacêutica, usos de uma composição farmacêutica, uso de um anticorpo e uso de uma combinação farmacêutica
EP2532365B1 (de) 2010-02-04 2016-05-04 Toray Industries, Inc. Pharmazeutische zusammensetzung zur behandlung und/oder prävention von krebs
EP2535358B1 (de) 2010-02-10 2017-12-20 Fujifilm RI Pharma Co., Ltd. Mit einem radioaktiven metall gekennzeichneter antikörper gegen cadherin
JPWO2011105573A1 (ja) 2010-02-26 2013-06-20 株式会社 未来創薬研究所 抗icam3抗体およびその用途
EP2543730B1 (de) 2010-03-04 2018-10-31 Chugai Seiyaku Kabushiki Kaisha Variante einer konstanten antikörperregion
TWI667346B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的FcRn親和力之抗體
EP2796563A1 (de) 2010-05-04 2014-10-29 MedImmune, LLC Optimierte Diagnose und Behandlung von Muskelabbauerkrankungen
WO2011145085A2 (en) 2010-05-21 2011-11-24 Procognia (Israel) Ltd Novel antibodies and methods of use for the treatment and diagnosis of cancer
US9485812B2 (en) 2010-07-08 2016-11-01 Honda Motor Co., Ltd. High frequency heating coil
EP2596025B1 (de) 2010-07-23 2018-06-20 INSERM (Institut National de la Santé et de la Recherche Médicale) Gegen co-029 gerichtete krebstherapieverfahren
WO2012043747A1 (ja) 2010-09-30 2012-04-05 独立行政法人理化学研究所 グリオーマの治療方法、グリオーマの検査方法、所望の物質をグリオーマに送達させる方法、及びそれらの方法に用いられる薬剤
AU2011323784A1 (en) 2010-10-25 2013-05-30 Regents Of The University Of Minnesota Therapeutic composition for treatment of glioblastoma
HRP20181438T1 (hr) 2010-10-29 2018-11-16 Perseus Proteomics Inc. Protutijelo protiv cdh3 s visokom sposobnošću internaliziranja
KR101398290B1 (ko) 2010-11-17 2014-05-22 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
MX349057B (es) 2010-11-30 2017-07-07 Chugai Pharmaceutical Co Ltd Agente terapeutico que induce citotoxicidad.
SG10201509790YA (en) 2010-11-30 2015-12-30 Chugai Pharmaceutical Co Ltd Antigen-Binding Molecule Capable Of Binding To Plurality Of Antigen Molecules Repeatedly
WO2012080769A1 (en) 2010-12-15 2012-06-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-cd277 antibodies and uses thereof
ES2684602T3 (es) 2010-12-22 2018-10-03 Orega Biotech Anticuerpos contra CD39 humano y uso de los mismos
US9085772B2 (en) 2010-12-27 2015-07-21 National University Corporation Nagoya University Method for suppressing receptor tyrosine kinase-mediated pro-survival signaling in cancer cell
US20140080153A1 (en) 2011-01-07 2014-03-20 Chugai Seiyaku Kabushiki Kaisha Method for improving physical properties of antibody
WO2012101125A1 (en) 2011-01-24 2012-08-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Specific antibodies against human cxcl4 and uses thereof
EP2487242A1 (de) 2011-02-09 2012-08-15 Ruprecht-Karls-Universität Heidelberg B-Plexin-Antagonisten und Verwendungen davon
WO2012133782A1 (ja) 2011-03-30 2012-10-04 中外製薬株式会社 抗原結合分子の血漿中滞留性と免疫原性を改変する方法
SG10201609665PA (en) 2011-02-25 2017-01-27 Chugai Pharmaceutical Co Ltd FcɣRIIb-SPECIFIC Fc ANTIBODY
US9376493B2 (en) 2011-03-31 2016-06-28 INSERM (Institut National de la Sante et de la Recherche Mediacale) Antibodies directed against ICOS and uses thereof
US20140030276A1 (en) 2011-03-31 2014-01-30 Oriental Yeast Co., Ltd. Cancer immunopotentiating agent containing rankl antagonist
MX356426B (es) 2011-04-04 2018-05-29 Univ Iowa Res Found Metodos para mejorar inmunogenicidad de vacuna.
EP2697394A4 (de) 2011-04-12 2015-01-14 Electronic Biosciences Inc Ortsspezifische chemisch modifizierte nanoporenvorrichtungen
WO2012144208A1 (ja) 2011-04-18 2012-10-26 国立大学法人東京大学 抗itm2a抗体を用いる癌の診断および治療
CN103890010B (zh) 2011-05-19 2017-04-19 法国国家健康医学研究院 抗‑人‑her3抗体及其用途
CN103635487B (zh) 2011-06-17 2016-10-12 诺沃—诺迪斯克有限公司 选择性消除侵蚀性细胞
EP2723377B1 (de) 2011-06-22 2018-06-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-axl-antikörper und verwendungen damit
AU2012273954A1 (en) 2011-06-22 2014-01-09 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-Axl antibodies and uses thereof
RU2641256C2 (ru) 2011-06-30 2018-01-16 Чугаи Сейяку Кабусики Кайся Гетеродимеризованный полипептид
EP2543678A1 (de) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur Behandlung und Vorbeugung von Thrombose
EP2543679A1 (de) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur Behandlung und Vorbeugung von Thrombose
EP2543677A1 (de) 2011-07-08 2013-01-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper zur Behandlung und Vorbeugung von Thrombose
EP2735315B1 (de) 2011-07-19 2019-10-02 Chugai Seiyaku Kabushiki Kaisha Proteinhaltige stabile zubereitung mit argininamid oder valinamid
WO2013017656A1 (en) 2011-08-02 2013-02-07 Medizinische Universität Wien Antagonists of ribonucleases for treating obesity
WO2013017691A1 (en) 2011-08-04 2013-02-07 Medizinische Universität Innsbruck Cahgt1p inhibitors for use in the treatment of candidiasis
WO2013018891A1 (ja) 2011-08-04 2013-02-07 東レ株式会社 癌の治療及び/又は予防用医薬組成物
AU2012290952B2 (en) 2011-08-04 2016-05-05 Toray Industries, Inc. Cancer treatment and/or prevention drug composition
CN103717737B (zh) 2011-08-04 2015-06-10 东丽株式会社 癌的治疗和/或预防用药物组合物
US20140242085A1 (en) 2011-08-12 2014-08-28 Medical & Biological Laboratories Co., Ltd. Methods and composition for testing, preventing, and treating aspergillus fumigatus infection
WO2013027802A1 (ja) 2011-08-23 2013-02-28 中外製薬株式会社 抗腫瘍活性を有する新規な抗ddr1抗体
WO2013035824A1 (ja) 2011-09-07 2013-03-14 ファーマロジカルズ・リサーチ プライベート リミテッド 癌幹細胞の分離
SG11201401100UA (en) 2011-09-30 2014-07-30 Chugai Pharmaceutical Co Ltd Antigen-binding molecule inducing immune response to target antigen
AU2012313594C1 (en) 2011-09-30 2018-05-10 Chugai Seiyaku Kabushiki Kaisha Ion concentration-dependent binding molecule library
JP6322411B2 (ja) 2011-09-30 2018-05-09 中外製薬株式会社 複数の生理活性を有する抗原の消失を促進する抗原結合分子
TW201817745A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之FcRn結合域的治療性抗原結合分子
US20140335089A1 (en) 2011-09-30 2014-11-13 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting elimination of antigens
US20150299313A1 (en) 2011-10-05 2015-10-22 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule for promoting clearance from plasma of antigen comprising suger chain receptor-binding domain
EP2772268B8 (de) 2011-10-28 2020-01-08 Chugai Seiyaku Kabushiki Kaisha Krebsstammzellenspezifisches molekül
MX359775B (es) 2011-10-31 2018-10-10 Chugai Pharmaceutical Co Ltd Molecula enlazada al antigeno que tiene conjugacion regulada entre cadena ligera y cadena pesada.
CN113416257A (zh) 2011-11-30 2021-09-21 中外制药株式会社 包含进入细胞内以形成免疫复合体的搬运体(载体)的药物
TWI593705B (zh) 2011-12-28 2017-08-01 Chugai Pharmaceutical Co Ltd Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient
US9512212B2 (en) 2012-01-11 2016-12-06 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Bispecific antibody fragments for neurological disease proteins and methods of use
CN104204204A (zh) 2012-02-09 2014-12-10 中外制药株式会社 抗体的Fc区变异体
US9573993B2 (en) 2012-02-21 2017-02-21 Toray Industries, Inc. Pharmaceutical composition for treatment of cancer comprising an anti-CAPRIN-1 peptide antibody
RU2632645C2 (ru) 2012-02-21 2017-10-06 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или профилактики рака
DK2824114T3 (da) 2012-02-21 2019-07-29 Toray Industries Farmaceutisk sammensætning til behandling af cancer
AU2013223137B2 (en) 2012-02-21 2017-10-19 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of cancer
KR102219987B1 (ko) 2012-02-24 2021-02-25 추가이 세이야쿠 가부시키가이샤 FcγRIIB를 매개로 항원의 소실을 촉진하는 항원 결합 분자
WO2013147153A1 (ja) 2012-03-29 2013-10-03 株式会社未来創薬研究所 抗lamp5抗体およびその利用
US9428581B2 (en) 2012-03-30 2016-08-30 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of gallbladder cancer
RU2640245C2 (ru) 2012-03-30 2017-12-27 Торэй Индастриз, Инк. Фармацевтическая композиция для лечения и/или предотвращения рака печени
WO2013150623A1 (ja) 2012-04-04 2013-10-10 株式会社ペルセウスプロテオミクス 抗cdh3(p-カドヘリン)抗体の薬剤コンジュゲート
WO2013161814A1 (ja) 2012-04-23 2013-10-31 ジーンフロンティア株式会社 抗ヒトcd69抗体、及びその医薬用途
WO2013168820A1 (ja) 2012-05-11 2013-11-14 公益財団法人微生物化学研究会 抗cxadr抗体
EP2857419B1 (de) 2012-05-30 2021-01-13 Chugai Seiyaku Kabushiki Kaisha Antigenbindende moleküle zur beseitigung von aggregierten antigenen
CN104487457B (zh) 2012-05-30 2018-01-26 中外制药株式会社 靶组织特异性抗原结合分子
EP2862875B1 (de) 2012-06-14 2023-09-06 Chugai Seiyaku Kabushiki Kaisha Antigenbindendes molekül mit modifizierter fc-region
EP2861998B1 (de) 2012-06-18 2020-07-22 Electronic Biosciences Inc. Zellfreie testvorrichtung und verfahren zur verwendung
WO2014001368A1 (en) 2012-06-25 2014-01-03 Orega Biotech Il-17 antagonist antibodies
US9840552B2 (en) 2012-07-30 2017-12-12 National University Corporation Nagoya University Monoclonal antibody against human midkine
US11236168B2 (en) 2012-08-24 2022-02-01 Chugai Seiyaku Kabushiki Kaisha Mouse FcγammaRII-specific Fc antibody
TWI717591B (zh) 2012-08-24 2021-02-01 日商中外製藥股份有限公司 FcγRIIb特異性Fc區域變異體
WO2014033327A1 (en) 2012-09-03 2014-03-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies directed against icos for treating graft-versus-host disease
WO2014042251A1 (ja) 2012-09-13 2014-03-20 中外製薬株式会社 遺伝子ノックイン非ヒト動物
CN107501413A (zh) 2012-09-27 2017-12-22 中外制药株式会社 Fgfr3融合基因和以其作为标靶的药物
ES2668455T3 (es) 2012-09-28 2018-05-18 Chugai Seiyaku Kabushiki Kaisha Método para evaluar la reacción de coagulación sanguínea
US9845364B2 (en) 2012-11-09 2017-12-19 Genefrontier Corporation Anti-ADAM28 antibody for treating cancer
EP2733153A1 (de) 2012-11-15 2014-05-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur Herstellung von Immunkonjugaten und Verwendungen davon
CN109180815B (zh) 2012-11-20 2022-06-21 赛诺菲 抗ceacam5抗体及其用途
JP6433297B2 (ja) 2012-12-27 2018-12-05 中外製薬株式会社 ヘテロ二量化ポリペプチド
EP3400961B1 (de) 2012-12-27 2021-02-24 Sanofi Anti-lamp1 antikörper und antikörper-konjugate und deren verwendung
US9932396B2 (en) 2013-02-08 2018-04-03 Medical & Biological Laboratories Co., Ltd. Antibody against human NRG1 protein
BR112015019328A2 (pt) 2013-02-15 2017-08-22 Perseus Proteomics Inc Anticorpo anti-cdh3 humanizado, conjugado do fármaco do anticorpo anti-cdh3 humanizado, e seu uso
JP6490574B2 (ja) 2013-02-28 2019-03-27 国立研究開発法人国立がん研究センター 不溶性フィブリンに対する抗体
TWI636062B (zh) 2013-04-02 2018-09-21 中外製藥股份有限公司 Fc region variant
WO2014174596A1 (ja) 2013-04-23 2014-10-30 株式会社医学生物学研究所 ヘパリン結合上皮増殖因子様増殖因子に対する機能性モノクローナル抗体
EP3168233A3 (de) 2013-05-16 2017-07-26 Kyoto University Verfahren zur bestimmung der prognose von krebs
US10005839B2 (en) 2013-05-17 2018-06-26 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antagonist of the BTLA/HVEM interaction for use in therapy
KR20160022354A (ko) 2013-06-24 2016-02-29 추가이 세이야쿠 가부시키가이샤 인간화 항에피레귤린 항체를 유효성분으로서 포함하는 선암 이외의 비소세포폐암의 치료제
DK3031826T3 (en) 2013-08-09 2018-12-17 Toray Industries Pharmaceutical composition for the treatment and / or prevention of cancer
WO2015041310A1 (ja) 2013-09-20 2015-03-26 中外製薬株式会社 抗プロテインc抗体による出血性疾患の治療
AU2014325063B2 (en) 2013-09-27 2019-10-31 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
PL3057992T3 (pl) 2013-10-15 2024-08-26 Genefrontier Corporation Przeciwciało ludzkie przeciwko gatunkom ADAMTS typu agrekanazy do leczenia chorób związanych z agrekanazą
JPWO2015068781A1 (ja) 2013-11-06 2017-03-09 国立大学法人大阪大学 インフルエンザウイルスa型のグループ1に対して広域な中和活性を有する抗体
US10196455B2 (en) 2013-11-07 2019-02-05 Inserm (Institut National De La Sante Et De La Recherche Medicale) Neuregulin allosteric anti-HER3 antibody
US20160280787A1 (en) 2013-11-11 2016-09-29 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule containing modified antibody variable region
EP3078744B1 (de) 2013-12-04 2020-08-26 Chugai Seiyaku Kabushiki Kaisha Antigenbindende moleküle mit variierender antigenbindender aktivität je nach der konzentration von verbindungen und bibliotheken solcher moleküle
CN105849562B (zh) 2013-12-24 2019-08-16 中外制药株式会社 可溶性gpc3蛋白质的测定方法
WO2015099165A1 (ja) 2013-12-27 2015-07-02 中外製薬株式会社 等電点の低い抗体の精製方法
TW201609093A (zh) 2013-12-27 2016-03-16 中外製藥股份有限公司 Fgfr門控蛋白變異基因及以其爲標的之醫藥
RU2016137179A (ru) 2014-03-31 2018-05-07 Дебиофарм Интернэшнл Са Гибридные белки fgfr
WO2015158851A1 (en) 2014-04-16 2015-10-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies for the prevention or the treatment of bleeding episodes
TWI831106B (zh) 2014-06-20 2024-02-01 日商中外製藥股份有限公司 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物
US10166304B2 (en) 2014-07-11 2019-01-01 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
EP3185004A4 (de) 2014-08-20 2018-05-30 Chugai Seiyaku Kabushiki Kaisha Verfahren zur messung der viskosität einer proteinlösung
MA40764A (fr) 2014-09-26 2017-08-01 Chugai Pharmaceutical Co Ltd Agent thérapeutique induisant une cytotoxicité
JP7125248B2 (ja) 2014-11-11 2022-08-24 中外製薬株式会社 改変された抗体可変領域を含む抗原結合分子のライブラリ
KR102650420B1 (ko) 2014-12-19 2024-03-21 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법
TN2017000275A1 (en) 2015-01-23 2018-10-19 Sanofi Sa Anti-cd3 antibodies, anti-cd123 antibodies and bispecific antibodies specifically binding to cd3 and/or cd123
CN112142844B (zh) 2015-02-05 2025-07-25 中外制药株式会社 包含离子浓度依赖性的抗原结合结构域的抗体,fc区变体,il-8-结合抗体及其应用
US10266584B2 (en) 2015-02-09 2019-04-23 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antibodies specific to glycoprotein (GP) of Ebolavirus and uses for the treatment and diagnosis of ebola virus infection
WO2016162368A1 (en) 2015-04-07 2016-10-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Non-invasive imaging of tumor pd-l1 expression
BR112017016952A2 (pt) 2015-04-17 2018-04-03 F. Hoffmann-La Roche Ag terapia de combinação com fatores de coagulação e anticorpos multiespecíficos
US20180201687A1 (en) 2015-07-07 2018-07-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to myosin 18a and uses thereof
EP3331569A1 (de) 2015-08-07 2018-06-13 Gamamabs Pharma Antikörper, antikörper-wirkstoff-konjugate und verfahren zur verwendung
AU2016323088B2 (en) * 2015-09-18 2020-12-10 Chugai Seiyaku Kabushiki Kaisha IL-8-binding antibodies and uses thereof
ES2941968T3 (es) 2015-10-01 2023-05-29 The Whitehead Institute For Biomedical Res Marcaje de anticuerpos
EP4524161A3 (de) 2015-10-08 2025-06-04 Zymeworks BC Inc. Antigenbindende polypeptidkonstrukte mit kappa- und lambda-leichtketten und verwendungen davon
WO2017060397A1 (en) 2015-10-09 2017-04-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting the survival time of subjects suffering from melanoma metastases
JP6902185B2 (ja) 2015-11-03 2021-07-14 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ Cd200阻害剤及びその使用方法
US11649293B2 (en) 2015-11-18 2023-05-16 Chugai Seiyaku Kabushiki Kaisha Method for enhancing humoral immune response
US11660340B2 (en) 2015-11-18 2023-05-30 Chugai Seiyaku Kabushiki Kaisha Combination therapy using T cell redirection antigen binding molecule against cell having immunosuppressing function
US11359009B2 (en) 2015-12-25 2022-06-14 Chugai Seiyaku Kabushiki Kaisha Anti-myostatin antibodies and methods of use
US20200270363A1 (en) 2015-12-25 2020-08-27 Chugai Seiyaku Kabushiki Kaisha Antibody having enhanced activity, and method for modifying same
CN108699154A (zh) 2016-02-26 2018-10-23 国家医疗保健研究所 对btla具有特异性的抗体及其用途
KR20180116215A (ko) 2016-03-14 2018-10-24 추가이 세이야쿠 가부시키가이샤 암의 치료에 이용하기 위한 세포상해 유도 치료제
RU2744959C2 (ru) 2016-03-23 2021-03-17 Мэбспейс Байосайнсиз (Сучжоу) Ко., Лтд Новые анти-pd-l1 антитела
BR112018069318A2 (pt) 2016-03-28 2019-01-22 Toray Industries composição farmacêutica para tratamento e/ou prevenção de um câncer, anticorpo ou fragmento do mesmo, combinação farmacêutica para tratamento e/ou prevenção de um câncer e método para tratar e/ou prevenir um câncer
EP3491022B1 (de) 2016-07-29 2025-09-10 Institut National de la Santé et de la Recherche Médicale (INSERM) Antikörper gegen tumor-assoziierte makrophagen und verwendungen davon
MX2019001448A (es) 2016-08-05 2019-09-13 Chugai Pharmaceutical Co Ltd Composicion para profilaxis o tratamiento de enfermedades relacionadas con interleucina 8 (il-8).
AU2017325240B9 (en) 2016-09-06 2025-02-13 Chugai Seiyaku Kabushiki Kaisha Methods of using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X
SG10201607778XA (en) 2016-09-16 2018-04-27 Chugai Pharmaceutical Co Ltd Anti-Dengue Virus Antibodies, Polypeptides Containing Variant Fc Regions, And Methods Of Use
JP7206590B2 (ja) 2016-10-28 2023-01-18 東レ株式会社 癌の治療及び/又は予防用医薬組成物
WO2018091720A1 (en) 2016-11-21 2018-05-24 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the prophylactic treatment of metastases
TWI776827B (zh) 2016-11-28 2022-09-11 日商中外製藥股份有限公司 能夠調節配體結合活性的配體結合分子
CA3046489A1 (en) 2016-12-07 2018-06-14 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
US10980739B2 (en) 2016-12-14 2021-04-20 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
EP3589654A1 (de) 2017-03-02 2020-01-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper mit spezifität gegen nectin-4 und verwendungen davon
EP3596126A4 (de) 2017-03-15 2021-03-03 Tsinghua University Neuartige anti-trkb-antikörper
KR102584011B1 (ko) 2017-03-16 2023-09-27 이나뜨 파르마 에스.에이. 암 치료를 위한 조성물 및 방법
WO2018174274A1 (ja) 2017-03-24 2018-09-27 全薬工業株式会社 抗IgM/B細胞表面抗原二重特異性抗体
CN110461358A (zh) 2017-03-31 2019-11-15 公立大学法人奈良县立医科大学 可用于预防和/或治疗凝血因子ⅸ异常、包含代替凝血因子ⅷ的功能的多特异性抗原结合分子的药物组合物
MX2019012136A (es) 2017-04-14 2020-07-20 Gamamabs Pharma Compuestos de union al receptor de la hormona antimulleriana tipo ii (amhrii) para prevenir o tratar canceres de pulmon.
WO2018189379A1 (en) 2017-04-14 2018-10-18 Gamamabs Pharma Amhrii-binding compounds for preventing or treating cancers
WO2018199214A1 (ja) 2017-04-27 2018-11-01 中外製薬株式会社 薬物動態が改善された血液凝固第ix因子
EP3658581A1 (de) 2017-07-24 2020-06-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Antikörper und peptide zur behandlung von erkrankungen im zusammenhang mit hcmv
US11085929B2 (en) 2017-08-31 2021-08-10 Arizona Board Of Regents On Behalf Of Arizona State University Nanoshell-structured material as co-matrix for peptide characterization in mass spectrometry
JP7226833B2 (ja) 2017-09-21 2023-02-21 イムチェック セラピューティクス エスエーエス Btn2に特異性を有する抗体及びその使用
US10752682B2 (en) * 2017-11-01 2020-08-25 Nantbio, Inc. Anti-IL8 antibodies
KR20200089312A (ko) 2017-11-28 2020-07-24 추가이 세이야쿠 가부시키가이샤 리간드 결합 활성을 조정 가능한 리간드 결합 분자
TWI817974B (zh) 2017-12-28 2023-10-11 日商中外製藥股份有限公司 細胞毒性誘導治療劑
JP2021510697A (ja) 2018-01-12 2021-04-30 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company がん処置のための坑il−8抗体及び坑pd−1抗体を用いる組合せ治療
CN116327926A (zh) 2018-03-15 2023-06-27 中外制药株式会社 对寨卡病毒具有交叉反应性的抗登革热病毒抗体及使用方法
CN112119098B (zh) 2018-03-28 2025-06-24 田边三菱制药株式会社 cMET单克隆结合剂的药物缀合物及其用途
AU2019242520B2 (en) 2018-03-30 2026-02-26 Toray Industries, Inc. Pharmaceutical composition for treatment and/or prevention of cancer
CA3091859A1 (en) 2018-04-06 2019-10-24 Dana-Farber Cancer Institute, Inc. Kir3dl3 as an hhla2 receptor, anti-hhla2 antibodies, and uses thereof
JP7549530B2 (ja) 2018-05-21 2024-09-11 中外製薬株式会社 ガラス容器に封入された凍結乾燥製剤
EP3805390A4 (de) 2018-05-31 2022-08-03 Shionogi & Co., Ltd Monoklonaler nav1.7-antikörper
BR112020024412A8 (pt) 2018-06-18 2023-03-21 Innate Pharma Anticorpos, composição farmacêutica, kit, ácido nucleico, célula hospedeira, métodos de tratamento ou prevenção de câncer, de redução da atividade, de aumento da atividade e de aumento da ativação
WO2020022499A1 (ja) 2018-07-27 2020-01-30 国立大学法人大阪大学 老化の抑制、加齢性の疾患もしくは症状の予防、改善、もしくは治療、または寿命の延長のための組成物
JP7475687B2 (ja) 2018-09-21 2024-04-30 国立大学法人 東京医科歯科大学 ヒトhmgb1に特異的に結合するヒトモノクローナル抗体、及びそれを含有するアルツハイマー病を治療又は予防するための医薬組成物
JP2022512860A (ja) 2018-11-06 2022-02-07 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 白血病幹細胞を根絶することによる急性骨髄性白血病の治療のための方法および医薬組成物
US20240252795A1 (en) 2018-11-19 2024-08-01 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
JP7609775B2 (ja) 2018-12-14 2025-01-07 インセルム(インスティチュート ナショナル デ ラ サンテ エ デ ラ リシェルシェ メディカル) 単離されたMHC由来ヒトペプチドおよびCD8+CD45RClowTregの抑制機能を刺激し、かつ活性化するためのその使用
BR112021011431A2 (pt) 2018-12-27 2021-11-23 Univ Osaka Anticorpo monoclonal ou um fragmento de anticorpo do mesmo que se liga ao ccr8, seu uso, bem como composição farmacêutica, polinucleotídeo, vetor de expressão e kit
US11680105B2 (en) 2019-01-17 2023-06-20 Regents Of The University Of Minnesota Antibody fragments for detecting cancer and methods of use
JPWO2020153467A1 (ja) 2019-01-24 2021-12-02 中外製薬株式会社 新規がん抗原及びそれらの抗原に対する抗体
WO2020169472A2 (en) 2019-02-18 2020-08-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods of inducing phenotypic changes in macrophages
KR20210134705A (ko) 2019-02-28 2021-11-10 각코우호우진 쥰텐도 절단형의 변이형 Calreticulin에 결합하는 항체, 및 골수 증식성 종양의 진단, 예방 또는 치료약
CN113613676A (zh) 2019-03-19 2021-11-05 中外制药株式会社 包含对抗原的结合活性因mta而变化的抗原结合结构域的抗原结合分子及用于获得该抗原结合结构域的文库
CN113811545B (zh) 2019-03-20 2025-05-23 感应检查疗法公司 对btn2具有特异性的抗体及其用途
US20220177558A1 (en) 2019-03-25 2022-06-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment of taupathy disorders by targeting new tau species
KR20210149779A (ko) 2019-04-10 2021-12-09 추가이 세이야쿠 가부시키가이샤 Fc 영역 개변 항체의 정제 방법
MX2021012608A (es) 2019-04-18 2021-11-12 Ac Immune Sa Nuevas moleculas para terapia y diagnostico.
WO2020246563A1 (ja) 2019-06-05 2020-12-10 中外製薬株式会社 抗体切断部位結合分子
EP4007775A1 (de) 2019-08-02 2022-06-08 Orega Biotech Neue il-17b-antikörper
US12441788B2 (en) 2019-09-27 2025-10-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Anti-müllerian inhibiting substance antibodies and uses thereof
WO2021058729A1 (en) 2019-09-27 2021-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Anti-müllerian inhibiting substance type i receptor antibodies and uses thereof
EP3812008A1 (de) 2019-10-23 2021-04-28 Gamamabs Pharma Amh-kompetitiver antagonistischer antikörper
EP4061944A1 (de) 2019-11-22 2022-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibitoren von adrenomedullin zur behandlung von akuter myeloischer leukämie durch vernichtung von leukämischen stammzellen
US20250340623A1 (en) 2019-12-04 2025-11-06 Ac Immune Sa Novel Molecules for Therapy and Diagnosis
US12577324B2 (en) 2019-12-09 2026-03-17 Inserm (Institut National De La Sante Et De La Recherche Medicale) Antibodies having specificity to HER4 and uses thereof
CN121197633A (zh) 2019-12-13 2025-12-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
CA3169521A1 (en) 2020-02-28 2021-09-02 Marie-Priscille Brun Modified binding polypeptides for optimized drug conjugation
WO2021175954A1 (en) 2020-03-04 2021-09-10 Imcheck Therapeutics Sas Antibodies having specificity for btnl8 and uses thereof
BR112022018157A2 (pt) 2020-03-12 2022-10-25 Toray Industries Medicamento para o tratamento e/ou prevenção do câncer, agentes que aumentam a eficácia de um fármaco e método para o tratamento e/ou prevenção do câncer
WO2021182570A1 (ja) 2020-03-12 2021-09-16 東レ株式会社 癌の治療及び/又は予防のための医薬品
JP7793985B2 (ja) 2020-03-12 2026-01-06 東レ株式会社 癌の治療及び/又は予防のための医薬品
WO2021182574A1 (ja) 2020-03-12 2021-09-16 東レ株式会社 癌の治療及び/又は予防のための医薬品
CA3175127A1 (en) 2020-03-12 2021-09-16 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
JP7329288B2 (ja) 2020-03-27 2023-08-18 株式会社PhotoQ3 腫瘍細胞を死滅させるための医薬
JPWO2021200131A1 (de) 2020-03-30 2021-10-07
WO2021206078A1 (ja) 2020-04-06 2021-10-14 株式会社PhotoQ3 腫瘍細胞を死滅させるための医薬
JP2023106635A (ja) 2020-04-17 2023-08-02 中外製薬株式会社 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法
WO2021214222A1 (en) 2020-04-24 2021-10-28 Sanofi Antitumor combinations containing anti-ceacam5 antibody conjugates, trifluridine and tipiracil
BR112022020477A2 (pt) 2020-04-24 2022-11-29 Sanofi Sa Combinações antitumor contendo conjugados de anticorpo anti-ceacam5 e cetuximabe
AU2021261553A1 (en) 2020-04-24 2023-01-05 Sanofi Antitumor combinations containing anti-CEACAM5 antibody conjugates and FOLFIFI
BR112022020497A2 (pt) 2020-04-24 2022-12-06 Sanofi Sa Combinações antitumor contendo conjugados de anticorpo anti-ceacam5 e folfox
EP4149558A1 (de) 2020-05-12 2023-03-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Neues verfahren zur behandlung von kutanen t-zell-lymphomen und tfh-abgeleiteten lymphomen
JP7752613B2 (ja) 2020-05-22 2025-10-10 中外製薬株式会社 凝固第viii因子(f.viii)機能代替活性を有する物質を中和する抗体
US20230242554A1 (en) 2020-06-24 2023-08-03 The University Of Tokyo Photosensitizing dye
WO2022004760A1 (ja) 2020-06-30 2022-01-06 塩野義製薬株式会社 抗ccr8抗体と化学療法剤の併用
BR112023000216A2 (pt) 2020-07-28 2023-02-07 Chugai Pharmaceutical Co Ltd Preparação de seringa pré-carregada com agulha, com proteção de agulha e incluindo anticorpo modificado
JPWO2022025220A1 (de) 2020-07-31 2022-02-03
US20250122282A2 (en) 2020-09-04 2025-04-17 Merck Patent Gmbh Anti-ceacam5 antibodies and conjugates and uses thereof
EP3981789A1 (de) 2020-10-12 2022-04-13 Commissariat À L'Énergie Atomique Et Aux Énergies Alternatives Anti-lilrb-antikörper und verwendungen davon
WO2022079297A1 (en) 2020-10-16 2022-04-21 Ac Immune Sa Antibodies binding to alpha-synuclein for therapy and diagnosis
CA3200955A1 (en) 2020-11-10 2022-05-19 Sanofi Ceacam5 antibody-drug conjugate formulation
JPWO2022124247A1 (de) 2020-12-09 2022-06-16
IL303758A (en) 2020-12-18 2023-08-01 Ac Immune Sa Antibody delivery
WO2022159575A1 (en) 2021-01-20 2022-07-28 Bioentre Llc Ctla4-binding proteins and methods of treating cancer
BR112023026985A2 (pt) 2021-06-23 2024-03-12 Toray Industries Medicamento para o tratamento e/ou prevenção do câncer, agente que aumenta a eficácia do medicamento em uma composição farmacêutica, agente para aumentar a eficácia do medicamento em uma composição farmacêutica e método para tratar e/ou prevenir o câncer
AU2022298240A1 (en) 2021-06-23 2024-01-18 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
KR20240042415A (ko) 2021-07-27 2024-04-02 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CN117677398A (zh) 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品
EP4378476A4 (de) 2021-07-27 2025-07-23 Toray Industries Medikament zur behandlung und/oder prävention von krebs
JP2024527982A (ja) 2021-07-29 2024-07-26 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル(イーエヌエスエーエールエム) ヒト化抗ヒトβig-h3タンパク質とその利用
CN118019548A (zh) 2021-08-06 2024-05-10 蒙彼利埃癌症研究所 用于治疗癌症的方法
MX2024002571A (es) 2021-09-03 2024-03-20 Toray Industries Composicion farmaceutica para tratamiento y/o prevencion de cancer.
JPWO2023048231A1 (de) 2021-09-24 2023-03-30
JP2024538654A (ja) 2021-10-04 2024-10-23 ノバルティス アーゲー 界面活性剤安定剤
US20240404622A1 (en) 2021-10-08 2024-12-05 Chugai Seiyaku Kabushiki Kaisha Method for preparing prefilled syringe formulation
TWI867354B (zh) 2021-11-01 2024-12-21 日商塩野義製藥股份有限公司 新穎Nav1.7單株抗體
IL312519A (en) 2021-11-05 2024-07-01 Lilly Co Eli Anticancer combinations containing antibody-drug conjugates anti-CEACAM5 and anti-VEGFR-2 antibodies
CN115466331B (zh) 2021-11-18 2023-05-30 合源生物科技(天津)有限公司 靶向bcma的嵌合抗原受体及其应用
AU2022399314A1 (en) 2021-12-01 2024-06-20 Chugai Seiyaku Kabushiki Kaisha Method for preparing antibody-containing formulation
KR20250005991A (ko) 2022-03-09 2025-01-10 가부시키가이샤 큐어드 Eva1 단백질에 결합하는 인간화 항체 또는 이의 기능적 단편, 항체-약물 복합체 및 키메라 항원 수용체
CN119677543A (zh) 2022-03-09 2025-03-21 默克专利股份公司 用于与抗体缀合的方法和工具
JP2025509269A (ja) 2022-03-09 2025-04-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗gd2抗体、免疫コンジュゲート、及びその治療的使用
WO2023192478A1 (en) 2022-04-01 2023-10-05 Bristol-Myers Squibb Company Combination therapy with anti-il-8 antibodies and anti-pd-1 antibodies for treating cancer
IL316445A (en) 2022-04-26 2024-12-01 Chugai Pharmaceutical Co Ltd A syringe containing a pharmaceutical preparation equipped with a filter
JPWO2023234406A1 (de) 2022-06-03 2023-12-07
EP4537842A1 (de) 2022-06-07 2025-04-16 Institute of Science Tokyo Mittel zur prävention oder therapie von amyotropher lateralsklerose, morbus parkinson, huntington, spinocerebellarer ataxie, alterungsdegeneration oder neurologischer erkrankung
WO2023240287A1 (en) 2022-06-10 2023-12-14 Bioentre Llc Combinations of ctla4 binding proteins and methods of treating cancer
AU2023298568A1 (en) 2022-06-30 2025-01-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention
WO2024043258A1 (ja) 2022-08-24 2024-02-29 東レ株式会社 癌の治療及び/又は予防のための医薬品
WO2024043252A1 (ja) 2022-08-24 2024-02-29 東レ株式会社 癌の治療及び/又は予防のための医薬品
KR20250052364A (ko) 2022-08-24 2025-04-18 도레이 카부시키가이샤 암의 치료 및/또는 예방을 위한 의약품
CN119768184A (zh) 2022-08-30 2025-04-04 东丽株式会社 用于癌的治疗和/或预防的药品
WO2024048541A1 (ja) 2022-08-30 2024-03-07 東レ株式会社 癌の治療及び/又は予防のための医薬品
WO2024054678A2 (en) 2022-09-09 2024-03-14 Regents Of The University Of Minnesota Antibodies against fentanyl and analogs and methods of use thereof
US20260035468A1 (en) 2022-09-12 2026-02-05 Institut National de la Santé et de la Recherche Médicale New anti-itgb8 antibodies and its uses thereof
EP4623931A1 (de) 2022-11-25 2025-10-01 The University of Osaka Antikörper gegen hämatologisches krebs
WO2024135809A1 (ja) 2022-12-23 2024-06-27 東レ株式会社 癌の治療及び/又は予防のための医薬品
CN120731226A (zh) 2023-02-21 2025-09-30 吉尼瑞姆股份公司 用于预防和治疗患有黏多糖贮积症ii型的受试者的溶酶体酶缺乏的药物组合物和方法
CN120813387A (zh) 2023-03-01 2025-10-17 赛诺菲 抗ceacam5免疫缀合物用于治疗表达ceacam5的神经内分泌癌症的用途
EP4427763A1 (de) 2023-03-06 2024-09-11 Sanofi Antitumorkombinationen mit anti-ceacam5-antikörper-wirkstoff-konjugaten, anti-vegfr-2-antikörpern und anti-pd1/pd-l1-antikörpern
AU2024240376A1 (en) 2023-03-23 2025-11-06 Sanofi CEACAM5 mRNA ASSAY FOR PATIENT SELECTION IN CANCER THERAPY
AU2024246833A1 (en) 2023-03-31 2025-09-25 Toray Industries, Inc. Pharmaceutical composition for treating and/or preventing cancer
EP4696321A1 (de) 2023-04-14 2026-02-18 Chugai Seiyaku Kabushiki Kaisha Verfahren zur stabilisierung einer proteinhaltigen pharmazeutischen zubereitung
CN121443320A (zh) 2023-06-05 2026-01-30 赛诺菲 含有抗ceacam5抗体-药物缀合物、抗pd1/pd-l1抗体和抗ctla4抗体的抗肿瘤组合
CN121605130A (zh) 2023-06-23 2026-03-03 感应检查疗法公司 靶向btn3a和pd-1/pd-l1抑制轴的双特异性抗体
WO2025012417A1 (en) 2023-07-13 2025-01-16 Institut National de la Santé et de la Recherche Médicale Anti-neurotensin long fragment and anti-neuromedin n long fragment antibodies and uses thereof
WO2025032158A1 (en) 2023-08-08 2025-02-13 Institut National de la Santé et de la Recherche Médicale Method to treat tauopathies
WO2025058000A1 (ja) 2023-09-13 2025-03-20 東レ株式会社 癌の治療、予防及び/又は診断用医薬組成物
WO2025073890A1 (en) 2023-10-06 2025-04-10 Institut National de la Santé et de la Recherche Médicale Method to capture circulating tumor extracellular vesicles
WO2025093720A1 (en) 2023-11-02 2025-05-08 Betasense Gmbh Methods for determining misfolded alpha-synuclein in a sample
WO2025172525A1 (en) 2024-02-15 2025-08-21 Merck Patent Gmbh Anti-gd2 antibodies and immunoconjugates for the treatment of gd2 positive cancer
WO2025210264A1 (en) 2024-04-04 2025-10-09 Merck Patent Gmbh Antibody-drug-conjugates binding napi2b
WO2025242732A1 (en) 2024-05-21 2025-11-27 Institut National de la Santé et de la Recherche Médicale Pan antibodies against sars-cov-2 spike protein and uses thereof for therapeutical purposes
WO2025242845A1 (en) 2024-05-22 2025-11-27 Merck Patent Gmbh Colorectal cancer treatment
WO2025248097A2 (en) 2024-05-31 2025-12-04 Gamamabs Pharma Humanized anti-human her3 antibodies and uses thereof
WO2025257181A1 (en) 2024-06-11 2025-12-18 Institut National de la Santé et de la Recherche Médicale Antibodies targeting trans-active response dna-binding protein-43 (tdp-43)
WO2026033259A1 (en) 2024-08-05 2026-02-12 Lys Therapeutics Antibodies for treating neurological and neurovascular disorders

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62201598A (ja) * 1986-02-28 1987-09-05 Teijin Ltd マウス−ヒトキメラ抗体h鎖、それをコ−ドするキメラdna配列、プラスミドおよび細胞
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB9014932D0 (en) * 1990-07-05 1990-08-22 Celltech Ltd Recombinant dna product and method
IE913192A1 (en) * 1990-09-12 1992-02-25 Scripps Research Inst Active site of interleukin-8: polypeptide analogs and¹antibodies
JPH04141095A (ja) * 1990-10-02 1992-05-14 Chemo Sero Therapeut Res Inst 組換え抗hiv改変抗体および改変抗体の調製方法
WO1995001997A1 (en) * 1993-07-09 1995-01-19 Smithkline Beecham Corporation RECOMBINANT AND HUMANIZED IL-1β ANTIBODIES FOR TREATMENT OF IL-1 MEDIATED INFLAMMATORY DISORDERS IN MAN
CA2181787A1 (en) * 1994-03-03 1995-09-08 Claire M. Doerschuk Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
US5874080A (en) * 1994-03-03 1999-02-23 Genentech, Inc. Anti-IL-8 monoclonal antibodies for treatment of asthma

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