ECSP15039103A - Formulación de liberación sostenida de mosapride que proporciona efectos farmacológicos y clínicos con administración una vez al día - Google Patents

Formulación de liberación sostenida de mosapride que proporciona efectos farmacológicos y clínicos con administración una vez al día

Info

Publication number
ECSP15039103A
ECSP15039103A ECIEPI201539103A ECPI201539103A ECSP15039103A EC SP15039103 A ECSP15039103 A EC SP15039103A EC IEPI201539103 A ECIEPI201539103 A EC IEPI201539103A EC PI201539103 A ECPI201539103 A EC PI201539103A EC SP15039103 A ECSP15039103 A EC SP15039103A
Authority
EC
Ecuador
Prior art keywords
sustained release
formulation
once daily
release formulation
daily administration
Prior art date
Application number
ECIEPI201539103A
Other languages
English (en)
Inventor
Yong Hee Kim
Dae-Chul Ha
Hee Yong Song
Youn Woong Choi
Byung Jin Kim
Myoung-Hwa Lim
Jong-Il Kim
Min Soo Kim
Original Assignee
Korea United Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51537143&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP15039103(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Korea United Pharm Inc filed Critical Korea United Pharm Inc
Publication of ECSP15039103A publication Critical patent/ECSP15039103A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La formulación para administración oral de la presente invención que contiene Mosapride o su sal es una formulación de capa doble que consiste en una capa de liberación rápida para liberación rápida de un fármaco y una capa de liberación sostenida para liberación lenta a fin de satisfacer simultáneamente la presentación rápida de actividades farmacológicas y el mantenimiento sostenido de las actividades farmacológicas durante 24 horas, en la que la hidroxipropil metilcelulosa (HPMC) de viscosidad alta y la HPMC de viscosidad baja se usan en una mezcla tal que el contenido de HPMC de viscosidad alta como una matriz de liberación controlada dentro de la capa de liberación sostenida tiene un contenido más alto, de este modo es capaz de controlar la velocidad de disolución en las regiones que tienen diferentes valores de pH dentro del tracto gastrointestinal y/o el tiempo de retención en el tracto gastrointestinal. De forma adicional, la formulación de la presente invención es una preparación de tamaño pequeño con un peso total de 200 mg o menos, preferentemente de 150 mg a 160 mg, de este modo es capaz de mejorar la conformidad con los fármacos de los pacientes.
ECIEPI201539103A 2013-03-15 2015-09-10 Formulación de liberación sostenida de mosapride que proporciona efectos farmacológicos y clínicos con administración una vez al día ECSP15039103A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20130027945 2013-03-15

Publications (1)

Publication Number Publication Date
ECSP15039103A true ECSP15039103A (es) 2015-11-30

Family

ID=51537143

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI201539103A ECSP15039103A (es) 2013-03-15 2015-09-10 Formulación de liberación sostenida de mosapride que proporciona efectos farmacológicos y clínicos con administración una vez al día

Country Status (11)

Country Link
US (1) US9962390B2 (es)
EP (1) EP2974720B1 (es)
JP (1) JP6273302B2 (es)
KR (1) KR101612931B1 (es)
CN (2) CN108653226A (es)
EC (1) ECSP15039103A (es)
HK (1) HK1212910A1 (es)
MX (1) MX2015011896A (es)
PE (1) PE20151592A1 (es)
PH (1) PH12015502134B1 (es)
WO (1) WO2014142616A1 (es)

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RU2697836C2 (ru) * 2015-06-26 2019-08-21 Кореа Юнайтед Фарм. Инк. Комбинированный препарат мозаприда и рабепразола
CN109069475B (zh) 2016-04-22 2022-01-28 受体控股公司 快速作用植物类医药化合物和营养补剂
EA201892396A1 (ru) 2016-12-02 2019-04-30 Ресептор Лайф Сайенсиз, Инк. Быстродействующие растительные лекарственные соединения и биологически активные добавки
KR101984892B1 (ko) 2017-06-23 2019-06-03 한국유나이티드제약 주식회사 신규한 용출 파라미터를 사용한 모사프리드 함유 서방제제
KR102465629B1 (ko) * 2017-06-23 2022-11-11 한국유나이티드제약 주식회사 1일 1회 경구투여하는 모사프리드 함유 서방제제
KR102294190B1 (ko) * 2017-06-23 2021-08-27 한국유나이티드제약 주식회사 신규한 용출 파라미터를 이용한 모사프리드 함유 서방제제
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Also Published As

Publication number Publication date
CN105142618A (zh) 2015-12-09
MX2015011896A (es) 2016-07-19
EP2974720B1 (en) 2024-02-21
JP2016512235A (ja) 2016-04-25
PH12015502134A1 (en) 2016-01-25
HK1212910A1 (zh) 2016-06-24
CN108653226A (zh) 2018-10-16
PE20151592A1 (es) 2015-11-04
KR20140113542A (ko) 2014-09-24
EP2974720A4 (en) 2016-08-31
PH12015502134B1 (en) 2019-04-12
JP6273302B2 (ja) 2018-01-31
US20160030436A1 (en) 2016-02-04
KR101612931B1 (ko) 2016-04-18
US9962390B2 (en) 2018-05-08
WO2014142616A1 (ko) 2014-09-18
EP2974720A1 (en) 2016-01-20

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