ECSP19034535A - Inhibidores de la magl - Google Patents

Inhibidores de la magl

Info

Publication number
ECSP19034535A
ECSP19034535A ECSENADI201934535A ECDI201934535A ECSP19034535A EC SP19034535 A ECSP19034535 A EC SP19034535A EC SENADI201934535 A ECSENADI201934535 A EC SENADI201934535A EC DI201934535 A ECDI201934535 A EC DI201934535A EC SP19034535 A ECSP19034535 A EC SP19034535A
Authority
EC
Ecuador
Prior art keywords
compounds
compositions
magl inhibitors
magl
useful
Prior art date
Application number
ECSENADI201934535A
Other languages
English (en)
Inventor
Michael B Shaghafi
Daniel J Buzard
Cheryl A Grice
Original Assignee
Abide Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=62145825&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP19034535(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abide Therapeutics Inc filed Critical Abide Therapeutics Inc
Publication of ECSP19034535A publication Critical patent/ECSP19034535A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En el presente documento se proporcionan carbamatos espirocíclicos y bicíclicos fusionados y composiciones farmacéuticas que comprenden dichos compuestos. Los compuestos y composiciones en cuestión son útiles como moduladores de la MAGL. Además, los presentes compuestos y composiciones son útiles para el tratamiento del dolor.
ECSENADI201934535A 2016-11-16 2019-05-15 Inhibidores de la magl ECSP19034535A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662423102P 2016-11-16 2016-11-16

Publications (1)

Publication Number Publication Date
ECSP19034535A true ECSP19034535A (es) 2019-05-31

Family

ID=62145825

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI201934535A ECSP19034535A (es) 2016-11-16 2019-05-15 Inhibidores de la magl

Country Status (27)

Country Link
US (2) US11059822B2 (es)
EP (1) EP3541820B1 (es)
JP (1) JP7042468B2 (es)
KR (1) KR20190080935A (es)
CN (1) CN110267962B (es)
AU (1) AU2017361253B2 (es)
BR (1) BR112019009880A2 (es)
CA (1) CA3043617A1 (es)
CL (1) CL2019001336A1 (es)
CO (1) CO2019004945A2 (es)
CR (1) CR20190239A (es)
DO (1) DOP2019000118A (es)
EA (1) EA038150B1 (es)
EC (1) ECSP19034535A (es)
ES (1) ES2952582T3 (es)
IL (1) IL266547B (es)
JO (1) JOP20190107A1 (es)
MA (1) MA46855A (es)
MX (1) MX389627B (es)
NI (1) NI201900049A (es)
PE (1) PE20191145A1 (es)
PH (1) PH12019501079A1 (es)
RU (1) RU2019115784A (es)
TN (1) TN2019000149A1 (es)
UA (1) UA125523C2 (es)
WO (1) WO2018093949A1 (es)
ZA (1) ZA201903099B (es)

Families Citing this family (17)

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Publication number Priority date Publication date Assignee Title
ES2861648T3 (es) * 2016-05-12 2021-10-06 Lundbeck La Jolla Research Center Inc Compuestos de espirociclo y procedimientos de fabricación y uso de los mismos
JOP20190105A1 (ar) * 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
EP3541807B1 (en) 2016-11-16 2021-09-29 H. Lundbeck A/S A crystalline form of a magl inhibitor
JOP20190107A1 (ar) 2016-11-16 2019-05-09 Lundbeck La Jolla Research Center Inc مثبطات أحادي أسيل جليسرول ليباز (magl)
AU2017361254B2 (en) 2016-11-16 2021-09-23 H. Lundbeck A/S. Pharmaceutical formulations
US10266497B2 (en) 2017-05-23 2019-04-23 Abide Therapeutics, Inc. Pyrazole MAGL inhibitors
US10927105B1 (en) 2017-05-23 2021-02-23 Lundbeck La Jolla Research Center, Inc. Pyrazole MAGL inhibitors
CA3072923A1 (en) 2017-08-29 2019-03-07 Lundbeck La Jolla Research Center, Inc. Spirocycle compounds and methods of making and using same
CR20200088A (es) 2017-08-29 2020-04-08 Lundbeck La Jolla Research Center Inc Compuestos espirocíclicos y sus métodos de preparación y uso
US20210309669A1 (en) * 2018-07-19 2021-10-07 Pfizer Inc. Heterocyclic Spiro Compounds As MAGL Inhibitors
EP3837263B1 (en) 2018-08-13 2024-07-03 F. Hoffmann-La Roche AG New heterocyclic compounds as monoacylglycerol lipase inhibitors
EP3883936B1 (en) 2018-11-22 2023-07-12 F. Hoffmann-La Roche AG New heterocyclic compounds
CN115427403A (zh) 2020-04-21 2022-12-02 H.隆德贝克有限公司 单酰基甘油脂肪酶抑制剂的合成
TWI904281B (zh) 2020-11-13 2025-11-11 丹麥商Ｈ 朗德貝克公司 Magl抑制劑
CA3242372A1 (en) 2021-12-29 2023-07-06 Psy Therapeutics, Inc. Inhibiting monoacylglycerol lipase (magl)
AU2023264787A1 (en) 2022-05-04 2024-10-31 H. Lundbeck A/S Crystalline form of 1,1,1,3,3,3-hexafluoropropan-2-yl (s)-1-(pyridazin-3-ylcarbamoyl)-6 azaspiro[2.5]octane-6-carboxylate as monoacylglycerol lipase inhibitor.
EP4665718A1 (en) 2023-02-13 2025-12-24 Apogee Pharmaceuticals, Inc. Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof

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UA121775C2 (uk) 2015-07-31 2020-07-27 Пфайзер Інк. 1,1,1-трифтор-3-гідроксипропан-2-ілкарбаматні похідні та 1,1,1-трифтор-4-гідроксибутан-2-ілкарбаматні похідні як інгібітори magl
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EP3541807B1 (en) 2016-11-16 2021-09-29 H. Lundbeck A/S A crystalline form of a magl inhibitor
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CR20200088A (es) 2017-08-29 2020-04-08 Lundbeck La Jolla Research Center Inc Compuestos espirocíclicos y sus métodos de preparación y uso
CA3072923A1 (en) 2017-08-29 2019-03-07 Lundbeck La Jolla Research Center, Inc. Spirocycle compounds and methods of making and using same
TWI904281B (zh) 2020-11-13 2025-11-11 丹麥商Ｈ 朗德貝克公司 Magl抑制劑

Also Published As

Publication number Publication date
PH12019501079A1 (en) 2019-08-19
CN110267962B (zh) 2022-04-01
MX389627B (es) 2025-03-20
IL266547B (en) 2022-06-01
MA46855A (fr) 2021-05-19
TN2019000149A1 (en) 2020-10-05
CR20190239A (es) 2019-06-26
KR20190080935A (ko) 2019-07-08
JP2020500178A (ja) 2020-01-09
EP3541820A4 (en) 2020-06-10
EP3541820B1 (en) 2023-07-05
ZA201903099B (en) 2021-01-27
US11059822B2 (en) 2021-07-13
EP3541820C0 (en) 2023-07-05
BR112019009880A2 (pt) 2019-08-13
RU2019115784A (ru) 2020-12-17
US11691975B2 (en) 2023-07-04
AU2017361253A1 (en) 2019-05-30
PE20191145A1 (es) 2019-09-02
AU2017361253B2 (en) 2021-08-05
MX2019005773A (es) 2019-12-05
CA3043617A1 (en) 2018-05-24
CN110267962A (zh) 2019-09-20
CL2019001336A1 (es) 2019-10-04
NI201900049A (es) 2019-10-30
IL266547A (en) 2019-07-31
US20200291023A1 (en) 2020-09-17
JOP20190107A1 (ar) 2019-05-09
WO2018093949A1 (en) 2018-05-24
DOP2019000118A (es) 2019-09-30
EA038150B1 (ru) 2021-07-14
EP3541820A1 (en) 2019-09-25
JP7042468B2 (ja) 2022-03-28
RU2019115784A3 (es) 2021-03-12
UA125523C2 (uk) 2022-04-13
US20220135563A1 (en) 2022-05-05
ES2952582T3 (es) 2023-11-02
EA201991029A1 (ru) 2019-12-30
NZ753471A (en) 2021-01-29
CO2019004945A2 (es) 2019-05-21

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