ECSP20029569A - Nuevas indol-2-carboxamidas sustituidas con pirazolo piperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas indol-2-carboxamidas sustituidas con pirazolo piperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb)

Info

Publication number
ECSP20029569A
ECSP20029569A ECSENADI202029569A ECDI202029569A ECSP20029569A EC SP20029569 A ECSP20029569 A EC SP20029569A EC SENADI202029569 A ECSENADI202029569 A EC SENADI202029569A EC DI202029569 A ECDI202029569 A EC DI202029569A EC SP20029569 A ECSP20029569 A EC SP20029569A
Authority
EC
Ecuador
Prior art keywords
hbv
virus
indool
carboxamides
high activity
Prior art date
Application number
ECSENADI202029569A
Other languages
English (en)
Inventor
Susanne Bonsmann
Andreas Urban
Anita Wegert
Alastair Donald
Jasper Springer
Original Assignee
Aicuris Gmbh Co Kg [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh Co Kg [De/De] filed Critical Aicuris Gmbh Co Kg [De/De]
Publication of ECSP20029569A publication Critical patent/ECSP20029569A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivirales. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
ECSENADI202029569A 2017-11-02 2020-06-01 Nuevas indol-2-carboxamidas sustituidas con pirazolo piperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb) ECSP20029569A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17199676 2017-11-02

Publications (1)

Publication Number Publication Date
ECSP20029569A true ECSP20029569A (es) 2020-07-31

Family

ID=60201937

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202029569A ECSP20029569A (es) 2017-11-02 2020-06-01 Nuevas indol-2-carboxamidas sustituidas con pirazolo piperidina, de alta actividad, activas contra el virus de la hepatitis b (vhb)

Country Status (22)

Country Link
US (1) US11236087B2 (es)
EP (1) EP3704119A1 (es)
JP (1) JP2021501768A (es)
KR (1) KR20200083552A (es)
CN (1) CN111527087A (es)
AR (1) AR115131A1 (es)
AU (1) AU2018361365C1 (es)
BR (1) BR112020008765A2 (es)
CA (1) CA3081399A1 (es)
CL (1) CL2020001146A1 (es)
CU (1) CU20200045A7 (es)
EA (1) EA202091114A1 (es)
EC (1) ECSP20029569A (es)
GE (2) GEP20227374B (es)
IL (1) IL274297A (es)
MA (1) MA50520A (es)
MX (1) MX2020004838A (es)
PH (1) PH12020550531A1 (es)
SG (1) SG11202003746UA (es)
TW (1) TW201925199A (es)
UY (1) UY37961A (es)
WO (1) WO2019086142A1 (es)

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PY1991603A (es) * 2018-11-02 2020-09-17 Aicuris Gmbh & Co Kg Nueva 6,7-dihidro-4h-pirazolo [1,5-a] pirazina indole -2-carboxamidas activas contra el virus de la hepatitis b (vhb)
UY38434A (es) * 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg Nuevas 6,7-dihidro-4h-pirazolo[1,5-a]pirazin indol-2-carboxamidas activas contra el virus de la hepatitis b (hbv)
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SG11202003746UA (en) 2020-05-28
WO2019086142A1 (en) 2019-05-09
GEP20227374B (en) 2022-04-25
GEAP202115353A (en) 2021-12-10
UY37961A (es) 2019-05-31
TW201925199A (zh) 2019-07-01
IL274297A (en) 2020-06-30
EP3704119A1 (en) 2020-09-09
AU2018361365A1 (en) 2020-05-21
CL2020001146A1 (es) 2020-10-09
AU2018361365B2 (en) 2021-04-01
JP2021501768A (ja) 2021-01-21
CA3081399A1 (en) 2019-05-09
AU2018361365C1 (en) 2021-08-05
EA202091114A1 (ru) 2020-07-24
US11236087B2 (en) 2022-02-01
US20210179608A1 (en) 2021-06-17
KR20200083552A (ko) 2020-07-08
MX2020004838A (es) 2020-10-16
BR112020008765A2 (pt) 2020-10-20
CU20200045A7 (es) 2021-03-11
MA50520A (fr) 2020-09-09
CN111527087A (zh) 2020-08-11
PH12020550531A1 (en) 2021-03-22
AR115131A1 (es) 2020-12-02

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