ECSP20029558A - Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb) - Google Patents

Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb)

Info

Publication number
ECSP20029558A
ECSP20029558A ECSENADI202029558A ECDI202029558A ECSP20029558A EC SP20029558 A ECSP20029558 A EC SP20029558A EC SENADI202029558 A ECSENADI202029558 A EC SENADI202029558A EC DI202029558 A ECDI202029558 A EC DI202029558A EC SP20029558 A ECSP20029558 A EC SP20029558A
Authority
EC
Ecuador
Prior art keywords
hbv
virus
thiazol
amino
high activity
Prior art date
Application number
ECSENADI202029558A
Other languages
English (en)
Inventor
Christiaan Gremmen
Anita Wegert
Alastair Donald
Andreas Urban
Susanne Bonsmann
Jasper Springer
Original Assignee
Aicuris Gmbh Co Kg [De/De]
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh Co Kg [De/De] filed Critical Aicuris Gmbh Co Kg [De/De]
Publication of ECSP20029558A publication Critical patent/ECSP20029558A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere, en general, a nuevos agentes antivirales. Específicamente, la presente invención se refiere a compuestos que pueden inhibir la proteína o proteínas codificada(s) por el virus de la hepatitis B (VHB) o interferir con la función del ciclo de replicación del VHB, a composiciones que comprenden estos compuestos, a métodos para inhibir la replicación del virus VHB, a métodos para tratar o prevenir la infección por VHB y a procesos o intermedios para fabricar los compuestos.
ECSENADI202029558A 2017-11-02 2020-06-01 Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb) ECSP20029558A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17199687 2017-11-02

Publications (1)

Publication Number Publication Date
ECSP20029558A true ECSP20029558A (es) 2020-07-31

Family

ID=60201941

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202029558A ECSP20029558A (es) 2017-11-02 2020-06-01 Nuevas indol-2-carboxamidas sustituidas con amino-tiazol, de alta actividad, activas contra el virus de la hepatitis b (vhb)

Country Status (23)

Country Link
US (1) US11267825B2 (es)
EP (1) EP3704127A1 (es)
JP (1) JP2021501764A (es)
KR (1) KR20200083551A (es)
CN (1) CN111448199A (es)
AR (1) AR113826A1 (es)
AU (1) AU2018361364B2 (es)
BR (1) BR112020008762A2 (es)
CA (1) CA3081386A1 (es)
CL (1) CL2020001145A1 (es)
CU (1) CU20200037A7 (es)
EA (1) EA202091113A1 (es)
EC (1) ECSP20029558A (es)
GE (2) GEP20227373B (es)
IL (1) IL274298A (es)
MA (1) MA50524A (es)
MX (1) MX2020004839A (es)
PH (1) PH12020550525A1 (es)
SG (1) SG11202003700TA (es)
TW (1) TW201930315A (es)
UY (1) UY37962A (es)
WO (1) WO2019086141A1 (es)
ZA (1) ZA202002249B (es)

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JP2021501764A (ja) 2021-01-21
WO2019086141A8 (en) 2019-08-29
US11267825B2 (en) 2022-03-08
AR113826A1 (es) 2020-06-17
MA50524A (fr) 2020-09-09
UY37962A (es) 2019-05-31
AU2018361364B2 (en) 2020-11-26
ZA202002249B (en) 2022-01-26
CN111448199A (zh) 2020-07-24
AU2018361364A1 (en) 2020-05-21
CA3081386A1 (en) 2019-05-09
MX2020004839A (es) 2020-10-16
TW201930315A (zh) 2019-08-01
KR20200083551A (ko) 2020-07-08
BR112020008762A2 (pt) 2020-10-20
CU20200037A7 (es) 2021-03-11
GEAP202115351A (en) 2021-12-10
US20200354379A1 (en) 2020-11-12
EP3704127A1 (en) 2020-09-09
SG11202003700TA (en) 2020-05-28
WO2019086141A1 (en) 2019-05-09
CL2020001145A1 (es) 2020-10-09
IL274298A (en) 2020-06-30
PH12020550525A1 (en) 2021-04-26
EA202091113A1 (ru) 2020-08-28
GEP20227373B (en) 2022-04-25

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