ECSP20040257A - Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 - Google Patents
Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1Info
- Publication number
- ECSP20040257A ECSP20040257A ECSENADI202040257A ECDI202040257A ECSP20040257A EC SP20040257 A ECSP20040257 A EC SP20040257A EC SENADI202040257 A ECSENADI202040257 A EC SENADI202040257A EC DI202040257 A ECDI202040257 A EC DI202040257A EC SP20040257 A ECSP20040257 A EC SP20040257A
- Authority
- EC
- Ecuador
- Prior art keywords
- sos1
- inhibitors
- pyridopyrimidinones
- benzylamine
- derivatives
- Prior art date
Links
- 101100404726 Arabidopsis thaliana NHX7 gene Proteins 0.000 title abstract 2
- 102000057028 SOS1 Human genes 0.000 title abstract 2
- 108700022176 SOS1 Proteins 0.000 title abstract 2
- 101100197320 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) RPL35A gene Proteins 0.000 title abstract 2
- 101150100839 Sos1 gene Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical group NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 title 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000771 oncological effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención abarca compuestos de fórmula (I) , donde los grupos R1 a R4, A y p tienen los significados dados en las reivindicaciones y la memoria descriptiva, su uso como inhibidores de SOS1, composiciones farmacéuticas que contienen compuestos de esta clase y su uso como medicamentos/usos médicos, especialmente como agentes para el tratamiento y/o la prevención de enfermedades oncológicas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17209865 | 2017-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP20040257A true ECSP20040257A (es) | 2020-08-31 |
Family
ID=60781991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202040257A ECSP20040257A (es) | 2017-12-21 | 2020-07-16 | Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1 |
Country Status (35)
| Country | Link |
|---|---|
| US (2) | US10829487B2 (es) |
| EP (2) | EP4219493A1 (es) |
| JP (1) | JP7189956B2 (es) |
| KR (1) | KR102746913B1 (es) |
| CN (1) | CN111372932B (es) |
| AR (1) | AR114164A1 (es) |
| AU (1) | AU2018390927B2 (es) |
| CA (1) | CA3085835A1 (es) |
| CL (2) | CL2020001501A1 (es) |
| CO (1) | CO2020007218A2 (es) |
| CR (2) | CR20210307A (es) |
| DK (1) | DK3728254T3 (es) |
| EA (1) | EA202091491A1 (es) |
| EC (1) | ECSP20040257A (es) |
| ES (1) | ES2944306T3 (es) |
| FI (1) | FI3728254T3 (es) |
| HR (1) | HRP20230400T1 (es) |
| HU (1) | HUE062076T2 (es) |
| IL (1) | IL275379B2 (es) |
| JO (1) | JOP20200154B1 (es) |
| LT (1) | LT3728254T (es) |
| MA (1) | MA51290A (es) |
| MX (1) | MX2020006438A (es) |
| MY (1) | MY208632A (es) |
| PE (1) | PE20210163A1 (es) |
| PH (1) | PH12020550786A1 (es) |
| PL (1) | PL3728254T3 (es) |
| PT (1) | PT3728254T (es) |
| RS (1) | RS64167B1 (es) |
| SA (1) | SA520412278B1 (es) |
| SG (1) | SG11202005881YA (es) |
| SI (1) | SI3728254T1 (es) |
| TW (2) | TWI810230B (es) |
| UA (1) | UA126173C2 (es) |
| WO (1) | WO2019122129A1 (es) |
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| CR20250050A (es) | 2018-09-05 | 2025-03-19 | Incyte Corp | Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165) |
| PH12021553105A1 (en) | 2019-06-19 | 2022-07-25 | Boehringer Ingelheim Int | Anticancer combination therapy |
| US20230029385A1 (en) * | 2019-10-15 | 2023-01-26 | Bayer Aktiengesellschaft | 2-methyl-aza-quinazolines |
| PE20230249A1 (es) | 2019-11-08 | 2023-02-07 | Revolution Medicines Inc | Compuestos de heteroarilo biciclicos y usos de estos |
| MX2022006475A (es) | 2019-11-29 | 2022-09-07 | Lupin Ltd | Compuestos triciclicos sustituidos. |
| KR20220130126A (ko) * | 2019-12-20 | 2022-09-26 | 미라티 테라퓨틱스, 인크. | Sos1 억제제 |
| MX2022008066A (es) | 2019-12-27 | 2022-08-15 | Lupin Ltd | Compuestos triciclicos sustituidos. |
| CN113045565A (zh) * | 2019-12-27 | 2021-06-29 | 微境生物医药科技(上海)有限公司 | 新型K-Ras G12C抑制剂 |
| US20230101312A1 (en) * | 2020-02-24 | 2023-03-30 | Mirati Therapeutics, Inc. | Sos1 inhibitors |
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| AU2021285032A1 (en) | 2020-06-02 | 2022-12-08 | Boehringer Ingelheim International Gmbh | Annulated 2-amino-3-cyano thiophenes and derivatives for the treatment of cancer |
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