ECSP20057488A - Formulación farmacéutica novedosa que comprende antagonistas del receptor dual nk-1/nk-3 - Google Patents

Formulación farmacéutica novedosa que comprende antagonistas del receptor dual nk-1/nk-3

Info

Publication number
ECSP20057488A
ECSP20057488A ECSENADI202057488A ECDI202057488A ECSP20057488A EC SP20057488 A ECSP20057488 A EC SP20057488A EC SENADI202057488 A ECSENADI202057488 A EC SENADI202057488A EC DI202057488 A ECDI202057488 A EC DI202057488A EC SP20057488 A ECSP20057488 A EC SP20057488A
Authority
EC
Ecuador
Prior art keywords
receptor
dual
pharmaceutical formulation
formulation including
novel pharmaceutical
Prior art date
Application number
ECSENADI202057488A
Other languages
English (en)
Inventor
Monica Lazaro
Mary Kerr
Derek Bush
Mike Trower
David Elder
Original Assignee
Kandy Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65817992&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ECSP20057488(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kandy Therapeutics Ltd filed Critical Kandy Therapeutics Ltd
Publication of ECSP20057488A publication Critical patent/ECSP20057488A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención se refiere en general a nuevas formulaciones farmacéuticas que contienen 2-[3,5-Bis(trifluorometil)fenil]-N-{4-(4-fluoro-2-metilfenil)-6-[(7S,9aS)-7-(hidroximetil)hexahidropirazino[2,1-c][1,4]oxazin-8(1H)-il]-3-piridinil}-N,2-dimetilpropanamida, métodos de preparación de los mismos y su uso en terapia médica.
ECSENADI202057488A 2018-03-14 2020-09-14 Formulación farmacéutica novedosa que comprende antagonistas del receptor dual nk-1/nk-3 ECSP20057488A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862642622P 2018-03-14 2018-03-14

Publications (1)

Publication Number Publication Date
ECSP20057488A true ECSP20057488A (es) 2020-12-31

Family

ID=65817992

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202057488A ECSP20057488A (es) 2018-03-14 2020-09-14 Formulación farmacéutica novedosa que comprende antagonistas del receptor dual nk-1/nk-3

Country Status (34)

Country Link
US (6) US10774091B2 (es)
EP (1) EP3765024B1 (es)
JP (1) JP7433252B2 (es)
KR (1) KR102833016B1 (es)
CN (2) CN112292132A (es)
AU (1) AU2019233606B2 (es)
CA (1) CA3092238A1 (es)
CL (1) CL2020002350A1 (es)
CO (1) CO2020011262A2 (es)
CR (1) CR20200385A (es)
DK (1) DK3765024T3 (es)
EA (1) EA202092131A1 (es)
EC (1) ECSP20057488A (es)
ES (1) ES2974300T3 (es)
FI (1) FI3765024T3 (es)
GE (2) GEAP202215464A (es)
HR (1) HRP20240120T1 (es)
HU (1) HUE065300T2 (es)
IL (1) IL276959B2 (es)
JO (1) JOP20200227B1 (es)
LT (1) LT3765024T (es)
MA (1) MA51999B1 (es)
MX (2) MX392190B (es)
MY (1) MY201590A (es)
PE (1) PE20210395A1 (es)
PH (1) PH12020551457A1 (es)
PL (1) PL3765024T3 (es)
PT (1) PT3765024T (es)
RS (1) RS65257B1 (es)
SA (1) SA520420126B1 (es)
SG (1) SG11202008226YA (es)
SI (1) SI3765024T1 (es)
UA (1) UA128159C2 (es)
WO (1) WO2019175253A1 (es)

Families Citing this family (11)

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AU2016264034B2 (en) * 2015-05-18 2020-03-05 KaNDy Therapeutics Limited Dual NK-1/NK-3 receptor antagonists for the treatment of sex-hormone-dependent diseases
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EA202092131A1 (ru) 2018-03-14 2020-11-27 Кэнди Терапьютикс Лимитед Новый фармацевтический препарат, содержащий двойные антагонисты рецептора nk-1/nk-3
WO2019178401A1 (en) 2018-03-14 2019-09-19 H. Lee Moffitt Cancer Center And Research Institute, Inc. Yap1 inhibitors that target the interaction of yap1 with oct4
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WO2025242584A1 (en) 2024-05-24 2025-11-27 Bayer Consumer Care Ag A stable soft gelatin capsule formulation for elinzanetant
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WO2025242583A1 (en) 2024-05-24 2025-11-27 Bayer Consumer Care Ag Novel formulation comprising elinzanetant in a solid dispersion
US12533358B1 (en) 2025-05-14 2026-01-27 Bayer Consumer Care Ag Methods of treatment with elinzanetant

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EA202092131A1 (ru) 2018-03-14 2020-11-27 Кэнди Терапьютикс Лимитед Новый фармацевтический препарат, содержащий двойные антагонисты рецептора nk-1/nk-3
EP4058433A1 (en) 2019-11-15 2022-09-21 KaNDy Therapeutics Limited New chemical process for making 6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-amine a key intermediate of nt-814

Also Published As

Publication number Publication date
IL276959B1 (en) 2024-03-01
EA202092131A1 (ru) 2020-11-27
AU2019233606B2 (en) 2024-10-03
SG11202008226YA (en) 2020-09-29
CR20200385A (es) 2021-05-21
MX2020009438A (es) 2022-05-11
JOP20200227B1 (ar) 2024-04-18
SA520420126B1 (ar) 2024-02-01
FI3765024T3 (fi) 2024-02-14
HRP20240120T1 (hr) 2024-04-12
PT3765024T (pt) 2024-02-19
KR102833016B1 (ko) 2025-07-14
JOP20200227A1 (ar) 2020-09-13
US20190284205A1 (en) 2019-09-19
US20230382922A1 (en) 2023-11-30
DK3765024T3 (da) 2024-02-12
CN112292132A (zh) 2021-01-29
MX392190B (es) 2025-03-21
LT3765024T (lt) 2024-02-26
US11767328B2 (en) 2023-09-26
US20200361956A1 (en) 2020-11-19
HUE065300T2 (hu) 2024-05-28
JP7433252B2 (ja) 2024-02-19
US10774091B2 (en) 2020-09-15
MA51999B1 (fr) 2024-02-29
MY201590A (en) 2024-03-04
UA128159C2 (uk) 2024-04-24
US12264164B2 (en) 2025-04-01
CL2020002350A1 (es) 2021-04-16
RS65257B1 (sr) 2024-03-29
AU2019233606A1 (en) 2020-09-17
MA51999A (fr) 2021-01-20
JP2021517590A (ja) 2021-07-26
US11591346B2 (en) 2023-02-28
ES2974300T3 (es) 2024-06-26
EP3765024B1 (en) 2023-11-22
IL276959A (en) 2020-10-29
US20230174552A1 (en) 2023-06-08
NZ767340A (en) 2025-11-28
KR20200139138A (ko) 2020-12-11
SI3765024T1 (sl) 2024-05-31
CN119950513A (zh) 2025-05-09
PL3765024T3 (pl) 2024-08-05
MX2022005706A (es) 2022-06-08
CA3092238A1 (en) 2019-09-19
US11787820B2 (en) 2023-10-17
GEP20237503B (en) 2023-04-25
PH12020551457A1 (en) 2021-11-22
EP3765024A1 (en) 2021-01-20
IL276959B2 (en) 2024-07-01
GEAP202215464A (en) 2022-11-25
CO2020011262A2 (es) 2020-12-10
WO2019175253A1 (en) 2019-09-19
US20200361957A1 (en) 2020-11-19
US20250154167A1 (en) 2025-05-15
BR112020017388A2 (pt) 2020-12-15
PE20210395A1 (es) 2021-03-02

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