ECSP20075234A - Anticuerpos anti-tmeff2 monoespecíficos y multiespecíficos y sus usos - Google Patents

Anticuerpos anti-tmeff2 monoespecíficos y multiespecíficos y sus usos

Info

Publication number
ECSP20075234A
ECSP20075234A ECSENADI202075234A ECDI202075234A ECSP20075234A EC SP20075234 A ECSP20075234 A EC SP20075234A EC SENADI202075234 A ECSENADI202075234 A EC SENADI202075234A EC DI202075234 A ECDI202075234 A EC DI202075234A EC SP20075234 A ECSP20075234 A EC SP20075234A
Authority
EC
Ecuador
Prior art keywords
monospecific
specific anti
tmeff2 antibodies
antibodies
tmeff2
Prior art date
Application number
ECSENADI202075234A
Other languages
English (en)
Inventor
Michael Russell
Rajkumar Ganesan
Sheng-Jiun Wu
Colleen Kane
Phillip Cooper
Sanjaya Singh
Sathyadevi Venkataramani
Robin Ernst
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of ECSP20075234A publication Critical patent/ECSP20075234A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La descripción proporcionada en la presente descripción se relaciona con anticuerpos anti-TMEFF2 monoespecíficos y multiespecíficos, y métodos para producir y usar los anticuerpos descritos.
ECSENADI202075234A 2018-05-24 2020-11-23 Anticuerpos anti-tmeff2 monoespecíficos y multiespecíficos y sus usos ECSP20075234A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201862675957P 2018-05-24 2018-05-24

Publications (1)

Publication Number Publication Date
ECSP20075234A true ECSP20075234A (es) 2020-12-31

Family

ID=67211771

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202075234A ECSP20075234A (es) 2018-05-24 2020-11-23 Anticuerpos anti-tmeff2 monoespecíficos y multiespecíficos y sus usos

Country Status (25)

Country Link
US (1) US11866499B2 (es)
EP (1) EP3802607A2 (es)
JP (2) JP2021524255A (es)
KR (1) KR20210011999A (es)
CN (1) CN112703203B (es)
AR (1) AR115419A1 (es)
AU (1) AU2019274652B2 (es)
BR (1) BR112020023416A2 (es)
CA (1) CA3101304A1 (es)
CL (1) CL2020003032A1 (es)
CO (1) CO2020014515A2 (es)
CR (1) CR20200564A (es)
EA (1) EA202092849A1 (es)
EC (1) ECSP20075234A (es)
IL (1) IL278862A (es)
JO (1) JOP20200295A1 (es)
MA (1) MA52772A (es)
MX (1) MX2020012589A (es)
NI (1) NI202000087A (es)
PE (1) PE20210634A1 (es)
PH (1) PH12020551948A1 (es)
SG (1) SG11202011268VA (es)
TW (1) TWI865451B (es)
UY (1) UY38243A (es)
WO (1) WO2019224713A2 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112912397B (zh) 2018-05-24 2025-03-14 詹森生物科技公司 抗cd3抗体及其用途
CA3164972A1 (en) * 2019-12-18 2021-06-24 Janssen Biotech, Inc. Materials and methods for in vivo biological targeting
CA3184189A1 (en) 2020-05-27 2021-12-02 Janssen Biotech, Inc. Proteins comprising cd3 antigen binding domains and uses thereof
CA3195114A1 (en) * 2020-10-09 2022-04-14 Martin Klatt Compositions targeting ndc80/mhc complexes and uses thereof
EP4228693A4 (en) 2020-10-13 2024-12-18 Janssen Biotech, Inc. BIOTECHNOLOGICALLY ENGINEERED T-CELL-MEDIATED IMMUNITY, MATERIALS AND OTHER METHODS FOR MODULATING A CLUSTER OF DIFFERENTIATION IV AND/OR VIII
CA3252619A1 (en) 2022-02-23 2023-08-31 Xencor, Inc. Anti-CD28 and anti-PSMA antibodies
AU2023337066A1 (en) * 2022-09-09 2025-04-24 Janssen Biotech, Inc. Method of treating cancer with an anti tmeff2xcd3 bispecific antibody

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US226A (en) 1837-06-03 Samuel goss
US7709A (en) 1850-10-08 Chas S Gaylord Improved spring-grapple
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
WO1988001649A1 (en) 1986-09-02 1988-03-10 Genex Corporation Single polypeptide chain binding molecules
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US6150584A (en) 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US6172197B1 (en) 1991-07-10 2001-01-09 Medical Research Council Methods for producing members of specific binding pairs
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
ATE255131T1 (de) 1991-06-14 2003-12-15 Genentech Inc Humanisierter heregulin antikörper
PT1696031E (pt) 1991-12-02 2010-06-25 Medical Res Council Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
JP3720353B2 (ja) 1992-12-04 2005-11-24 メディカル リサーチ カウンシル 多価および多重特異性の結合タンパク質、それらの製造および使用
AUPO591797A0 (en) 1997-03-27 1997-04-24 Commonwealth Scientific And Industrial Research Organisation High avidity polyvalent and polyspecific reagents
WO1998052976A1 (en) 1997-05-21 1998-11-26 Biovation Limited Method for the production of non-immunogenic proteins
US6818749B1 (en) 1998-10-31 2004-11-16 The United States Of America As Represented By The Department Of Health And Human Services Variants of humanized anti carcinoma monoclonal antibody cc49
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
IL155977A0 (en) 2000-11-30 2003-12-23 Medarex Inc Transgenic transchromosomal rodents for making human antibodies
MXPA05000511A (es) 2001-07-12 2005-09-30 Jefferson Foote Anticuepros super humanizados.
DE60321041D1 (de) 2002-03-08 2008-06-26 Pdl Biopharma Inc Antikörper gegen krebsantigen tmeff2 und seine anwendungen
CA2577082A1 (en) 2004-09-02 2006-03-16 Genentech, Inc. Heteromultimeric molecules
CN101198698B (zh) 2005-03-31 2014-03-19 中外制药株式会社 通过调节多肽缔合制备多肽的方法
DE102005028778A1 (de) 2005-06-22 2006-12-28 SUNJÜT Deutschland GmbH Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage
PE20071101A1 (es) 2005-08-31 2007-12-21 Amgen Inc Polipeptidos y anticuerpos
WO2007110205A2 (en) 2006-03-24 2007-10-04 Merck Patent Gmbh Engineered heterodimeric protein domains
WO2007147901A1 (en) 2006-06-22 2007-12-27 Novo Nordisk A/S Production of bispecific antibodies
US20090155275A1 (en) 2007-07-31 2009-06-18 Medimmune, Llc Multispecific epitope binding proteins and uses thereof
AU2008312457B2 (en) 2007-10-19 2014-04-17 Genentech, Inc. Cysteine engineered anti-TENB2 antibodies and antibody drug conjugates
US8748356B2 (en) 2007-10-19 2014-06-10 Janssen Biotech, Inc. Methods for use in human-adapting monoclonal antibodies
JP2011507519A (ja) 2007-12-19 2011-03-10 セントコア・オーソ・バイオテツク・インコーポレーテツド ｐＩＸ又はｐＶＩＩへの融合を介したヒトデノボｐＩＸファージディスプレイライブラリの設計及び作製、ベクター、抗体、及び方法
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
US8227577B2 (en) 2007-12-21 2012-07-24 Hoffman-La Roche Inc. Bivalent, bispecific antibodies
JP2012505654A (ja) 2008-10-14 2012-03-08 ヤンセン バイオテツク，インコーポレーテツド 抗体をヒト化及び親和性成熟する方法
AU2010245011B2 (en) 2009-04-27 2015-09-03 Oncomed Pharmaceuticals, Inc. Method for making heteromultimeric molecules
JP6040148B2 (ja) 2010-04-20 2016-12-07 ゲンマブ エー／エス ヘテロ二量体抗体Ｆｃ含有タンパク質およびその産生方法
PL2635607T3 (pl) 2010-11-05 2020-05-18 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerowego z mutacjami w domenie FC
PL2773671T3 (pl) 2011-11-04 2022-01-24 Zymeworks Inc. Projekt stabilnego przeciwciała heterodimerycznego z mutacjami w domenie fc
US20150030602A1 (en) * 2011-12-23 2015-01-29 Phenoquest Ag Antibodies for the treatment and diagnosis of affective and anxiety disorders
SG11201504676VA (en) 2012-12-14 2015-07-30 Omt Inc Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same
AU2014237635B2 (en) 2013-03-15 2020-03-12 Janssen Biologics B.V. Manufacturing methods to control C-terminal lysine, galactose and sialic acid content in recombinant proteins
TWI680138B (zh) * 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
DK3189081T3 (da) 2014-09-05 2020-05-04 Janssen Pharmaceutica Nv Cd123-bindende midler og anvendelser deraf
HK1250997A1 (zh) 2015-05-01 2019-01-18 基因泰克公司 掩蔽抗cd3抗体和使用方法
WO2016204966A1 (en) * 2015-06-16 2016-12-22 Genentech, Inc. Anti-cd3 antibodies and methods of use
KR20250099459A (ko) * 2015-11-03 2025-07-01 얀센 바이오테크 인코포레이티드 Pd-1과 특이적으로 결합하는 항체 및 그의 용도
SG11202011306TA (en) * 2018-05-16 2020-12-30 Janssen Biotech Inc Bcma/cd3 and gprdc5d/cd3 bispecific antibodies for use in cancer therapy
CN112912397B (zh) 2018-05-24 2025-03-14 詹森生物科技公司 抗cd3抗体及其用途

Also Published As

Publication number Publication date
AU2019274652A1 (en) 2020-11-26
US20190359711A1 (en) 2019-11-28
WO2019224713A2 (en) 2019-11-28
CR20200564A (es) 2021-06-21
TW202003584A (zh) 2020-01-16
IL278862A (en) 2021-01-31
PH12020551948A1 (en) 2021-08-16
SG11202011268VA (en) 2020-12-30
PE20210634A1 (es) 2021-03-23
AU2019274652B2 (en) 2026-03-26
UY38243A (es) 2019-11-29
CN112703203B (zh) 2025-02-25
WO2019224713A3 (en) 2020-01-02
AR115419A1 (es) 2021-01-13
EP3802607A2 (en) 2021-04-14
US11866499B2 (en) 2024-01-09
CN112703203A (zh) 2021-04-23
BR112020023416A2 (pt) 2021-02-17
NI202000087A (es) 2021-03-23
JOP20200295A1 (ar) 2020-11-22
JP2021524255A (ja) 2021-09-13
EA202092849A1 (ru) 2021-03-16
CL2020003032A1 (es) 2021-04-16
KR20210011999A (ko) 2021-02-02
MX2020012589A (es) 2021-01-29
CA3101304A1 (en) 2019-11-28
JP2024105476A (ja) 2024-08-06
CO2020014515A2 (es) 2020-12-10
MA52772A (fr) 2021-04-14
TWI865451B (zh) 2024-12-11

Similar Documents

Publication Publication Date Title
CL2020003032A1 (es) Anticuerpos anti-tmeff2 monoespecíficos y multiespecíficos y sus usos.
PE20211603A1 (es) Anticuerpos que se unen a cd3
ECSP19050049A (es) Anticuerpos anti-ox40 y sus usos
CO2019009365A2 (es) Anticuerpos anti-lag3
ECSP19026178A (es) Anticuerpos anti-pd-1 y sus usos
CO2019007092A2 (es) Receptores inmunes sintéticos y métodos de uso de los mismos
CL2019002793A1 (es) Composición para producir tagatosa y procedimiento de producción de tagatosa usando la misma.
CL2018000595A1 (es) Anticuerpos anti-pd1 y métodos de uso
MX2020007266A (es) Moleculas del receptor quimerico de engullido y metodos de uso.
TR2021016542A2 (tr) Plazma bazlı filmler ve bunları üretme ve kullanma usulleri.
MX2019003489A (es) Moleculas del receptor de envolvimiento quimerico.
UY40770A (es) Antianticuerpos gprc5d, moléculas de unión al antígeno biespecíficas que se unen a gprc5d y cd3, y usos de éstas
MX2018014630A (es) Anticuerpos anti-cd40 y sus usos.
MX2017007585A (es) Anticuerpos anti-c10orf54 y usos de los mismos.
ECSP14005975A (es) Anticuerpos anti-PHF-tau y sus usos
AR114001A1 (es) Anticuerpos que se unen a hla- a2 / wt1
MX2019011758A (es) Composicion para producir tagatosa y procedimiento de produccion de tagatosa usando la misma.
ECSP20021132A (es) Enantiómeros de tiazoles sustituidos compuestos antivirales
AR095348A1 (es) Medios de cultivo celular y métodos de producción de anticuerpos
MX2019015868A (es) Nueva psicosa-6-fosfato fosfatasa, composición para producir psicosa que incluye dicha enzima, método para producir psicosa usando dicha enzima.
MX2020002552A (es) Métodos y composiciones para preparar proteína surfactante d (sp-d).
DOP2017000264A (es) Metodo para crear un compuesto a base de mercurio, compuesto a base de mercurio, metodos de uso del compuesto a base de mercurio y usos del compuesto a base de mercurio
AR113695A1 (es) Una d-psicosa 3-epimerasa y el uso de un método para producir d-psicosa
UA104842U (uk) Застосування біс(2,2,2-трифлуоретил)карбонату як конденсуючого реагента в однореакторному паралельному синтезі несиметричних аліфатичних сечовин
CL2016001884A1 (es) Método para sintetizar florfenicol.