ECSP21073246A - Compuestos tricíclicos condensados útiles como agentes anticancerígenos - Google Patents
Compuestos tricíclicos condensados útiles como agentes anticancerígenosInfo
- Publication number
- ECSP21073246A ECSP21073246A ECSENADI202173246A ECDI202173246A ECSP21073246A EC SP21073246 A ECSP21073246 A EC SP21073246A EC SENADI202173246 A ECSENADI202173246 A EC SENADI202173246A EC DI202173246 A ECDI202173246 A EC DI202173246A EC SP21073246 A ECSP21073246 A EC SP21073246A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds useful
- anticancer agents
- tricyclic compounds
- condensed tricyclic
- condensed
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
La memoria descriptiva se refiere a compuestos de Fórmula (A) y sales farmacéuticamente aceptables de los mismos. La memoria descriptiva también se refiere a procesos e intermedios utilizados para su preparación, a composiciones farmacéuticas que los contienen y a su uso en el tratamiento de trastornos proliferativos celulares.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962813885P | 2019-03-05 | 2019-03-05 | |
| US201962951146P | 2019-12-20 | 2019-12-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP21073246A true ECSP21073246A (es) | 2021-11-30 |
Family
ID=69740367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202173246A ECSP21073246A (es) | 2019-03-05 | 2021-10-01 | Compuestos tricíclicos condensados útiles como agentes anticancerígenos |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US12410187B2 (es) |
| EP (1) | EP3935060B1 (es) |
| JP (1) | JP7453989B2 (es) |
| CN (1) | CN113508118B (es) |
| AU (1) | AU2020231045B2 (es) |
| BR (1) | BR112021017408A2 (es) |
| CA (1) | CA3131156A1 (es) |
| CL (1) | CL2021002296A1 (es) |
| CO (1) | CO2021012381A2 (es) |
| CR (1) | CR20210504A (es) |
| DO (1) | DOP2021000183A (es) |
| EC (1) | ECSP21073246A (es) |
| ES (1) | ES3010507T3 (es) |
| IL (1) | IL285761B2 (es) |
| JO (1) | JOP20210241A1 (es) |
| MA (1) | MA55198A (es) |
| MX (1) | MX2021010674A (es) |
| PE (1) | PE20220140A1 (es) |
| PH (1) | PH12021552083A1 (es) |
| SG (1) | SG11202109451TA (es) |
| TW (1) | TW202100532A (es) |
| UY (1) | UY38602A (es) |
| WO (1) | WO2020178282A1 (es) |
| ZA (1) | ZA202106192B (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019217307A1 (en) | 2018-05-07 | 2019-11-14 | Mirati Therapeutics, Inc. | Kras g12c inhibitors |
| IL281344B2 (en) | 2018-09-10 | 2025-09-01 | Mirati Therapeutics Inc | Combination of adagrasib and cetuximab for cancer treatment |
| JP2022500385A (ja) | 2018-09-10 | 2022-01-04 | ミラティ セラピューティクス， インコーポレイテッド | 組み合わせ療法 |
| CA3111980A1 (en) | 2018-09-10 | 2020-03-19 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3849537B1 (en) | 2018-09-10 | 2024-10-23 | Mirati Therapeutics, Inc. | Combination therapies |
| JP7451419B2 (ja) | 2018-10-26 | 2024-03-18 | 大鵬薬品工業株式会社 | 新規なインダゾール化合物又はその塩 |
| CA3112129A1 (en) | 2018-12-05 | 2020-06-11 | Mirati Therapeutics, Inc. | Combination therapies |
| EP3908283A4 (en) | 2019-01-10 | 2022-10-12 | Mirati Therapeutics, Inc. | KRAS G12C INHIBITORS |
| AU2020337938B2 (en) | 2019-08-29 | 2025-09-25 | Array Biopharma Inc. | KRas G12D inhibitors |
| MX2022003537A (es) | 2019-09-24 | 2022-07-11 | Mirati Therapeutics Inc | Terapias de combinacion. |
| CR20220230A (es) | 2019-10-28 | 2022-06-15 | Merck Sharp & Dohme | Inhibidores de pequeñas moléculas de mutante g12c de kras |
| WO2021108683A1 (en) | 2019-11-27 | 2021-06-03 | Revolution Medicines, Inc. | Covalent ras inhibitors and uses thereof |
| EP4067343A4 (en) | 2019-11-29 | 2024-01-03 | Taiho Pharmaceutical Co., Ltd. | NEW PHENOLIC COMPOUND OR SALT THEREOF |
| UA128806C2 (uk) * | 2019-12-11 | 2024-10-23 | Елі Ліллі Енд Компані | Інгібітори kras g12c |
| EP4076418A4 (en) | 2019-12-20 | 2024-01-24 | Mirati Therapeutics, Inc. | Sos1 inhibitors |
| TWI799871B (zh) * | 2020-05-27 | 2023-04-21 | 大陸商勁方醫藥科技(上海)有限公司 | 三環并環類化合物，其製法與醫藥上的用途 |
| CA3183032A1 (en) | 2020-06-18 | 2021-12-23 | Mallika Singh | Methods for delaying, preventing, and treating acquired resistance to ras inhibitors |
| MX2023002248A (es) | 2020-09-03 | 2023-05-16 | Revolution Medicines Inc | Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. |
| AU2021340716A1 (en) | 2020-09-11 | 2023-03-30 | Mirati Therapeutics, Inc. | Crystalline forms of a KRas G12C inhibitor |
| US12162893B2 (en) | 2020-09-23 | 2024-12-10 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| CN114437107B (zh) * | 2020-11-06 | 2025-04-04 | 江苏先声药业有限公司 | 哌嗪类化合物及其应用 |
| CN114539286B (zh) * | 2020-11-24 | 2024-02-02 | 成都百裕制药股份有限公司 | 哌嗪衍生物及其在医药上的应用 |
| TWI880049B (zh) * | 2020-12-04 | 2025-04-11 | 美商美國禮來大藥廠 | Kras g12c抑制劑 |
| AU2021401232A1 (en) | 2020-12-15 | 2023-06-22 | Mirati Therapeutics, Inc. | Azaquinazoline pan-kras inhibitors |
| US11999753B2 (en) | 2020-12-16 | 2024-06-04 | Mirati Therapeutics, Inc. | Tetrahydropyridopyrimidine pan-KRas inhibitors |
| WO2022133345A1 (en) | 2020-12-18 | 2022-06-23 | Erasca, Inc. | Tricyclic pyridones and pyrimidones |
| AU2022254674A1 (en) * | 2021-04-08 | 2023-10-12 | Genentech, Inc. | Oxazepine compounds and uses thereof in the treatment of cancer |
| TW202327569A (zh) | 2021-09-01 | 2023-07-16 | 瑞士商諾華公司 | 包含ｔｅａｄ抑制劑的藥物組合及其用於癌症治療之用途 |
| AU2022371727A1 (en) | 2021-10-22 | 2024-05-02 | Jiangsu Hengrui Pharmaceuticals Co., Ltd. | Nitrogen-containing tetracyclic compound, preparation method therefor, and medical use thereof |
| TW202325298A (zh) * | 2021-11-01 | 2023-07-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 含氮的四環化合物、其製備方法及其在醫藥上的應用 |
| EP4456899A1 (en) | 2021-12-28 | 2024-11-06 | AstraZeneca UK Limited | Combination of antibody-drug conjugate and rasg12c inhibitor |
| US20250177389A1 (en) | 2022-03-04 | 2025-06-05 | Eli Lilly And Company | Method of treatment including kras g12c inhibitors and shp2 inhibitors |
| EP4504209A1 (en) | 2022-04-08 | 2025-02-12 | Eli Lilly and Company | Method of treatment including kras g12c inhibitors and aurora a inhibitors |
| AU2024241633A1 (en) | 2023-03-30 | 2025-11-06 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
| TW202506128A (zh) | 2023-04-14 | 2025-02-16 | 瑞典商阿斯特捷利康公司 | 用於治療癌症之ｋｒａｓ抑制劑及ａｔｒ抑制劑之組合 |
| WO2024229406A1 (en) | 2023-05-04 | 2024-11-07 | Revolution Medicines, Inc. | Combination therapy for a ras related disease or disorder |
| KR20260020406A (ko) | 2023-06-02 | 2026-02-11 | 다이이찌 산쿄 가부시키가이샤 | 항 her3 항체-약물 콘주게이트와 rasg12c 저해제의 조합 |
| US20250049810A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| TW202530228A (zh) | 2023-10-12 | 2025-08-01 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| TW202535891A (zh) | 2023-10-20 | 2025-09-16 | 美商默沙東有限責任公司 | Ｋｒａｓ蛋白之小分子抑制劑 |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| TW202547461A (zh) | 2024-05-17 | 2025-12-16 | 美商銳新醫藥公司 | Ｒａｓ抑制劑 |
| WO2025255438A1 (en) | 2024-06-07 | 2025-12-11 | Revolution Medicines, Inc. | Methods of treating a ras protein-related disease or disorder |
| WO2025265060A1 (en) | 2024-06-21 | 2025-12-26 | Revolution Medicines, Inc. | Therapeutic compositions and methods for managing treatment-related effects |
| WO2026006747A1 (en) | 2024-06-28 | 2026-01-02 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2026015796A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015801A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015790A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Methods of treating a ras related disease or disorder |
| WO2026015825A1 (en) | 2024-07-12 | 2026-01-15 | Revolution Medicines, Inc. | Use of ras inhibitor for treating pancreatic cancer |
| WO2026050446A1 (en) | 2024-08-29 | 2026-03-05 | Revolution Medicines, Inc. | Ras inhibitors |
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-
2020
- 2020-03-03 CR CR20210504A patent/CR20210504A/es unknown
- 2020-03-03 MA MA055198A patent/MA55198A/fr unknown
- 2020-03-03 JP JP2021552640A patent/JP7453989B2/ja active Active
- 2020-03-03 AU AU2020231045A patent/AU2020231045B2/en active Active
- 2020-03-03 US US17/436,137 patent/US12410187B2/en active Active
- 2020-03-03 BR BR112021017408A patent/BR112021017408A2/pt unknown
- 2020-03-03 EP EP20708488.0A patent/EP3935060B1/en active Active
- 2020-03-03 JO JOP/2021/0241A patent/JOP20210241A1/ar unknown
- 2020-03-03 PE PE2021001444A patent/PE20220140A1/es unknown
- 2020-03-03 WO PCT/EP2020/055551 patent/WO2020178282A1/en not_active Ceased
- 2020-03-03 PH PH1/2021/552083A patent/PH12021552083A1/en unknown
- 2020-03-03 SG SG11202109451TA patent/SG11202109451TA/en unknown
- 2020-03-03 IL IL285761A patent/IL285761B2/en unknown
- 2020-03-03 MX MX2021010674A patent/MX2021010674A/es unknown
- 2020-03-03 ES ES20708488T patent/ES3010507T3/es active Active
- 2020-03-03 CA CA3131156A patent/CA3131156A1/en active Pending
- 2020-03-03 CN CN202080018236.1A patent/CN113508118B/zh active Active
- 2020-03-05 TW TW109107275A patent/TW202100532A/zh unknown
- 2020-03-05 UY UY0001038602A patent/UY38602A/es not_active Application Discontinuation
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- 2021-09-22 CO CONC2021/0012381A patent/CO2021012381A2/es unknown
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| US12410187B2 (en) | 2025-09-09 |
| AU2020231045B2 (en) | 2023-03-16 |
| TW202100532A (zh) | 2021-01-01 |
| JOP20210241A1 (ar) | 2023-01-30 |
| EP3935060A1 (en) | 2022-01-12 |
| BR112021017408A2 (pt) | 2022-01-18 |
| KR20210135539A (ko) | 2021-11-15 |
| MA55198A (fr) | 2022-01-12 |
| CO2021012381A2 (es) | 2021-10-20 |
| WO2020178282A1 (en) | 2020-09-10 |
| MX2021010674A (es) | 2021-09-28 |
| CN113508118A (zh) | 2021-10-15 |
| EP3935060B1 (en) | 2023-11-15 |
| CA3131156A1 (en) | 2020-09-10 |
| JP2022523981A (ja) | 2022-04-27 |
| US20220204527A1 (en) | 2022-06-30 |
| CR20210504A (es) | 2022-02-08 |
| IL285761B1 (en) | 2024-08-01 |
| ES3010507T3 (en) | 2025-04-03 |
| IL285761A (en) | 2021-10-31 |
| EP3935060C0 (en) | 2023-11-15 |
| AU2020231045A1 (en) | 2021-10-28 |
| PH12021552083A1 (en) | 2022-06-06 |
| PE20220140A1 (es) | 2022-01-27 |
| UY38602A (es) | 2020-09-30 |
| IL285761B2 (en) | 2024-12-01 |
| ZA202106192B (en) | 2022-08-31 |
| CL2021002296A1 (es) | 2022-04-29 |
| CN113508118B (zh) | 2024-07-19 |
| DOP2021000183A (es) | 2021-09-30 |
| SG11202109451TA (en) | 2021-09-29 |
| JP7453989B2 (ja) | 2024-03-21 |
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