ECSP21077887A - Protacs que degradan el receptor de estrógeno - Google Patents
Protacs que degradan el receptor de estrógenoInfo
- Publication number
- ECSP21077887A ECSP21077887A ECSENADI202177887A ECDI202177887A ECSP21077887A EC SP21077887 A ECSP21077887 A EC SP21077887A EC SENADI202177887 A ECSENADI202177887 A EC SENADI202177887A EC DI202177887 A ECDI202177887 A EC DI202177887A EC SP21077887 A ECSP21077887 A EC SP21077887A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- protacs
- degrade
- estrogen receptor
- pharmaceutically acceptable
- Prior art date
Links
- 102000015694 estrogen receptors Human genes 0.000 title 1
- 108010038795 estrogen receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La memoria descriptiva se refiere en general a compuestos de Fórmula (I): (I) y sales farmacéuticamente aceptables de los mismos, donde R1, R2, R3, R4, R6, R7, R8, enlazador, A, G, D y E tienen cualquiera de los significados definidos en la presente. Esta memoria descriptiva también se refiere al uso de tales compuestos y sales farmacéuticamente aceptables de estos en métodos de tratamiento del cuerpo humano o animal, por ejemplo, en la prevención o el tratamiento del cáncer. Esta memoria descriptiva también se refiere a procesos y compuestos intermedios implicados en la preparación de dichos compuestos y a composiciones farmacéuticas que los contienen.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962825924P | 2019-03-29 | 2019-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP21077887A true ECSP21077887A (es) | 2021-11-30 |
Family
ID=70050126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202177887A ECSP21077887A (es) | 2019-03-29 | 2021-10-21 | Protacs que degradan el receptor de estrógeno |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US20220169643A1 (es) |
| EP (1) | EP3947376A1 (es) |
| JP (1) | JP2022526370A (es) |
| KR (1) | KR20210146984A (es) |
| CN (1) | CN113646306A (es) |
| AR (1) | AR118515A1 (es) |
| AU (1) | AU2020252116B2 (es) |
| BR (1) | BR112021019007A2 (es) |
| CA (1) | CA3133763A1 (es) |
| CL (1) | CL2021002489A1 (es) |
| CO (1) | CO2021013927A2 (es) |
| CR (1) | CR20210532A (es) |
| DO (1) | DOP2021000198A (es) |
| EA (1) | EA202192553A1 (es) |
| EC (1) | ECSP21077887A (es) |
| IL (1) | IL286461A (es) |
| JO (1) | JOP20210259A1 (es) |
| MA (1) | MA55495A (es) |
| MX (1) | MX2021011811A (es) |
| PE (1) | PE20220131A1 (es) |
| PH (1) | PH12021552362A1 (es) |
| SG (1) | SG11202110527RA (es) |
| TW (1) | TW202102497A (es) |
| UY (1) | UY38625A (es) |
| WO (1) | WO2020201080A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20220348595A1 (en) * | 2021-04-09 | 2022-11-03 | Endotarget Inc. | Compounds and methods for the targeted degradation of estrogen receptors |
| TW202321219A (zh) | 2021-08-11 | 2023-06-01 | 大陸商四川海思科製藥有限公司 | 雜環衍生物及其組合物和藥學上的應用 |
| EP4455133A1 (en) * | 2021-12-24 | 2024-10-30 | Suzhou Kintor Pharmaceuticals, Inc. | Multi-protein degradation agent having imide skeleton |
| EP4457225A4 (en) | 2021-12-30 | 2025-09-24 | Beigene Switzerland Gmbh | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH AN E3 LIGASE LIGAND AND METHODS OF USE |
| WO2023212599A2 (en) * | 2022-04-26 | 2023-11-02 | Endotarget Inc. | Compounds and methods for targeted degradation of estrogen receptors |
| CN114853751B (zh) * | 2022-05-13 | 2024-01-16 | 郑州大学第一附属医院 | 一组吩噻嗪类衍生物及其应用 |
| JP2025518252A (ja) | 2022-06-02 | 2025-06-12 | シーザン ハイスーク ファーマシューティカル カンパニー リミテッド | Ｂｃｌ６を阻害又は分解する化合物及びその医薬的な応用 |
| US20260007681A1 (en) * | 2022-07-12 | 2026-01-08 | Regents Of The University Of Michigan | Indole derivatives as estrogen receptor degraders |
| CN118271284A (zh) * | 2022-12-30 | 2024-07-02 | 江苏威凯尔医药科技有限公司 | 雌激素受体调节剂及其用途 |
| WO2025090847A1 (en) | 2023-10-25 | 2025-05-01 | Bpgbio, Inc. | Estrogen receptor degraders and their use in the treatment of cancer |
| WO2025117682A1 (en) | 2023-12-01 | 2025-06-05 | Blueprint Medicines Corporation | Cyclin-dependent kinase 2 degraders |
| WO2025114875A1 (en) | 2023-12-01 | 2025-06-05 | Astrazeneca Ab | Er degraders and uses thereof |
| CN118027003B (zh) * | 2024-02-03 | 2024-10-29 | 山东大学 | 一种protac化合物及其制备方法和作为雌激素受体降解剂的用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008152394A1 (en) * | 2007-06-12 | 2008-12-18 | F.Hoffmann-La Roche Ag | Pharmaceutical compounds |
| US20180228907A1 (en) | 2014-04-14 | 2018-08-16 | Arvinas, Inc. | Cereblon ligands and bifunctional compounds comprising the same |
| NO2714752T3 (es) * | 2014-05-08 | 2018-04-21 | ||
| US10149839B2 (en) * | 2016-07-25 | 2018-12-11 | Astrazeneca Ab | Chemical compounds |
| IL318681A (en) | 2016-10-11 | 2025-03-01 | Arvinas Operations Inc | Compounds and methods for targeted reduction of androgen receptor |
| CN118834201A (zh) | 2016-12-01 | 2024-10-25 | 阿尔维纳斯运营股份有限公司 | 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物 |
| CA3049912A1 (en) * | 2017-01-26 | 2018-08-02 | Arvinas Operations, Inc. | Modulators of estrogen receptor proteolysis and associated methods of use |
-
2020
- 2020-03-18 TW TW109109065A patent/TW202102497A/zh unknown
- 2020-03-27 CA CA3133763A patent/CA3133763A1/en active Pending
- 2020-03-27 MA MA055495A patent/MA55495A/fr unknown
- 2020-03-27 BR BR112021019007A patent/BR112021019007A2/pt not_active Application Discontinuation
- 2020-03-27 WO PCT/EP2020/058702 patent/WO2020201080A1/en not_active Ceased
- 2020-03-27 CN CN202080026741.0A patent/CN113646306A/zh active Pending
- 2020-03-27 EP EP20715055.8A patent/EP3947376A1/en active Pending
- 2020-03-27 CR CR20210532A patent/CR20210532A/es unknown
- 2020-03-27 JO JOP/2021/0259A patent/JOP20210259A1/ar unknown
- 2020-03-27 KR KR1020217035041A patent/KR20210146984A/ko not_active Ceased
- 2020-03-27 UY UY0001038625A patent/UY38625A/es not_active Application Discontinuation
- 2020-03-27 PH PH1/2021/552362A patent/PH12021552362A1/en unknown
- 2020-03-27 AU AU2020252116A patent/AU2020252116B2/en active Active
- 2020-03-27 SG SG11202110527RA patent/SG11202110527RA/en unknown
- 2020-03-27 JP JP2021557786A patent/JP2022526370A/ja active Pending
- 2020-03-27 AR ARP200100864A patent/AR118515A1/es not_active Application Discontinuation
- 2020-03-27 PE PE2021001583A patent/PE20220131A1/es unknown
- 2020-03-27 MX MX2021011811A patent/MX2021011811A/es unknown
- 2020-03-27 US US17/442,329 patent/US20220169643A1/en not_active Abandoned
- 2020-03-27 EA EA202192553A patent/EA202192553A1/ru unknown
-
2021
- 2021-09-19 IL IL286461A patent/IL286461A/en unknown
- 2021-09-23 DO DO2021000198A patent/DOP2021000198A/es unknown
- 2021-09-24 CL CL2021002489A patent/CL2021002489A1/es unknown
- 2021-10-15 CO CONC2021/0013927A patent/CO2021013927A2/es unknown
- 2021-10-21 EC ECSENADI202177887A patent/ECSP21077887A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022526370A (ja) | 2022-05-24 |
| US20220169643A1 (en) | 2022-06-02 |
| TW202102497A (zh) | 2021-01-16 |
| KR20210146984A (ko) | 2021-12-06 |
| IL286461A (en) | 2021-10-31 |
| AR118515A1 (es) | 2021-10-20 |
| CA3133763A1 (en) | 2020-10-08 |
| BR112021019007A2 (pt) | 2021-11-30 |
| CN113646306A (zh) | 2021-11-12 |
| CR20210532A (es) | 2022-02-10 |
| MA55495A (fr) | 2022-02-09 |
| MX2021011811A (es) | 2021-10-22 |
| EA202192553A1 (ru) | 2022-02-21 |
| UY38625A (es) | 2020-10-30 |
| SG11202110527RA (en) | 2021-10-28 |
| EP3947376A1 (en) | 2022-02-09 |
| PE20220131A1 (es) | 2022-01-27 |
| JOP20210259A1 (ar) | 2023-01-30 |
| PH12021552362A1 (en) | 2022-09-05 |
| AU2020252116B2 (en) | 2023-04-27 |
| WO2020201080A1 (en) | 2020-10-08 |
| CO2021013927A2 (es) | 2021-10-29 |
| CL2021002489A1 (es) | 2022-06-03 |
| AU2020252116A1 (en) | 2021-11-11 |
| DOP2021000198A (es) | 2021-10-31 |
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