ECSP21080548A - Formas de dosificación sólidas farmacéuticas o nutracéuticas de múltiples capas que comprenden pirimidina y/o derivados de purina y vitaminas B, preparación y usos de estas - Google Patents

Formas de dosificación sólidas farmacéuticas o nutracéuticas de múltiples capas que comprenden pirimidina y/o derivados de purina y vitaminas B, preparación y usos de estas

Info

Publication number
ECSP21080548A
ECSP21080548A ECSENADI202180548A ECDI202180548A ECSP21080548A EC SP21080548 A ECSP21080548 A EC SP21080548A EC SENADI202180548 A ECSENADI202180548 A EC SENADI202180548A EC DI202180548 A ECDI202180548 A EC DI202180548A EC SP21080548 A ECSP21080548 A EC SP21080548A
Authority
EC
Ecuador
Prior art keywords
solid dosage
pyrimidine
dosage forms
nutraceutical
pharmaceutical
Prior art date
Application number
ECSENADI202180548A
Other languages
English (en)
Inventor
Mollar Berta Fernández
Sáiz Pablo Martín
Original Assignee
Ferrer Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrer Int filed Critical Ferrer Int
Publication of ECSP21080548A publication Critical patent/ECSP21080548A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A61K31/51—Thiamines, e.g. vitamin B1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7135—Compounds containing heavy metals
    • A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Pyridine Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención hace referencia a una forma de dosificación sólida farmacéutica o nutracéutica de múltiples capas que comprende al menos un derivado de pirimidina, un derivado de purina o cualquier sal o solvato de estos y al menos una vitamina del grupo B, que proporciona ventajosamente grandes cantidades de derivados de pirimidina y/o purina y, al mismo tiempo, garantizan una mayor estabilidad química de la forma de dosificación sólida frente a la humedad y/o condiciones ácidas. La presente invención también proporciona métodos para producir dichas formas de dosificación sólidas farmacéuticas o nutracéuticas de múltiples capas. Además, la presente invención también se refiere a los usos terapéuticos de dichas formas de dosificación farmacéuticas sólidas o nutracéuticas de múltiples capas, particularmente, para el tratamiento y/o la prevención de la neuropatía periférica.
ECSENADI202180548A 2019-05-06 2021-11-15 Formas de dosificación sólidas farmacéuticas o nutracéuticas de múltiples capas que comprenden pirimidina y/o derivados de purina y vitaminas B, preparación y usos de estas ECSP21080548A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP19382340 2019-05-06

Publications (1)

Publication Number Publication Date
ECSP21080548A true ECSP21080548A (es) 2022-02-25

Family

ID=66529933

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202180548A ECSP21080548A (es) 2019-05-06 2021-11-15 Formas de dosificación sólidas farmacéuticas o nutracéuticas de múltiples capas que comprenden pirimidina y/o derivados de purina y vitaminas B, preparación y usos de estas

Country Status (22)

Country Link
US (1) US12533371B2 (es)
EP (1) EP3965744B1 (es)
JP (1) JP2022531663A (es)
KR (1) KR20220005024A (es)
CN (1) CN113784706B (es)
AU (1) AU2019444412B2 (es)
BR (1) BR112021021769A2 (es)
CA (1) CA3137221A1 (es)
CL (1) CL2021002874A1 (es)
CO (1) CO2021015353A2 (es)
DO (1) DOP2021000225A (es)
EA (1) EA202193041A1 (es)
EC (1) ECSP21080548A (es)
JO (1) JOP20210296A1 (es)
MA (1) MA55857A (es)
MX (1) MX2021013565A (es)
PE (1) PE20220498A1 (es)
PH (1) PH12021552618A1 (es)
SG (1) SG11202111084WA (es)
TW (1) TWI827736B (es)
UA (1) UA127913C2 (es)
WO (1) WO2020224795A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20250175556A (ko) 2024-06-10 2025-12-17 최종배 제3자 개입을 통한 보이스 피싱 예방 방법
KR20250179027A (ko) 2024-06-20 2025-12-29 제이제이소프트 주식회사 본인인증정보 관리 및 이를 통한 금융사기 방지 방법

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA995133A (en) * 1973-03-29 1976-08-17 Shunkichi Tamura Uridine-5'-monophosphate compositions
GB1363398A (en) * 1973-03-29 1974-08-14 Yamasa Shoyu Kk Uridine-5.-monophosphate compositions
AU587863B2 (en) * 1985-10-07 1989-08-31 Basf Aktiengesellschaft Vitamin-containing granules and production thereof
JPH01308232A (ja) * 1988-06-03 1989-12-12 Takeda Chem Ind Ltd 固型医薬およびその製造法
JPH05194275A (ja) * 1991-09-03 1993-08-03 Takeda Chem Ind Ltd 製剤用組成物、固形製剤および薬物の防臭方法
CA2110313C (en) 1992-12-01 2004-10-26 Edward John Roche Pharmaceutical compositions containing a guanidinothiazole compound and antacids
DE10215753A1 (de) 2002-04-10 2003-10-30 Trommsdorff Arzneimittel Verwendung von Pyrimidinnukleotiden zur Behandlung von Schädigungen des peripheren Nervensystems
AR051950A1 (es) 2004-11-10 2007-02-21 Osmotica Pharmaceutical Argent Comprimido multicapa con capas que se separan
JP4775879B2 (ja) * 2004-11-17 2011-09-21 塩野義製薬株式会社 ビタミン組成物
CN101184496A (zh) * 2005-05-27 2008-05-21 兴和株式会社 用于恢复疲劳的药品
US7638142B2 (en) * 2005-10-12 2009-12-29 Vitamin Science, Inc. Therapeutic composition for the treatment of dry eye syndrome
KR100870104B1 (ko) * 2005-11-28 2008-11-26 주식회사 머젠스 안구건조증 치료 및 예방용 조성물
KR100869444B1 (ko) 2007-07-11 2008-11-18 주식회사 중외제약 유비데카레논을 함유하는 다층정 비타민 복합제제
WO2012091542A1 (en) * 2010-12-28 2012-07-05 N.V. Nutricia Combination of components for the prevention and treatment of frailty
WO2012125020A1 (en) 2011-03-14 2012-09-20 N.V. Nutricia Method for treating neurotrauma
WO2016148561A1 (en) * 2015-03-16 2016-09-22 N.V. Nutricia Method for improving bladder function
US11291683B2 (en) * 2016-04-01 2022-04-05 Access Business Group International Llc Bilayer tablets of B vitamins and process for preparing the same
MX391725B (es) * 2016-04-21 2025-03-21 Astrocyte Pharmaceuticals Inc Compuestos y metodos para tratamiento de afecciones neurologicas y cardiovasculares.
EP3366291A1 (en) 2017-02-22 2018-08-29 Montero Gida Sanayi Ve Ticaret A.S. Solid oral pharmaceutical compositions comprising alpha lipoic acid and water-soluble vitamins

Also Published As

Publication number Publication date
CA3137221A1 (en) 2020-11-12
JOP20210296A1 (ar) 2023-01-30
MA55857A (fr) 2022-03-16
WO2020224795A1 (en) 2020-11-12
BR112021021769A2 (pt) 2021-12-28
TW202108132A (zh) 2021-03-01
US20220160744A1 (en) 2022-05-26
PH12021552618A1 (en) 2022-07-18
MX2021013565A (es) 2022-01-04
EP3965744C0 (en) 2025-12-31
TWI827736B (zh) 2024-01-01
EP3965744A1 (en) 2022-03-16
CL2021002874A1 (es) 2022-06-17
EA202193041A1 (ru) 2022-02-10
KR20220005024A (ko) 2022-01-12
JP2022531663A (ja) 2022-07-08
PE20220498A1 (es) 2022-04-07
CN113784706A (zh) 2021-12-10
UA127913C2 (uk) 2024-02-07
DOP2021000225A (es) 2022-03-15
AU2019444412B2 (en) 2025-02-20
CO2021015353A2 (es) 2021-11-19
US12533371B2 (en) 2026-01-27
EP3965744B1 (en) 2025-12-31
AU2019444412A1 (en) 2021-11-04
SG11202111084WA (en) 2021-11-29
CN113784706B (zh) 2024-01-05

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