ECSP21089217A - Quelantes macrocíclicos y métodos de uso de estos - Google Patents

Quelantes macrocíclicos y métodos de uso de estos

Info

Publication number
ECSP21089217A
ECSP21089217A ECSENADI202189217A ECDI202189217A ECSP21089217A EC SP21089217 A ECSP21089217 A EC SP21089217A EC SENADI202189217 A ECSENADI202189217 A EC SENADI202189217A EC DI202189217 A ECDI202189217 A EC DI202189217A EC SP21089217 A ECSP21089217 A EC SP21089217A
Authority
EC
Ecuador
Prior art keywords
radioimmunoconjugates
radiometal
methods
alpha
macrocyclic
Prior art date
Application number
ECSENADI202189217A
Other languages
English (en)
Inventor
Shalom Goldberg
Fengbin Song
Rhys Salter
Vadim Dudkin
Wei Zhang
John Keith
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of ECSP21089217A publication Critical patent/ECSP21089217A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/025—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus inorganic Tc complexes or compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se proporcionan quelantes macrocíclicos (I) para la quelación de iones de radiometal emisores alfa, tales como actinio-225. También se proporcionan complejos de radiometal que contienen un ion de radiometal emisor alfa unido al quelante macrocíclico a través de enlace coordinado, y radioinmunoconjugados que contienen los complejos de radiometal unidos covalentemente a un ligando dirigido, tal como un anticuerpo o fragmento de unión al antígeno de este. Los radioinmunoconjugados pueden producirse mediante reacciones químicas clic. También se describen métodos para usar los radiocomplejos y radioinmunoconjugados para dirigirse selectivamente a células neoplásicas para radioterapia y para tratar enfermedades y trastornos neoplásicos.
ECSENADI202189217A 2019-05-10 2021-12-09 Quelantes macrocíclicos y métodos de uso de estos ECSP21089217A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962846044P 2019-05-10 2019-05-10

Publications (1)

Publication Number Publication Date
ECSP21089217A true ECSP21089217A (es) 2022-01-31

Family

ID=70804855

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202189217A ECSP21089217A (es) 2019-05-10 2021-12-09 Quelantes macrocíclicos y métodos de uso de estos

Country Status (22)

Country Link
US (2) US11576986B2 (es)
EP (1) EP3966211B1 (es)
JP (2) JP7734078B2 (es)
CN (1) CN114127059B (es)
AU (2) AU2020273654B2 (es)
BR (1) BR112021022237A2 (es)
CA (1) CA3139806A1 (es)
CL (1) CL2021002960A1 (es)
CO (1) CO2021015713A2 (es)
CR (1) CR20210556A (es)
DO (1) DOP2021000233A (es)
EA (1) EA202193076A1 (es)
EC (1) ECSP21089217A (es)
ES (1) ES3075769T3 (es)
IL (1) IL287909A (es)
MA (1) MA55885A (es)
MX (1) MX2021013667A (es)
PE (1) PE20220935A1 (es)
PH (1) PH12021552791A1 (es)
SG (1) SG11202112100PA (es)
UA (1) UA129220C2 (es)
WO (1) WO2020229974A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201811482YA (en) 2016-06-23 2019-01-30 Univ Cornell Double targeted constructs to affect tumor kill
US10806806B2 (en) 2016-06-23 2020-10-20 Cornell University Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies
KR102724812B1 (ko) 2017-04-05 2024-11-01 코넬 유니버시티 영상화 및 항종양 치료요법에 유용한 조정 가능한 약동학을 갖는 삼작용성 작제물
KR20210116437A (ko) 2018-11-20 2021-09-27 코넬 유니버시티 방사성핵종의 마크로사이클릭 복합체 및 암의 방사선 요법에서의 이의 용도
ES3075769T3 (en) 2019-05-10 2026-08-07 Janssen Biotech Inc Macrocyclic chelators and methods of use thereof
HUE065486T2 (hu) 2019-05-10 2024-05-28 Deciphera Pharmaceuticals Llc Fenilaminopirimidinamid autophágia inhibitorok és azok felhasználási eljárásai
HRP20231310T1 (hr) 2019-05-10 2024-02-02 Deciphera Pharmaceuticals, Llc Heteroarilaminopirimidin amidni inhibitori autofagije i postupci njihove primjene
ES3072710T3 (en) 2019-06-17 2026-07-03 Deciphera Pharmaceuticals Llc Aminopyrimidine amide autophagy inhibitors and methods of use thereof
WO2021250240A1 (en) * 2020-06-12 2021-12-16 Orano Diaza-18-crown-6 derivative useful for chelating radium, conjugate and radium chelate comprising the same, and uses thereof
TW202233244A (zh) * 2020-11-10 2022-09-01 美商健生生物科技公司 巨環化合物及其使用方法
AU2022213825A1 (en) * 2021-01-27 2023-09-14 Janssen Biotech, Inc. Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses
CN116806159A (zh) * 2021-01-27 2023-09-26 詹森生物科技公司 包含激肽释放酶相关肽酶2抗原结合结构域的免疫缀合物及其用途
US20240166631A1 (en) * 2021-03-26 2024-05-23 Nihon Medi-Physics Co., Ltd Compound, method for producing and method for storing compound, method for producing targeting agent, and composition
CA3215787A1 (en) * 2021-03-31 2022-10-06 Nihon Medi-Physics Co., Ltd. Radioactive complex of anti-egfr antibody, and radiopharmaceutical
MX2023014069A (es) 2021-05-27 2024-03-15 Janssen Biotech Inc Composiciones y métodos para el tratamiento del cáncer de próstata.
MX2024001620A (es) * 2021-08-02 2024-02-28 Rayzebio Inc Composiciones estabilizadas de radionucleidos y sus usos.
JP2024125438A (ja) * 2021-08-03 2024-09-19 住友化学株式会社 放射性金属錯体及びその製造方法、並びに放射性金属捕捉剤
WO2023026236A1 (en) * 2021-08-27 2023-03-02 Janssen Biotech, Inc. Anti-psma radioconjugates and uses thereof
WO2023026235A1 (en) 2021-08-27 2023-03-02 Janssen Biotech, Inc. Anti-psma antibodies and uses thereof
JPWO2023033022A1 (es) * 2021-08-31 2023-03-09
EP4408839A4 (en) * 2021-09-29 2025-08-06 Univ Melbourne MACROCYCLE-CONTAINING COMPOUNDS AND THEIR RADIOLABELED COMPLEXES, USED AS LIGANDS IN TARGETED RADIOTHERAPY APPLICATIONS
EP4429718A1 (en) * 2021-11-09 2024-09-18 Janssen Biotech, Inc. Macrocyclic compounds and diagnostic uses thereof
WO2023084396A1 (en) * 2021-11-09 2023-05-19 Janssen Biotech, Inc. Macrocyclic compounds and methods of making the same
WO2023144723A1 (en) 2022-01-26 2023-08-03 Janssen Biotech, Inc. Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses
JP2023135733A (ja) * 2022-03-16 2023-09-29 Ｊｆｅエンジニアリング株式会社 ジルコニウム錯体およびその合成方法
CN114656422B (zh) * 2022-04-22 2023-05-23 重庆理工大学 一种新型氮杂冠醚化合物及其阳离子脂质体、制备方法与应用
CN114874214B (zh) * 2022-05-31 2023-03-21 南京航空航天大学 可偶联巯基的双功能大环螯合剂衍生物及其制备方法
CN114949259B (zh) * 2022-07-11 2023-09-19 重庆理工大学 一种氮杂冠醚结构的基因递送载体及其制备方法和应用
CN121666388A (zh) 2023-09-01 2026-03-13 江苏恒瑞医药股份有限公司 一种大环化合物及其用途
KR20260085122A (ko) 2023-09-29 2026-06-08 악티스 온콜로지, 인크. 미니단백질, 접합체 및 이의 용도

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0353450B1 (en) * 1988-06-24 1995-03-29 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
AU4450100A (en) 1999-03-23 2000-10-23 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 225Ac-heha and related compounds, methods of synthesis and methods of use
CN103221398B (zh) 2010-07-23 2016-03-23 特拉华大学 用于快速构建放射性核素标记探针的四嗪-反式环辛烯连接反应
US10556024B2 (en) 2013-11-13 2020-02-11 Whitehead Institute For Biomedical Research 18F labeling of proteins using sortases
WO2015075445A1 (en) 2013-11-19 2015-05-28 Fredax Ab Humanised anti kallikrein-2 antibody
UA126788C2 (uk) 2015-08-11 2023-02-08 Ґалера Лебз, Елелсі Комплексні сполуки, що містять макроциклічне кільце пентаази, які мають пероральну біодоступність
US12048753B2 (en) 2015-10-01 2024-07-30 Whitehead Institute For Biomedical Research Labeling of antibodies
FR3045606B1 (fr) 2015-12-18 2019-04-05 Ecole Normale Superieure De Lyon Complexes de lanthanide pour la cristallisation de macromolecules biologiques et la determination de leur structure cristallographique
CR20180499A (es) 2016-04-22 2019-01-25 Astrazeneca Ab Inhibidores de mcl1 macrocicliclos para tratar el cancer
MX392700B (es) 2016-08-10 2025-03-11 Cancer Targeted Tech Llc Inhibidores de antígeno de la membrana específico para la próstata (psma) quelados.
JP2018068834A (ja) * 2016-11-01 2018-05-10 オリンパス株式会社 走査型内視鏡および走査型内視鏡の製造方法
ES2992988T3 (en) 2017-03-30 2024-12-20 Univ Cornell Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer
KR102724812B1 (ko) * 2017-04-05 2024-11-01 코넬 유니버시티 영상화 및 항종양 치료요법에 유용한 조정 가능한 약동학을 갖는 삼작용성 작제물
US11400165B2 (en) 2017-11-04 2022-08-02 Advanced Proteome Therapeutics Inc. Composition and method for modifying polypeptides
JP2021506842A (ja) 2017-12-18 2021-02-22 ヤンセン バイオテツク，インコーポレーテツド ポリペプチドの放射性標識
MX2020012598A (es) 2018-05-24 2021-05-27 Janssen Biotech Inc Agentes aglutinantes del psma y usos de estos.
KR20210116437A (ko) * 2018-11-20 2021-09-27 코넬 유니버시티 방사성핵종의 마크로사이클릭 복합체 및 암의 방사선 요법에서의 이의 용도
KR20210099073A (ko) 2018-12-03 2021-08-11 퓨전 파마슈티칼즈 인크. 방사성면역접합체와 체크포인트 억제제의 조합 요법
ES3075769T3 (en) 2019-05-10 2026-08-07 Janssen Biotech Inc Macrocyclic chelators and methods of use thereof
TWI925817B (zh) 2019-05-10 2026-05-21 日商武田藥品工業股份有限公司 抗體藥物結合物
TW202233244A (zh) 2020-11-10 2022-09-01 美商健生生物科技公司 巨環化合物及其使用方法
AU2022213825A1 (en) 2021-01-27 2023-09-14 Janssen Biotech, Inc. Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses
WO2023084396A1 (en) 2021-11-09 2023-05-19 Janssen Biotech, Inc. Macrocyclic compounds and methods of making the same
EP4429718A1 (en) 2021-11-09 2024-09-18 Janssen Biotech, Inc. Macrocyclic compounds and diagnostic uses thereof

Also Published As

Publication number Publication date
US20200353105A1 (en) 2020-11-12
US12453785B2 (en) 2025-10-28
EP3966211A1 (en) 2022-03-16
KR20220006613A (ko) 2022-01-17
EA202193076A1 (ru) 2022-02-16
CO2021015713A2 (es) 2021-11-30
SG11202112100PA (en) 2021-11-29
CR20210556A (es) 2021-12-17
MA55885A (fr) 2022-03-16
JP2025176045A (ja) 2025-12-03
IL287909A (en) 2022-01-01
BR112021022237A2 (pt) 2022-03-29
DOP2021000233A (es) 2022-07-31
CN114127059A (zh) 2022-03-01
WO2020229974A1 (en) 2020-11-19
AU2020273654A1 (en) 2021-11-25
AU2026202492A1 (en) 2026-04-23
EP3966211C0 (en) 2026-06-17
AU2020273654B2 (en) 2026-04-09
US20230110178A1 (en) 2023-04-13
UA129220C2 (uk) 2025-02-12
US11576986B2 (en) 2023-02-14
JP2022532157A (ja) 2022-07-13
PH12021552791A1 (en) 2022-09-05
PE20220935A1 (es) 2022-05-31
CA3139806A1 (en) 2020-11-19
EP3966211B1 (en) 2026-06-17
MX2021013667A (es) 2022-01-31
JP7734078B2 (ja) 2025-09-04
CL2021002960A1 (es) 2022-06-24
ES3075769T3 (en) 2026-08-07
CN114127059B (zh) 2024-09-24

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