ECSP22013340A - Métodos para preparar análogos de incretina - Google Patents

Métodos para preparar análogos de incretina

Info

Publication number
ECSP22013340A
ECSP22013340A ECSENADI202213340A ECDI202213340A ECSP22013340A EC SP22013340 A ECSP22013340 A EC SP22013340A EC SENADI202213340 A ECSENADI202213340 A EC SENADI202213340A EC DI202213340 A ECDI202213340 A EC DI202213340A EC SP22013340 A ECSP22013340 A EC SP22013340A
Authority
EC
Ecuador
Prior art keywords
preparing
methods
incretin analogs
incretin
analogs
Prior art date
Application number
ECSENADI202213340A
Other languages
English (en)
Inventor
Ankur Jalan
Michael E Kobierski
Michael E Kopach
Jinju James
Sergey Vladimirovich Tsukanov
Yu Lu
Timothy Donald White
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of ECSP22013340A publication Critical patent/ECSP22013340A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)

Abstract

Se describen compuestos intermediarios para preparar análogos de incretina o sales farmacéuticamente aceptables de estos. Además, se describen métodos para preparar análogos de incretina mediante el acoplamiento de dos a cuatro de los compuestos intermediarios de la presente descripción mediante síntesis en fase híbrida sólida líquida o unión química nativa.
ECSENADI202213340A 2019-08-19 2022-02-18 Métodos para preparar análogos de incretina ECSP22013340A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962888756P 2019-08-19 2019-08-19

Publications (1)

Publication Number Publication Date
ECSP22013340A true ECSP22013340A (es) 2022-03-31

Family

ID=72322545

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202213340A ECSP22013340A (es) 2019-08-19 2022-02-18 Métodos para preparar análogos de incretina

Country Status (18)

Country Link
US (1) US20220411461A1 (es)
EP (1) EP4017866A1 (es)
JP (2) JP2022545200A (es)
KR (2) KR102812908B1 (es)
CN (1) CN114269775A (es)
AU (1) AU2020334993B2 (es)
BR (1) BR112022001081A2 (es)
CA (1) CA3148347A1 (es)
CL (3) CL2022000374A1 (es)
CO (1) CO2022001413A2 (es)
EC (1) ECSP22013340A (es)
IL (1) IL289957A (es)
MX (1) MX2022002115A (es)
MY (1) MY201700A (es)
PE (1) PE20221049A1 (es)
PH (1) PH12022550398A1 (es)
WO (1) WO2021034815A1 (es)
ZA (1) ZA202200948B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20240118914A (ko) 2021-01-20 2024-08-05 바이킹 테라퓨틱스 인코포레이티드 대사 및 간 질환 치료를 위한 조성물 및 방법
BR112023022400A2 (pt) 2021-05-07 2024-01-16 Lilly Co Eli Comprimido erodível, método de fabricação e usos do mesmo
CN118265720A (zh) 2021-09-15 2024-06-28 维京治疗公司 用于治疗代谢病症和肝病的组合物和方法
TW202404996A (zh) * 2022-04-04 2024-02-01 美商美國禮來大藥廠 製備glp-1/升糖素雙重促效劑之方法
CN115368234B (zh) * 2022-08-19 2024-01-26 淄博矿业集团有限责任公司 一种索马鲁肽侧链及其中间体的合成方法
IL320036A (en) 2022-10-05 2025-06-01 Lilly Co Eli Peptides for incretin synthesis
AU2023385357A1 (en) * 2022-11-21 2025-06-05 Eli Lilly And Company Process for preparing a gip/glp1 dual agonist
CN119080910B (zh) * 2023-10-07 2025-08-15 北京泽勤生物医药有限公司 长效ggg三靶点激动剂
TW202539727A (zh) * 2023-11-10 2025-10-16 大陸商信達生物製藥（蘇州）有限公司 用於製備胰高血糖素和ｇｌｐ－１雙重促效劑的中間體及其製備方法
CN119350469B (zh) * 2024-12-23 2025-05-23 杭州诺澳生物医药科技有限公司 大片段SPPS-LPPS混合法合成Cagrilintide的方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011006644A2 (en) * 2009-07-15 2011-01-20 Lonza Ltd Process for the production of exenatide and of an exenatide analogue
JP6228187B2 (ja) 2012-05-03 2017-11-08 ジーランド ファーマ アクティーゼルスカブ Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法
WO2014049610A2 (en) 2012-09-26 2014-04-03 Cadila Healthcare Limited Peptides as gip, glp-1 and glucagon receptors triple-agonist
HRP20212014T1 (hr) * 2013-05-28 2022-04-01 Takeda Pharmaceutical Company Limited Spoj peptida
US10131702B2 (en) 2013-11-06 2018-11-20 Zealand Pharma A/S Glucagon-GLP-1-GIP triple agonist compounds
CN103613656B (zh) * 2013-11-20 2015-03-04 陕西东大生化科技有限责任公司 一种艾塞那肽的固相片段合成方法
CN103864918B (zh) * 2014-03-31 2016-08-17 哈尔滨吉象隆生物技术有限公司 一种利拉鲁肽的固相合成方法
AR103242A1 (es) 2015-01-09 2017-04-26 Lilly Co Eli Compuestos co-agonistas de gip y glp-1
WO2016198624A1 (en) 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
MX2018008128A (es) 2015-12-31 2018-12-06 Hanmi Pharm Ind Co Ltd Conjugado persistente de triple activador que activa el receptor de glucagon, glp-1 y gip.
US10676517B2 (en) 2016-03-10 2020-06-09 Medimmune Limited Glucagon and GLP-1 co-agonists for the treatment of obesity
TW201833131A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 作為胜肽類ｇｌｐ１／升糖素／ｇｉｐ受體促效劑之新化合物
CN106749610A (zh) * 2016-12-29 2017-05-31 陕西慧康生物科技有限责任公司 一种艾塞那肽的制备方法及其产品
TWI809515B (zh) * 2017-12-21 2023-07-21 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
TWI767095B (zh) 2017-12-21 2022-06-11 美商美國禮來大藥廠 腸促胰島素(incretin)類似物及其用途
AU2019311000B2 (en) 2018-07-23 2023-02-02 Eli Lilly And Company GIP/GLP1 co-agonist compounds
AR125086A1 (es) * 2021-03-23 2023-06-07 Lilly Co Eli Composiciones que contienen análogos de incretina y usos de estas
KR20240024936A (ko) * 2021-06-23 2024-02-26 일라이 릴리 앤드 캄파니 혈당 조절 및 체중 관리에 사용하기 위한 인크레틴 유사체를 포함하는 제약 조성물

Also Published As

Publication number Publication date
NZ785006A (en) 2025-09-26
MX2022002115A (es) 2022-03-17
CA3148347A1 (en) 2021-02-25
KR20220035199A (ko) 2022-03-21
WO2021034815A1 (en) 2021-02-25
KR102812908B1 (ko) 2025-05-28
AU2020334993B2 (en) 2023-07-13
CL2022000374A1 (es) 2022-11-18
MY201700A (en) 2024-03-13
IL289957A (en) 2022-03-01
PE20221049A1 (es) 2022-06-30
US20220411461A1 (en) 2022-12-29
CL2024003748A1 (es) 2025-04-04
JP2022545200A (ja) 2022-10-26
CN114269775A (zh) 2022-04-01
CL2024003747A1 (es) 2025-03-28
AU2020334993A1 (en) 2022-02-24
JP2024147650A (ja) 2024-10-16
EP4017866A1 (en) 2022-06-29
ZA202200948B (en) 2024-09-25
KR20250074694A (ko) 2025-05-27
PH12022550398A1 (en) 2023-10-23
CO2022001413A2 (es) 2022-03-18
BR112022001081A2 (pt) 2022-05-24

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