CR20120460A - Compuestos de sililo tricíclicos fusionados y métodos de uso de los mismos para el tratamiento de enfermedades virales - Google Patents

Compuestos de sililo tricíclicos fusionados y métodos de uso de los mismos para el tratamiento de enfermedades virales

Info

Publication number
CR20120460A
CR20120460A CR20120460A CR20120460A CR20120460A CR 20120460 A CR20120460 A CR 20120460A CR 20120460 A CR20120460 A CR 20120460A CR 20120460 A CR20120460 A CR 20120460A CR 20120460 A CR20120460 A CR 20120460A
Authority
CR
Costa Rica
Prior art keywords
compounds
trichyclic
sililo
fusioned
treatment
Prior art date
Application number
CR20120460A
Other languages
English (en)
Inventor
Anilkumar Gopinadhan Nair
Kerry M Keertikar
Seong Heon Kim
Joseph A Kozlowski
Stuart Rosenblum
Oleg B Selyutin
Michael Wong
Wensheng Yu
Qingbei Zeng
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43939669&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120460(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CR20120460A publication Critical patent/CR20120460A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C07F7/0816—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring said ring comprising Si as a ring atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de sililo tricíclicos fucionados de fórmula (I), y sales farmacéuticamente aceptables de los mismos, en donde A, B, C, D, M1, X1 y X2 son como se definen en el presente documento.
CR20120460A 2010-03-09 2012-09-10 Compuestos de sililo tricíclicos fusionados y métodos de uso de los mismos para el tratamiento de enfermedades virales CR20120460A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31201610P 2010-03-09 2010-03-09
US37193510P 2010-08-09 2010-08-09

Publications (1)

Publication Number Publication Date
CR20120460A true CR20120460A (es) 2012-11-01

Family

ID=43939669

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120460A CR20120460A (es) 2010-03-09 2012-09-10 Compuestos de sililo tricíclicos fusionados y métodos de uso de los mismos para el tratamiento de enfermedades virales

Country Status (26)

Country Link
US (1) US8609635B2 (es)
EP (1) EP2545060B1 (es)
JP (1) JP2013522202A (es)
KR (1) KR20130008040A (es)
CN (1) CN102918049A (es)
AR (1) AR080676A1 (es)
AU (1) AU2011224698A1 (es)
BR (1) BR112012022125A2 (es)
CA (1) CA2792121A1 (es)
CL (1) CL2012002489A1 (es)
CO (1) CO6592102A2 (es)
CR (1) CR20120460A (es)
DO (1) DOP2012000243A (es)
EA (1) EA201290882A1 (es)
EC (1) ECSP12012147A (es)
ES (1) ES2558554T3 (es)
MA (1) MA34147B1 (es)
MX (1) MX2012010392A (es)
NI (1) NI201200139A (es)
PE (1) PE20130062A1 (es)
PH (1) PH12012501748A1 (es)
SG (1) SG183526A1 (es)
TN (1) TN2012000416A1 (es)
TW (1) TW201136943A (es)
WO (1) WO2011112429A1 (es)
ZA (1) ZA201206716B (es)

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MA34147B1 (fr) 2013-04-03
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AR080676A1 (es) 2012-05-02
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CA2792121A1 (en) 2011-09-15
ES2558554T3 (es) 2016-02-05
CN102918049A (zh) 2013-02-06
TW201136943A (en) 2011-11-01
US8609635B2 (en) 2013-12-17
BR112012022125A2 (pt) 2016-11-01
US20110223134A1 (en) 2011-09-15
EP2545060B1 (en) 2015-11-25
TN2012000416A1 (en) 2014-01-30
DOP2012000243A (es) 2012-12-31
CL2012002489A1 (es) 2012-11-30
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EP2545060A1 (en) 2013-01-16
KR20130008040A (ko) 2013-01-21
AU2011224698A1 (en) 2012-11-01
NI201200139A (es) 2013-01-24
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MX2012010392A (es) 2012-10-03
ZA201206716B (en) 2013-05-29

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