ECSP22031078A - Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca - Google Patents

Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca

Info

Publication number
ECSP22031078A
ECSP22031078A ECSENADI202231078A ECDI202231078A ECSP22031078A EC SP22031078 A ECSP22031078 A EC SP22031078A EC SENADI202231078 A ECSENADI202231078 A EC SENADI202231078A EC DI202231078 A ECDI202231078 A EC DI202231078A EC SP22031078 A ECSP22031078 A EC SP22031078A
Authority
EC
Ecuador
Prior art keywords
heart failure
angiotensin
receptor antagonist
treatment
nep inhibitor
Prior art date
Application number
ECSENADI202231078A
Other languages
English (en)
Inventor
Jingchao Sun
Xiaolong Jing
Original Assignee
Shenzhen Salubris Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Salubris Pharm Co Ltd filed Critical Shenzhen Salubris Pharm Co Ltd
Publication of ECSP22031078A publication Critical patent/ECSP22031078A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Los usos de un complejo de un metabolito antagonista del receptor de angiotensina II y un inhibidor de NEP para la insuficiencia card?aca, se relacionan espec?ficamente los usos del complejo en la preparaci?n de un medicamento para su uso en la insuficiencia card?aca con fracci?n de expulsi?n reducida (HFrEF).
ECSENADI202231078A 2019-09-20 2022-04-19 Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca ECSP22031078A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910890853 2019-09-20
CN202010901984 2020-09-01

Publications (1)

Publication Number Publication Date
ECSP22031078A true ECSP22031078A (es) 2022-08-31

Family

ID=74883393

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202231078A ECSP22031078A (es) 2019-09-20 2022-04-19 Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca

Country Status (13)

Country Link
US (1) US12508246B2 (es)
EP (1) EP4032532A4 (es)
JP (1) JP7316449B2 (es)
KR (1) KR102752382B1 (es)
CN (2) CN115487175B (es)
AU (1) AU2020348813B2 (es)
CA (1) CA3151788A1 (es)
CO (1) CO2022004910A2 (es)
EC (1) ECSP22031078A (es)
MX (1) MX2022003408A (es)
TW (1) TWI809313B (es)
WO (1) WO2021052441A1 (es)
ZA (1) ZA202204370B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI809313B (zh) * 2019-09-20 2023-07-21 大陸商深圳信立泰藥業股份有限公司 血管緊張素ii受體拮抗劑代謝產物與nep抑制劑的複合物的新心衰用途
WO2022037512A1 (zh) * 2020-08-17 2022-02-24 深圳信立泰药业股份有限公司 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的心衰应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004203284A1 (en) * 1998-11-06 2004-08-12 G.D. Searle & Co. Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
US20060014829A1 (en) * 2004-07-16 2006-01-19 Nitromed, Inc. Methods for reducing hospitalizations related to heart failure
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
EP2415739A4 (en) 2009-04-01 2014-01-08 Mitsui Chemicals Inc PROCESS FOR THE PRODUCTION OF OLEFIN
AR089954A1 (es) * 2012-02-15 2014-10-01 Theravance Inc Forma cristalina del ester 5-metil-2-oxo-[1,3]dioxol-4-ilmetilico del acido (2s,4r)-5-bifenil-4-il-2-hidroximetil-2-metil-4-[(1h-[1,2,3]triazol-4-carbonil)amino]pentanoico
SI4321157T1 (sl) * 2013-08-26 2025-03-31 Novartis Ag Nova uporaba kombinacije blokatorja receptorja angiotenzina (arb) z nevtralnim zaviralcem endopeptidaze (nepi)
CN105503760A (zh) 2014-10-10 2016-04-20 上海翰森生物医药科技有限公司 结晶型ARB-NEPi双阳离子复合物及其制备方法和应用
CN106146472A (zh) * 2015-04-15 2016-11-23 苏州朗科生物技术有限公司 一种双重作用的阿利沙坦复合物
CN106138041A (zh) * 2015-04-15 2016-11-23 苏州朗科生物技术有限公司 一种双重作用的氯沙坦复合物
RS64242B1 (sr) * 2015-05-11 2023-06-30 Novartis Ag Režim doziranja sakubitril-valsartana za lečenje srčane insuficijencije
WO2017006254A1 (en) * 2015-07-08 2017-01-12 Novartis Ag Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist
CN105669581B (zh) 2015-11-09 2017-03-22 成都苑东生物制药股份有限公司 一种血管紧张受体拮抗剂和中性内肽酶抑制剂复合物
HRP20250328T1 (hr) * 2016-01-20 2025-05-09 Shenzhen Salubris Pharmaceuticals Co., Ltd Metabolit antagonista receptora angiotenzina ii i kompozit inhibitora nep, te postupak njegove pripreme
RS62172B1 (sr) 2016-03-08 2021-08-31 Theravance Biopharma R&D Ip Llc Kristalna (2s,4r)-5-(5’-hloro-2-fluoro-[1,1’-bifenil]-4-il)-2-(etoksimetil)-4-(3-hidroksi izoksazol-5-karboksamido)-2-metilpentanska kiselina i njene upotrebe
CN108619138B (zh) * 2016-08-01 2020-07-03 珠海赛隆药业股份有限公司（长沙）医药研发中心 血管紧张素受体拮抗剂和脑啡肽酶抑制剂的复合物及其用途
CN106924241A (zh) * 2017-04-28 2017-07-07 广州医科大学 川陈皮素在预防或治疗心衰药物中的应用
JP2022535195A (ja) * 2019-05-19 2022-08-05 マイオカーディア，インク 収縮不全の処置
WO2020238885A1 (zh) * 2019-05-30 2020-12-03 深圳信立泰药业股份有限公司 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的治疗方法
TWI809313B (zh) * 2019-09-20 2023-07-21 大陸商深圳信立泰藥業股份有限公司 血管緊張素ii受體拮抗劑代謝產物與nep抑制劑的複合物的新心衰用途
WO2022037512A1 (zh) * 2020-08-17 2022-02-24 深圳信立泰药业股份有限公司 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的心衰应用

Also Published As

Publication number Publication date
US20220395491A1 (en) 2022-12-15
WO2021052441A1 (zh) 2021-03-25
KR20220012317A (ko) 2022-02-03
AU2020348813A1 (en) 2022-04-14
CN113286585A (zh) 2021-08-20
CN115487175A (zh) 2022-12-20
JP2022545904A (ja) 2022-11-01
AU2020348813B2 (en) 2025-09-11
CO2022004910A2 (es) 2022-05-31
TW202114652A (zh) 2021-04-16
MX2022003408A (es) 2022-07-12
CN115487175B (zh) 2024-05-14
JP7316449B2 (ja) 2023-07-27
EP4032532A1 (en) 2022-07-27
CA3151788A1 (en) 2021-03-25
CN113286585B (zh) 2022-11-08
EP4032532A4 (en) 2023-10-04
KR102752382B1 (ko) 2025-01-09
ZA202204370B (en) 2022-11-30
TWI809313B (zh) 2023-07-21
US12508246B2 (en) 2025-12-30

Similar Documents

Publication Publication Date Title
CO2023011071A2 (es) Agonistas del receptor gpcr, composiciones farmacéuticas que los comprenden y métodos para su uso
MX2024013963A (es) Un antagonista de il-4r util para el tratamiento o la prevencion del asma
MX2020013624A (es) Agonistas del receptor glp-1 y usos de los mismos.
CL2019001465A1 (es) Nuevos compuestos como agonistas peptídicos trigonales de los receptores de glp1/glucagón/gip.
CL2008003222A1 (es) Peptidos con actividad antagonista de glucagon y composicion farmaceutica que los comprende, utiles para el tratamiento de la hiperglicemia, para suprimir el apetito, reducir el aumento de peso y para tratar el desgaste catabolico.
DOP2018000297A (es) Derivado de glucagon, conjugado del mismo, composición que comprende el mismo y uso terapéutico del mismo
AR105284A1 (es) Derivados de exendina-4 como agonistas peptídicos duales específicos de los receptores de glp-1 / glucagón
MX2017001512A (es) Compuestos activos hacia bromodominios.
CO2017002160A2 (es) Derivados de pirimidina sustituidos con heterociclilo opcionalmente condensados útiles para el tratamiento de enfermedades inflamatorias, metabólicas, oncológicas y autoinmunitarias
CL2012003745A1 (es) Compuestos derivados de aminopirazoloquinazolinas, como inhibidores frente a la actividad fosforilante del receptor igf-1 localizado en membranas celulares; preparacion farmaceutica que los contiene; y su uso en el tratamiento y/o prevencion de cancer, infecciones, enfermedades inflamatorias y autoinmunitarias.
MX2016010998A (es) Terapia celular adoptiva que usa un agonista de receptor huérfano gamma relacionado con receptor de ácido retinoico y métodos terapéuticos relacionados.
CO2017008031A2 (es) Compuestos con actividad antagonista de los receptores muscarínicos y actividad agonista del receptor beta2 adrenérgico
AR111360A1 (es) Tratamiento usando células t de receptor quimérico incorporando células t polifuncionales optimizadas
ECSP22031078A (es) Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca
CO2022009510A2 (es) Compuestos activos frente a receptores nucleares
MX2018005715A (es) Uso de antagonistas del receptor ep4 para el tratamiento de cancer de higado asociado con nash.
MX2021008268A (es) Tratamiento de cefalea por uso excesivo de medicamentos usando anticuerpos anti-cgrp o anti-cgrp-r.
PE20211196A1 (es) Metodos para tratar inflamacion mediada por il-6 sin inmunosupresion
CL2018003045A1 (es) Semaglutida en afecciones cardiovasculares.
ECSP19062381A (es) Moduladores del receptor de estrógeno
CO7461127A2 (es) Código para la configuración de un dispositivo de atención al paciente
CR20120617A (es) Combinación de inhibidores de xantna oxidasa y antagonistas del receptor de angiotensina ii y su uso
MX376160B (es) Compuestos que tienen actividad antagonista del receptor muscarínico y actividad agonista del receptor beta2 adrenérgico.
CO6640306A2 (es) Combinación de inhibidores de xantina oxidasa y antagonistas del receptor de angiotensina ii y su uso
MX389729B (es) Uso de antagonistas de aplnr e inhibidores de vegf para tratar trastornos oculares.