ECSP22031078A - Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca - Google Patents

Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca

Info

Publication number
ECSP22031078A
ECSP22031078A ECSENADI202231078A ECDI202231078A ECSP22031078A EC SP22031078 A ECSP22031078 A EC SP22031078A EC SENADI202231078 A ECSENADI202231078 A EC SENADI202231078A EC DI202231078 A ECDI202231078 A EC DI202231078A EC SP22031078 A ECSP22031078 A EC SP22031078A
Authority
EC
Ecuador
Prior art keywords
heart failure
angiotensin
receptor antagonist
treatment
nep inhibitor
Prior art date
Application number
ECSENADI202231078A
Other languages
English (en)
Inventor
Jingchao Sun
Xiaolong Jing
Original Assignee
Shenzhen Salubris Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shenzhen Salubris Pharm Co Ltd filed Critical Shenzhen Salubris Pharm Co Ltd
Publication of ECSP22031078A publication Critical patent/ECSP22031078A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Los usos de un complejo de un metabolito antagonista del receptor de angiotensina II y un inhibidor de NEP para la insuficiencia card?aca, se relacionan espec?ficamente los usos del complejo en la preparaci?n de un medicamento para su uso en la insuficiencia card?aca con fracci?n de expulsi?n reducida (HFrEF).
ECSENADI202231078A 2019-09-20 2022-04-19 Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca ECSP22031078A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201910890853 2019-09-20
CN202010901984 2020-09-01

Publications (1)

Publication Number Publication Date
ECSP22031078A true ECSP22031078A (es) 2022-08-31

Family

ID=74883393

Family Applications (1)

Application Number Title Priority Date Filing Date
ECSENADI202231078A ECSP22031078A (es) 2019-09-20 2022-04-19 Usos del complejo de metabolito antagonista del receptor de angiotensina ii e inhibidor de nep en el tratamiento de la insuficiencia card?aca

Country Status (13)

Country Link
US (1) US12508246B2 (es)
EP (1) EP4032532A4 (es)
JP (1) JP7316449B2 (es)
KR (1) KR102752382B1 (es)
CN (2) CN115487175B (es)
AU (1) AU2020348813B2 (es)
CA (1) CA3151788A1 (es)
CO (1) CO2022004910A2 (es)
EC (1) ECSP22031078A (es)
MX (1) MX2022003408A (es)
TW (1) TWI809313B (es)
WO (1) WO2021052441A1 (es)
ZA (1) ZA202204370B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102752382B1 (ko) * 2019-09-20 2025-01-09 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 안지오텐신 ii 수용체 길항제 대사물질 및 nep 억제제의 복합체의 심부전 치료에서의 용도
TWI894333B (zh) * 2020-08-17 2025-08-21 大陸商深圳信立泰藥業股份有限公司 血管收縮素ii受體拮抗劑代謝產物與ｎｅｐ抑制劑的複合物用於心臟衰竭的應用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
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AU2004203284A1 (en) * 1998-11-06 2004-08-12 G.D. Searle & Co. Combination therapy of angiotensin converting enzyme inhibitor and aldosterone antagonist for reducing morbidity and mortality from cardiovascular disease
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
EP1778267A4 (en) * 2004-07-16 2010-01-06 Nitromed Inc COMPOSITIONS AND METHODS RELATED TO HEART ERROR
AR057882A1 (es) 2005-11-09 2007-12-26 Novartis Ag Compuestos de accion doble de bloqueadores del receptor de angiotensina e inhibidores de endopeptidasa neutra
EP2415739A4 (en) 2009-04-01 2014-01-08 Mitsui Chemicals Inc PROCESS FOR THE PRODUCTION OF OLEFIN
TW201336839A (zh) * 2012-02-15 2013-09-16 Theravance Inc （２ｓ，４ｒ）－５－聯苯－４－基－２－羥甲基－２－甲基－４－［（１ｈ－［１，２，３］三唑－４－羰基）－胺基］－戊酸５－甲基－２－酮基－［１，３］二氧雜環戊烯－４－基甲酯之結晶型
RS65037B1 (sr) * 2013-08-26 2024-02-29 Novartis Ag Lečenje kardiovaskularnih oboljenja
CN105503760A (zh) 2014-10-10 2016-04-20 上海翰森生物医药科技有限公司 结晶型ARB-NEPi双阳离子复合物及其制备方法和应用
CN106146472A (zh) 2015-04-15 2016-11-23 苏州朗科生物技术有限公司 一种双重作用的阿利沙坦复合物
CN106138041A (zh) 2015-04-15 2016-11-23 苏州朗科生物技术有限公司 一种双重作用的氯沙坦复合物
HUE071910T2 (hu) * 2015-05-11 2025-10-28 Novartis Ag Szakubitril-valzartán adagolási rend krónikus szisztolés szívelégtelenség kezelésére
WO2017006254A1 (en) * 2015-07-08 2017-01-12 Novartis Ag Drug combination comprising an angiotensin ii receptor antagonist, a neutral endopeptidase inhibitor and a mineralcorticoid receptor antagonist
CN105669581B (zh) 2015-11-09 2017-03-22 成都苑东生物制药股份有限公司 一种血管紧张受体拮抗剂和中性内肽酶抑制剂复合物
SMT202500110T1 (it) * 2016-01-20 2025-05-12 Shenzhen Salubris Pharm Co Ltd Metabolita antagonista del recettore dell'angiotensina ii e composito inibitore della nep e relativo metodo di preparazione
PT3408260T (pt) * 2016-03-08 2021-07-23 Theravance Biopharma R&D Ip Llc Ácido (2s,4r)-5-(5¿-cloro-2¿-fluoro-[1,1¿-bifenil]-4-il)-2- (etoximetil)-4-(3-hidroxi-isoxazole-5-carboxamido)-2- metilpentanoico cristalino e suas utilizações
CN108619138B (zh) * 2016-08-01 2020-07-03 珠海赛隆药业股份有限公司（长沙）医药研发中心 血管紧张素受体拮抗剂和脑啡肽酶抑制剂的复合物及其用途
CN106924241A (zh) * 2017-04-28 2017-07-07 广州医科大学 川陈皮素在预防或治疗心衰药物中的应用
CA3138080A1 (en) * 2019-05-19 2020-11-26 Jean-Francois TAMBY Treatment of systolic dysfunction and heart failure with reduced ejection fraction with the compound(r)-4-(1-((3-(difluoromethyl)-1-methyl-1h-pyrazol-4-yl)sulfonyl)-1-fluoroethyl) n-(isoxazol-3-yl)piperidine-1-carboxamid
WO2020238885A1 (zh) * 2019-05-30 2020-12-03 深圳信立泰药业股份有限公司 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的治疗方法
KR102752382B1 (ko) * 2019-09-20 2025-01-09 심천 사루브리스 퍼머수티칼스 컴퍼니 리미티드 안지오텐신 ii 수용체 길항제 대사물질 및 nep 억제제의 복합체의 심부전 치료에서의 용도
TWI894333B (zh) * 2020-08-17 2025-08-21 大陸商深圳信立泰藥業股份有限公司 血管收縮素ii受體拮抗劑代謝產物與ｎｅｐ抑制劑的複合物用於心臟衰竭的應用

Also Published As

Publication number Publication date
ZA202204370B (en) 2022-11-30
CN115487175B (zh) 2024-05-14
US12508246B2 (en) 2025-12-30
CA3151788A1 (en) 2021-03-25
AU2020348813B2 (en) 2025-09-11
CO2022004910A2 (es) 2022-05-31
CN115487175A (zh) 2022-12-20
KR102752382B1 (ko) 2025-01-09
JP7316449B2 (ja) 2023-07-27
MX2022003408A (es) 2022-07-12
TWI809313B (zh) 2023-07-21
AU2020348813A1 (en) 2022-04-14
CN113286585A (zh) 2021-08-20
JP2022545904A (ja) 2022-11-01
TW202114652A (zh) 2021-04-16
US20220395491A1 (en) 2022-12-15
KR20220012317A (ko) 2022-02-03
WO2021052441A1 (zh) 2021-03-25
EP4032532A1 (en) 2022-07-27
CN113286585B (zh) 2022-11-08
EP4032532A4 (en) 2023-10-04

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