ECSP22082569A - Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación - Google Patents
Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparaciónInfo
- Publication number
- ECSP22082569A ECSP22082569A ECSENADI202282569A ECDI202282569A ECSP22082569A EC SP22082569 A ECSP22082569 A EC SP22082569A EC SENADI202282569 A ECSENADI202282569 A EC SENADI202282569A EC DI202282569 A ECDI202282569 A EC DI202282569A EC SP22082569 A ECSP22082569 A EC SP22082569A
- Authority
- EC
- Ecuador
- Prior art keywords
- modified release
- pharmaceutically acceptable
- preparation
- dosage form
- oral dosage
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000006186 oral dosage form Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- KBAUFVUYFNWQFM-UHFFFAOYSA-N Doxylamine succinate Chemical compound OC(=O)CCC(O)=O.C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 KBAUFVUYFNWQFM-UHFFFAOYSA-N 0.000 title abstract 2
- 229960005008 doxylamine succinate Drugs 0.000 title abstract 2
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 title abstract 2
- 229960004172 pyridoxine hydrochloride Drugs 0.000 title abstract 2
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 title abstract 2
- 239000011764 pyridoxine hydrochloride Substances 0.000 title abstract 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 abstract 4
- 239000011248 coating agent Substances 0.000 abstract 3
- 238000000576 coating method Methods 0.000 abstract 3
- 239000002245 particle Substances 0.000 abstract 3
- 239000011247 coating layer Substances 0.000 abstract 2
- 229960005178 doxylamine Drugs 0.000 abstract 2
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 abstract 2
- 239000010410 layer Substances 0.000 abstract 2
- 239000008188 pellet Substances 0.000 abstract 2
- 235000008160 pyridoxine Nutrition 0.000 abstract 2
- 239000011677 pyridoxine Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229940011671 vitamin b6 Drugs 0.000 abstract 2
- 239000011229 interlayer Substances 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Botany (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación La presente invención se refiere una forma de dosificación oral de múltiples unidades de liberación modificada que comprende: una primera pluralidad de microgránulos de liberación modificada de doxilamina que comprende: un núcleo inerte farmacéuticamente aceptable; una capa interna de recubrimiento activo que comprende una doxilamina; opcionalmente, una capa intermedia de recubrimiento de liberación entérica; y una capa externa de recubrimiento de liberación modificada; y una segunda pluralidad de microgránulos de liberación modificada de piridoxina o de una sal farmacéuticamente aceptable de la misma que comprende: un núcleo inerte farmacéuticamente aceptable; una capa interna de recubrimiento activo que comprende piridoxina o una sal farmacéuticamente aceptable de la misma; y una capa externa de recubrimiento de liberación modificada; en donde el tamaño de partícula del núcleo inerte farmacéuticamente aceptable de la primera y segunda pluralidad de microgránulos es tal que al menos el 90 % de los núcleos inertes tienen un tamaño de partícula de 300 µm a 1.700 µm y una variabilidad del tamaño de partícula de no más de 200 µm medida mediante tamizado analítico. También se refiere a un procedimiento para su preparación y su uso en terapia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20382227 | 2020-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP22082569A true ECSP22082569A (es) | 2022-12-30 |
Family
ID=70189866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSENADI202282569A ECSP22082569A (es) | 2020-03-25 | 2022-10-21 | Una forma de dosificación oral de múltiples unidades de liberación modificada de succinato de doxilamina y clorhidrato de piridoxina y un procedimiento para su preparación |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP4125825B1 (es) |
| JP (1) | JP7735301B2 (es) |
| KR (1) | KR20220158703A (es) |
| CN (1) | CN115697311B (es) |
| AR (1) | AR121619A1 (es) |
| AU (1) | AU2021243600B2 (es) |
| BR (1) | BR112022018366A2 (es) |
| CL (1) | CL2022002572A1 (es) |
| CO (1) | CO2022013621A2 (es) |
| CR (1) | CR20220527A (es) |
| DK (1) | DK4125825T3 (es) |
| EC (1) | ECSP22082569A (es) |
| ES (1) | ES2973785T3 (es) |
| FI (1) | FI4125825T3 (es) |
| HR (1) | HRP20240284T1 (es) |
| HU (1) | HUE065414T2 (es) |
| JO (1) | JOP20220229A1 (es) |
| LT (1) | LT4125825T (es) |
| MA (1) | MA59146B1 (es) |
| MX (1) | MX2022011737A (es) |
| PE (1) | PE20221832A1 (es) |
| PH (1) | PH12022552521A1 (es) |
| PL (1) | PL4125825T3 (es) |
| PT (1) | PT4125825T (es) |
| RS (1) | RS65226B1 (es) |
| SI (1) | SI4125825T1 (es) |
| SM (1) | SMT202400158T1 (es) |
| UA (1) | UA129276C2 (es) |
| WO (1) | WO2021191268A1 (es) |
| ZA (1) | ZA202211174B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20260122A1 (es) | 2023-05-22 | 2026-01-16 | Italfarmaco Spa | Una forma de dosificacion oral de unidades multiples de succinato de doxilamina y clorhidrato de piridoxina sin dioxido de titanio |
| US12303604B1 (en) | 2024-10-16 | 2025-05-20 | Currax Pharmaceuticals Llc | Pharmaceutical formulations comprising naltrexone and/or bupropion |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2558396B2 (ja) * | 1990-06-28 | 1996-11-27 | 田辺製薬株式会社 | 放出制御型製剤 |
| CA2392486A1 (en) * | 2002-07-05 | 2002-12-08 | Duchesnay Inc. | Pharmaceutical dosage form bearing pregnancy-friendly indicia |
| CA2406592C (en) * | 2002-10-04 | 2003-09-30 | Duchesnay Inc. | Method of preparing pharmaceutical dosage forms containing multiple active ingredients |
| CA2432945C (en) * | 2003-07-10 | 2004-11-23 | Duchesnay Inc. | Use of doxylamime succinate and pyridoxine hydrochloride for prophylaxis and treatment of post-surgical vomiting |
| US20070141147A1 (en) * | 2005-12-21 | 2007-06-21 | Auriga Laboratories, Inc. | Sequential release pharmaceutical formulations |
| RU2607595C2 (ru) * | 2010-02-03 | 2017-01-10 | Фарма Ту Б Лтд. | Составы разагилина с пролонгированным высвобождением и их применение |
| CA2761212A1 (en) * | 2011-12-07 | 2013-06-07 | Pharmascience Inc. | Disintegrant-free delayed release doxylamine and pyridoxine formulation and process of it manufacturing |
| WO2013123569A1 (en) | 2012-02-22 | 2013-08-29 | Duchesnay Inc. | Formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| MX355912B (es) * | 2012-02-22 | 2018-05-04 | Duchesnay Inc | Formulación de doxilamina y piridoxina y/o sus metabolitos o sales. |
| EP3185856B1 (en) * | 2014-08-29 | 2018-05-23 | Duchesnay Inc. | Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| US9526703B2 (en) * | 2014-08-29 | 2016-12-27 | Duchesnay Inc. | Plurimodal release formulation of doxylamine and pyridoxine and/or metabolites or salts thereof |
| CN106606502B (zh) * | 2015-10-27 | 2019-12-31 | 四川海思科制药有限公司 | 一种琥珀酸多西拉敏盐酸吡哆醇肠溶片药物组合物及其制备方法 |
| RS61368B1 (sr) * | 2018-09-27 | 2021-02-26 | Inibsa Ginecologia S A | Postupak za pripremu višejediničnog oralnog doznog oblika sa modifikovanim oslobađanjem doksilamin sukcinata i piridoksin hidrohlorida |
-
2021
- 2021-03-19 AR ARP210100692A patent/AR121619A1/es unknown
- 2021-03-24 RS RS20240227A patent/RS65226B1/sr unknown
- 2021-03-24 PE PE2022002070A patent/PE20221832A1/es unknown
- 2021-03-24 EP EP21712892.5A patent/EP4125825B1/en active Active
- 2021-03-24 AU AU2021243600A patent/AU2021243600B2/en active Active
- 2021-03-24 SI SI202130114T patent/SI4125825T1/sl unknown
- 2021-03-24 PL PL21712892.5T patent/PL4125825T3/pl unknown
- 2021-03-24 HU HUE21712892A patent/HUE065414T2/hu unknown
- 2021-03-24 FI FIEP21712892.5T patent/FI4125825T3/fi active
- 2021-03-24 BR BR112022018366A patent/BR112022018366A2/pt unknown
- 2021-03-24 CN CN202180037889.9A patent/CN115697311B/zh active Active
- 2021-03-24 MX MX2022011737A patent/MX2022011737A/es unknown
- 2021-03-24 CR CR20220527A patent/CR20220527A/es unknown
- 2021-03-24 ES ES21712892T patent/ES2973785T3/es active Active
- 2021-03-24 KR KR1020227032023A patent/KR20220158703A/ko active Pending
- 2021-03-24 UA UAA202203961A patent/UA129276C2/uk unknown
- 2021-03-24 DK DK21712892.5T patent/DK4125825T3/da active
- 2021-03-24 JP JP2022558004A patent/JP7735301B2/ja active Active
- 2021-03-24 MA MA59146A patent/MA59146B1/fr unknown
- 2021-03-24 PH PH1/2022/552521A patent/PH12022552521A1/en unknown
- 2021-03-24 HR HRP20240284TT patent/HRP20240284T1/hr unknown
- 2021-03-24 SM SM20240158T patent/SMT202400158T1/it unknown
- 2021-03-24 PT PT217128925T patent/PT4125825T/pt unknown
- 2021-03-24 LT LTEPPCT/EP2021/057555T patent/LT4125825T/lt unknown
- 2021-03-24 WO PCT/EP2021/057555 patent/WO2021191268A1/en not_active Ceased
- 2021-09-30 JO JOJO/P/2022/0229A patent/JOP20220229A1/ar unknown
-
2022
- 2022-09-22 CL CL2022002572A patent/CL2022002572A1/es unknown
- 2022-09-22 CO CONC2022/0013621A patent/CO2022013621A2/es unknown
- 2022-10-12 ZA ZA2022/11174A patent/ZA202211174B/en unknown
- 2022-10-21 EC ECSENADI202282569A patent/ECSP22082569A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2022002572A1 (es) | 2023-05-26 |
| JP2023520671A (ja) | 2023-05-18 |
| BR112022018366A2 (pt) | 2022-11-08 |
| JP7735301B2 (ja) | 2025-09-08 |
| SMT202400158T1 (it) | 2024-05-14 |
| MA59146B1 (fr) | 2024-03-29 |
| RS65226B1 (sr) | 2024-03-29 |
| WO2021191268A1 (en) | 2021-09-30 |
| HUE065414T2 (hu) | 2024-05-28 |
| CO2022013621A2 (es) | 2022-10-11 |
| PL4125825T3 (pl) | 2024-05-06 |
| AR121619A1 (es) | 2022-06-22 |
| AU2021243600A1 (en) | 2022-09-29 |
| CR20220527A (es) | 2022-11-23 |
| MX2022011737A (es) | 2022-10-13 |
| ES2973785T3 (es) | 2024-06-24 |
| PE20221832A1 (es) | 2022-11-29 |
| JOP20220229A1 (ar) | 2021-09-30 |
| EP4125825A1 (en) | 2023-02-08 |
| PT4125825T (pt) | 2024-02-28 |
| CN115697311A (zh) | 2023-02-03 |
| ZA202211174B (en) | 2024-02-28 |
| LT4125825T (lt) | 2024-03-12 |
| AU2021243600B2 (en) | 2026-03-19 |
| CN115697311B (zh) | 2025-01-28 |
| EP4125825B1 (en) | 2024-01-31 |
| SI4125825T1 (sl) | 2024-04-30 |
| UA129276C2 (uk) | 2025-03-05 |
| FI4125825T3 (fi) | 2024-02-23 |
| DK4125825T3 (da) | 2024-02-26 |
| HRP20240284T1 (hr) | 2024-05-24 |
| PH12022552521A1 (en) | 2024-02-19 |
| KR20220158703A (ko) | 2022-12-01 |
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