ECSP941031A - Derivados de timosina alfa 1 - Google Patents

Derivados de timosina alfa 1

Info

Publication number
ECSP941031A
ECSP941031A EC1994001031A ECSP941031A ECSP941031A EC SP941031 A ECSP941031 A EC SP941031A EC 1994001031 A EC1994001031 A EC 1994001031A EC SP941031 A ECSP941031 A EC SP941031A EC SP941031 A ECSP941031 A EC SP941031A
Authority
EC
Ecuador
Prior art keywords
glu
derivatives
thr
lys
val
Prior art date
Application number
EC1994001031A
Other languages
English (en)
Inventor
Wang Su-Sun
Original Assignee
Sciclone Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sciclone Pharmaceuticals Inc filed Critical Sciclone Pharmaceuticals Inc
Publication of ECSP941031A publication Critical patent/ECSP941031A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57581—Thymosin; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de la fórmula: R1-X-R2-Y (I) en donde X es Ser-Asp-Ala-Ala-Val-Asp-Thr-Ser-Ser-Glu-Ile-Thr-Thr-Lys-Asp-Leu-Lys-Glu-Lys-Glu-Val-Val-Glu-Glu-Ala-Glu o un derivado o un fragmento del mismo biológicamente activo, R1 es Ac o Z en donde, Ac es un grupo acetilo y Z es (fórmula)
EC1994001031A 1993-02-03 1994-01-28 Derivados de timosina alfa 1 ECSP941031A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1308793A 1993-02-03 1993-02-03

Publications (1)

Publication Number Publication Date
ECSP941031A true ECSP941031A (es) 1994-09-16

Family

ID=21758238

Family Applications (1)

Application Number Title Priority Date Filing Date
EC1994001031A ECSP941031A (es) 1993-02-03 1994-01-28 Derivados de timosina alfa 1

Country Status (7)

Country Link
US (1) US5512656A (es)
CN (2) CN1058500C (es)
AU (1) AU6235194A (es)
EC (1) ECSP941031A (es)
MY (1) MY111439A (es)
PH (1) PH30414A (es)
WO (1) WO1994018233A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5273963A (en) * 1991-03-29 1993-12-28 The George Washington University Compositions and methods for treating small cell and nonsmall cell lung cancers
WO2001096527A2 (en) * 2000-06-14 2001-12-20 Chanda Zaveri Peptides with physiological activity
BR0114642A (pt) * 2000-10-13 2004-01-20 Univ Monash Prevenção de doenças através da reativação do timo
WO2004048971A1 (en) * 2002-11-25 2004-06-10 Sciclone Pharmaceuticals, Inc. Methods of protecting against radiation damage using alpha thymosin
EP1613340B1 (en) 2003-03-28 2010-05-12 SciClone Pharmaceuticals, Inc. Treatment of aspergillus infections with thymosin alpha 1
KR20070119615A (ko) * 2005-01-14 2007-12-20 리지너크스 바이오 파마소티컬스, 인코포레이티드 개질된 베타 티모신 펩티드
ES2288118B1 (es) * 2006-05-10 2008-11-01 Bcn Peptides, S.A. Procedimiento para sintetizar timosinas.
WO2009151689A2 (en) 2008-03-17 2009-12-17 Regenerx Biopharmaceuticals, Inc. Improved beta thymosin fragments
CN102580059A (zh) * 2012-03-28 2012-07-18 厦门大学 胸腺素α原在制备预防和治疗肝癌药物中的应用
CN113135988B (zh) * 2021-04-08 2022-04-01 润辉生物技术（威海）有限公司 一种胸腺肽β4的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US447926A (en) * 1891-03-10 Process of obtaining bromine and iodine
US4079127A (en) * 1976-10-28 1978-03-14 Board Of Regents Of The University Of Texas Thymosin alpha 1
CH641152A5 (en) * 1977-04-22 1984-02-15 Hoffmann La Roche Process for preparing thymosin alpha-1 and an analogue
US4116951A (en) * 1977-04-22 1978-09-26 Hoffmann-La Roche Inc. [Asn2 ]-thymosin α1 and analogs thereof
US4148788A (en) * 1978-01-23 1979-04-10 Hoffmann-La Roche Inc. Synthesis of thymosin α1
DE2919592A1 (de) * 1979-05-15 1981-01-15 Max Planck Gesellschaft Verfahren zur herstellung von thymosin- alpha 1 und derivaten davon
DE3100974A1 (de) * 1980-01-18 1982-01-21 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente enthaltende arzneimittel mit immunregulierender wirkung, und thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-fragmente
US4293455A (en) * 1980-04-07 1981-10-06 Rockefeller University N.sup.α -Desacetylthymosinα1 and process
EP0056594B1 (de) * 1981-01-14 1984-09-12 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Thymosin-alpha-1-Fragmente enthaltende Arzneimittel mit immunregulierender Wirkung und Thymosin-alpha-1-Fragmente
DE3137231A1 (de) * 1981-09-18 1983-04-14 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Bis-thymosin(alpha)(pfeil abwaerts)1(pfeil abwaerts)-verbindungen
US4855407A (en) * 1985-04-11 1989-08-08 Alpha-1 Biomedicals, Inc. Solid phase process for synthesizing peptides

Also Published As

Publication number Publication date
PH30414A (en) 1997-05-09
CN1058500C (zh) 2000-11-15
AU6235194A (en) 1994-08-29
CN1150208C (zh) 2004-05-19
US5512656A (en) 1996-04-30
MY111439A (en) 2000-05-31
CN1223266A (zh) 1999-07-21
WO1994018233A1 (en) 1994-08-18
CN1094411A (zh) 1994-11-02

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