ECSP972112A - INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS - Google Patents
INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDSInfo
- Publication number
- ECSP972112A ECSP972112A ECSP972112A ECSP972112A EC SP972112 A ECSP972112 A EC SP972112A EC SP972112 A ECSP972112 A EC SP972112A EC SP972112 A ECSP972112 A EC SP972112A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- disorders
- diseases
- pharmaceutical compositions
- matrix metalloprotease
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 239000011159 matrix material Substances 0.000 title abstract 3
- 230000005764 inhibitory process Effects 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 208000035475 disorder Diseases 0.000 abstract 3
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010053555 Arthritis bacterial Diseases 0.000 abstract 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 abstract 1
- 208000016192 Demyelinating disease Diseases 0.000 abstract 1
- 206010053177 Epidermolysis Diseases 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 206010060820 Joint injury Diseases 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000028911 Temporomandibular Joint disease Diseases 0.000 abstract 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 abstract 1
- 208000007474 aortic aneurysm Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 208000002528 coronary thrombosis Diseases 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
- 230000009401 metastasis Effects 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 201000001474 proteinuria Diseases 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 201000001223 septic arthritis Diseases 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada: (gráfico), donde R25 es una porción feniletilo sustituída. Estos compuestos son útiles para inhibir la metaloproteasa de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis, la artritis rematoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la osteoporosis en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso; la metátasis de tumores o la pérdida degenerativa de cartílago posterior a la lesión articular traumática, y la trombosis coronaria por ruptura de placa aterosclerótica. La presente invención se relaciona asi mismo con composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula: (graph), where R25 is a substituted phenylethyl moiety. These compounds are useful for inhibiting matrix metalloprotease and, therefore, for combating disorders to which MMPs contribute, such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that produce inflammatory responses, osteoporosis in which MMP activity mediates, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastasis or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis due to atherosclerotic plaque rupture. The present invention likewise relates to pharmaceutical compositions and methods of treating such disorders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972112 ECSP972112A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972112 ECSP972112A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972112A true ECSP972112A (en) | 1998-04-24 |
Family
ID=42042943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972112 ECSP972112A (en) | 1997-05-12 | 1997-05-12 | INHIBITION OF MATRIX METALOPROTEASES BY SUBSTITUTED FENETILE COMPOUNDS |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972112A (en) |
-
1997
- 1997-05-12 EC ECSP972112 patent/ECSP972112A/en unknown
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