ECSP972114A - BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE - Google Patents
BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASEInfo
- Publication number
- ECSP972114A ECSP972114A ECSP972114A ECSP972114A EC SP972114 A ECSP972114 A EC SP972114A EC SP972114 A ECSP972114 A EC SP972114A EC SP972114 A ECSP972114 A EC SP972114A
- Authority
- EC
- Ecuador
- Prior art keywords
- compounds
- disorders
- diseases
- graph
- pharmaceutical compositions
- Prior art date
Links
- 239000011159 matrix material Substances 0.000 title abstract 3
- 239000003112 inhibitor Substances 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 208000035475 disorder Diseases 0.000 abstract 3
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 2
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 206010053555 Arthritis bacterial Diseases 0.000 abstract 1
- 208000037260 Atherosclerotic Plaque Diseases 0.000 abstract 1
- 206010011091 Coronary artery thrombosis Diseases 0.000 abstract 1
- 208000016192 Demyelinating disease Diseases 0.000 abstract 1
- 206010053177 Epidermolysis Diseases 0.000 abstract 1
- 208000004575 Infectious Arthritis Diseases 0.000 abstract 1
- 206010060820 Joint injury Diseases 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 206010027476 Metastases Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 208000028911 Temporomandibular Joint disease Diseases 0.000 abstract 1
- 101000998548 Yersinia ruckeri Alkaline proteinase inhibitor Proteins 0.000 abstract 1
- 208000007474 aortic aneurysm Diseases 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 201000007717 corneal ulcer Diseases 0.000 abstract 1
- 208000002528 coronary thrombosis Diseases 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000028709 inflammatory response Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
- 210000000653 nervous system Anatomy 0.000 abstract 1
- 201000008482 osteoarthritis Diseases 0.000 abstract 1
- 208000028169 periodontal disease Diseases 0.000 abstract 1
- 201000001474 proteinuria Diseases 0.000 abstract 1
- 201000001223 septic arthritis Diseases 0.000 abstract 1
- 230000000472 traumatic effect Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se presentan compuestos inhibidores de la metaloproteasa de matriz, composiciones farmacéuticas de los mismos y un método de tratamiento de enfermedades mediante el uso de dichos compuestos. Los compuestos de la presente invención tiene la fórmula generalizada (gráfico), donde R15 es seleccionado entre el grupo que consiste en HOCH2, MEOCH2, (N-Pr)2Nch2, CH3CO2CH2, EtOCO2CH2, HO(CH2)2CH3CO2 (CH2)2, HO; C(CH2)2, OHC(CH2)3, HO(CH2)4, Ph, y 3 -HO-Ph, y Ph y PhCH2OCH2:y (gráfico), Estos compuestos son útiles para inhibir las metaloproteasas de matriz y, por lo tanto, para combatir los trastornos a los cuales contribuyen las MMP, tales como la osteoartritis reumatoidea, la artritis séptica, las enfermedades periodontales, las úlceras de córnea, la proteinuria, la enfermedad de aneurisma aórtico, la epidermólisis vesicular distrófica, los trastornos que producen respuestas inflamatorias, la osteoporosis en las que media la actividad de MMP, la enfermedad de la articulación temporomandibular, las enfermedades desmielinizantes del sistema nervioso; las metástasis de tumores o la pérdida degenerativa de cartilago posterior a la lesión articular traumática, y la trombosis coronaria a partir de la ruptura de placa ateroesclerótica. La presente invención presenta asi mismo composiciones farmacéuticas y métodos para tratar dichos trastornos.Matrix metalloprotease inhibitor compounds, pharmaceutical compositions thereof and a method of treating diseases by using such compounds are presented. The compounds of the present invention have the generalized formula (graph), where R15 is selected from the group consisting of HOCH2, MEOCH2, (N-Pr) 2Nch2, CH3CO2CH2, EtOCO2CH2, HO (CH2) 2CH3CO2 (CH2) 2, HO ; C (CH2) 2, OHC (CH2) 3, HO (CH2) 4, Ph, and 3 -HO-Ph, and Ph and PhCH2OCH2: and (graph), These compounds are useful for inhibiting matrix metalloproteases and, for Therefore, to combat the disorders to which MMPs contribute, such as rheumatoid osteoarthritis, septic arthritis, periodontal diseases, corneal ulcers, proteinuria, aortic aneurysm disease, dystrophic vesicular epidermolysis, disorders that they produce inflammatory responses, osteoporosis in which they mediate MMP activity, temporomandibular joint disease, demyelinating diseases of the nervous system; tumor metastases or degenerative cartilage loss following traumatic joint injury, and coronary thrombosis from atherosclerotic plaque rupture. The present invention also presents pharmaceutical compositions and methods for treating said disorders.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972114 ECSP972114A (en) | 1997-05-12 | 1997-05-12 | BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ECSP972114 ECSP972114A (en) | 1997-05-12 | 1997-05-12 | BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP972114A true ECSP972114A (en) | 1998-04-24 |
Family
ID=42042945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ECSP972114 ECSP972114A (en) | 1997-05-12 | 1997-05-12 | BIARYLACETYLENE AS INHIBITORS OF MATRIX METALOPROTEASE |
Country Status (1)
| Country | Link |
|---|---|
| EC (1) | ECSP972114A (en) |
-
1997
- 1997-05-12 EC ECSP972114 patent/ECSP972114A/en unknown
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